{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:37:51Z","timestamp":1783355871929,"version":"3.54.6"},"reference-count":99,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","bmn.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.pt.2024.05.006","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T22:07:05Z","timestamp":1717884425000},"page":"549-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Using our understanding of interactions between helminth metabolism and host immunity to target worm survival"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8480-5049","authenticated-orcid":false,"given":"Ella K.","family":"Reed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8150-5702","authenticated-orcid":false,"given":"Katherine A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2024.05.006_bb0005","doi-asserted-by":"crossref","first-page":"R252","DOI":"10.1016\/j.cub.2017.02.016","article-title":"Platyhelminthes","volume":"27","author":"Collins","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.pt.2024.05.006_bb0010","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3390\/ani13101599","article-title":"The Economic impact of parasitism from nematodes, trematodes and ticks on beef cattle production","volume":"13","author":"Strydom","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.pt.2024.05.006_bb0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules","volume":"49","author":"Maizels","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.pt.2024.05.006_bb0020","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41385-022-00531-w","article-title":"Tissue-specific immunity in helminth infections","volume":"15","author":"Vacca","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.pt.2024.05.006_bb0025","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1128\/CMR.05040-11","article-title":"Helminth infections and host immune regulation","volume":"25","author":"McSorley","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.pt.2024.05.006_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006591","article-title":"Soil-transmitted helminth reinfection four and six months after mass drug administration: results from the delta region of Myanmar","volume":"13","author":"Dunn","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2024.05.006_bb0035","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1016\/S2214-109X(20)30398-3","article-title":"Prevalence and intensity of soil-transmitted helminth infections of children in sub-Saharan Africa, 2000\u201318: a geospatial analysis","volume":"9","author":"Sartorius","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.pt.2024.05.006_bb0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13071-019-3532-6","article-title":"The role of water, sanitation and hygiene interventions in reducing soil-transmitted helminths: interpreting the evidence and identifying next steps","volume":"12","author":"Vaz Nery","year":"2019","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2024.05.006_bb0045","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.2147\/IDR.S332378","article-title":"Anthelmintic resistance and its mechanism: a review","volume":"14","author":"Fissiha","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.pt.2024.05.006_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1051\/parasite\/2020062","article-title":"Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database","volume":"27","author":"Rose Vineer","year":"2020","journal-title":"Parasite"},{"key":"10.1016\/j.pt.2024.05.006_bb0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/pathogens13010077","article-title":"First report of benzimidazole resistance in field population of Haemonchus contortus from sheep, goats and cattle in Bosnia and Herzegovina","volume":"13","author":"Kapo","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.pt.2024.05.006_bb0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/1389203717999160226180733","article-title":"Metabolic enzymes of helminth parasites: potential as drug targets","volume":"17","author":"Timson","year":"2016","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.pt.2024.05.006_bb0065","series-title":"In Silico Drug Design","first-page":"329","article-title":"Chapter 12 - Omics-Driven Knowledge-Based Discovery of Anthelmintic Targets and Drugs","author":"Tyagi","year":"2019"},{"key":"10.1016\/j.pt.2024.05.006_bb0070","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1111\/jcmm.17913","article-title":"Programmed cell death pathways as targets for developing antifilarial drugs: lessons from the recent findings","volume":"27","author":"Das","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.pt.2024.05.006_bb0075","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/EBC20190041","article-title":"Metabolism","volume":"64","author":"Judge","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.pt.2024.05.006_bb0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbabio.2012.08.002","article-title":"Anaerobic energy metabolism in unicellular photosynthetic eukaryotes","volume":"1827","author":"Atteia","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2024.05.006_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009991","article-title":"Identification of enzymes that have helminth-specific active sites and are required for rhodoquinone-dependent metabolism as targets for new anthelmintics","volume":"15","author":"Lautens","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2024.05.006_bb0090","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0166-6851(94)90154-6","article-title":"Differential expression of two succinate dehydrogenase subunit-B genes and a transition in energy metabolism during the development of the parasitic nematode Haemonchus contortus","volume":"66","author":"Roos","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0166-6851(92)90153-B","article-title":"The