{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:58:31Z","timestamp":1791230311906,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.pt.2019.07.010","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T08:17:07Z","timestamp":1565943427000},"page":"747-759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Delayed Death by Plastid Inhibition in Apicomplexan Parasites"],"prefix":"10.1016","volume":"35","author":[{"given":"Kit","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M.","family":"Crisafulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-7808","authenticated-orcid":false,"given":"Stuart A.","family":"Ralph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2019.07.010_bb0005","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4269\/ajtmh.2011.10-0285","article-title":"Doxycycline for malaria chemoprophylaxis and treatment: Report from the CDC expert meeting on malaria chemoprophylaxis","volume":"84","author":"Tan","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2019.07.010_bb0010","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00057-17","article-title":"Treatment of toxoplasmosis: Historical perspective, animal models, and current clinical practice","volume":"31","author":"Dunay","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.pt.2019.07.010_bb0015","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1128\/AAC.00527-07","article-title":"Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast","volume":"51","author":"Dahl","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0020","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.pt.2016.09.011","article-title":"Targeting protein translation in organelles of the Apicomplexa","volume":"32","author":"Goodman","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2019.07.010_bb0025","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1749-6632.1952.tb22668.x","article-title":"The use of antibiotics in the treatment of malaria","volume":"55","author":"Coatney","year":"1952","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.pt.2019.07.010_bb0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4269\/ajtmh.1983.32.221","article-title":"Effects of antibiotics on Plasmodium falciparum in\u00a0vitro","volume":"32","author":"Geary","year":"1983","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2019.07.010_bb0035","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1128\/AAC.36.5.1091","article-title":"Parasiticidal effect of clindamycin on Toxoplasma gondii grown in cultured cells and selection of a drug-resistant mutant","volume":"36","author":"Pfefferkorn","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1128\/AAC.38.1.31","article-title":"Comparison of mutants of Toxoplasma gondii selected for resistance to azithromycin, spiramycin, or clindamycin","volume":"38","author":"Pfefferkorn","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0045","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1128\/AAC.39.7.1530","article-title":"In\u00a0vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii","volume":"39","author":"Fichera","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molbiopara.2007.01.005","article-title":"The effects of anti-bacterials on the malaria parasite Plasmodium falciparum","volume":"152","author":"Goodman","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2019.07.010_bb0055","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1128\/AAC.00394-06","article-title":"Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum","volume":"50","author":"Dahl","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0060","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1128\/AAC.00808-06","article-title":"Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum","volume":"51","author":"Ramya","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0065","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1074\/jbc.M608615200","article-title":"In\u00a0vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin","volume":"282","author":"Bir","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pt.2019.07.010_bb0070","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/37132","article-title":"A plastid organelle as a drug target in apicomplexan parasites","volume":"390","author":"Fichera","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.pt.2019.07.010_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/srep27531","article-title":"Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum","volume":"6","author":"Pasaje","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2019.07.010_bb0080","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/emboj.2013.113","article-title":"Toxoplasma gondii myosin F, an essential motor for centrosomes positioning and apicoplast inheritance","volume":"32","author":"Jacot","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.pt.2019.07.010_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15710","article-title":"Myosin-dependent cell\u2013cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii","volume":"8","author":"Fr\u00e9nal","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2019.07.010_bb0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cub.2008.12.048","article-title":"A novel dynamin-related protein has been recruited for apicoplast fission in Toxoplasma gondii","volume":"19","author":"van Dooren","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0095","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/emboj\/20.3.330","article-title":"A plastid segregation defect in the protozoan parasite Toxoplasma gondii","volume":"20","author":"He","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.pt.2019.07.010_bb0100","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02021-17","article-title":"ATG8 is essential specifically for an autophagy-independent function in apicoplast biogenesis in blood-stage malaria parasites","volume":"9","author":"Walczak","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.pt.2019.07.010_bb0105","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01468-17","article-title":"Autophagy-related protein ATG18 regulates apicoplast biogenesis in apicomplexan parasites","volume":"8","author":"Bansal","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.pt.2019.07.010_bb0110","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.celrep.2017.10.081","article-title":"PfClpC Is an essential Clp chaperone required for plastid integrity and Clp protease stability in Plasmodium falciparum","volume":"21","author":"Florentin","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2019.07.010_bb0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrmicro843","article-title":"Metabolic maps and functions of the Plasmodium falciparum apicoplast","volume":"2","author":"Ralph","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pt.2019.07.010_bb0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jmbi.1996.0449","article-title":"Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum","volume":"261","author":"Wilson (Iain)","year":"1996","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0125","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1128\/AAC.00126-08","article-title":"Theileria