{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:16:03Z","timestamp":1780064163734,"version":"3.54.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["VI.Veni.232.160"],"award-info":[{"award-number":["VI.Veni.232.160"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006209","name":"Radboud University Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.pt.2025.06.011","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T02:11:03Z","timestamp":1752631863000},"page":"641-656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The apicoplast transportome of the malaria parasite"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7946-1174","authenticated-orcid":false,"given":"Laura J.","family":"Akkerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-7523","authenticated-orcid":false,"given":"Taco W.A.","family":"Kooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-3311","authenticated-orcid":false,"given":"Laura E.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2025.06.011_bb0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-micro-092412-155741","article-title":"The algal past and parasite present of the apicoplast","volume":"67","author":"van Dooren","year":"2013","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0010","doi-asserted-by":"crossref","DOI":"10.1111\/jeu.12947","article-title":"Roles of the apicoplast across the life cycles of rodent and human malaria parasites","volume":"69","author":"Buchanan","year":"2022","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0015","article-title":"Validation of putative apicoplast-targeting drugs using a chemical supplementation assay in cultured human malaria parasites","volume":"62","author":"Uddin","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2025.06.011_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000376","article-title":"Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking","volume":"17","author":"Kennedy","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1475-2875-12-25","article-title":"Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast","volume":"12","author":"Lemgruber","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2025.06.011_bb0030","doi-asserted-by":"crossref","first-page":"9572","DOI":"10.1073\/pnas.0602293103","article-title":"Membrane transporters in the relict plastid of malaria parasites","volume":"103","author":"Mullin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.06.011_bb0035","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/brv.12565","article-title":"The transportome of the malaria parasite","volume":"95","author":"Martin","year":"2020","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.pt.2025.06.011_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2022.102255","article-title":"New insights into apicoplast metabolism in blood-stage malaria parasites","volume":"71","author":"Elahi","year":"2023","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.mib.2021.07.016","article-title":"The metabolic pathways and transporters of the plastid organelle in Apicomplexa","volume":"63","author":"Kloehn","year":"2021","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1021\/acsinfecdis.3c00426","article-title":"Plasmodium falciparum ZIP1 is a zinc-selective transporter with stage-dependent targeting to the apicoplast and plasma membrane in erythrocytic parasites","volume":"10","author":"Shrivastava","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.pt.2025.06.011_bb0055","article-title":"A pyruvate transporter in the apicoplast of apicomplexan parasites","volume":"121","author":"Chen","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.06.011_bb0060","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.88866.3","article-title":"The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival","volume":"12","author":"Dong","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.06.011_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008316","article-title":"A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites","volume":"16","author":"Swift","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.06.011_bb0070","doi-asserted-by":"crossref","first-page":"D808","DOI":"10.1093\/nar\/gkad1003","article-title":"VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center in 2023","volume":"52","author":"Alvarez-Jarreta","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.06.011_bb0075","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1126\/science.1078599","article-title":"Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum","volume":"299","author":"Foth","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.06.011_bb0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrmicro843","article-title":"Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast","volume":"2","author":"Ralph","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005895","article-title":"Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites","volume":"16","author":"Boucher","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0090","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.chom.2020.09.011","article-title":"A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions","volume":"28","author":"Barylyuk","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.06.011_bb0095","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12789","article-title":"A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites","volume":"20","author":"Sayers","year":"2018","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13266","article-title":"An apicoplast-resident folate transporter is essential for sporogony of malaria parasites","volume":"23","author":"Korbmacher","year":"2021","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0105","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2020.102160","article-title":"Characterization of mitochondrial carrier proteins of malaria parasite Plasmodium falciparum based on in vitro translation and reconstitution","volume":"79","author":"Nozawa","year":"2020","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.pt.2025.06.011_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73208","article-title":"Critical role for isoprenoids in apicoplast biogenesis by malaria parasites","volume":"11","author":"Okada","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.06.011_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012484","article-title":"Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum","volume":"20","author":"Bulloch","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.06.011_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001138","article-title":"Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum","volume":"9","author":"Yeh","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/EC.00198-14","article-title":"Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum","volume":"14","author":"Wiley","year":"2015","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.pt.2025.06.011_bb0135","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50807","article-title":"The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum","volume":"9","author":"Swift","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.06.011_bb0140","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1046\/j.1432-1327.2001.02265.x","article-title":"The