{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:28:24Z","timestamp":1777494504769,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2026574"],"award-info":[{"award-number":["APP2026574"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.pt.2025.04.006","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T12:06:32Z","timestamp":1746619592000},"page":"460-470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Malaria parasite phenotypic heterogeneity and the power of single-cell technologies"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6208-8660","authenticated-orcid":false,"given":"Emmanuel","family":"Gyamfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-352X","authenticated-orcid":false,"given":"Jake","family":"Baum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2025.04.006_bb0005","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01107","article-title":"A proteomic view of the Plasmodium falciparum life cycle","volume":"419","author":"Florens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.04.006_bb0010","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1101\/gr.2523904","article-title":"Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle","volume":"14","author":"Le Roch","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.pt.2025.04.006_bb0015","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1371\/journal.pbio.0000005","article-title":"The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum","volume":"1","author":"Bozdech","year":"2003","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2025.04.006_bb0020","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1038\/s41467-021-23434-z","article-title":"A single-cell atlas of Plasmodium falciparum transmission through the mosquito","volume":"12","author":"Real","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.04.006_bb0025","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jgg.2022.03.008","article-title":"Sources of transcription variation in Plasmodium falciparum","volume":"49","author":"Turnbull","year":"2022","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.pt.2025.04.006_bb0030","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.chom.2021.08.009","article-title":"Single-genome sequencing reveals within-host evolution of human malaria parasites","volume":"29","author":"Dia","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.04.006_bb0035","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1101\/gr.129692.111","article-title":"Transcriptional variation in the malaria parasite Plasmodium falciparum","volume":"22","author":"Rovira-Graells","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.pt.2025.04.006_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004812","article-title":"Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis","volume":"10","author":"Claessens","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2025.04.006_bb0045","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/nar\/gky1268","article-title":"Complex DNA structures trigger copy number variation across the Plasmodium falciparum genome","volume":"47","author":"Huckaby","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.04.006_bb0050","first-page":"1889","article-title":"Extreme mutation bias and high AT content in Plasmodium falciparum","volume":"45","author":"Hamilton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.04.006_bb0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pt.2022.11.002","article-title":"Measurably recombining malaria parasites","volume":"39","author":"Camponovo","year":"2023","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.04.006_bb0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.chom.2019.12.001","article-title":"Co-transmission of related malaria parasite lineages shapes within-host parasite diversity","volume":"27","author":"Nkhoma","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.04.006_bb0065","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1186\/gb-2011-12-4-r33","article-title":"High recombination rates and hotspots in a Plasmodium falciparum genetic cross","volume":"12","author":"Jiang","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.pt.2025.04.006_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000271","article-title":"Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum","volume":"17","author":"Zhang","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2025.04.006_bb0075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-micro-032521-041554","article-title":"Epigenetic regulation and chromatin remodeling in malaria parasites","volume":"77","author":"Hollin","year":"2023","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.pt.2025.04.006_bb0080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature12970","article-title":"A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium","volume":"507","author":"Sinha","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.04.006_bb0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12920","article-title":"A transcriptional switch underlies commitment to sexual development in malaria parasites","volume":"507","author":"Kafsack","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.04.006_bb0090","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1126\/science.aan6042","article-title":"GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing","volume":"359","author":"Filarsky","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.04.006_bb0095","doi-asserted-by":"crossref","DOI":"10.1128\/mmbr.00114-23","article-title":"Variable surface antigen expression, virulence, and persistent infection by Plasmodium falciparum malaria parasites","volume":"89","author":"Hadjimichael","year":"2025","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.pt.2025.04.006_bb0100","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02014-23","article-title":"The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries","volume":"14","author":"Azizan","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.pt.2025.04.006_bb0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83840","article-title":"A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites","volume":"11","author":"Zhang","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.pt.2025.04.006_bb0110","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1126\/science.8009217","article-title":"Malaria pathogenesis","volume":"264","author":"Miller","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.04.006_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002287","article-title":"The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands","volume":"3","author":"Saenz","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2025.04.006_bb0120","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1093\/nar\/gkq1223","article-title":"RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts","volume":"39","author":"Sorber","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.04.006_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13059-019-1756-6","article-title":"Alternative