facultative anaerobic energy metabolism of Schistosoma mansoni sporocysts","volume":"56","author":"Tielens","year":"1992","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0100","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3389\/fgene.2018.00504","article-title":"The genetic makeup and expression of the glycolytic and fermentative pathways are highly conserved within the Saccharomyces genus","volume":"9","author":"Boonekamp","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.pt.2024.05.006_bb0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/acsinfecdis.0c00658","article-title":"Areas of metabolomic exploration for helminth infections","volume":"7","author":"Whitman","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.pt.2024.05.006_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1052352","article-title":"Toward novel treatment against filariasis: insight into genome-wide co-evolutionary analysis of filarial nematodes and Wolbachia","volume":"14","author":"Wangwiwatsin","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pt.2024.05.006_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010881","article-title":"Characterization of a novel pyruvate kinase from Trichinella spiralis and its participation in sugar metabolism, larval molting and development","volume":"16","author":"Yue","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2024.05.006_bb0120","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.vetpar.2005.10.008","article-title":"Field trial on comparative efficacy of four fasciolicides against natural liver fluke infection in cattle","volume":"135","author":"Elitok","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2023.1268658","article-title":"Coadministration of ivermectin and abamectin affects milk pharmacokinetics of the antiparasitic clorsulon in Assaf sheep","volume":"10","author":"Blanco-Paniagua","year":"2023","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.pt.2024.05.006_bb0130","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.pt.2016.03.002","article-title":"Current threat of triclabendazole resistance in Fasciola hepatica","volume":"32","author":"Kelley","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0135","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4269\/ajtmh.2010.09-0461","article-title":"Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice","volume":"82","author":"Keiser","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2024.05.006_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152995","article-title":"Cellular targets of mefloquine","volume":"464","author":"Ghosh","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.pt.2024.05.006_bb0145","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0167-4889(97)00150-X","article-title":"Evolution and regulatory role of the hexokinases","volume":"1401","author":"C\u00e1rdenas","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2024.05.006_bb0150","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1016\/0006-2952(85)90359-4","article-title":"The effect of 5-thioglucose on the energy metabolism of Schistosoma mansoni in vitro","volume":"34","author":"Tielens","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pt.2024.05.006_bb0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/(SICI)1099-1263(199601)16:1<57::AID-JAT305>3.0.CO;2-R","article-title":"Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate","volume":"16","author":"Jones","year":"1996","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.pt.2024.05.006_bb0160","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S0031182011002204","article-title":"Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase","volume":"139","author":"Manneck","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2024.05.006_bb0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13567-019-0710-7","article-title":"In vitro and in vivo effects of 3-bromopyruvate against Echinococcus metacestodes","volume":"50","author":"Xin","year":"2019","journal-title":"Vet. Res."},{"key":"10.1016\/j.pt.2024.05.006_bb0170","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3348\/kjr.2009.10.6.596","article-title":"The antitumor effect and hepatotoxicity of a hexokinase II inhibitor 3-bromopyruvate: in vivo investigation of intraarterial administration in a rabbit VX2 hepatoma model","volume":"10","author":"Jae","year":"2009","journal-title":"Korean J. Radiol."},{"key":"10.1016\/j.pt.2024.05.006_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176403","article-title":"Molecular docking studies of 3-bromopyruvate and its derivatives to metabolic regulatory enzymes: implication in designing of novel anticancer therapeutic strategies","volume":"12","author":"Yadav","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2024.05.006_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002151","article-title":"A potential role for the interaction of Wolbachia surface proteins with the Brugia malayi glycolytic enzymes and cytoskeleton in maintenance of endosymbiosis","volume":"7","author":"Melnikow","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2024.05.006_bb0185","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51850","article-title":"Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets","volume":"9","author":"Curran","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.pt.2024.05.006_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008085","article-title":"Pyruvate produced by Brugia spp. via glycolysis is essential for maintaining the mutualistic association between the parasite and its