{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:48:41Z","timestamp":1786996121219,"version":"build-2736575974"},"reference-count":15,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220211"],"award-info":[{"award-number":["220211"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223253\/Z\/21\/Z"],"award-info":[{"award-number":["223253\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.pt.2021.10.005","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:31:14Z","timestamp":1638318674000},"page":"11-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-0325","authenticated-orcid":false,"given":"James A.","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1978","authenticated-orcid":false,"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-2395","authenticated-orcid":false,"given":"Arjen M.","family":"Dondorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2021.10.005_bb0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-micro-020518-115628","article-title":"Ape origins of human malaria","volume":"74","author":"Sharp","year":"2020","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.pt.2021.10.005_bb0010","series-title":"World Malaria Report 2020","author":"WHO","year":"2021"},{"key":"10.1016\/j.pt.2021.10.005_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017439","article-title":"Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey","volume":"6","author":"Lubell","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2021.10.005_bb0020","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJMra1510865","article-title":"Sickle cell disease","volume":"376","author":"Piel","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2021.10.005_bb0025","doi-asserted-by":"crossref","first-page":"S398","DOI":"10.1016\/j.amepre.2011.09.013","article-title":"Sickle cell disease in Africa: a neglected cause of early childhood mortality","volume":"41","author":"Grosse","year":"2011","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.pt.2021.10.005_bb0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molbiopara.2006.05.007","article-title":"Red blood cell defects and malaria","volume":"149","author":"Williams","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2021.10.005_bb0035","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1016\/S2352-3026(18)30107-8","article-title":"Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case\u2013control association study","volume":"5","author":"Ndila","year":"2018","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.pt.2021.10.005_bb0040","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.4269\/ajtmh.15-0672","article-title":"Absence of association between sickle trait hemoglobin and placental malaria outcomes","volume":"94","author":"Patel","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2021.10.005_bb0045","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ng.3107","article-title":"Reappraisal of known malaria resistance loci in a large multicenter study","volume":"46","author":"Malaria Genomic Epidemiology","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pt.2021.10.005_bb0050","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1086\/430744","article-title":"Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases","volume":"192","author":"Williams","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2021.10.005_bb0055","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0140-6736(11)60888-X","article-title":"Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study","volume":"378","author":"Scott","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2021.10.005_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1469-1809.1954.tb01261.x","article-title":"Notes on sickle-cell polymorphism","volume":"19","author":"Allison","year":"1954","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.pt.2021.10.005_bb0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ncomms1104","article-title":"Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis","volume":"1","author":"Piel","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2021.10.005_bb0070","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1093\/hmg\/ddab004","article-title":"Evolutionary history of sickle-cell mutation: implications for global genetic medicine","volume":"30","author":"Esoh","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pt.2021.10.005_bb0075","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1056\/NEJMoa1303944","article-title":"Parasite burden and severity of malaria in Tanzanian children","volume":"370","author":"Goncalves","year":"2014","journal-title":"N. Engl. J. Med."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492221002622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492221002622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:38:34Z","timestamp":1761464314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492221002622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1471492221002622"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2021.10.005","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2021.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}