drug\/metabolite transporter superfamily","volume":"268","author":"Jack","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.pt.2025.06.011_bb0145","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.molbiopara.2012.09.008","article-title":"Apicoplast triose phosphate transporter (TPT) gene knockout is lethal for Plasmodium","volume":"186","author":"Banerjee","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2025.06.011_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/science.aap7847","article-title":"Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis","volume":"360","author":"Zhang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.06.011_bb0155","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq6241","article-title":"The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility","volume":"387","author":"Elsworth","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.06.011_bb0160","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cell.2017.06.030","article-title":"Functional profiling of a Plasmodium genome reveals an abundance of essential genes","volume":"170","author":"Bushell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pt.2025.06.011_bb0165","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.febslet.2009.11.097","article-title":"The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite","volume":"584","author":"Lim","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pt.2025.06.011_bb0170","first-page":"453","article-title":"A new class of plastidic phosphate translocators: a putative link between primary and secondary metabolism by the phosphoenolpyruvate\/phosphate antiporter","volume":"9","author":"Fischer","year":"1997","journal-title":"Plant Cell"},{"key":"10.1016\/j.pt.2025.06.011_bb0175","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41556-023-01250-5","article-title":"Hem25p is required for mitochondrial IPP transport in fungi","volume":"25","author":"Tai","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010124","article-title":"Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets","volume":"17","author":"de Vries","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.06.011_bb0185","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020107247","article-title":"Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption","volume":"40","author":"Swift","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.pt.2025.06.011_bb0190","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41467-022-27996-4","article-title":"Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii","volume":"13","author":"Lunghi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.06.011_bb0195","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.pt.2018.05.010","article-title":"Recent advances in the [Fe-S] cluster biogenesis (SUF) pathway functional in the apicoplast of Plasmodium","volume":"34","author":"Pala","year":"2018","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.06.011_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003655","article-title":"The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites","volume":"9","author":"Gisselberg","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.06.011_bb0205","article-title":"Roles of ferredoxin-dependent proteins in the apicoplast of Plasmodium falciparum parasites","volume":"13","author":"Swift","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.pt.2025.06.011_bb0210","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0021-9258(17)49928-5","article-title":"Vitamin and cofactor acquisition in apicomplexans: synthesis versus salvage","volume":"295","author":"Krishnan","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2025.06.011_bb0215","article-title":"Deep-learning protein structure predictions suggest likely molecular functions for three uncharacterised polytopic membrane proteins from the P. falciparum apicoplast","author":"Murphy","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2025.06.011_bb0220","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/mp\/ssr033","article-title":"Root UV-B sensitive mutants are suppressed by specific mutations in ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin B6","volume":"4","author":"Leasure","year":"2011","journal-title":"Mol. Plant"},{"key":"10.1016\/j.pt.2025.06.011_bb0225","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0014-5793(97)01414-2","article-title":"The ABC transporter Atm1p is required for mitochondrial iron homeostasis","volume":"418","author":"Kispal","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pt.2025.06.011_bb0230","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/febs.15445","article-title":"Supply and demand-heme synthesis, salvage and utilization by Apicomplexa","volume":"288","author":"Kloehn","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.pt.2025.06.011_bb0235","doi-asserted-by":"crossref","first-page":"34827","DOI":"10.1074\/jbc.M114.615831","article-title":"The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages","volume":"289","author":"Ke","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2025.06.011_bb0240","doi-asserted-by":"crossref","first-page":"9273","DOI":"10.1021\/bi9702602","article-title":"Reconstitution of the holoenzyme form of Escherichia coli porphobilinogen deaminase from apoenzyme with porphobilinogen and preuroporphyrinogen: a study using circular dichroism spectroscopy","volume":"36","author":"Awan","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.pt.2025.06.011_bb0245","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molbiopara.2015.03.004","article-title":"Fatty acid metabolism in the Plasmodium apicoplast: drugs, doubts and knockouts","volume":"199","author":"Shears","year":"2015","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2025.06.011_bb0250","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1128\/EC.00264-13","article-title":"Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes","volume":"13","author":"van Schaijk","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.pt.2025.06.011_bb0255","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1462-5822.2008.01270.x","article-title":"Type II fatty acid synthesis is essential only for malaria parasite late liver stage development","volume":"11","author":"Vaughan","year":"2009","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0260","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2958.2004.04407.x","article-title":"The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast","volume":"55","author":"Foth","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0265","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/microorganisms10071419","article-title":"Plasmodium