endosymbiont, Wolbachia","volume":"15","author":"Voronin","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.pt.2024.05.006_bb0195","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","article-title":"Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection","volume":"350","author":"Gardon","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2024.05.006_bb0200","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0035-9203(98)91091-4","article-title":"Impact of repeated large scale ivermectin treatments on the transmission of Loa loa","volume":"92","author":"Chippaux","year":"1998","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2024.05.006_bb0205","doi-asserted-by":"crossref","first-page":"494","DOI":"10.2174\/1568026618666180523111351","article-title":"Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer","volume":"18","author":"Akins","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.pt.2024.05.006_bb0210","article-title":"Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: a review","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.pt.2024.05.006_bb0215","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1038\/s41467-019-10042-1","article-title":"Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis","volume":"10","author":"Cheng","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2024.05.006_bb0220","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13046-017-0530-4","article-title":"Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2","volume":"36","author":"Li","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.pt.2024.05.006_bb0225","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/s41598-022-05653-6","article-title":"The protective effect of licochalcone A against inflammation injury of primary dairy cow claw dermal cells induced by lipopolysaccharide","volume":"12","author":"Tian","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2024.05.006_bb0230","first-page":"1181","article-title":"Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway","volume":"39","author":"Wu","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.pt.2024.05.006_bb0235","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.molbiopara.2007.12.013","article-title":"The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1","volume":"158","author":"Chambers","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0240","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopha.2017.09.128","article-title":"Licochalcone A induces morphological and biochemical alterations in Schistosoma mansoni adult worms","volume":"96","author":"Souza","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.pt.2024.05.006_bb0245","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0166-6851(87)90055-7","article-title":"Biochemical changes during the aerobic-anaerobic transition in Ascaris suum larvae","volume":"22","author":"Komuniecki","year":"1987","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0250","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0005-2728(01)00237-7","article-title":"Role of complex II in anaerobic respiration of the parasite mitochondria from Ascaris suum and Plasmodium falciparum","volume":"1553","author":"Kita","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2024.05.006_bb0255","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0020-711X(79)90133-2","article-title":"The formation of propionate and acetate as terminal processes in the energy metabolism of the adult liver fluke Fasciola hepatica","volume":"10","author":"van Vugt","year":"1979","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.pt.2024.05.006_bb0260","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0166-6851(87)90159-9","article-title":"Differences in intermediary energy metabolism between juvenile and adult Fasciola hepatica","volume":"24","author":"Tielens","year":"1987","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0265","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1292\/jvms.17-0406","article-title":"Hybrid origin of Asian aspermic Fasciola flukes is confirmed by analyzing two single-copy genes, pepck and pold","volume":"80","author":"Hayashi","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.pt.2024.05.006_bb0270","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46456-6","article-title":"Phosphoproteomics analysis of male and female Schistosoma mekongi adult worms","volume":"9","author":"Simanon","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2024.05.006_bb0275","first-page":"1327","article-title":"Malate dehydrogenase in helminth parasites. Inhibition by benzimidazoles and pyrimidine derivatives","volume":"37","author":"Sanchez-Moreno","year":"1987","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.pt.2024.05.006_bb0280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bj.2017.12.001","article-title":"Structure and mechanism of mitochondrial electron transport chain","volume":"41","author":"Guo","year":"2018","journal-title":"Biomed. J."},{"key":"10.1016\/j.pt.2024.05.006_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2020.148278","article-title":"Rhodoquinone in bacteria and animals: two distinct pathways for biosynthesis of this key electron transporter used in anaerobic bioenergetics","volume":"1861","author":"Salinas","year":"2020","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.pt.2024.05.006_bb0290","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1074\/jbc.270.2.928","article-title":"Stage-specific isoforms of complex II (succinate-ubiquinone oxidoreductase) in mitochondria from the parasitic nematode, Ascaris