apicoplast as a target for chemotherapy","volume":"53","author":"Lizundia","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0130","doi-asserted-by":"crossref","DOI":"10.1080\/19420889.2015.1116653","article-title":"Metabolic pathway redundancy within the apicomplexan-dinoflagellate radiation argues against an ancient chromalveolate plastid","volume":"9","author":"Waller","year":"2016","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0135","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1937-6448(10)81005-6","article-title":"Metabolic pathways in the apicoplast of Apicomplexa","volume":"281","author":"Seeber","year":"2010","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0140","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1073\/pnas.0603391103","article-title":"Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii","volume":"103","author":"Mazumdar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2019.07.010_bb0145","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.cell.2016.08.019","article-title":"A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes","volume":"166","author":"Sidik","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.pt.2019.07.010_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006396","article-title":"A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite","volume":"13","author":"Rathnapala","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2019.07.010_bb0155","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1128\/EC.00264-13","article-title":"Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of anopheles mosquitoes","volume":"13","author":"van Schaijk","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.pt.2019.07.010_bb0160","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1462-5822.2008.01270.x","article-title":"Type II fatty acid synthesis is essential only for malaria parasite late liver stage development","volume":"11","author":"Vaughan","year":"2009","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2019.07.010_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001138","article-title":"Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum","volume":"9","author":"Yeh","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0170","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/EC.00198-14","article-title":"Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum","volume":"14","author":"Wiley","year":"2015","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.pt.2019.07.010_bb0175","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1128\/AAC.00427-13","article-title":"Improved efficacy of fosmidomycin against Plasmodium and mycobacterium species by combination with the cell-penetrating peptide octaarginine","volume":"57","author":"Sparr","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0180","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/mp\/sss088","article-title":"New insights into plant isoprenoid metabolism","volume":"5","author":"Pulido","year":"2012","journal-title":"Mol. Plant"},{"key":"10.1016\/j.pt.2019.07.010_bb0185","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1128\/EC.00160-14","article-title":"Isoprenoid biosynthesis in Plasmodium falciparum","volume":"13","author":"Guggisberg","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.pt.2019.07.010_bb0190","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.285.5433.1573","article-title":"Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs","volume":"285","author":"Jomaa","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.pt.2019.07.010_bb0195","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.20110039","article-title":"Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii","volume":"208","author":"Nair","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.pt.2019.07.010_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003665","article-title":"Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2019.07.010_bb0205","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01646-18","article-title":"Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in Toxoplasma gondii","volume":"63","author":"Amberg-Johnson","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019334","article-title":"Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways","volume":"6","author":"Baumeister","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2019.07.010_bb0215","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/AAC.01500-13","article-title":"Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box","volume":"58","author":"Bowman","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0220","article-title":"Validation of putative apicoplast-targeting drugs using a chemical supplementation assay in cultured human malaria parasites","volume":"62","author":"Uddin","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0225","doi-asserted-by":"crossref","first-page":"30316","DOI":"10.1074\/jbc.273.46.30316","article-title":"Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis","volume":"273","author":"Heath","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pt.2019.07.010_bb0230","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1242\/jcs.185223","article-title":"Apicoplast fatty acid synthesis is essential for pellicle formation at the end of cytokinesis in Toxoplasma gondii","volume":"129","author":"Martins-Duarte","year":"2016","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.pt.2019.07.010_bb0235","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.chom.2008.11.001","article-title":"The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites","volume":"4","author":"Yu","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2019.07.010_bb0240","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1021\/bi200113y","article-title":"A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling","volume":"50","author":"Zhang","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.pt.2019.07.010_bb0245","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s13071-018-3038-7","article-title":"The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development","volume":"11","author":"He","year":"2018","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2019.07.010_bb0250","first-page":"71","article-title":"In\u00a0vitro inhibitory effect of fosmidomycin on the asexual growth of Babesia bovis and Babesia bigemina","volume":"18","author":"Sivakumar","year":"2008","journal-title":"J.\u00a0Protozool. Res."