{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:41:47Z","timestamp":1778323307422,"version":"3.51.4"},"reference-count":87,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.pt.2021.08.011","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:13:20Z","timestamp":1632212000000},"page":"136-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Drug-induced hypersensitivity to artemisinin-based therapies for malaria"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-8409","authenticated-orcid":false,"given":"Tamara","family":"Nordmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-4393","authenticated-orcid":false,"given":"Steffen","family":"Borrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-1885","authenticated-orcid":false,"given":"Michael","family":"Ramharter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2021.08.011_bb0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/00034989859375","article-title":"Economics and its contribution to the fight against malaria","volume":"92","author":"Foster","year":"1998","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.pt.2021.08.011_bb0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4269\/ajtmh.2001.64.85","article-title":"The economic burden of malaria","volume":"64","author":"Gallup","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0015","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.4269\/ajtmh.19-0386","article-title":"The economic burden of malaria: revisiting the evidence","volume":"101","author":"Sarma","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0020","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0140-6736(93)90362-K","article-title":"Qinghaosu","volume":"341","author":"Hien","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2021.08.011_bb0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1475-2875-12-54","article-title":"Safety monitoring of artemisinin combination therapy through a national pharmacovigilance system in an endemic malaria setting","volume":"12","author":"Thiam","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2165\/00002018-200427010-00003","article-title":"Antimalarial drug toxicity: a review","volume":"27","author":"Taylor","year":"2004","journal-title":"Drug Saf."},{"key":"10.1016\/j.pt.2021.08.011_bb0035","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1056\/NEJMct0709050","article-title":"Artesunate for the treatment of severe falciparum malaria","volume":"358","author":"Rosenthal","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature15535","article-title":"The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015","volume":"526","author":"Bhatt","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.pt.2021.08.011_bb0045","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4269\/ajtmh.2001.65.690","article-title":"Artemisinin for treatment of uncomplicated falciparum malaria: Is there a place for monotherapy?","volume":"65","author":"Giao","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1128\/mr.60.2.301-315.1996","article-title":"Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy","volume":"60","author":"Meshnick","year":"1996","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.pt.2021.08.011_bb0055","series-title":"World Malaria Report 2018","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.pt.2021.08.011_bb0060","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJMc0900231","article-title":"Artemisinin-resistant malaria in Asia","volume":"361","author":"Noedl","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0065","series-title":"Artemisinin Resistance and Artemisinin-based Combination Therapy Efficacy, Global Malaria Programme","author":"World Health Organization","year":"2019"},{"key":"10.1016\/j.pt.2021.08.011_bb0070","series-title":"The Use of Artesunate-Pyronaridine for the Treatment of Uncomplicated Malaria","author":"World Health Organization","year":"2019"},{"key":"10.1016\/j.pt.2021.08.011_bb0075","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1093\/cid\/cix617","volume":"65","author":"Toure","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1475-2875-11-217","article-title":"The efficacy and tolerability of artemisinin-piperaquine (Artequick(R)) versus artesunate-amodiaquine (Coarsucam) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam","volume":"11","author":"Thanh","year":"2012","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0085","article-title":"Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria","volume":"2","author":"Isba","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pt.2021.08.011_bb0090","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1586\/eri.10.90","article-title":"Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria","volume":"8","author":"John","year":"2010","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"10.1016\/j.pt.2021.08.011_bb0095","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial","volume":"376","author":"Dondorp","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2021.08.011_bb0100","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(05)67176-0","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial","volume":"366","author":"Dondorp","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2021.08.011_bb0105","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4269\/ajtmh.1999.60.547","article-title":"Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives","volume":"60","author":"Price","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0110","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0035-9203(97)90032-8","article-title":"Artesunate\/mefloquine treatment of multi-drug resistant falciparum malaria","volume":"91","author":"Price","year":"1997","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/0972-5229.94440","article-title":"Anaphylaxis