{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:16:45Z","timestamp":1790003805477,"version":"4.0.1"},"reference-count":100,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.pt.2020.05.013","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T09:06:24Z","timestamp":1592816784000},"page":"735-744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["\u2018Artemisinin Resistance\u2019: Something New or Old? Something of a Misnomer?"],"prefix":"10.1016","volume":"36","author":[{"given":"Thomas E.","family":"Wellems","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana M.","family":"S\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-zhuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean V.","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2020.05.013_bb0005","series-title":"World Malaria Report 2019","isbn-type":"print","author":"World Health Organization","year":"2019","ISBN":"https:\/\/id.crossref.org\/isbn\/9789241565721"},{"key":"10.1016\/j.pt.2020.05.013_bb0010","first-page":"811","article-title":"Antimalaria studies on Qinghaosu","volume":"92","author":"Qinghaosu Antimalaria Coordinating Research Group","year":"1979","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.pt.2020.05.013_bb0015","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nm.2471","article-title":"The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine","volume":"17","author":"Tu","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2020.05.013_bb0020","series-title":"Guidelines for the Treatment of Malaria","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.pt.2020.05.013_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(03)15162-8","article-title":"Artesunate combinations for treatment of malaria: meta-analysis","volume":"363","author":"Adjuik","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2020.05.013_bb0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0035-9203(88)90417-8","article-title":"Antagonism of chloroquine with other antimalarials","volume":"82","author":"Stahel","year":"1988","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2020.05.013_bb0035","author":"World Health Organization Global Malaria Programme"},{"key":"10.1016\/j.pt.2020.05.013_bb0040","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/tmi.12458","article-title":"Treatment of uncomplicated malaria with artesunate plus sulfadoxine-pyrimethamine is failing in Somalia: evidence from therapeutic efficacy studies and Pfdhfr and Pfdhps mutant alleles","volume":"20","author":"Warsame","year":"2015","journal-title":"Tropical Med. Int. Health"},{"key":"10.1016\/j.pt.2020.05.013_bb0045","doi-asserted-by":"crossref","DOI":"10.1186\/s12936-016-1339-x","article-title":"High efficacy of artemether-lumefantrine and declining efficacy of artesunate + sulfadoxine-pyrimethamine against Plasmodium falciparum in Sudan (2010\u20132015): evidence from in vivo and molecular marker studies","volume":"15","author":"Adeel","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2020.05.013_bb0050","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/S0140-6736(84)92057-9","article-title":"Randomised comparative study of mefloquine, qinghaosu, and pyrimethamine-sulfadoxine in patients with falciparum malaria","volume":"2","author":"Li","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2020.05.013_bb0055","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1128\/mr.60.2.301-315.1996","article-title":"Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy","volume":"60","author":"Meshnick","year":"1996","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.pt.2020.05.013_bb0060","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(05)67176-0","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial","volume":"366","author":"Dondorp","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2020.05.013_bb0065","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial","volume":"376","author":"Dondorp","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2020.05.013_bb0070","first-page":"539","article-title":"Double blind randomised clinical trial of oral artesunate at once or twice daily dose in falciparum malaria","volume":"22","author":"Bunnag","year":"1991","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.pt.2020.05.013_bb0075","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4269\/ajtmh.1993.48.398","article-title":"Treatment of malaria in Vietnam with oral artemisinin","volume":"48","author":"Nguyen","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2020.05.013_bb0080","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0140-6736(92)90276-9","article-title":"Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria","volume":"339","author":"Looareesuwan","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2020.05.013_bb0085","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/0035-9203(94)90460-X","article-title":"Clinical trials of artemisinin and its derivatives in the treatment of malaria in China","volume":"88","author":"Li","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2020.05.013_bb0090","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4269\/ajtmh.2001.65.690","article-title":"Artemisinin for treatment of uncomplicated falciparum malaria: is there a place for monotherapy?","volume":"65","author":"Giao","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2020.05.013_bb0095","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1073\/pnas.1600459113","article-title":"Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7","volume":"113","author":"Ismail","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2020.05.013_bb0100","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1365-2958.2004.04035.x","article-title":"Dissecting the loci of low-level quinine resistance in malaria parasites","volume":"52","author":"Ferdig","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2020.05.013_bb0105","first-page":"380","article-title":"Clinical trial of artesunate and artemether on multidrug resistant falciparum malaria in Thailand. A preliminary report","volume":"22","author":"Bunnag","year":"1991","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.pt.2020.05.013_bb0110","first-page":"534","article-title":"Double blind randomised clinical trial of two different regimens of oral artesunate in falciparum malaria","volume":"22","author":"Bunnag","year":"1991","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.pt.2020.05.013_bb0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1365-2125.1998.00655.x","article-title":"A pharmacokinetic and pharmacodynamic study of intravenous vs oral artesunate in