},{"key":"10.1016\/j.pt.2019.07.010_bb0255","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0098-2997(03)00030-X","article-title":"Antioxidant activity of carotenoids","volume":"24","author":"Stahl","year":"2003","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.pt.2019.07.010_bb0260","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.290.5497.1721","article-title":"How cells handle cholesterol","volume":"290","author":"Simons","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pt.2019.07.010_bb0265","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrm.2015.11","article-title":"Protein prenylation: unique fats make their mark on biology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0270","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3389\/fpls.2016.01898","article-title":"Plastoquinone and ubiquinone in plants: biosynthesis, physiological function and metabolic engineering","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.pt.2019.07.010_bb0275","doi-asserted-by":"crossref","first-page":"13073","DOI":"10.1074\/jbc.272.20.13073","article-title":"Regulation of substrate recognition by the MiaA tRNA prenyltransferase modification enzyme of Escherichia coli K-12","volume":"272","author":"Leung","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pt.2019.07.010_bb0280","doi-asserted-by":"crossref","first-page":"18236","DOI":"10.1016\/S0021-9258(19)81351-0","article-title":"Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component","volume":"263","author":"Anderegg","year":"1988","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pt.2019.07.010_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep38615","article-title":"Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue","volume":"6","author":"Suazo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2019.07.010_bb0290","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1074\/mcp.M116.064550","article-title":"The prenylated proteome of Plasmodium falciparum reveals pathogen-specific prenylation activity and drug mechanism-of-action","volume":"16","author":"Gisselberg","year":"2017","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.pt.2019.07.010_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003213","article-title":"An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes","volume":"9","author":"Kremer","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2019.07.010_bb0300","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1073\/pnas.0711067105","article-title":"Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum","volume":"105","author":"Elliott","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.\u00a0S.\u00a0A."},{"key":"10.1016\/j.pt.2019.07.010_bb0305","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/EC.00073-12","article-title":"Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum","volume":"12","author":"Howe","year":"2013","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.pt.2019.07.010_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000270","article-title":"Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis","volume":"5","author":"Agop-Nersesian","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2019.07.010_bb0315","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/j.1365-2958.2008.06125.x","article-title":"Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum","volume":"67","author":"Struck","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2019.07.010_bb0320","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molbiopara.2006.12.007","article-title":"Identification of Plasmodium falciparum family of SNAREs","volume":"152","author":"Ayong","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2019.07.010_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000376","article-title":"Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking","volume":"17","author":"Kennedy","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0330","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature05572","article-title":"Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum","volume":"446","author":"Painter","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.pt.2019.07.010_bb0335","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.molbiopara.2013.05.008","article-title":"Identification of dihydroorotate dehydrogenase as a relevant drugtarget for 1-hydroxyquinolones in Toxoplasma gondii","volume":"190","author":"Hegewald","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2019.07.010_bb0340","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/138945007779315524","article-title":"Targeting purine and pyrimidine metabolism in human apicomplexan parasites","volume":"8","author":"Hyde","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.pt.2019.07.010_bb0345","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1574-6968.2002.tb11021.x","article-title":"Characterization of the isoprenoid chain of coenzyme Q in Plasmodium falciparum","volume":"207","author":"De Macedo","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.pt.2019.07.010_bb0350","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1042\/BJ20050441","article-title":"Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum","volume":"392","author":"Tonhosolo","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.pt.2019.07.010_bb0355","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0378-8741(99)00072-0","article-title":"Antimalarial use of volatile oil from leaves of Virola surinamensis (Rol.) Warb. by Waiapi Amazon Indians","volume":"67","author":"Lopes","year":"1999","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.pt.2019.07.010_bb0360","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/bj3410629","article-title":"Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene units","volume":"341","author":"Couto","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.pt.2019.07.010_bb0365","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.1074\/jbc.272.10.6428","article-title":"Glycosylphosphatidylinositol anchors represent the major carbohydrate modification in proteins of intraerythrocytic stage Plasmodium falciparum","volume":"272","author":"Gowda","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pt.2019.07.010_bb0370","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1074\/mcp.M600035-MCP200","article-title":"Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum","volume":"5","author":"Gilson","year":"2006","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.pt.2019.07.010_bb0375","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/femsre\/fuw001","article-title":"Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria","volume":"40","author":"Beeson","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.pt.2019.07.010_bb0380","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0300-9084(03)00065-8","article-title":"Inhibitors of glycosyl-phosphatidylinositol anchor biosynthesis","volume":"85","author":"Santos De Macedo","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.pt.2019.07.010_bb0385","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29865","article-title":"Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens","volume":"6","author":"Amberg-Johnson","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.pt.2019.07.010_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074408","article-title":"An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum","volume":"8","author":"Tanveer","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2019.07.010_bb0395","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00710-18","article-title":"Disruption of apicoplast biogenesis by chemical