splicing is required for stage differentiation in malaria parasites","volume":"20","author":"Yeoh","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.pt.2025.04.006_bb0130","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1021\/acs.jproteome.2c00108","article-title":"Distinct Histone post-translational modifications during Plasmodium falciparum gametocyte development","volume":"21","author":"Shrestha","year":"2022","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.pt.2025.04.006_bb0135","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.RA120.002375","article-title":"Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes","volume":"20","author":"Wang","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.pt.2025.04.006_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2021.104279","article-title":"The main post-translational modifications and related regulatory pathways in the malaria parasite Plasmodium falciparum: an update","volume":"245","author":"Rashidi","year":"2021","journal-title":"J. Proteome"},{"key":"10.1016\/j.pt.2025.04.006_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-018-1207-3","article-title":"Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments\u2014a WWARN individual patient data meta-analysis","volume":"17","author":"WWARN K13 Genotype-Phenotype Study Group","year":"2019","journal-title":"BMC Med."},{"key":"10.1016\/j.pt.2025.04.006_bb0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41579-024-01008-2","article-title":"Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa","volume":"22","author":"Rosenthal","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pt.2025.04.006_bb0155","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/S1473-3099(21)00072-4","article-title":"Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study","volume":"21","author":"Andolina","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2025.04.006_bb0160","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100685118","article-title":"Mapping partner drug resistance to guide antimalarial combination therapy policies in sub-Saharan Africa","volume":"118","author":"Ehrlich","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.04.006_bb0165","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1038\/s41467-022-33873-x","article-title":"Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda","volume":"13","author":"Tumwebaze","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.04.006_bb0170","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202317556","article-title":"A sting in the tail-are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective?","volume":"15","author":"Murdoch","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.pt.2025.04.006_bb0175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(15)60721-8","article-title":"Efficacy and safety of RTS,S\/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial","volume":"386","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2025.04.006_bb0180","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1056\/NEJMoa1505819","article-title":"Genetic diversity and protective efficacy of the RTS,S\/AS01 malaria vaccine","volume":"373","author":"Neafsey","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2025.04.006_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124243","article-title":"Heterologous protection against malaria after immunization with Plasmodium falciparum sporozoites","volume":"10","author":"Schats","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2025.04.006_bb0190","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12916-017-0923-4","article-title":"Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial","volume":"15","author":"Walk","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.pt.2025.04.006_bb0195","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fimmu.2014.00359","article-title":"Strategies for designing and monitoring malaria vaccines targeting diverse antigens","volume":"5","author":"Barry","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pt.2025.04.006_bb0200","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S1473-3099(22)00442-X","article-title":"Efficacy and immunogenicity of R21\/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1\/2b randomised controlled trial","volume":"22","author":"Datoo","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2025.04.006_bb0205","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1473-3099(24)00752-7","article-title":"Safety and efficacy of the blood-stage malaria vaccine RH5.1\/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children","volume":"25","author":"Natama","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2025.04.006_bb0210","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1126\/science.1115257","article-title":"Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes","volume":"309","author":"Stubbs","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.04.006_bb0215","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pt.2019.12.004","article-title":"HRP2: transforming malaria diagnosis, but with caveats","volume":"36","author":"Poti","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.04.006_bb0220","series-title":"World Malaria Report 2024","author":"World Health Organization","year":"2024"},{"key":"10.1016\/j.pt.2025.04.006_bb0225","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/S0140-6736(18)30324-6","article-title":"Malaria","volume":"391","author":"Ashley","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2025.04.006_bb0230","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/infdis\/jiac240","article-title":"Fitness costs of pfhrp2 and pfhrp3 deletions underlying diagnostic evasion in malaria parasites","volume":"226","author":"Nair","year":"2022","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2025.04.006_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008091","article-title":"A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests","volume":"5","author":"Gamboa","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2025.04.006_bb0240","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12936-024-04904-3","article-title":"Widespread pfhrp2\/3 deletions and HRP2-based false-negative results in southern Ethiopia","volume":"23","author":"Mekonen","year":"2024","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2025.04.006_bb0245","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01081-20","article-title":"Direct