{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:44:18Z","timestamp":1789703058128,"version":"4.0.1"},"reference-count":134,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.pt.2018.02.005","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T18:22:58Z","timestamp":1520533378000},"page":"524-540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells"],"prefix":"10.1016","volume":"34","author":[{"given":"Jack P.","family":"Carson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant A.","family":"Ramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"McManus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-6453","authenticated-orcid":false,"given":"Geoffrey N.","family":"Gobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2018.02.005_bib0005","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2001-17550","article-title":"History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells","volume":"21","author":"Geerts","year":"2001","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0010","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1432-1033.1988.tb13782.x","article-title":"Distributions of retinoids, retinoid-binding proteins and related parameters in different types of liver cells isolated from young and old rats","volume":"171","author":"Hendriks","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.pt.2018.02.005_bib0015","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0014-4827(85)90243-5","article-title":"Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver","volume":"160","author":"Hendriks","year":"1985","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.pt.2018.02.005_bib0020","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1182\/blood.V84.6.1823.1823","article-title":"Expression of a homologously recombined erythopoietin-SV40T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells","volume":"84","author":"Maxwell","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.pt.2018.02.005_bib0025","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1432-2277.2009.00861.x","article-title":"Erythropoietin reduces ischemia-reperfusion injury after liver transplantation in rats","volume":"22","author":"Schmeding","year":"2009","journal-title":"Transpl. Int."},{"key":"10.1016\/j.pt.2018.02.005_bib0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI115561","article-title":"Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis","volume":"89","author":"Bachem","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pt.2018.02.005_bib0035","first-page":"344","article-title":"Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology","volume":"3","author":"Weiskirchen","year":"2014","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.pt.2018.02.005_bib0040","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pt.2018.02.005_bib0045","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.bbadis.2013.02.019","article-title":"Origins and functions of liver myofibroblasts","volume":"1832","author":"Lemoinne","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2018.02.005_bib0050","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2353\/ajpath.2007.051212","article-title":"Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule","volume":"170","author":"March","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pt.2018.02.005_bib0055","first-page":"397","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Publ. Gr."},{"key":"10.1016\/j.pt.2018.02.005_bib0060","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0168-8278(97)80257-7","article-title":"Transforming growth factor-beta gene expression in normal and fibrotic rat liver","volume":"26","author":"De Bleser","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","article-title":"The role of TGF\u03b21 in initiating hepatic stellate cell activation in vivo","volume":"30","author":"Hellerbrand","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0070","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-\u03b2 Signal transduction","volume":"67","author":"Massagu\u00e9","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.pt.2018.02.005_bib0075","first-page":"1221","article-title":"Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease","volume":"139","author":"Milani","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pt.2018.02.005_bib0080","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI118055","article-title":"Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation","volume":"96","author":"Bissell","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pt.2018.02.005_bib0085","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1053\/he.2000.6126","article-title":"Modulation of transforming growth factor \u03b2 response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts","volume":"31","author":"Dooley","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.pt.2018.02.005_bib0090","doi-asserted-by":"crossref","first-page":"9500","DOI":"10.1073\/pnas.95.16.9500","article-title":"Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis","volume":"95","author":"Ratziu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2018.02.005_bib0095","first-page":"11039","article-title":"Raf and mitogen-activated protein kinase regulate stellate cell collagen gene expression","volume":"41","author":"Davis","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.pt.2018.02.005_bib0100","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1371\/journal.ppat.0020054","article-title":"Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene","volume":"2","author":"Osman","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2018.02.005_bib0105","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1371\/journal.ppat.0030052","article-title":"TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni","volume":"3","author":"Freitas","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2018.02.005_bib0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.molbiopara.2012.02.008","article-title":"Effect of human TGF-\u03b2 on the gene expression profile of Schistosoma mansoni adult worms","volume":"183","author":"Oliveira","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0115","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep.510300425","article-title":"Expression of connective tissue growth factor in experimental rat and human liver fibrosis","volume":"30","author":"Paradis","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.pt.2018.02.005_bib0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.patbio.2013.01.005","article-title":"Genetic analysis of human predisposition to hepatosplenic disease caused by schistosomes reveals the crucial role of connective tissue growth factor in rapid progression to severe hepatic fibrosis","volume":"61","author":"Dessein","year":"2013","journal-title":"Pathol. Biol."