falciparum S-adenosylmethionine synthetase is essential for parasite survival through a complex interaction network with cytoplasmic and nuclear proteins","volume":"10","author":"Musabyimana","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.pt.2025.06.011_bb0270","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1105\/tpc.105.040741","article-title":"Arabidopsis SAMT1 defines a plastid transporter regulating plastid biogenesis and plant development","volume":"18","author":"Bouvier","year":"2006","journal-title":"Plant Cell"},{"key":"10.1016\/j.pt.2025.06.011_bb0275","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1186\/gb-2005-6-3-r26","article-title":"The \u2018permeome\u2019 of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum","volume":"6","author":"Martin","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0280","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1111\/cmi.12137","article-title":"A key role for lipoic acid synthesis during Plasmodium liver stage development","volume":"15","author":"Falkard","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0285","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1365-2958.2007.05592.x","article-title":"Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum","volume":"63","author":"Allary","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0290","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12633","article-title":"Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast","volume":"19","author":"Shears","year":"2017","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0295","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.plipres.2009.10.003","article-title":"Chloroplast proteomics highlights the subcellular compartmentation of lipid metabolism","volume":"49","author":"Joyard","year":"2010","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.pt.2025.06.011_bb0300","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molbiopara.2006.06.004","article-title":"Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum","volume":"150","author":"Bethke","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2025.06.011_bb0305","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-1119(01)00776-4","article-title":"Deciphering apicoplast targeting signals \u2013 feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins","volume":"280","author":"Zuegge","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.pt.2025.06.011_bb0310","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq7347","article-title":"Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites","volume":"387","author":"Oberstaller","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.06.011_bb2005","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1038\/s41467-025-61155-9","article-title":"A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma","volume":"16","author":"Arnold","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.06.011_bb0315","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/mmi.12485","article-title":"Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development","volume":"91","author":"Lindner","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0320","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58629","article-title":"A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance","volume":"9","author":"Goodman","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.06.011_bb0325","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29865","article-title":"Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens","volume":"6","author":"Amberg-Johnson","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.06.011_bb0330","article-title":"Validated antimalarial drug target discovery using genome-scale metabolic modelling","author":"Taweechai","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2025.06.011_bb0335","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1126\/science.1220281","article-title":"LAAT-1 is the lysosomal lysine\/arginine transporter that maintains amino acid homeostasis","volume":"337","author":"Liu","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.06.011_bb0340","doi-asserted-by":"crossref","first-page":"16315","DOI":"10.1074\/jbc.270.27.16315","article-title":"Substrate specificity and expression profile of amino acid transporters (AAPs) in Arabidopsis","volume":"270","author":"Fischer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2025.06.011_bb0345","doi-asserted-by":"crossref","first-page":"13719","DOI":"10.1073\/pnas.1919501117","article-title":"Plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the Clp proteolytic system","volume":"117","author":"Florentin","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.06.011_bb0350","article-title":"tRNA modifying enzymes MnmE and MnmG are essential for Plasmodium falciparum apicoplast maintenance","author":"Elahi","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2025.06.011_bb0355","doi-asserted-by":"crossref","first-page":"44659","DOI":"10.1074\/jbc.M111.286054","article-title":"The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters","volume":"286","author":"Salcedo-Sora","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2025.06.011_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(08)00401-9","article-title":"Folate-mediated one-carbon metabolism","volume":"79","author":"Fox","year":"2008","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.pt.2025.06.011_bb0365","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.pt.2016.07.005","article-title":"Translation in organelles of Apicomplexan parasites","volume":"32","author":"Habib","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.06.011_bb0370","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2019.10.030","article-title":"Genome-scale identification of essential metabolic processes for targeting the plasmodium liver stage","volume":"179","author":"Stanway","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.pt.2025.06.011_bb0375","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1016\/j.jmb.2016.07.016","article-title":"Crystal structure of the apicoplast DNA polymerase from Plasmodium falciparum: the first look at a plastidic A-family DNA polymerase","volume":"428","author":"Milton","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0380","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12275-017-6525-1","article-title":"Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling","volume":"55","author":"Rai","year":"2017","journal-title":"J. