{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:46:18Z","timestamp":1791935178400,"version":"4.3.4"},"reference-count":100,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016962","name":"Department of Science and Innovation, South Africa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001343","name":"University of Pretoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.pt.2022.01.011","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T23:42:46Z","timestamp":1645227766000},"page":"390-403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Transmission-blocking drugs for malaria elimination"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5888-2905","authenticated-orcid":false,"given":"Lyn-Mari\u00e9","family":"Birkholtz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-9840","authenticated-orcid":false,"given":"Pietro","family":"Alano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-3204","authenticated-orcid":false,"given":"Didier","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2022.01.011_bb0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12936-016-1675-x","article-title":"New developments in anti-malarial target candidate and product profiles","volume":"16","author":"Burrows","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002456","article-title":"malERA: An updated research agenda for malaria elimination and eradication","volume":"14","author":"Rabinovich","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.pt.2022.01.011_bb0015","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.4155\/fmc.12.182","article-title":"Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs","volume":"4","author":"Delves","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.pt.2022.01.011_bb0020","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/cmi.12413","article-title":"The cell biology of malaria infection of mosquito: advances and opportunities","volume":"17","author":"Sinden","year":"2015","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2022.01.011_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006336","article-title":"Developing transmission-blocking strategies for malaria control","volume":"13","author":"Sinden","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2022.01.011_bb0030","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S0031182000076721","article-title":"Heterogeneity in patterns of malarial oocyst infections in the mosquito vector","volume":"106","author":"Medley","year":"1993","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2022.01.011_bb0035","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/S1473-3099(21)00072-4","article-title":"Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study","volume":"21","author":"Andolina","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2022.01.011_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009672","article-title":"Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities","volume":"15","author":"Koepfli","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2022.01.011_bb0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/infdis\/jiv370","article-title":"Dynamics of the human infectious reservoir for malaria determined by mosquito feeding assays and ultrasensitive malaria diagnosis in Burkina Faso","volume":"213","author":"Ouedraogo","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2022.01.011_bb0050","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.pt.2016.04.017","article-title":"Discovering new transmission-blocking antimalarial compounds: challenges and opportunities","volume":"32","author":"Birkholtz","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0055","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12936-019-2841-8","article-title":"Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial","volume":"18","author":"Raman","year":"2019","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0060","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1038\/s41467-021-22573-7","article-title":"Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections","volume":"12","author":"Barry","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2022.01.011_bb0065","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1186\/s12936-016-1633-7","article-title":"Environmental determinants of malaria transmission in African villages","volume":"15","author":"Endo","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0070","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1172\/JCI21682","article-title":"Antimalarial drug resistance","volume":"113","author":"White","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pt.2022.01.011_bb0075","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/mmi.13397","article-title":"CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs","volume":"101","author":"Ng","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2022.01.011_bb0080","article-title":"Transmission of artemisinin-resistant malaria parasites to mosquitoes under antimalarial drug pressure","volume":"65","author":"Witmer","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0085","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ijpara.2020.12.002","article-title":"Transgenic pyrimethamine-resistant Plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug","volume":"51","author":"Posayapisit","year":"2021","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0090","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.aad9279","article-title":"Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes","volume":"352","author":"Goodman","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.pt.2022.01.011_bb0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.chom.2015.12.001","article-title":"High-throughput assay and discovery of small molecules that interrupt malaria transmission","volume":"19","author":"Plouffe","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2022.01.011_bb0100","doi-asserted-by":"crossref","first-page":"7389","DOI":"10.1038\/s41598-017-06708-9","article-title":"Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa","volume":"7","author":"Okell","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2022.01.011_bb0105","first-page":"CD008152","article-title":"Primaquine or other 8-aminoquinolines for reducing Plasmodium falciparum transmission","volume":"2","author":"Graves","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pt.2022.01.011_bb0110","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1038\/s41467-019-11239-0","article-title":"Antimalarial activity of primaquine operates via a two-step biochemical relay","volume":"10","author":"Camarda","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2022.01.011_bb0115","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.pt.2018.07.001","article-title":"Antimalarial transmission-blocking interventions: past, present, and future","volume":"34","author":"Delves","year":"2018","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135139","article-title":"A