suum","volume":"270","author":"Saruta","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2024.05.006_bb0295","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/AAC.00378-07","article-title":"Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis","volume":"52","author":"Matsumoto","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2024.05.006_bb0300","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1073\/pnas.98.1.60","article-title":"An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria","volume":"98","author":"Omura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2024.05.006_bb0305","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1073\/pnas.0237315100","article-title":"Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)","volume":"100","author":"Miyadera","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2024.05.006_bb0310","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.3390\/nu13072474","article-title":"Mechanisms of glucose absorption in the small intestine in health and metabolic diseases and their role in appetite regulation","volume":"13","author":"Gromova","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.pt.2024.05.006_bb0315","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"Tsai","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.pt.2024.05.006_bb0320","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0065-308X(08)60306-1","article-title":"Amino acid metabolism in helminths","volume":"30","author":"Barrett","year":"1991","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0325","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1021\/bi5004519","article-title":"Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis","volume":"53","author":"Hai","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.pt.2024.05.006_bb0330","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/CMR.00019-06","article-title":"Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by \u2018amitochondriate\u2019 protozoan parasites","volume":"20","author":"Ali","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.pt.2024.05.006_bb0335","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijpara.2008.06.015","article-title":"Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity","volume":"39","author":"Fitzpatrick","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0340","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.4049\/jimmunol.143.12.4208","article-title":"Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates","volume":"143","author":"James","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2024.05.006_bb0345","doi-asserted-by":"crossref","first-page":"8446","DOI":"10.4049\/jimmunol.179.12.8446","article-title":"An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis","volume":"179","author":"Gaur","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2024.05.006_bb0350","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.plefa.2006.05.012","article-title":"Polyunsaturated fatty acids and inflammation","volume":"75","author":"Calder","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.pt.2024.05.006_bb0355","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2016.17","article-title":"Regulation of immune cell function by short-chain fatty acids","volume":"5","author":"Corr\u00eaa-Oliveira","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.pt.2024.05.006_bb0360","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11306-019-1561-y","article-title":"Metabolomic profiling of the excretory-secretory products of hookworm and whipworm","volume":"15","author":"Wangchuk","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.pt.2024.05.006_bb0365","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00851-18","article-title":"Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes","volume":"87","author":"Wangchuk","year":"2019","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pt.2024.05.006_bb0370","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijpara.2009.12.006","article-title":"Acetate formation in the energy metabolism of parasitic helminths and protists","volume":"40","author":"Tielens","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0375","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00225-21","article-title":"Small intestinal levels of the branched short-chain fatty acid isovalerate are elevated during infection with Heligmosomoides polygyrus and can promote helminth fecundity","volume":"89","author":"Kennedy","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pt.2024.05.006_bb0380","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0001-706X(90)90033-V","article-title":"The surface lipid of parasitic nematodes: organization, and modifications during transition to the mammalian host environment","volume":"47","author":"Proudfoot","year":"1990","journal-title":"Acta Trop."},{"key":"10.1016\/j.pt.2024.05.006_bb0385","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aca.2017.11.058","article-title":"The Schistosoma mansoni lipidome: leads for immunomodulation","volume":"1037","author":"Giera","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.pt.2024.05.006_bb0390","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/eji.202048909","article-title":"Prostaglandin regulation of type 2 inflammation: from basic biology to therapeutic interventions","volume":"51","author":"Oyesola","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.pt.2024.05.006_bb0395","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.3390\/nu15183899","article-title":"The role of lipids in the regulation of immune responses","volume":"15","author":"Garcia","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.pt.2024.05.006_bb0400","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.4049\/jimmunol.168.4.1704","article-title":"Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals","volume":"168","author":"de Jong","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2024.05.006_bb0405","first-page":"511","article-title":"Blockade of PGE2, PGD2 receptors confers protection against prepatent Schistosomiasis mansoni in