uncomplicated falciparum malaria","volume":"45","author":"Batty","year":"1998","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.pt.2020.05.013_bb0120","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1128\/AAC.00044-12","article-title":"Pharmacokinetics and pharmacodynamics of oral artesunate monotherapy in patients with uncomplicated Plasmodium falciparum malaria in western Cambodia","volume":"56","author":"Saunders","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0031182099006332","article-title":"Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens","volume":"121","author":"Hoshen","year":"2000","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2020.05.013_bb0130","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4269\/ajtmh.2003.68.147","article-title":"Recrudescence in artesunate-treated patients with falciparum malaria is dependent on parasite burden not on parasite factors","volume":"68","author":"Ittarat","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2020.05.013_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026689","article-title":"Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei","volume":"6","author":"LaCrue","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2020.05.013_bb0140","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1006\/expr.1995.1149","article-title":"Plasmodium falciparum: recrudescence of parasites in culture","volume":"81","author":"Nakazawa","year":"1995","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2020.05.013_bb0145","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1128\/AAC.46.4.958-965.2002","article-title":"Malaria parasites giving rise to recrudescence in vitro","volume":"46","author":"Nakazawa","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0150","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1086\/656476","article-title":"Artemisinin-induced dormancy in Plasmodium falciparum: duration, recovery rates, and implications in treatment failure","volume":"202","author":"Teuscher","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0155","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1128\/AAC.01636-09","article-title":"Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism","volume":"54","author":"Witkowski","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0160","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1475-2875-10-56","article-title":"Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure","volume":"10","author":"Codd","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2020.05.013_bb0165","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1128\/AAC.05456-11","article-title":"Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition","volume":"56","author":"Teuscher","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0170","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/AAC.05540-11","article-title":"Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum","volume":"56","author":"Tucker","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0175","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1128\/AAC.02838-15","article-title":"The spiroindolone KAE609 does not induce dormant ring stages in Plasmodium falciparum parasites","volume":"60","author":"Chavchich","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002121","article-title":"'Persisters': survival at the cellular level","volume":"7","author":"Dawson","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2020.05.013_bb0185","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12275-019-8629-2","article-title":"Ribosome dependence of persister cell formation and resuscitation","volume":"57","author":"Wood","year":"2019","journal-title":"J. Microbiol."},{"key":"10.1016\/j.pt.2020.05.013_bb0190","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34039","article-title":"Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure","volume":"7","author":"Sanchez-Valdez","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.pt.2020.05.013_bb0195","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1128\/AAC.00684-06","article-title":"Candida albicans biofilms produce antifungal-tolerant persister cells","volume":"50","author":"LaFleur","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0200","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bcp.2018.11.004","article-title":"Dormant, quiescent, tolerant and persister cells: four synonyms for the same target in cancer","volume":"162","author":"Vallette","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pt.2020.05.013_bb0205","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2958.2006.05249.x","article-title":"Bistability in bacteria","volume":"61","author":"Dubnau","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2020.05.013_bb0210","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.cell.2009.12.001","article-title":"Growth rate-dependent global effects on gene expression in bacteria","volume":"139","author":"Klumpp","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.pt.2020.05.013_bb0215","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1365-2958.2006.05264.x","article-title":"Different genetic programmes within identical bacteria under identical conditions: the phenomenon of bistability greatly modifies our view on bacterial populations","volume":"61","author":"Graumann","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2020.05.013_bb0220","doi-asserted-by":"crossref","DOI":"10.1126\/science.1237435","article-title":"The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria","volume":"342","author":"Deris","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.pt.2020.05.013_bb0225","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1260403","article-title":"Drug resistance. population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance","volume":"347","author":"Mok","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.pt.2020.05.013_bb0230","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1128\/AAC.02647-14","article-title":"Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum","volume":"58","author":"Chen","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0235","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/infdis\/jiv048","article-title":"Mitochondrial membrane potential in a small subset of artemisinin-induced dormant Plasmodium falciparum parasites in