new set of chemical starting points with Plasmodium falciparum transmission-blocking potential for antimalarial drug discovery","volume":"10","author":"Almela","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2022.01.011_bb0125","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1128\/AAC.04684-14","article-title":"Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation","volume":"59","author":"Miguel-Blanco","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0130","doi-asserted-by":"crossref","first-page":"15160","DOI":"10.1038\/ncomms15160","article-title":"Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen","volume":"8","author":"Miguel-Blanco","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2022.01.011_bb0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12936-017-1805-0","article-title":"Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening","volume":"16","author":"Sun","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0140","first-page":"1","article-title":"Chemical signatures and new drug targets for gametocytocidal drug development","volume":"4","author":"Sun","year":"2014","journal-title":"Nat. Sci. Rep."},{"key":"10.1016\/j.pt.2022.01.011_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-12-134","article-title":"Temporal evaluation of commitment to sexual development in Plasmodium falciparum","volume":"12","author":"Peatey","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0150","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.molbiopara.2011.09.002","article-title":"A high throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes","volume":"180","author":"Peatey","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0155","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.molbiopara.2011.02.005","article-title":"A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue","volume":"177","author":"Tanaka","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035019","article-title":"Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence 'transmission blocking' assay","volume":"7","author":"Lelievre","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2022.01.011_bb0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jep.2016.03.036","article-title":"In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species","volume":"185","author":"Moyo","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.pt.2022.01.011_bb0170","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1086\/644645","article-title":"Effect of antimalarial drugs on Plasmodium falciparum gametocytes","volume":"200","author":"Peatey","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2022.01.011_bb0175","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1073\/pnas.1112037108","article-title":"Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue","volume":"108","author":"Adjalley","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2022.01.011_bb0180","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/1475-2875-12-408","article-title":"Identification of inhibitors of Plasmodium falciparum gametocyte development","volume":"12","author":"Duffy","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0185","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1021\/acs.jmedchem.7b00671","article-title":"Development of a potent inhibitor of the Plasmodium proteasome with reduced mammalian toxicity","volume":"60","author":"LaMonte","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.pt.2022.01.011_bb0190","doi-asserted-by":"crossref","first-page":"7292","DOI":"10.1128\/AAC.03666-14","article-title":"A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs","volume":"58","author":"Ruecker","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0195","first-page":"16414","article-title":"A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds","volume":"5","author":"Lucantoni","year":"2015","journal-title":"Nat. Sci. Rep."},{"key":"10.1016\/j.pt.2022.01.011_bb0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12936-015-0718-z","article-title":"Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination","volume":"14","author":"Reader","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0205","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1128\/AAC.00870-13","article-title":"Identification of MMV malaria box inhibitors of Plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay","volume":"57","author":"Lucantoni","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0210","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1128\/AAC.01949-15","article-title":"Luciferase-based, high-throughput assay for screening and profiling transmission-blocking compounds against Plasmodium falciparum gametocytes","volume":"60","author":"Lucantoni","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0215","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/jac\/dkv493","article-title":"A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays","volume":"71","author":"D'Alessandro","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0220","doi-asserted-by":"crossref","first-page":"8814","DOI":"10.1021\/ac502098w","article-title":"Multicolor bioluminescence boosts malaria research: quantitative dual-color assay and single-cell imaging in Plasmodium falciparum parasites","volume":"86","author":"Cevenini","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.pt.2022.01.011_bb0225","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41467-020-20629-8","article-title":"Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box","volume":"12","author":"Reader","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2022.01.011_bb0230","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molbiopara.2013.02.005","article-title":"A quantitative high throughput assay for identifying gametocytocidal compounds","volume":"188","author":"Tanaka","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0235","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1128\/AAC.00325-13","article-title":"Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs","volume":"57","author":"Delves","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0240","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3389\/fmicb.2019.02134","article-title":"Fueling open innovation for malaria transmission-blocking drugs: hundreds of molecules targeting early parasite mosquito stages","volume":"10","author":"Delves","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pt.2022.01.011_bb0245","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1475-2875-9-136","article-title":"Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs","volume":"9","author":"Bousema","year":"2010","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2022.01.011_bb0250","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41586-019-0973-1","article-title":"Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission","volume":"567","author":"Paton","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.pt.2022.01.011_bb0255","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1186\/s12864-019-6322-9","article-title":"Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation","volume":"20","author":"van Biljon","year":"2019","journal-title":"BMC Genom."