},{"key":"10.1016\/j.pt.2018.02.005_bib0125","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1017\/S0031182014001115","article-title":"Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis","volume":"142","author":"Li","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2018.02.005_bib0130","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0168-8278(00)80244-5","article-title":"Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells","volume":"32","author":"Williams","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0135","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.LAB.0000017365.18894.D3","article-title":"Effects and regulation of connective tissue growth factor on hepatic stellate cells","volume":"82","author":"Paradis","year":"2002","journal-title":"Lab. Invest."},{"key":"10.1016\/j.pt.2018.02.005_bib0140","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.1.06719","article-title":"Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor","volume":"188","author":"Tong","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.pt.2018.02.005_bib0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1478-811X-3-14","article-title":"Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells","volume":"3","author":"Gao","year":"2005","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.pt.2018.02.005_bib0150","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jhep.2003.11.012","article-title":"Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44\/42 MAP kinase in primary rat hepatic stellate cells","volume":"40","author":"Gao","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0155","first-page":"469","article-title":"A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene","volume":"7","author":"Grotendorst","year":"1996","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.pt.2018.02.005_bib0160","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.pt.2018.02.005_bib0165","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2013.07.018","article-title":"Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis","volume":"39","author":"Mchedlidze","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.pt.2018.02.005_bib0170","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2018.02.005_bib0175","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1084\/jem.194.6.809","article-title":"Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)","volume":"194","author":"Lee","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2018.02.005_bib0180","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.4049\/jimmunol.173.6.4020","article-title":"IL-13 activates a mechanism of tissue fibrosis that is completely TGF-\u03b2 independent","volume":"173","author":"Kaviratne","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0185","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.4049\/jimmunol.1003260","article-title":"IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-\u03b2-independent Smad signaling","volume":"187","author":"Liu","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0190","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.4049\/jimmunol.181.7.4656","article-title":"Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model","volume":"181","author":"Shimamura","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0195","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s40139-015-0091-1","article-title":"IL-13 and TGF-\u03b21: Core mediators of fibrosis","volume":"3","author":"Borthwick","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.pt.2018.02.005_bib0200","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0205","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4049\/jimmunol.159.2.777","article-title":"IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis","volume":"159","author":"Brunet","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0210","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/CMR.2.3.250","article-title":"Immunopathology of Schistosoma mansoni infection","volume":"2","author":"Boros","year":"1989","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.pt.2018.02.005_bib0215","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2018.02.005_bib0220","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1046\/j.1365-3156.1998.00285.x","article-title":"Sonographic prediction of variceal bleeding in patients with liver fibrosis due to Schistosoma mansoni","volume":"3","author":"Richter","year":"1998","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.pt.2018.02.005_bib0225","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jare.2012.12.001","article-title":"Hepatic and intestinal schistosomiasis: review","volume":"4","author":"Elbaz","year":"2013","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.pt.2018.02.005_bib0230","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrgastro.2011.115","article-title":"New insights into gastrointestinal and hepatic granulomatous disorders","volume":"8","author":"Almadi","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0235","first-page":"149","article-title":"Comparative histopathology of schistosome granulomas in the hamster","volume":"72","author":"Von Lichtenberg","year":"1973","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pt.2018.02.005_bib0240","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/00034983.1972.11686801","article-title":"Comparative studies on the lesions caused by eggs of Schistosoma japonicum and Schistosoma mansoni in livers of albino mice and rhesus monkeys","volume":"66","author":"Hs\u00fc","year":"1972","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.1212653","article-title":"Spatial and temporal transcriptomics of Schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils","volume":"94","author":"Chuah","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.pt.2018.02.005_bib0250","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pt.2013.12.009","article-title":"Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology","volume":"30","author":"Chuah","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0255","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molbiopara.2006.01.003","article-title":"IPSE\/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs","volume":"147","author":"Schramm","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0260","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.20050955","article-title":"Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity","volume":"202","author":"Smith","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2018.02.005_bib0265","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1016\/S0021-9258(18)68680-6","article-title":"H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen","volume":"263","author":"Collier","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2018.02.005_bib0270","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1517\/14728222.12.2.145","article-title":"Targeting neutrophil elastase in cystic fibrosis","volume":"12","author":"Kelly","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.pt.2018.02.005_bib0275","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.pt.2018.02.005_bib0280","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1462-5822.2005.00659.x","article-title":"Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms","volume":"8","author":"Urban","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2018.02.005_bib0285","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/cyto.a.21178","article-title":"Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential","volume":"81","author":"Keshari","year":"2012","journal-title":"Cytometry