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Parasitol."},{"key":"10.1016\/j.pt.2024.07.009_bb0440","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1017\/S0031182014001760","article-title":"Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location","volume":"142","author":"Bajnok","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/j.pt.2024.07.009_bb0445","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3390\/ani11041048","article-title":"Seroprevalence of Toxoplasma gondii among sylvatic rodents in Poland","volume":"11","author":"Grzybek","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.pt.2024.07.009_bb0450","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2307\/1381089","article-title":"Food habits and prey impact by feral and house-based domestic cats in a rural area in Southern Sweden","volume":"65","author":"Liberg","year":"1984","journal-title":"J. Mammal."},{"key":"10.1016\/j.pt.2024.07.009_bb0455","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.micro.62.081307.162925","article-title":"Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps","volume":"62","author":"Sibley","year":"2008","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.pt.2024.07.009_bb0460","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1148037","article-title":"Type I and III interferons shape the retinal cytokine network and barrier function in an in vitro model of ocular toxoplasmosis","volume":"14","author":"Geiller","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pt.2024.07.009_bb0465","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.4049\/jimmunol.144.7.2725","article-title":"Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine","volume":"144","author":"Adams","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2024.07.009_bb0470","doi-asserted-by":"crossref","first-page":"29336","DOI":"10.1074\/jbc.M211973200","article-title":"IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization","volume":"278","author":"Uthaiah","year":"2003","journal-title":"J. Biol. 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Immunol."},{"key":"10.1016\/j.pt.2024.07.009_bb0500","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100926","article-title":"Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis","volume":"38","author":"Fisch","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.pt.2024.07.009_bb0505","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/cmi.12579","article-title":"Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii","volume":"18","author":"Johnston","year":"2016","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2024.07.009_bb0510","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1462-5822.2011.01597.x","article-title":"The moving junction of apicomplexan parasites: a key structure for invasion","volume":"13","author":"Besteiro","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2024.07.009_bb0515","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1038\/s41467-021-24083-y","article-title":"Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion","volume":"12","author":"Lentini","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2024.07.009_bb0520","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/life11090988","article-title":"Secreted effectors modulating immune responses to Toxoplasma gondii","volume":"11","author":"Tomita","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.pt.2024.07.009_bb0525","first-page":"895","article-title":"Membrane contact sites between pathogen-containing compartments and host organelles","volume":"1861","author":"Dumoux","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Cell Biol. 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Dis."},{"key":"10.1016\/j.pt.2024.07.009_bb0540","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/359082a0","article-title":"Virulent strains of Toxoplasma gondii comprise a single clonal lineage","volume":"359","author":"Sibley","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.pt.2024.07.009_bb0545","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ijpara.2011.01.005","article-title":"Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America","volume":"41","author":"Khan","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2024.07.009_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.fawpar.2019.e00052","article-title":"Diversity of Toxoplasma gondii strains at the global level and its determinants","volume":"15","author":"Galal","year":"2019","journal-title":"Food Waterborne Parasitol."},{"key":"10.1016\/j.pt.2024.07.009_bb0555","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002541","article-title":"Severe South American ocular toxoplasmosis is associated with decreased Ifn-\u03b3\/Il-17a and increased Il-6\/Il-13 intraocular levels","volume":"7","author":"de-la-Torre","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2024.07.009_bb0560","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0002-9394(00)00830-8","article-title":"A follow-up study of Toxoplasma gondii infection in southern Brazil","volume":"131","author":"Silveira","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.pt.2024.07.009_bb0565","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3201\/eid1204.051081","article-title":"Recently acquired Toxoplasma gondii infection, Brazil","volume":"12","author":"Jones","year":"2006","journal-title":"Emerg. Infect. 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