{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:10:40Z","timestamp":1790187040931,"version":"4.1.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.pt.2017.11.010","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T08:39:42Z","timestamp":1513586382000},"page":"184-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Reasons to Be Nervous about Flukicide Discovery"],"prefix":"10.1016","volume":"34","author":[{"given":"Paul","family":"McVeigh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"McCusker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mousley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki J.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron G.","family":"Maule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2017.11.010_bib0005","series-title":"Fasciolosis","first-page":"465","article-title":"Fasciola gigantica: epidemiology, control, immunology and molecular biology","author":"Spithill","year":"1999"},{"key":"10.1016\/j.pt.2017.11.010_bib0010","series-title":"Liver Fluke Control in Sheep","author":"NADIS","year":"2016"},{"key":"10.1016\/j.pt.2017.11.010_bib0015","unstructured":"Gray, G.D. et al. (eds) (2008) Overcoming Liver Fluke as a Constraint to Ruminant Production in South-East Asia, Australian Center for International Agriculture Research"},{"key":"10.1016\/j.pt.2017.11.010_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016126","article-title":"Predicting impacts of climate change on Fasciola hepatica risk","volume":"6","author":"Fox","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2017.11.010_bib0025","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI34261","article-title":"Helminth infections: the great neglected tropical diseases","volume":"118","author":"Hotez","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pt.2017.11.010_bib0030","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3201\/eid1806.120302","article-title":"Apparent triclabendazole-resistant human Fasciola hepatica infection, the Netherlands","volume":"18","author":"Winkelhagen","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004361","article-title":"Treatment failure after multiple courses of triclabendazole among patients with fasciolosis in Cusco, Peru: a case series","volume":"10","author":"Cabada","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0040","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ijpara.2014.07.011","article-title":"Liver fluke vaccines in ruminants: strategies, progress and future opportunities","volume":"44","author":"Toet","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0045","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.pt.2016.03.002","article-title":"Current threat of triclabendazole resistance in Fasciola hepatica","volume":"32","author":"Kelley","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-03094-0","article-title":"Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica","volume":"7","author":"Ruiz-Campillo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2017.11.010_bib0055","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2307\/3283469","article-title":"The nervous systems of helminths as targets for drugs","volume":"78","author":"Geary","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijpddr.2011.10.004","article-title":"Parasite neuropeptide biology: seeding rational drug target selection?","volume":"2","author":"McVeigh","year":"2012","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.pt.2017.11.010_bib0065","series-title":"The Oxford Handbook of Invertebrate Neurobiology","article-title":"Flatworm neurobiology in the postgenomic era","author":"McVeigh","year":"2017"},{"key":"10.1016\/j.pt.2017.11.010_bib0070","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1017\/S0031182000066531","article-title":"Physiological effects of platyhelminth RFamide peptides on muscle-strip preparations of Fasciola hepatica (Trematoda: Digenea)","volume":"113","author":"Marks","year":"1996","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.11.010_bib0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpara.2003.10.007","article-title":"Pharmacological characterisation of neuropeptide F (NPF)-induced effects on the motility of Mesocestoides corti (syn. Mesocestoides vogae) larvae","volume":"24","author":"Hr\u010dkov\u00e1","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0080","doi-asserted-by":"crossref","first-page":"39880","DOI":"10.1074\/jbc.M405624200","article-title":"Structure and bioactivity of neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum","volume":"279","author":"Humphries","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2017.11.010_bib0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0169-4758(97)01182-4","article-title":"Muscling in on parasitic flatworms","volume":"14","author":"Mair","year":"1998","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.pt.2017.11.010_bib0090","series-title":"Neuropeptide Systems as Targets for Parasite and Pest Control","first-page":"49","article-title":"Neuropeptides in helminths: occurrence and distribution","author":"Marks","year":"2010"},{"key":"10.1016\/j.pt.2017.11.010_bib0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002457","article-title":"GPCRs direct germline development and somatic gonad function in planarians","volume":"14","author":"Saberi","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2017.11.010_bib0100","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijpara.2006.12.019","article-title":"Identification of a platyhelminth neuropeptide receptor","volume":"37","author":"Omar","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40588-014-0007-6","article-title":"Ion channels and drug transporters as targets for anthelmintics","volume":"1","author":"Greenberg","year":"2014","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"10.1016\/j.pt.2017.11.010_bib0110","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"Berriman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.pt.2017.11.010_bib0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"Tsai","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.pt.2017.11.010_bib0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13071-016-1428-2","article-title":"Pipeline for the identification and classification of ion channels in parasitic flatworms","volume":"9","author":"Nor","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2017.11.010_bib0125","doi-asserted-by":"crossref","first-page":"41650","DOI":"10.1074\/jbc.M408203200","article-title":"Functional characterization of a P2X receptor from Schistosoma mansoni","volume":"279","author":"Agboh","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2017.11.010_bib0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbamem.2005.01.009","article-title":"High zinc sensitivity and pore formation in an