},{"key":"10.1016\/j.pt.2022.01.011_bb0260","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1093\/nar\/gkw536","article-title":"Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression","volume":"44","author":"Lasonder","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2022.01.011_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004871","article-title":"Targeting human transmission biology for malaria elimination","volume":"11","author":"Nilsson","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2022.01.011_bb0270","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025452","article-title":"Biology of malaria transmission","volume":"7","author":"Meibalan","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.pt.2022.01.011_bb0275","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/femsre\/fuz010","article-title":"Revisiting gametocyte biology in malaria parasites","volume":"43","author":"Ngotho","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.pt.2022.01.011_bb0280","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature19804","article-title":"Diversity-oriented synthesis yields novel multistage antimalarial inhibitors","volume":"538","author":"Kato","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pt.2022.01.011_bb0285","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature14451","article-title":"A novel multiple-stage antimalarial agent that inhibits protein synthesis","volume":"522","author":"Baragana","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.pt.2022.01.011_bb0290","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature16936","article-title":"Structure- and function-based design of Plasmodium-selective proteasome inhibitors","volume":"530","author":"Li","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pt.2022.01.011_bb0295","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ejmech.2018.03.024","volume":"150","author":"Vallone","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.pt.2022.01.011_bb0300","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1128\/AAC.01930-13","article-title":"Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen","volume":"59","author":"Tanaka","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0305","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(04)00449-0","article-title":"Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite","volume":"117","author":"Billker","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.pt.2022.01.011_bb0310","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.chom.2012.05.014","article-title":"A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs","volume":"12","author":"Sebastian","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2022.01.011_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.602803","article-title":"Targeting the malaria parasite cGMP-dependent protein kinase to develop new drugs","volume":"11","author":"Baker","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pt.2022.01.011_bb0320","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1128\/AAC.01183-15","article-title":"ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria","volume":"59","author":"Miley","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0325","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.chom.2018.01.008","article-title":"Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites","volume":"23","author":"Fraschka","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2022.01.011_bb0330","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41598-017-00687-7","article-title":"Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites","volume":"7","author":"Coetzee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2022.01.011_bb0335","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1038\/s41598-020-59298-4","article-title":"Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites","volume":"10","author":"Coetzee","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2022.01.011_bb0340","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1021\/acsinfecdis.9b00455","article-title":"Disruption of the Plasmodium falciparum life cycle through transcriptional reprogramming by inhibitors of Jumonji demethylases","volume":"6","author":"Matthews","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.pt.2022.01.011_bb0345","doi-asserted-by":"crossref","first-page":"17680","DOI":"10.1038\/s41598-017-16671-0","article-title":"Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission","volume":"7","author":"Dechering","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2022.01.011_bb0350","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1517\/17460441.2016.1154037","article-title":"Resisting resistance: is there a solution for malaria?","volume":"11","author":"Verlinden","year":"2016","journal-title":"Exp. Opin. Drug Discov."},{"key":"10.1016\/j.pt.2022.01.011_bb0355","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1126\/science.aan4472","article-title":"Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics","volume":"359","author":"Cowell","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pt.2022.01.011_bb0360","doi-asserted-by":"crossref","DOI":"10.1177\/1178636118808529","article-title":"Exploration of the Plasmodium falciparum resistome and druggable genome reveals new mechanisms of drug resistance and antimalarial targets","volume":"11","author":"Cowell","year":"2018","journal-title":"Microb. Insights"},{"key":"10.1016\/j.pt.2022.01.011_bb0365","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13073-019-0673-3","article-title":"Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections","volume":"11","author":"Cowell","year":"2019","journal-title":"Genome Med."