A"},{"key":"10.1016\/j.pt.2018.02.005_bib0290","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1053\/hupa.2000.8440","article-title":"Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver","volume":"31","author":"Washington","year":"2000","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.pt.2018.02.005_bib0295","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4321\/S1130-01082006000900005","article-title":"Hepatic stellate cells and alcoholic liver disease","volume":"98","author":"Vera","year":"2006","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"10.1016\/j.pt.2018.02.005_bib0300","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/jgh.12023","article-title":"Hepatic stellate cells, liver innate immunity, and hepatitis C virus","volume":"28","author":"Wang","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0305","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0168-8278(97)80424-2","article-title":"Hepatic stellate cell activation in genetic haemochromatosis","volume":"26","author":"Ramm","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0310","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)65595-2","article-title":"Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia","volume":"153","author":"Ramm","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pt.2018.02.005_bib0315","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/S0002-9440(10)61117-0","article-title":"The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease","volume":"160","author":"Lewindon","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pt.2018.02.005_bib0320","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.actatropica.2005.12.006","article-title":"Hepatic stellate cells in human schistosomiasis mansoni: a comparative immunohistochemical study with liver cirrhosis","volume":"97","author":"Chang","year":"2006","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2018.02.005_bib0325","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1365-2184.2003.00287.x","article-title":"Stages of activation of hepatic stellate cells: effects of ellagic acid, an inhibiter of liver fibrosis, on their differentiation in culture","volume":"36","author":"Buniatian","year":"2003","journal-title":"Cell Prolif."},{"key":"10.1016\/j.pt.2018.02.005_bib0330","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1768-322X.1996.tb00967.x","article-title":"Glial fibrillary acidic protein as a marker of perisinusoidal stellate cells that can distinguish between the normal and myofibroblast-like phenotypes","volume":"87","author":"Buniatian","year":"1996","journal-title":"Biol. Cell"},{"key":"10.1016\/j.pt.2018.02.005_bib0335","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1590\/S0074-02761999000100018","article-title":"Myofibroblasts in schistosomal portal fibrosis of man","volume":"94","author":"Andrade","year":"1999","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.pt.2018.02.005_bib0340","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0016-5085(99)70407-5","article-title":"Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential","volume":"117","author":"Knittel","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pt.2018.02.005_bib0345","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00418-008-0503-y","article-title":"Thy-1 is expressed in myofibroblasts but not found in hepatic stellate cells following liver injury","volume":"131","author":"Dudas","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.pt.2018.02.005_bib0350","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.ijpara.2006.04.015","article-title":"A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis","volume":"36","author":"Bartley","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0355","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4269\/ajtmh.1978.27.271","article-title":"The Schistosoma japonicum egg granuloma. II. Cellular composition, granuloma size, and immunologic concomitants","volume":"27","author":"Warren","year":"1978","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2018.02.005_bib0360","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exppara.2009.12.009","article-title":"Schistosoma mansoni: Egg-induced downregulation of hepatic stellate cell activation and fibrogenesis","volume":"124","author":"Anthony","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0068479","article-title":"Schistosoma japonicum eggs induce a proinflammatory, anti-fibrogenic phenotype in hepatic stellate cells","volume":"8","author":"Anthony","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2018.02.005_bib0370","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1189\/jlb.0805468","article-title":"Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver","volume":"79","author":"Khandoga","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.pt.2018.02.005_bib0375","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.22637","article-title":"Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment","volume":"49","author":"Ramm","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.pt.2018.02.005_bib0380","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.pt.2018.02.005_bib0385","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1586\/17474124.2.2.233","article-title":"Chemokine-directed immune cell infiltration in acute and chronic liver disease","volume":"2","author":"Karlmark","year":"2016","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.pt.2018.02.005_bib0390","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-0030-1255351","article-title":"Chemokines in liver inflammation and fibrosis","volume":"30","author":"Wasmuth","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042490","article-title":"Gene profile of Chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9\/10 on liver non-parenchymal cells","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2018.02.005_bib0400","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002605","article-title":"A novel mouse model of Schistosoma haematobium egg-induced immunopathology","volume":"8","author":"Fu","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2018.02.005_bib0405","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0002-9440(10)64177-6","article-title":"Eosinophil recruitment in type-2 hypersensitivity pulmonary granulomas","volume":"161","author":"Shang","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pt.2018.02.005_bib0410","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actatropica.2008.04.016","article-title":"The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection","volume":"108","author":"Souza","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2018.02.005_bib0415","doi-asserted-by":"crossref","first-page":"39316","DOI":"10.1096\/fasebj.30.1_supplement.1024.1","article-title":"Activation of Nlrp3 inflammasomes in mouse hepatic stellate cells during schistosoma