to artesunate?","volume":"16","author":"Dube","year":"2012","journal-title":"Indian J. Crit. Care Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0120","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/infdis\/jit841","article-title":"Delayed hemolysis after treatment with parenteral artesunate in African children with severe malaria \u2013 a double-center prospective study","volume":"209","author":"Rolling","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0125","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijid.2014.09.007","article-title":"Haemolysis associated with the treatment of malaria with artemisinin derivatives: a systematic review of current evidence","volume":"29","author":"Rehman","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0130","doi-asserted-by":"crossref","DOI":"10.1086\/657402","article-title":"Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria","volume":"51","author":"Bethell","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jaip.2018.10.044","article-title":"Association between maternal pre-pregnancy body mass index, gestational weight gain, and offspring atopic dermatitis: a prospective cohort study","volume":"7","author":"Drucker","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.pt.2021.08.011_bb0140","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/s12936-015-0918-6","article-title":"Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study","volume":"14","author":"Ndounga","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0145","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1128\/AAC.02682-14","article-title":"Randomized comparison of the efficacies and tolerabilities of three artemisinin-based combination treatments for children with acute Plasmodium falciparum malaria in the Democratic Republic of the Congo","volume":"58","author":"Onyamboko","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2021.08.011_bb0150","first-page":"45","article-title":"Comparative analysis of the safety and tolerability of fixed-dose artesunate\/amodiaquine versus artemether\/lumefantrine combinations for uncomplicated falciparum malaria in pregnancy: a randomized open label study","volume":"9","author":"Iribhogbe","year":"2017","journal-title":"Clin. Pharmacol. Adv. Applic."},{"key":"10.1016\/j.pt.2021.08.011_bb0155","doi-asserted-by":"crossref","first-page":"e0222379","DOI":"10.1371\/journal.pone.0222379","article-title":"Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo","volume":"14","author":"Lula Ntamba","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2021.08.011_bb0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12936-016-1655-1","article-title":"Safety of a fixed-dose combination of artesunate and amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in real-life conditions of use in Cote d'Ivoire","volume":"16","author":"Assi","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0165","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1475-2875-9-97","article-title":"Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria","volume":"9","author":"Phu","year":"2010","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0170","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/j.1365-3156.2006.01724.x","article-title":"An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand","volume":"11","author":"Ashley","year":"2006","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.pt.2021.08.011_bb0175","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s12936-015-0948-0","article-title":"A randomized trial of the efficacy of artesunate and three quinine regimens in the treatment of severe malaria in children at the Ebolowa Regional Hospital, Cameroon","volume":"14","author":"Maka","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0180","first-page":"149","article-title":"Anaphylactic reaction to intravenous artesunate: a case report","volume":"28","author":"Neki","year":"2015","journal-title":"JIMSA"},{"key":"10.1016\/j.pt.2021.08.011_bb0185","first-page":"183","article-title":"Anaphylactic reaction to intravenous artesunate","volume":"57","author":"Mohapatra","year":"2009","journal-title":"J. Assoc. Physicians India"},{"key":"10.1016\/j.pt.2021.08.011_bb0190","article-title":"Severe allergic reaction to oral artesunate-amodiaquine combination treatment for malaria: case report in the Democratic Republic of Congo","volume":"4","author":"Swana","year":"2017","journal-title":"Open Access Library J."},{"key":"10.1016\/j.pt.2021.08.011_bb0195","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2310\/7060.2003.2744","article-title":"Suspected allergy to artemether-lumefantrine treatment of malaria","volume":"10","author":"Krippner","year":"2003","journal-title":"J. Travel. Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0200","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0035-9203(01)90157-9","article-title":"Severe allergic reactions to oral artesunate: a report of two cases","volume":"95","author":"Leonardi","year":"2001","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003669","article-title":"Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study","volume":"18","author":"Tona Lutete","year":"2021","journal-title":"PLoS Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0050253","article-title":"A randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated Plasmodium falciparum treatment in pregnancy","volume":"5","author":"McGready","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0215","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4103\/0972-5229.146313","article-title":"Drug-induced anaphylactic reactions in Indian population: A systematic review","volume":"18","author":"Patel","year":"2014","journal-title":"Indian