vitro","volume":"212","author":"Peatey","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001138","article-title":"Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum","volume":"9","author":"Yeh","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2020.05.013_bb0245","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature05572","article-title":"Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum","volume":"446","author":"Painter","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.pt.2020.05.013_bb0250","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01771-17","article-title":"Phytohormones, isoprenoids and role of the apicoplast in recovery from dihydroartemisinin-induced dormancy of Plasmodium falciparum","volume":"62","author":"Duvalsaint","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0255","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1073\/pnas.1121567109","article-title":"PK4, a eukaryotic initiation factor 2alpha(eIF2alpha) kinase, is essential for the development of the erythrocytic cycle of Plasmodium","volume":"109","author":"Zhang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2020.05.013_bb0260","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1016\/j.celrep.2019.10.095","article-title":"Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance","volume":"29","author":"Yang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2020.05.013_bb0265","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01134-19","article-title":"Role of Plasmodium falciparum Kelch 13 protein mutations in P. falciparum populations from Northeastern Myanmar in mediating artemisinin resistance","volume":"11","author":"Siddiqui","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.pt.2020.05.013_bb0270","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMc0805011","article-title":"Evidence of artemisinin-resistant malaria in western Cambodia","volume":"359","author":"Noedl","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2020.05.013_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019283","article-title":"Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial","volume":"6","author":"Bethell","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2020.05.013_bb0280","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.pt.2020.02.005","article-title":"Malaria parasite clearance: what are we really measuring?","volume":"36","author":"Khoury","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2020.05.013_bb0285","doi-asserted-by":"crossref","first-page":"12513","DOI":"10.1073\/pnas.1813386115","article-title":"Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model","volume":"115","author":"S\u00e1","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2020.05.013_bb0290","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/infdis\/jiu427","article-title":"Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria","volume":"211","author":"Ndour","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0295","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/infdis\/jiz115","article-title":"Plasmodium falciparum clearance is pitting-dependent with artemisinin-based drugs but pitting-independent with atovaquone-proguanil or mefloquine","volume":"220","author":"Wojnarski","year":"2019","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0300","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/infdis\/jit082","article-title":"Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity","volume":"207","author":"Lopera-Mesa","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0305","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.1128\/AAC.00481-15","article-title":"How robust are malaria parasite clearance rates as indicators of drug effectiveness and resistance?","volume":"59","author":"Hastings","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0310","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/infdis\/jiz247","article-title":"The contribution of functional antimalarial immunity to measures of parasite clearance in therapeutic efficacy studies of artemisinin derivatives","volume":"220","author":"O'Flaherty","year":"2019","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0315","article-title":"Kelch mutations in Plasmodium falciparum protein K13 do not modulate dormancy after artemisinin exposure and sorbitol selection in vitro","volume":"62","author":"Breglio","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0320","article-title":"A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2020.05.013_bb0325","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pt.2020.03.001","article-title":"The human spleen in malaria: filter or shelter?","volume":"36","author":"Henry","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2020.05.013_bb0330","doi-asserted-by":"crossref","first-page":"18883","DOI":"10.1073\/pnas.0911317106","article-title":"Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine","volume":"106","author":"S\u00e1","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2020.05.013_bb0335","doi-asserted-by":"crossref","first-page":"467","DOI":"10.4269\/ajtmh.1996.55.467","article-title":"Community pyrimethamine-sulfadoxine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: a model for deterring resistance","volume":"55","author":"Plowe","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2020.05.013_bb0340","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJM200101253440403","article-title":"A molecular marker for chloroquine-resistant falciparum malaria","volume":"344","author":"Djimde","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2020.05.013_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05652-0","article-title":"Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine","volume":"9","author":"Ross","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2020.05.013_bb0350","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2165\/00003495-200565010-00004","article-title":"Piperaquine: a resurgent antimalarial drug","volume":"65","author":"Davis","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.pt.2020.05.013_bb0355","first-page":"602","article-title":"Randomised comparison on the treatment of falciparum malaria with dihydroartemisinin and piperaquine","volume":"73","author":"Guo","year":"1993","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.pt.2020.05.013_bb0360","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1475-2875-9-57","article-title":"Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine","volume":"9","author":"Song","year":"2010","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2020.05.013_bb0365","first-page":"90","article-title":"One-year report on the fast elimination of malaria by source eradication (FEMSE) project in Moheli Island of