nanopore sequencing of mRNA reveals landscape of transcript isoforms in Apicomplexan parasites","volume":"6","author":"Lee","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.pt.2025.04.006_bb0250","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.pt.2022.05.009","article-title":"Single-cell views of the Plasmodium life cycle","volume":"38","author":"Real","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.04.006_bb0255","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw2619","article-title":"The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle","volume":"365","author":"Howick","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.04.006_bb0260","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41586-022-05406-5","article-title":"A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage","volume":"611","author":"Afriat","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.04.006_bb0265","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41564-024-01905-5","article-title":"Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice","volume":"10","author":"Zanghi","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2025.04.006_bb0270","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33105","article-title":"Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites","volume":"7","author":"Reid","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.pt.2025.04.006_bb0275","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1038\/s41467-024-51201-3","article-title":"Single-cell transcriptomics reveal transcriptional programs underlying male and female cell fate during Plasmodium falciparum gametocytogenesis","volume":"15","author":"Mohammed","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.04.006_bb0280","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.chom.2022.12.011","article-title":"Regulators of male and female sexual development are critical for the transmission of a malaria parasite","volume":"31","author":"Russell","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.04.006_bb0285","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023438118","article-title":"Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development","volume":"118","author":"Bogale","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.04.006_bb0290","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1038\/s41598-021-82914-w","article-title":"Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites","volume":"11","author":"Ruberto","year":"2021","journal-title":"Sci. Rep. Uk"},{"key":"10.1016\/j.pt.2025.04.006_bb0295","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1038\/s41467-024-51418-2","article-title":"Host-pathogen interactions in the Plasmodium-infected mouse liver at spatial and single-cell resolution","volume":"15","author":"Hildebrandt","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.04.006_bb0300","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41467-024-52223-7","article-title":"The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.04.006_bb0305","article-title":"Mapping Plasmodium transitions and interactions in the Anopheles female","author":"Yan","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2025.04.006_bb0310","article-title":"Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity","author":"Florini","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2025.04.006_bb0315","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/IAI.03009-14","article-title":"Variation in Plasmodium falciparum erythrocyte invasion phenotypes and merozoite ligand gene expression across different populations in areas of malaria endemicity","volume":"83","author":"Bowyer","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pt.2025.04.006_bb0320","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.molbiopara.2006.05.014","article-title":"Expression of Plasmodium falciparum genes involved in erythrocyte invasion varies among isolates cultured directly from patients","volume":"149","author":"Nery","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2025.04.006_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010991","article-title":"Long read single cell RNA sequencing reveals the isoform diversity of Plasmodium vivax transcripts","volume":"16","author":"Hazzard","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2025.04.006_bb0330","doi-asserted-by":"crossref","DOI":"10.1126\/science.adj4088","article-title":"A single cell atlas of sexual development in Plasmodium falciparum","volume":"384","author":"Dogga","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.04.006_bb0335","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-021-00889-9","article-title":"Single-cell sequencing of the small and AT-skewed genome of malaria parasites","volume":"13","author":"Liu","year":"2021","journal-title":"Genome Med."},{"key":"10.1016\/j.pt.2025.04.006_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010210","article-title":"Perspectives on rigor and reproducibility in single cell genomics","volume":"18","author":"Gibson","year":"2022","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2025.04.006_bb0345","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1093\/gbe\/evx256","article-title":"High-resolution single-cell sequencing of malaria parasites","volume":"9","author":"Trevino","year":"2017","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.pt.2025.04.006_bb0350","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.00008-21","article-title":"Single-cell RNA sequencing reveals cellular heterogeneity and stage transition under temperature stress in synchronized Plasmodium falciparum cells","volume":"9","author":"Rawat","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.pt.2025.04.006_bb0355","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1038\/s41467-023-40883-w","article-title":"Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum","volume":"14","author":"Batugedara","year":"2023","journal-title":"Nat. Commun."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149222500100X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149222500100X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:05:19Z","timestamp":1750147519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147149222500100X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S147149222500100X"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2025.04.006","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malaria parasite phenotypic heterogeneity and the power of single-cell technologies","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2025.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}