{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:35:12Z","timestamp":1792902912057,"version":"4.5.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 21KK0138"],"award-info":[{"award-number":["JP 21KK0138"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 23KK0140"],"award-info":[{"award-number":["JP 23KK0140"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","bmn.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.pt.2024.09.001","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T12:39:34Z","timestamp":1726231174000},"page":"870-872","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["RH5: rationally-designed malaria vaccine antigen improving efficacy"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-8499","authenticated-orcid":false,"given":"Eizo","family":"Takashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7415-1325","authenticated-orcid":false,"given":"Takafumi","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2024.09.001_bb0005","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3390\/biom14010100","article-title":"The need for novel asexual blood-stage malaria vaccine candidates for Plasmodium falciparum","volume":"14","author":"Takashima","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.pt.2024.09.001_bb0010","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10606","article-title":"Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum","volume":"480","author":"Crosnier","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.pt.2024.09.001_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.pt.2020.04.003","article-title":"The RH5-CyRPA-Ripr complex as a malaria vaccine target","volume":"36","author":"Ragotte","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2024.09.001_bb0020","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1038\/s41564-022-01261-2","article-title":"PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum","volume":"7","author":"Scally","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2024.09.001_bb0025","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96381","article-title":"Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions","volume":"2","author":"Payne","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.pt.2024.09.001_bb0030","first-page":"701","article-title":"Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination","volume":"2","author":"Minassian","year":"2021","journal-title":"Med. (N. Y.)"},{"key":"10.1016\/j.pt.2024.09.001_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(24)00312-8","article-title":"Blood-stage malaria vaccine candidate RH5.1\/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial","author":"Silk","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2024.09.001_bb0040","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1073\/pnas.1616903114","article-title":"One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen","volume":"114","author":"Campeotto","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2024.09.001_bb0045","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-023-06856-1","article-title":"The PfRCR complex bridges malaria parasite and erythrocyte during invasion","volume":"625","author":"Farrell","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.pt.2024.09.001_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.06.015","article-title":"Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype","author":"Barrett","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.pt.2024.09.001_bb0055","article-title":"Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5","author":"Wang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.pt.2024.09.001_bb0060","article-title":"Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies","volume":"5","author":"King","year":"2024","journal-title":"Cell. Rep. Med."},{"key":"10.1016\/j.pt.2024.09.001_bb0065","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature13715","article-title":"Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies","volume":"515","author":"Wright","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pt.2024.09.001_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1002430","article-title":"A novel asexual blood-stage malaria vaccine candidate: PfRipr5 formulated with human-use adjuvants induces potent growth inhibitory antibodies","volume":"13","author":"Takashima","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pt.2024.09.001_bb0075","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1038\/s41467-024-48721-3","article-title":"Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex","volume":"15","author":"Williams","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492224002447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492224002447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T01:18:16Z","timestamp":1739323096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492224002447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1471492224002447"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2024.09.001","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RH5: rationally-designed malaria vaccine antigen improving efficacy","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2024.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2024.06.015","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2024.06.037","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101654","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}