Comoros","volume":"27","author":"Li","year":"2010","journal-title":"J. Guangzhou Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.pt.2020.05.013_bb0370","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/cid\/ciy196","article-title":"A controlled trial of mass drug administration to interrupt transmission of multi drug resistant falciparum malaria in Cambodian villages","volume":"67","author":"Tripura","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0375","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1093\/cid\/ciy364","article-title":"Large-scale artemisinin-piperaquine mass drug administration with or without primaquine dramatically reduces malaria in a highly endemic region of Africa","volume":"67","author":"Deng","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0380","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1056\/NEJMc1403007","article-title":"Dihydroartemisinin-piperaquine failure in Cambodia","volume":"371","author":"Saunders","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2020.05.013_bb0385","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1473-3099(15)70049-6","article-title":"Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study","volume":"15","author":"Spring","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0390","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1473-3099(15)00487-9","article-title":"Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study","volume":"16","author":"Amaratunga","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0395","doi-asserted-by":"crossref","DOI":"10.1186\/s12936-019-2864-1","article-title":"High therapeutic efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Somalia","volume":"18","author":"Warsame","year":"2019","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2020.05.013_bb0400","doi-asserted-by":"crossref","DOI":"10.1186\/s12936-019-2909-5","article-title":"Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial","volume":"18","author":"Sevene","year":"2019","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2020.05.013_bb0405","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1128\/AAC.06350-11","article-title":"pfmdr1 amplification is related to increased Plasmodium falciparum in vitro sensitivity to the bisquinoline piperaquine","volume":"56","author":"Veiga","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0410","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11553","article-title":"Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies","volume":"7","author":"Veiga","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2020.05.013_bb0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005647","article-title":"Na+ influx induced by new antimalarials causes rapid alterations in the cholesterol content and morphology of Plasmodium falciparum","volume":"12","author":"Das","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2020.05.013_bb0420","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3390\/toxins6020650","article-title":"Breakdown of phosphatidylserine asymmetry following treatment of erythrocytes with lumefantrine","volume":"6","author":"Alzoubi","year":"2014","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.pt.2020.05.013_bb0425","series-title":"Chemotherapy and Drug Resistance in Malaria","author":"Peters","year":"1987"},{"key":"10.1016\/j.pt.2020.05.013_bb0430","series-title":"Experimental Chemotherapy","first-page":"1","article-title":"History of chemotherapy","author":"Hawking","year":"1963"},{"key":"10.1016\/j.pt.2020.05.013_bb0435","series-title":"Drug Resistance of Microorganisms","author":"Schnitzer","year":"1957"},{"key":"10.1016\/j.pt.2020.05.013_bb0440","first-page":"1","article-title":"Chemotherapy of Malaria","volume":"27","author":"Covell","year":"1955"},{"key":"10.1016\/j.pt.2020.05.013_bb0445","author":"World Health Organization"},{"key":"10.1016\/j.pt.2020.05.013_bb0450","author":"World Health Organization"},{"key":"10.1016\/j.pt.2020.05.013_bb0455","author":"World Health Organization"},{"key":"10.1016\/j.pt.2020.05.013_bb0460","author":"World Health Organization"},{"key":"10.1016\/j.pt.2020.05.013_bb0465","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1473-3099(13)70252-4","article-title":"Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in vitro and ex vivo drug-response studies","volume":"13","author":"Witkowski","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2020.05.013_bb0470","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2020.05.013_bb0475","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01426-18","article-title":"Gametocytes from K13-propeller mutant Plasmodium falciparum clinical isolates demonstrate reduced susceptibility to dihydroartemisinin in the male gamete exflagellation inhibition assay","volume":"62","author":"Lozano","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0480","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pt.2020.05.013_bb0485","doi-asserted-by":"crossref","DOI":"10.1186\/s12936-017-1845-5","article-title":"Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia","volume":"16","author":"Mukherjee","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2020.05.013_bb0490","doi-asserted-by":"crossref","first-page":"12799","DOI":"10.1073\/pnas.1812317115","article-title":"Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility","volume":"115","author":"Demas","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2020.05.013_bb0495","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01542-19","article-title":"Modification of pfap2mu and pfubp1 markedly reduces ring-stage susceptibility of Plasmodium falciparum to artemisinin in vitro","volume":"64","author":"Henrici","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2020.05.013_bb0500","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1473-3099(14)70777-7","article-title":"Artemisinin resistance in Plasmodium falciparum","volume":"14","author":"Amaratunga","year":"2014","journal-title":"Lancet Infect. Dis."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492220301586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492220301586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:36:25Z","timestamp":1761464185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492220301586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":100,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1471492220301586"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2020.05.013","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u2018Artemisinin Resistance\u2019: Something New or Old? Something of a Misnomer?","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2020.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}