invertebrate P2X receptor","volume":"1669","author":"Raouf","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2017.11.010_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003586","article-title":"Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni","volume":"9","author":"Dufour","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.11.010_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004181","article-title":"Functional characterization of a novel family of acetylcholine-gated chloride channels in Schistosoma mansoni","volume":"10","author":"MacDonald","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.11.010_bib0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S0031182000066270","article-title":"Cholinergic inhibition of muscle fibres isolated from Schistosoma mansoni (Trematoda:Digenea)","volume":"113","author":"Day","year":"1996","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.11.010_bib0150","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1074\/jbc.M412644200","article-title":"A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans","volume":"280","author":"Putrenko","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2017.11.010_bib0155","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuroscience.2010.03.038","article-title":"Analysis of motor function modulated by cholinergic neurons in planarian Dugesia japonica","volume":"168","author":"Nishimura","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.pt.2017.11.010_bib0160","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.neuroscience.2008.03.026","article-title":"Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia japonica","volume":"153","author":"Nishimura","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.pt.2017.11.010_bib0165","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuint.2008.09.006","article-title":"Characterization of tyramine beta-hydroxylase in planarian Dugesia japonica: cloning and expression","volume":"53","author":"Nishimura","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.pt.2017.11.010_bib0170","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.devcel.2005.02.014","article-title":"Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria","volume":"8","author":"Reddien","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.pt.2017.11.010_bib0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1017\/S0031182000080707","article-title":"Structure\u2013activity relationships of FMRFamide-related peptides contracting Schistosoma mansoni (Trematoda: Digenea) muscle fibres in vitro","volume":"109","author":"Day","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.11.010_bib0180","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1096\/fj.03-0429com","article-title":"A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni","volume":"18","author":"Mair","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.pt.2017.11.010_bib0185","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molbiopara.2010.05.009","article-title":"A PAL for Schistosoma mansoni PHM","volume":"173","author":"Atkinson","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0190","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/1570159X11311030006","article-title":"Actylcholinesterase inhibitors: pharmacology and toxicology","volume":"11","author":"\u010colovi\u0107","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.pt.2017.11.010_bib0195","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.parint.2013.06.003","article-title":"Neurotransmitter transporters in schistosomes: structure, function and prospects for drug discovery","volume":"62","author":"Ribeiro","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.pt.2017.11.010_bib0200","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tips.2006.05.003","article-title":"Neurotransmitter transporters: molecular function of important drug targets","volume":"27","author":"Gether","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.pt.2017.11.010_bib0205","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molbiopara.2012.11.008","article-title":"The functional role of a serotonin transporter in Schistosoma mansoni elucidated through immunolocalization and RNA interference (RNAi)","volume":"187","author":"Patocka","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pt.2017.11.010_bib0215","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbiopara.2015.09.001","article-title":"A constitutively active G protein-coupled acetylcholine receptor regulates motility of larval Schistosoma mansoni","volume":"202","author":"MacDonald","year":"2015","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molbiopara.2009.06.003","article-title":"Investigation of a dopamine receptor in Schistosoma mansoni: functional studies and immunolocalization","volume":"168","author":"Taman","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0225","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exppara.2009.01.001","article-title":"Developmental expression analysis and immunolocalization of a biogenic amine receptor in Schistosoma mansoni","volume":"122","author":"El-Shehabi","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001523","article-title":"A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system","volume":"6","author":"El-Shehabi","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0235","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0166-6851(01)00400-5","article-title":"A novel Schistosoma mansoni G protein-coupled receptor is responsive to histamine","volume":"119","author":"Hamdan","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0240","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.ijpara.2010.04.006","article-title":"Histamine signalling in Schistosoma mansoni: immunolocalization and characterisation of a new histamine-responsive receptor (SmGPR-2)","volume":"40","author":"El-Shehabi","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003878","article-title":"Serotonin signaling in Schistosoma mansoni: a serotonin-activated G protein-coupled receptor controls parasite movement","volume":"10","author":"Patocka","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.11.010_bib0250","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1248\/bpb.32.1672","article-title":"Identification of a novel planarian G protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes","volume":"32","author":"Nishimura","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.pt.2017.11.010_bib0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040787","article-title":"Novel RNAi-mediated approach to G protein-coupled receptor deorphanization: proof of principle and characterization of a planarian 5-HT receptor","volume":"7","author":"Zamanian","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2017.11.010_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005651","article-title":"A