J. infection","volume":"30","author":"Meng","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.pt.2018.02.005_bib0420","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.pt.2018.02.005_bib0425","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pt.2018.02.005_bib0430","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/SHK.0b013e318234f7ff","article-title":"A protective role for inflammasome activation following injury","volume":"37","author":"Osuka","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.pt.2018.02.005_bib0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003760","article-title":"An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs","volume":"9","author":"Gobert","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0440","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1089\/ars.2014.6148","article-title":"Molecular activation of the NLRP3 inflammasome in fibrosis: common threads linking divergent fibrogenic diseases","volume":"22","author":"Artlett","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.pt.2018.02.005_bib0445","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbamcr.2014.11.012","article-title":"Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis","volume":"1853","author":"Chen","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2018.02.005_bib0450","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.pt.2018.02.005_bib0455","doi-asserted-by":"crossref","first-page":"30957","DOI":"10.1038\/srep30957","article-title":"Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3\/p53\/p21 pathway","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2018.02.005_bib0460","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaut.2013.07.008","article-title":"STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib","volume":"46","author":"Deng","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.pt.2018.02.005_bib0465","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1074\/jbc.M114.590943","article-title":"p53 Protein-mediated up-regulation of MAP kinase phosphatase 3 (MKP-3) contributes to the establishment of the cellular senescent phenotype through dephosphorylation of extracellular signal-regulated kinase 1\/2 (ERK1\/2)","volume":"290","author":"Zhang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2018.02.005_bib0470","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1073\/pnas.1117218109","article-title":"Signal transducer and activator of transcription-3\/suppressor of cytokine signaling-3 (STAT3\/SOCS3) axis in myeloid cells regulates neuroinflammation","volume":"109","author":"Qin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2018.02.005_bib0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005268","article-title":"Soluble egg antigens of Schistosoma japonicum induce senescence of activated hepatic stellate cells by activation of the FoxO3a\/SKP2\/P27 pathway","volume":"10","author":"Duan","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0480","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5732\/cjc.011.10319","article-title":"Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis","volume":"31","author":"Wang","year":"2012","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.pt.2018.02.005_bib0485","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nature08815","article-title":"Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence","volume":"464","author":"Lin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pt.2018.02.005_bib0490","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yjmcc.2015.01.022","article-title":"FoxO3a suppresses the senescence of cardiac microvascular endothelial cells by regulating the ROS-mediated cell cycle","volume":"81","author":"Qi","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.pt.2018.02.005_bib0495","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nm761","article-title":"PKB\/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest","volume":"8","author":"Liang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2018.02.005_bib0500","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0003106","article-title":"Schistosoma japonicum soluble egg antigens facilitate hepatic stellate cell apoptosis by downregulating Akt expression and upregulating p53 and DR5 expression","volume":"8","author":"Wang","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0505","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/35096067","article-title":"PKB\/AKT: functional insights from genetic models","volume":"2","author":"Scheid","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.pt.2018.02.005_bib0510","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1038\/sj.onc.1205276","article-title":"Phosphorylation of HDM2 by Akt","volume":"21","author":"Ashcroft","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.pt.2018.02.005_bib0515","doi-asserted-by":"crossref","first-page":"16183","DOI":"10.1074\/jbc.M109.002105","article-title":"Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by Inhibiting Akt\/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2018.02.005_bib0520","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijpara.2013.11.003","article-title":"Schistosoma japonicum soluble egg antigens induce apoptosis and inhibit activation of hepatic stellate cells: a possible molecular mechanism","volume":"44","author":"Duan","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0525","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1053\/jhep.2003.50002","article-title":"Activated stellate cells express the TRAIL receptor-2\/death receptor-5 and undergo TRAIL-mediated apoptosis","volume":"37","author":"Taimr","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.pt.2018.02.005_bib0530","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1038\/onc.2010.221","article-title":"New insights into apoptosis signaling by Apo2L\/TRAIL","volume":"29","author":"Gonzalvez","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.pt.2018.02.005_bib0535","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molbiopara.2007.06.002","article-title":"Proteomic analysis of Schistosoma mansoni egg secretions","volume":"155","author":"Cass","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0540","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ijpara.2005.03.012","article-title":"Murine immune responses to a novel schistosome egg antigen, SmEP25","volume":"35","author":"Williams","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0545","doi-asserted-by":"crossref","first-page":"18384","DOI":"10.1074\/jbc.M300497200","article-title":"Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs","volume":"278","author":"Schramm","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2018.02.005_bib0550","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1034\/j.1398-9995.1999.00063.x","article-title":"Strain-dependent induction of allergic rhinitis without adjuvant in