J. Crit. Care Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0220","doi-asserted-by":"crossref","first-page":"336","DOI":"10.18176\/jiaci.0199","article-title":"Update on the genetic basis of drug hypersensitivity reactions","volume":"27","author":"Jurado-Escobar","year":"2017","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.pt.2021.08.011_bb0225","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12936-016-1172-2","article-title":"Factors influencing adverse events reporting within the health care system: the case of artemisinin-based combination treatments in northern Ghana","volume":"15","author":"Chatio","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0230","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/0394632015589518","article-title":"Skin prick test results to artesunate in children sensitized to Artemisia vulgaris L","volume":"28","author":"Mori","year":"2015","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.pt.2021.08.011_bb0235","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jaip.2015.12.019","article-title":"Safety, costs, and efficacy of rapid drug desensitizations to chemotherapy and monoclonal antibodies","volume":"4","author":"Sloane","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.pt.2021.08.011_bb0240","series-title":"WHOPAR4 MA044 \u2013 Drug Information Artesunate 50 mg Tablets","author":"World Health Organization","year":"2006"},{"key":"10.1016\/j.pt.2021.08.011_bb0245","series-title":"Artesunate Rectal Capsules. FDA Division of Anti-Infective Drug Products Advisory Committee Briefing Document","author":"World Health Organization","year":"2002"},{"key":"10.1016\/j.pt.2021.08.011_bb0250","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.jaip.2020.08.006","article-title":"Practical guidance for the evaluation and management of drug hypersensitivity: specific drugs","volume":"8","author":"Broyles","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.pt.2021.08.011_bb0255","first-page":"501","article-title":"Drug hypersensitivity","volume":"115","author":"B\u00f6hm","year":"2018","journal-title":"Deutsch. Arztebl. Int."},{"key":"10.1016\/j.pt.2021.08.011_bb0260","series-title":"Guidelines for the Treatment of Malaria","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.pt.2021.08.011_bb0265","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4269\/ajtmh.2005.73.263","article-title":"Effectiveness of quinine monotherapy for the treatment of Plasmodium falciparum infection in pregnant women in Lambarene, Gabon","volume":"73","author":"Adegnika","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0270","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S1473-3099(14)70855-2","article-title":"Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis","volume":"14","author":"Price","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0275","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0764-4469(98)80009-7","article-title":"Impact of chloroquine resistance on malaria mortality","volume":"321","author":"Trape","year":"1998","journal-title":"C. R. Acad. Sci. III"},{"key":"10.1016\/j.pt.2021.08.011_bb0280","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12936-020-03281-x","article-title":"Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates","volume":"19","author":"Foguim","year":"2020","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0285","author":"Centers for Disease Control and Prevention"},{"key":"10.1016\/j.pt.2021.08.011_bb0290","series-title":"World Malaria Report 2020","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.pt.2021.08.011_bb0295","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s40265-018-0911-9","article-title":"Drugs in development for malaria","volume":"78","author":"Ashley","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.pt.2021.08.011_bb0300","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40249-016-0196-8","article-title":"Alternatives to currently used antimalarial drugs: in search of a magic bullet","volume":"5","author":"Bhagavathula","year":"2016","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.pt.2021.08.011_bb0305","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s12936-016-1511-3","article-title":"A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study","volume":"15","author":"McCarthy","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0310","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature14451","article-title":"A novel multiple-stage antimalarial agent that inhibits protein synthesis","volume":"522","author":"Baragana","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.pt.2021.08.011_bb0315","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01371-19","article-title":"A single-dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers","volume":"64","author":"McCarthy","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2021.08.011_bb0320","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1056\/NEJMoa1602250","article-title":"Antimalarial activity of KAF156 in falciparum and vivax malaria","volume":"375","author":"White","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0325","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S1473-3099(17)30365-1","article-title":"AQ-13, an investigational antimalarial, versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised, phase 2, non-inferiority clinical trial","volume":"17","author":"Koita","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0330","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0140-6736(02)11860-5","article-title":"Fosmidomycin for malaria","volume":"360","author":"Missinou","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2021.08.011_bb0335","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/cid\/cix1122","article-title":"Efficacy