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0385","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2958.2009.06863.x","article-title":"Membrane transport proteins of the malaria parasite","volume":"74","author":"Martin","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0390","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1051\/parasite\/2019069","article-title":"P-type transport ATPases in Leishmania and Trypanosoma","volume":"26","author":"Meade","year":"2019","journal-title":"Parasite"},{"key":"10.1016\/j.pt.2025.06.011_bb0395","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1248\/bpb.b13-00554","article-title":"Role of MerC, MerE, MerF, MerT, and\/or MerP in resistance to mercurials and the transport of mercurials in Escherichia coli","volume":"36","author":"Sone","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.pt.2025.06.011_bb0400","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1515\/BC.2003.135","article-title":"The N\u2032-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes","volume":"384","author":"Daubenberger","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.pt.2025.06.011_bb0405","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molbiopara.2012.01.007","article-title":"Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2","volume":"183","author":"Zocher","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2025.06.011_bb0410","doi-asserted-by":"crossref","first-page":"31249","DOI":"10.1074\/jbc.M109.041830","article-title":"Molecular identification and functional characterization of Arabidopsis thaliana mitochondrial and chloroplastic NAD+ carrier proteins","volume":"284","author":"Palmieri","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2025.06.011_bb0415","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-4939-8654-5_14","article-title":"Isolating the Plasmodium falciparum apicoplast using magnetic beads","volume":"1829","author":"Bott\u00e9","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159603","article-title":"Targeting of a transporter to the outer apicoplast membrane in the human malaria parasite Plasmodium falciparum","volume":"11","author":"Lim","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2025.06.011_bb0425","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/tra.12226","article-title":"Protein traffic to the Plasmodium falciparum apicoplast: evidence for a sorting branch point at the Golgi","volume":"15","author":"Heiny","year":"2014","journal-title":"Traffic"},{"key":"10.1016\/j.pt.2025.06.011_bb0430","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijpara.2011.11.008","article-title":"Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum","volume":"42","author":"Jackson","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.pt.2025.06.011_bb0435","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1111\/j.1742-4658.2012.08746.x","article-title":"A novel trafficking pathway in Plasmodium falciparum for the organellar localization of glutathione peroxidase-like thioredoxin peroxidase","volume":"279","author":"Chaudhari","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.pt.2025.06.011_bb0440","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00898-19","article-title":"Pyruvate homeostasis as a determinant of parasite growth and metabolic plasticity in Toxoplasma gondii","volume":"10","author":"Xia","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.pt.2025.06.011_bb0445","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1038\/s41467-021-23919-x","article-title":"Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum","volume":"12","author":"Evers","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.06.011_bb0450","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1038\/s41467-021-25987-5","article-title":"A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.06.011_bb0455","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1016\/j.celrep.2020.02.072","article-title":"Division and adaptation to host environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelle remodeling","volume":"30","author":"Amiar","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2025.06.011_bb0460","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1038\/s41467-025-57302-x","article-title":"Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.06.011_bb0465","article-title":"Inheritance of the genome-less apicoplast in the \u2018apicoplast-minus\u2019 Plasmodium falciparum","author":"Xu","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2025.06.011_bb0470","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1038\/ncomms7284","article-title":"Identity of a Plasmodium lactate\/H+ symporter structurally unrelated to human transporters","volume":"6","author":"Wu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.06.011_bb0475","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.1038\/ncomms10519","article-title":"Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite","volume":"7","author":"Kenthirapalan","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.06.011_bb0480","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/mmi.13373","article-title":"Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development","volume":"101","author":"Rijpma","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.06.011_bb0485","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00232-020-00139-w","article-title":"Structural and functional diversity among the members of CTR, the membrane copper transporter family","volume":"253","author":"Mandal","year":"2020","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.pt.2025.06.011_bb0490","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1349-7006.2008.01058.x","article-title":"Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis","volume":"100","author":"Kashiwaya","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.pt.2025.06.011_bb0495","doi-asserted-by":"crossref","first-page":"45936","DOI":"10.1038\/srep45936","article-title":"A UPF0118 family protein with uncharacterized function from the moderate halophile Halobacillus andaensis represents a novel class of Na+Li+\/H+ antiporter","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2025.06.011_bb0500","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/ncb1773","article-title":"GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus","volume":"10","author":"Maeda","year":"2008","journal-title":"Nat. Cell Biol."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492225001801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492225001801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T16:04:18Z","timestamp":1754755458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492225001801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":101,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1471492225001801"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2025.06.011","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The apicoplast transportome of the malaria parasite","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2025.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}