stabilization of an imported protein evades the delayed-death phenotype in malaria parasites","volume":"4","author":"Boucher","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.pt.2019.07.010_bb0400","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01446-15","article-title":"Autophagy-related protein ATG8 has a noncanonical function for apicoplast inheritance in Toxoplasma gondii","volume":"6","author":"L\u00e9v\u00eaque","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.pt.2019.07.010_bb0405","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1074\/jbc.272.4.2046","article-title":"Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton","volume":"272","author":"McConkey","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pt.2019.07.010_bb0410","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(02)02437-7","article-title":"Inhibition of mitochondrial and plastid activity of Plasmodium falciparum by minocycline","volume":"515","author":"Lin","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pt.2019.07.010_bb0415","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/AAC.27.1.21","article-title":"Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture","volume":"27","author":"Divo","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0420","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1128\/AAC.45.6.1746-1750.2001","article-title":"In\u00a0vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron","volume":"45","author":"Pradines","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020633","article-title":"Characterization of two malaria parasite organelle translation elongation factor G proteins: The likely targets of the anti-malarial fusidic acid","volume":"6","author":"Johnson","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2019.07.010_bb0430","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molbiopara.2013.10.003","article-title":"The effect of fusidic acid on Plasmodium falciparum elongation factor G (EF-G)","volume":"192","author":"Gupta","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2019.07.010_bb0435","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(88)92056-9","article-title":"Ciprofloxacin and malaria","volume":"331","author":"Krishna","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2019.07.010_bb0440","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1128\/AAC.32.8.1182","article-title":"Activity of fluoroquinolone antibiotics against Plasmodium falciparum in\u00a0vitro","volume":"32","author":"Divo","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2019.07.010_bb0445","doi-asserted-by":"crossref","first-page":"33683","DOI":"10.1074\/jbc.M109.044024","article-title":"Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins","volume":"284","author":"Agrawal","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pt.2019.07.010_bb0450","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/tra.12333","article-title":"Toxoplasma gondii Toc75 functions in import of stromal but not peripheral apicoplast proteins","volume":"16","author":"Sheiner","year":"2015","journal-title":"Traffic"},{"key":"10.1016\/j.pt.2019.07.010_bb0455","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00018-011-0646-1","article-title":"The apicomplexan plastid and its evolution","volume":"68","author":"Sato","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.pt.2019.07.010_bb0460","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2307\/3276925","article-title":"The fine structure and reproduction of Toxoplasma gondii","volume":"54","author":"Sheffield","year":"1968","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.pt.2019.07.010_bb0465","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4269\/ajtmh.1966.15.449","article-title":"The fine structure of the erythrocytic stages of three avian malarial parasites, Plasmodium fallax, P.\u00a0lophurae, and P.\u00a0cathemerium","volume":"15","author":"Aikawa","year":"1966","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2019.07.010_bb0470","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.30.2.333","article-title":"The fine structure of the exoerythrocytic stages of Plasmodium fallax","volume":"30","author":"Hepler","year":"1966","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.pt.2019.07.010_bb0475","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00348725","article-title":"Elektronenmikroskopische Unitersuchungen an Merozoiten von Eimerien (Eimeria perforans und E. stiedae) und Toxoplasma gondii \u2013 Zur systematischen Stellung von T.\u00a0gondii","volume":"26","author":"Scholtyseck","year":"1965","journal-title":"Z.\u00a0Parasitenkd."},{"key":"10.1016\/j.pt.2019.07.010_bb0480","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0005-2787(75)90348-2","article-title":"Circular mitochondrial DNA from the avian malarial parasite Plasmodium lophurae","volume":"390","author":"Kilejian","year":"1975","journal-title":"Biochim. Biophys. Acta \u2013 Nucleic Acids Protein Synth."},{"key":"10.1016\/j.pt.2019.07.010_bb0485","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/381482a0","article-title":"Plastid in human parasites","volume":"381","author":"McFadden","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.pt.2019.07.010_bb0490","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1126\/science.275.5305.1485","article-title":"A plastid of probable green algal origin in Apicomplexan parasites","volume":"275","author":"K\u00f6hler","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.pt.2019.07.010_bb0495","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1104\/pp.118.1.9","article-title":"Gene transfer from organelles to the nucleus: how much, what happens, and why?","volume":"118","author":"Martin","year":"1998","journal-title":"Plant Physiol."},{"key":"10.1016\/j.pt.2019.07.010_bb0500","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0166-6851(88)90031-X","article-title":"Depression of Plasmodium falciparum dihydroorotate dehydrogenase activity in in\u00a0vitro culture by\u00a0tetracycline","volume":"27","author":"Prapunwattana","year":"1988","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2019.07.010_bb0505","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0166-6851(89)90002-9","article-title":"Mitochondria as\u00a0the\u00a0site of action of tetracycline on Plasmodium\u00a0falciparum","volume":"34","author":"Kiatfuengfoo","year":"1989","journal-title":"Mol. Biochem. Parasitol."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492219301916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492219301916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:34:39Z","timestamp":1761464079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492219301916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":101,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1471492219301916"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2019.07.010","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delayed Death by Plastid Inhibition in Apicomplexan Parasites","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2019.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}