mice","volume":"45","author":"Abdel-Ghany","year":"2015","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0410","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1096\/fj.201600841R","article-title":"The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells","volume":"31","author":"Laan","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.pt.2024.05.006_bb0415","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1476-5381.2009.00290.x","article-title":"Resolvins and protectins: mediating solutions to inflammation","volume":"158","author":"Kohli","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pt.2024.05.006_bb0420","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.curtheres.2019.06.001","article-title":"Schistosomiasis: life cycle, diagnosis, and control","volume":"91","author":"Nelwan","year":"2019","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"10.1016\/j.pt.2024.05.006_bb0425","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1182\/blood-2012-07-442640","article-title":"The biology of nematode- and IL4R\u03b1-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics","volume":"120","author":"Thomas","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.pt.2024.05.006_bb0430","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay0605","article-title":"An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products","volume":"12","author":"de Los Reyes Jimenez","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2024.05.006_bb0435","doi-asserted-by":"crossref","DOI":"10.3389\/fpara.2023.1214136","article-title":"Chronic small intestinal helminth infection perturbs bile acid homeostasis and disrupts bile acid signaling in the murine small intestine","volume":"2","author":"Lane","year":"2023","journal-title":"Front. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0440","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41385-019-0162-4","article-title":"Emerging roles of bile acids in mucosal immunity and inflammation","volume":"12","author":"Chen","year":"2019","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.pt.2024.05.006_bb0445","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0020-7519(81)90079-5","article-title":"The location of parasites within their hosts: bile and the site selection behaviour of Nematospiroides dubius","volume":"11","author":"Sukhdeo","year":"1981","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0450","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/biom9020054","article-title":"Combination anthelmintic\/antioxidant activity against Schistosoma mansoni","volume":"9","author":"Gouveia","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.pt.2024.05.006_bb0455","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0305-0491(86)90186-0","article-title":"Transfer of [14C] cholesterol and its metabolites between adult male and female worms of Schistosoma mansoni","volume":"85","author":"Silveira","year":"1986","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.pt.2024.05.006_bb0460","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0005-2760(72)90256-1","article-title":"Metabolism of steroid hormones by schistosomes","volume":"280","author":"Briggs","year":"1972","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pt.2024.05.006_bb0465","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijantimicag.2017.01.037","article-title":"Anthelmintic activity of cytochrome P450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke Opisthorchis felineus","volume":"50","author":"Mordvinov","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.pt.2024.05.006_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004279","article-title":"The Schistosoma mansoni cytochrome P450 (CYP3050A1) is essential for worm survival and egg development","volume":"9","author":"Ziniel","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2024.05.006_bb0475","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijpara.2014.12.001","article-title":"The cytochrome P450 family in the parasitic nematode Haemonchus contortus","volume":"45","author":"Laing","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0480","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0020-7519(96)00161-0","article-title":"Cytochrome P450 monooxygenase activity in Haemonchus contortus (Nematoda)","volume":"27","author":"Kotze","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0485","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.molbiopara.2011.11.005","article-title":"Cytochrome P450 in fluke Opisthorchis felineus: identification and characterization","volume":"181","author":"Pakharukova","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2024.05.006_bb0490","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1038\/s41467-023-42552-4","article-title":"A genome-scale metabolic model of parasitic whipworm","volume":"14","author":"Bay","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2024.05.006_bb0495","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1038\/s41467-022-29334-0","article-title":"Defining the early stages of intestinal colonisation by whipworms","volume":"13","author":"Duque-Correa","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492224001351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492224001351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T08:54:54Z","timestamp":1744448094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492224001351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":99,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S1471492224001351"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2024.05.006","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Using our understanding of interactions between helminth metabolism and host immunity to target worm survival","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2024.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2024 Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}