},{"key":"10.1016\/j.pt.2022.01.011_bb0370","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/acsinfecdis.7b00276","article-title":"Using in vitro evolution and whole genome analysis to discover next generation targets for antimalarial drug discovery","volume":"4","author":"Luth","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.pt.2022.01.011_bb0375","article-title":"Plasmodium falciparum protein Pfs16 is a target for transmission blocking antimalarial drug development","author":"Yahiya","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2022.01.011_bb0380","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1471-4922(02)02292-4","article-title":"Sexual differentiation and sex determination in the Apicomplexa","volume":"18","author":"Smith","year":"2002","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0385","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1741-7007-11-67","article-title":"Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum","volume":"11","author":"MacRae","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.pt.2022.01.011_bb0390","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pt.2014.02.001","article-title":"The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development","volume":"30","author":"Salcedo-Sora","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0395","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1038\/s41467-018-05777-2","article-title":"A high throughput screen for next-generation leads targeting malaria parasite transmission","volume":"9","author":"Delves","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2022.01.011_bb0400","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/465297a","article-title":"Drug discovery: Priming the antimalarial pipeline","volume":"465","author":"Fidock","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pt.2022.01.011_bb0405","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1172\/JCI98012","article-title":"A controlled human malaria infection model enabling evaluation of transmission-blocking interventions","volume":"128","author":"Collins","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pt.2022.01.011_bb0410","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/CMR.00025-08","article-title":"Acquired immunity to malaria","volume":"22","author":"Doolan","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.pt.2022.01.011_bb0415","series-title":"Updated WHO Policy Recommendation. Single Dose Primaquine as a Gametocytocide in Plasmodium falciparum Malaria","author":"WHO","year":"2012"},{"key":"10.1016\/j.pt.2022.01.011_bb0420","doi-asserted-by":"crossref","first-page":"eaas9917","DOI":"10.1126\/scitranslmed.aas9917","article-title":"Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum","volume":"11","author":"Schalkwijk","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2022.01.011_bb0425","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1038\/s41467-021-24954-4","article-title":"CRISPR\/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research","volume":"12","author":"Boltryk","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2022.01.011_bb0430","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31549","article-title":"A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model","volume":"7","author":"Reuling","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.pt.2022.01.011_bb0435","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.pt.2015.02.006","article-title":"Erythrocyte remodeling by Plasmodium falciparum gametocytes in the human host interplay","volume":"31","author":"Tiburcio","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb0440","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fcimb.2018.00050","article-title":"Gametocytes of the malaria parasite Plasmodium falciparum interact with and stimulate bone marrow mesenchymal cells to secrete angiogenetic factors","volume":"8","author":"Messina","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.pt.2022.01.011_bb0445","doi-asserted-by":"crossref","first-page":"244re5","DOI":"10.1126\/scitranslmed.3008882","article-title":"Plasmodium falciparum transmission stages accumulate in the human bone marrow","volume":"6","author":"Joice","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2022.01.011_bb0450","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1182\/blood.2019004746","article-title":"Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis","volume":"136","author":"Neveu","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.pt.2022.01.011_bb0455","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.3389\/fmicb.2019.02652","article-title":"Erythrocyte membrane makeover by Plasmodium falciparum gametocytes","volume":"10","author":"Neveu","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pt.2022.01.011_bb0460","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s42003-020-01454-7","article-title":"Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability","volume":"3","author":"Bouyer","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.pt.2022.01.011_bb0465","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI61822","article-title":"Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors","volume":"122","author":"Ojo","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pt.2022.01.011_bb0470","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.1103717","article-title":"A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses","volume":"307","author":"Hall","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.pt.2022.01.011_bb0475","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1038\/s41467-021-23919-x","article-title":"Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum","volume":"12","author":"Evers","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2022.01.011_bb0480","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1128\/AAC.06377-11","article-title":"The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector","volume":"56","author":"van Pelt-Koops","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0485","doi-asserted-by":"crossref","first-page":"eaad9735","DOI":"10.1126\/scitranslmed.aad9735","article-title":"Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase","volume":"9","author":"Paquet","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2022.01.011_bb0490","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1128\/AAC.02727-13","article-title":"KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission","volume":"58","author":"Kuhen","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2022.01.011_bb0495","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.pt.2021.04.006","article-title":"Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials","volume":"37","author":"Duffey","year":"2021","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2022.01.011_bb2005","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag2374","article-title":"Oral, ultra-long-lasting drug delivery: application toward malaria elimination goals","volume":"8","author":"Bellinger","year":"2016","journal-title":"Sci. Transl. Med."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492222000125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492222000125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:38:40Z","timestamp":1761464320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492222000125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":100,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1471492222000125"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2022.01.011","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transmission-blocking drugs for malaria elimination","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2022.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}