and safety of fosmidomycin-piperaquine as nonartemisinin-based combination therapy for uncomplicated falciparum malaria: a single-arm, age de-escalation proof-of-concept study in Gabon","volume":"66","author":"Mombo-Ngoma","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0340","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJMp1403340","article-title":"The origins of antimalarial-drug resistance","volume":"371","author":"Packard","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0345","series-title":"The Making of a Tropical Disease: a Short History of Malaria","author":"Packard","year":"2007"},{"key":"10.1016\/j.pt.2021.08.011_bb0350","first-page":"41","article-title":"Drug resistant malaria on the Thai\u2013Myanmar and Thai\u2013Cambodian borders","volume":"32","author":"Wongsrichanalai","year":"2001","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.pt.2021.08.011_bb0355","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.3390\/ijms21144986","article-title":"Artemisia annua, a traditional plant brought to light","volume":"21","author":"Septembre-Malaterre","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pt.2021.08.011_bb0360","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1021\/jm030571c","article-title":"A medicinal chemistry perspective on artemisinin and related endoperoxides","volume":"47","author":"O'Neill","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.pt.2021.08.011_bb0365","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nm.2471","article-title":"The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine","volume":"17","author":"Tu","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2021.08.011_bb0370","series-title":"Malaria: Artemisinin Resistance","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.pt.2021.08.011_bb0375","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/infdis\/170.4.971","article-title":"Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination","volume":"170","author":"Nosten","year":"1994","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0380","first-page":"739","article-title":"Antimalarial drug resistance and combination chemotherapy","volume":"354","author":"White","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.pt.2021.08.011_bb0385","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4269\/ajtmh.2007.77.193","article-title":"A major transition in malaria treatment: the adoption and deployment of artemisinin-based combination therapies","volume":"77","author":"Bosman","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.08.011_bb0390","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1073\/pnas.1217452110","article-title":"Altered temporal response of malaria parasites determines differential sensitivity to artemisinin","volume":"110","author":"Klonis","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2021.08.011_bb0395","article-title":"Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2021.08.011_bb0400","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/infdis\/jiv048","article-title":"Mitochondrial membrane potential in a small subset of artemisinin-induced dormant Plasmodium falciparum parasites in vitro","volume":"212","author":"Peatey","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2021.08.011_bb0405","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1871526513666131129155708","article-title":"Considerations on the mechanism of action of artemisinin antimalarials: part 1 \u2013 the 'carbon radical' and 'heme' hypotheses","volume":"13","author":"Haynes","year":"2013","journal-title":"Infect. Disord. Drug Targets"},{"key":"10.1016\/j.pt.2021.08.011_bb0410","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0006-2952(98)00184-1","article-title":"Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action","volume":"56","author":"Ginsburg","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pt.2021.08.011_bb0415","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s00436-020-06786-1","article-title":"Enhancing the antimalarial activity of artesunate","volume":"119","author":"Adebayo","year":"2020","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.pt.2021.08.011_bb0420","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000252658","article-title":"Pharmacokinetic and toxicological profile of artemisinin compounds: an update","volume":"84","author":"Medhi","year":"2009","journal-title":"Pharmacology"},{"key":"10.1016\/j.pt.2021.08.011_bb0425","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/1475-2875-10-263","article-title":"Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration","volume":"10","author":"Morris","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2021.08.011_bb0430","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/157488507781695649","article-title":"Pharmacokinetic and pharmacodynamic profiles of rapid-acting artemisinins in the antimalarial therapy","volume":"2","author":"Li","year":"2007","journal-title":"Curr. Drug Ther."},{"key":"10.1016\/j.pt.2021.08.011_bb0435","series-title":"World Malaria Report 2019","author":"World Health Organization","year":"2019"}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492221002245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492221002245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:37:33Z","timestamp":1761464253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492221002245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S1471492221002245"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2021.08.011","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug-induced hypersensitivity to artemisinin-based therapies for malaria","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2021.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}