miniaturized screen of a Schistosoma mansoni serotonergic G protein-coupled receptor identifies novel classes of parasite-selective inhibitors","volume":"12","author":"Chan","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2017.11.010_bib0265","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijpddr.2016.06.001","article-title":"Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist","volume":"6","author":"Chan","year":"2016","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.pt.2017.11.010_bib0270","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijpddr.2016.06.002","article-title":"Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist","volume":"6","author":"Chan","year":"2016","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.pt.2017.11.010_bib0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004063","article-title":"Ergot alkaloids (re)generate new leads as antiparasitics","volume":"9","author":"Chan","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000509","article-title":"Genome-wide analyses reveal a role for peptide hormones in planarian germline development","volume":"8","author":"Collins","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2017.11.010_bib0285","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3947\/ic.2013.45.1.32","article-title":"Praziquantel treatment in trematode and cestode infections: an update","volume":"45","author":"Chai","year":"2013","journal-title":"Infect. Chemother."},{"key":"10.1016\/j.pt.2017.11.010_bib0290","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.actatropica.2017.08.002","article-title":"Schistosomiasis: drugs used and treatment strategies","volume":"176","author":"Da Paix\u00e3o Siqueira","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2017.11.010_bib0295","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/inthealth\/ihx031","article-title":"A comparative study on the efficacy of praziquantel and albendazole in the treatment of urinary schistosomiasis in Adim, Cross River State, Nigeria","volume":"9","author":"Ben","year":"2017","journal-title":"Int. Health"},{"key":"10.1016\/j.pt.2017.11.010_bib0300","first-page":"171","article-title":"The efficacy of antihelmintic compound; Clorsulon against experimental Schistosoma mansoni infection","volume":"37","author":"Mossallam","year":"2007","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0305","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4269\/ajtmh.2006.75.287","article-title":"Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model","volume":"75","author":"Keiser","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2017.11.010_bib0310","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S0031182000052306","article-title":"How anthelmintics help us to understand helminths","volume":"90","author":"Vanden Bossche","year":"1985","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.11.010_bib0315","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13059-015-0632-2","article-title":"The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution","volume":"16","author":"Cwiklinski","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.pt.2017.11.010_bib0320","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biotechadv.2009.12.003","article-title":"Elucidating the transcriptome of Fasciola hepatica \u2013 a key to fundamental and biotechnological discoveries for a neglected parasite","volume":"28","author":"Young","year":"2010","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.pt.2017.11.010_bib0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001004","article-title":"A portrait of the transcriptome of the neglected trematode, Fasciola gigantica \u2013 biological and biotechnological implications","volume":"5","author":"Young","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0330","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.micinf.2011.11.012","article-title":"Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective","volume":"14","author":"McVeigh","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.pt.2017.11.010_bib0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006537","article-title":"Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia endobacteria related to the agents of Potomac horse and human sennetsu fevers","volume":"13","author":"McNulty","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2017.11.010_bib0340","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpara.2007.10.007","article-title":"The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration","volume":"38","author":"McGonigle","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000260","article-title":"Development of functional genomic tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica","volume":"2","author":"Rinaldi","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003185","article-title":"RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitro","volume":"8","author":"McVeigh","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0355","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molbiopara.2014.10.001","article-title":"RNA interference in Fasciola hepatica newly excysted juveniles: Long dsRNA induces more persistent silencing than siRNA","volume":"197","author":"Dell\u2019Oca","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004994","article-title":"Stimulating neoblast-like cell proliferation in juvenile Fasciola hepatica supports growth and progression towards the adult phenotype in vitro","volume":"10","author":"McCusker","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2017.11.010_bib0365","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13071-016-1324-9","article-title":"Calmodulin disruption impacts growth and motility in juvenile liver fluke","volume":"9","author":"McCammick","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2017.11.010_bib0370","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/dvdy.21849","article-title":"A formaldehyde-based whole-mount in situ hybridisation method for planarians","volume":"238","author":"Pearson","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.pt.2017.11.010_bib0375","article-title":"Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes","author":"McVeigh","year":"2017","journal-title":"bioRXiv"},{"key":"10.1016\/j.pt.2017.11.010_bib0380","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1124\/mol.63.6.1256","article-title":"The G protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups and fingerprints","volume":"63","author":"Fredriksson","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.pt.2017.11.010_bib0385","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1186\/1471-2164-12-596","article-title":"The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea","volume":"12","author":"Zamanian","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pt.2017.11.010_bib0390","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/1756-3305-7-242","article-title":"Identification