mice","volume":"54","author":"Okano","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.pt.2018.02.005_bib0555","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.4049\/jimmunol.148.7.2283","article-title":"CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage","volume":"148","author":"Vella","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0560","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/380630a0","article-title":"Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene","volume":"380","author":"Shimoda","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.pt.2018.02.005_bib0565","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1073\/pnas.89.13.6065","article-title":"Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system","volume":"89","author":"Hsieh","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2018.02.005_bib0570","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1084\/jem.176.4.1091","article-title":"The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice","volume":"176","author":"Seder","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2018.02.005_bib0575","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.4049\/jimmunol.167.11.6533","article-title":"Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1\/Type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of l-arginine metabolism","volume":"167","author":"Hesse","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0580","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0001368","article-title":"Proteomic identification of IPSE\/alpha-1 as a major Hepatotoxin secreted by Schistosoma mansoni eggs","volume":"5","author":"Abdulla","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0585","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0035-9203(81)90013-4","article-title":"Identification and partial purification of an antigen (omega 1) from Schistosoma mansoni eggs which is putatively hepatotoxic in T-cell deprived mice","volume":"75","author":"Dunne","year":"1981","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2018.02.005_bib0590","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molbiopara.2005.08.003","article-title":"Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs","volume":"144","author":"Fitzsimmons","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0595","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20082460","article-title":"Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses","volume":"206","author":"Everts","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2018.02.005_bib0600","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.4049\/jimmunol.164.6.3047","article-title":"Single cell analysis reveals that IL-4 receptor\/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile","volume":"164","author":"Jankovic","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0605","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/eji.1830260323","article-title":"Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-\u03b3 production by T helper 1 cells","volume":"26","author":"Heufler","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0610","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1084\/jem.20111381","article-title":"Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor","volume":"209","author":"Everts","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2018.02.005_bib0615","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0166-6851(86)90021-6","article-title":"Sequence and expression of a major egg antigen from Schistosoma mansoni. Homologies to heat shock proteins and alpha-crystallins","volume":"21","author":"Nene","year":"1986","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2018.02.005_bib0620","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.diagmicrobio.2010.03.003","article-title":"Identification and characterization of Schistosoma japonicum Sjp40, a potential antigen candidate for the early diagnosis of schistosomiasis","volume":"67","author":"Zhou","year":"2010","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0625","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/IAI.64.5.1750-1755.1996","article-title":"A cloned major Schistosoma mansoni egg antigen with homologies to small heat shock proteins elicits Th1 responsiveness","volume":"64","author":"Cai","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pt.2018.02.005_bib0630","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00054725-199911000-00009","article-title":"Th1\/Th2 cells","volume":"5","author":"Romagnani","year":"1999","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0635","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1046\/j.1365-3024.1998.00150.x","article-title":"The immune response and immunopathology in infection with Schistosoma mansoni: a key role of major egg antigen Sm-p40","volume":"20","author":"Stadecker","year":"1998","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.pt.2018.02.005_bib0640","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1590\/S0074-02762006000400004","article-title":"Schistosoma mansoni major egg antigen Smp40: molecular modeling and potential immunoreactivity for anti-pathology vaccine development","volume":"101","author":"Abouel-Nour","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.pt.2018.02.005_bib0645","first-page":"2092","article-title":"Antifibrotic effects of interleukin-10 on experimental hepatic fibrosis","volume":"54","author":"Zhang","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.pt.2018.02.005_bib0650","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1128\/IAI.74.3.1471-1479.2006","article-title":"Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity","volume":"74","author":"Reiman","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pt.2018.02.005_bib0655","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1007\/s00436-015-4663-0","article-title":"Schistosoma japonicum protein SjP40 inhibits TGF-\u03b21-induced activation of hepatic stellate cells","volume":"114","author":"Sun","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.pt.2018.02.005_bib0660","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yexcr.2014.04.014","article-title":"High glucose increases Cdk5 activity in podocytes via transforming growth factor-\u03b21 signaling pathway","volume":"326","author":"Zhang","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.pt.2018.02.005_bib0665","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.228","article-title":"Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3\/p53\/p21 pathway","volume":"7","author":"Chen","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.pt.2018.02.005_bib0670","doi-asserted-by":"crossref","first-page":"40705","DOI":"10.18632\/oncotarget.17248","article-title":"Recombinant SjP40 protein enhances p27 promoter expression in hepatic stellate cells via an E2F1-dependent mechanism","volume":"8","author":"Duan","year":"2017","journal-title":"Oncotarget"}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492218300278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492218300278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T18:03:41Z","timestamp":1719857021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492218300278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":134,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S1471492218300278"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2018.02.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732833774.793550921","asserted-by":"object"}]},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2018.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}