of G protein-coupled receptors in Schistosoma haematobium and S. mansoni by comparative genomics","volume":"7","author":"Campos","year":"2014","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2017.11.010_bib0395","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-381272-8.00002-7","article-title":"Orphan GPCRs and methods for identifying their ligands","volume":"514","author":"Yoshida","year":"2012","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.pt.2017.11.010_bib0400","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fphar.2015.00100","article-title":"Advancements in therapeutically targeting orphan GPCRs","volume":"6","author":"Stockert","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.pt.2017.11.010_bib0405","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.regpep.2010.04.011","article-title":"Mutagenesis of human neuropeptide Y\/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions","volume":"163","author":"\u00c5kerberg","year":"2010","journal-title":"Regul. Pept."},{"key":"10.1016\/j.pt.2017.11.010_bib0410","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0014-5793(02)02534-6","article-title":"Reciprocal mutations of neuropeptide Y receptor Y2 in human and chicken identify amino acids important for antagonist binding","volume":"518","author":"Berglund","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pt.2017.11.010_bib0415","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.npep.2011.05.006","article-title":"Identification of positions in the human neuropeptide Y\/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes","volume":"45","author":"F\u00e4llmar","year":"2011","journal-title":"Neuropeptides"},{"key":"10.1016\/j.pt.2017.11.010_bib0420","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0303-7207(95)03603-5","article-title":"Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding","volume":"112","author":"Sautel","year":"1995","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.pt.2017.11.010_bib0425","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0026-895X(25)09222-3","article-title":"Neuropeptide Y and the non-peptide antagonist BIBP 3226 share an overlapping binding site at the human Y1 receptor","volume":"50","author":"Sautel","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.pt.2017.11.010_bib0430","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fendo.2013.00193","article-title":"Phylogenetic investigation of peptide hormone and growth factor receptors in five dipteran genomes","volume":"4","author":"Vogel","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.pt.2017.11.010_bib0435","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1002\/bit.25597","article-title":"Applications of yeast-based signaling sensor for characterization of antagonist and analysis of site-directed mutants of the human serotonin 1A receptor","volume":"112","author":"Nakamura","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.pt.2017.11.010_bib0440","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.compbiolchem.2008.03.001","article-title":"Homology modeling, agonist binding site identification, and docking in octopamine receptor of Periplaneta americana","volume":"32","author":"Hirashima","year":"2008","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.pt.2017.11.010_bib0445","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1021\/bi602593t","article-title":"Identification of critical structural determinants responsible for octopamine binding to the alpha-adrenergic-like Bombyx mori octopamine receptor","volume":"46","author":"Huang","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.pt.2017.11.010_bib0450","doi-asserted-by":"crossref","unstructured":"Kremer, M. and Snyder, C.M. (2003) Why are drugs more profitable than vaccines? NBER Working Paper No. 9833. Published online July 2003. https:\/\/doi.org\/10\/3386\/w9833","DOI":"10.3386\/w9833"},{"key":"10.1016\/j.pt.2017.11.010_bib0455","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1478-7547-11-23","article-title":"Drug versus vaccine investment: a modelled comparison of economic incentives","volume":"11","author":"R\u00e9gnier","year":"2013","journal-title":"Cost Eff. Resour. Alloc."},{"key":"10.1016\/j.pt.2017.11.010_bib0460","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S0031182000062648","article-title":"Neuropeptide F: a novel parasitic flatworm regulatory peptide from Moniezia expansa (Cestoda: Cyclophyllidea)","volume":"102","author":"Maule","year":"1991","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.11.010_bib0465","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0014-4894(84)90035-3","article-title":"Fasciola hepatica: the effects of neuropharmacological agents upon in vitro motility","volume":"58","author":"Holmes","year":"1984","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0470","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2307\/3281834","article-title":"Effects of cholinergic drugs on longitudinal muscle contractions of Fasciola hepatica","volume":"72","author":"Sukhdeo","year":"1986","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2017.11.010_bib0475","first-page":"531","article-title":"Pharmacological effects of nematode FMRFamide-related peptides (FaRPs) on muscle contractility of the trematode, Fasciola hepatica","volume":"114","author":"Marks","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.11.010_bib0480","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1017\/S0031182096008712","article-title":"The effects of FaRPs on the motility of isolated muscle strips from the liver fluke, Fasciola hepatica","volume":"114","author":"Graham","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2017.11.010_bib0485","doi-asserted-by":"crossref","first-page":"R2089","DOI":"10.1152\/ajpregu.2000.279.6.R2089","article-title":"Second messengers mediating responses to the FaRP GYIRFamide in the fluke Fasciola hepatica","volume":"279","author":"Graham","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492217302842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492217302842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:33:43Z","timestamp":1761464023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492217302842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":97,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1471492217302842"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2017.11.010","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reasons to Be Nervous about Flukicide Discovery","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2017.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}