{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:43:58Z","timestamp":1793321038053,"version":"4.5.0"},"reference-count":114,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR905\/20-1"],"award-info":[{"award-number":["PR905\/20-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR905\/19-1"],"award-info":[{"award-number":["PR905\/19-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG2740"],"award-info":[{"award-number":["RTG2740"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.pt.2025.09.011","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T04:17:36Z","timestamp":1760588256000},"page":"1140-1156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pink or blue: sex determination in malaria gametocytes"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-5558","authenticated-orcid":false,"given":"Gabriele","family":"Pradel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-2756","authenticated-orcid":false,"given":"Michaela","family":"Petter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2025.09.011_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001899","article-title":"Sex determination: why so many ways of doing it?","volume":"12","author":"Bachtrog","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pt.2025.09.011_bb0010","article-title":"Sex determination without sex chromosomes","volume":"376","author":"Weber","year":"2021","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.pt.2025.09.011_bb0015","doi-asserted-by":"crossref","DOI":"10.1242\/dev.204592","article-title":"Gonadal sex determination in vertebrates: rethinking established mechanisms","volume":"152","author":"Wilhelm","year":"2025","journal-title":"Development"},{"key":"10.1016\/j.pt.2025.09.011_bb0020","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.tig.2024.10.003","article-title":"Yes, polygenic sex determination is a thing!","volume":"40","author":"Kocher","year":"2024","journal-title":"Trends Genet."},{"key":"10.1016\/j.pt.2025.09.011_bb0025","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000518272","article-title":"DMRT1: an ancient sexual regulator required for human gonadogenesis","volume":"16","author":"Zarkower","year":"2022","journal-title":"Sex Dev."},{"key":"10.1016\/j.pt.2025.09.011_bb0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000074336","article-title":"Turning on the male \u2013 SRY, SOX9 and sex determination in mammals","volume":"101","author":"Knower","year":"2003","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.pt.2025.09.011_bb0035","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ygcen.2009.03.002","article-title":"Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish","volume":"165","author":"Guiguen","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.pt.2025.09.011_bb0040","doi-asserted-by":"crossref","first-page":"10743","DOI":"10.1074\/jbc.CL119.009620","article-title":"On the trail of steroid aromatase: the work of Kenneth J. Ryan","volume":"294","author":"Spiering","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2025.09.011_bb0045","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nprot.2015.072","article-title":"An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development","volume":"10","author":"Brancucci","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.pt.2025.09.011_bb0050","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1086\/644645","article-title":"Effect of antimalarial drugs on Plasmodium falciparum gametocytes","volume":"200","author":"Peatey","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2025.09.011_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104198","article-title":"Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients","volume":"83","author":"Portugaliza","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pt.2025.09.011_bb0060","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1038\/s41467-019-10172-6","article-title":"Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes","volume":"10","author":"Usui","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.790067","article-title":"Stressed out about Plasmodium falciparum gametocytogenesis","volume":"11","author":"Usui","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm7348","article-title":"Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium berghei","volume":"8","author":"Hentzschel","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pt.2025.09.011_bb0075","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41467-018-04108-9","article-title":"A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0080","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008882","article-title":"Plasmodium falciparum transmission stages accumulate in the human bone marrow","volume":"6","author":"Joice","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2025.09.011_bb0085","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1182\/blood.2019004746","article-title":"Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis","volume":"136","author":"Neveu","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.pt.2025.09.011_bb0090","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/infdis\/jit309","article-title":"Enhanced gametocyte formation in erythrocyte progenitor cells: a site-specific adaptation by Plasmodium falciparum","volume":"208","author":"Peatey","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2025.09.011_bb0095","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.cell.2017.10.020","article-title":"Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum","volume":"171","author":"Brancucci","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pt.2025.09.011_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13146","article-title":"A patatin-like phospholipase functions during gametocyte induction in the malaria parasite Plasmodium falciparum","volume":"22","author":"Flammersfeld","year":"2020","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0105","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.chom.2015.08.003","article-title":"Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of Plasmodium falciparum","volume":"18","author":"Gulati","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0110","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.chom.2014.11.006","article-title":"Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection","volume":"16","author":"Itoe","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0115","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1194\/jlr.M085589","article-title":"Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite","volume":"59","author":"Wein","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.pt.2025.09.011_bb0120","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41564-023-01396-w","article-title":"Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation","volume":"8","author":"Harris","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2024.102469","article-title":"Regulation of sexual commitment in malaria parasites - a complex affair","volume":"79","author":"Voss","year":"2024","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41564-018-0291-7","article-title":"Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum","volume":"4","author":"Bancells","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0135","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12920","article-title":"A transcriptional switch underlies commitment to sexual development in malaria parasites","volume":"507","author":"Kafsack","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.09.011_bb0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature24280","article-title":"Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites","volume":"551","author":"Poran","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.09.011_bb0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature12970","article-title":"A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium","volume":"507","author":"Sinha","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.09.011_bb0150","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.chom.2014.07.004","article-title":"Heterochromatin protein 1 secures survival and transmission of malaria parasites","volume":"16","author":"Brancucci","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0155","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1101\/gr.129692.111","article-title":"Transcriptional variation in the malaria parasite Plasmodium falciparum","volume":"22","author":"Rovira-Graells","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.pt.2025.09.011_bb0160","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.chom.2014.06.014","article-title":"A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion","volume":"16","author":"Coleman","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0165","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1038\/s41467-025-59476-w","article-title":"PfPPM2 signalling regulates asexual division and sexual conversion of human malaria parasite Plasmodium falciparum","volume":"16","author":"Rawat","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0170","doi-asserted-by":"crossref","first-page":"9264","DOI":"10.1093\/nar\/gkab683","article-title":"A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum","volume":"49","author":"Shang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.09.011_bb0175","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/s41467-020-15026-0","article-title":"Dissecting the role of PfAP2-G in malaria gametocytogenesis","volume":"11","author":"Josling","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0180","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.92499.3","article-title":"PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum","volume":"12","author":"Chahine","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.09.011_bb0185","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/s41564-025-02038-z","article-title":"High-resolution map of the Plasmodium falciparum genome reveals MORC\/ApiAP2-mediated links between distant, functionally related genes","volume":"10","author":"Singh","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009351","article-title":"A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum","volume":"17","author":"Miao","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0195","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf218","article-title":"PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure","volume":"53","author":"Tang","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.09.011_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002964","article-title":"Plasmodium falciparum gametocyte development 1 (Pfgdv1) and gametocytogenesis early gene identification and commitment to sexual development","volume":"8","author":"Eksi","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0205","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1126\/science.aan6042","article-title":"GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing","volume":"359","author":"Filarsky","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.09.011_bb0210","article-title":"A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation","author":"Prajapati","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2025.09.011_bb0215","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03049-22","article-title":"Patterns of heterochromatin transitions linked to changes in the expression of Plasmodium falciparum clonally variant genes","volume":"11","author":"Michel-Todo","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.pt.2025.09.011_bb0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.chom.2016.12.003","article-title":"A knockout screen of ApiAP2 genes reveals networks of interacting transcriptional regulators controlling the Plasmodium life cycle","volume":"21","author":"Modrzynska","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0225","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/mmi.14676","article-title":"The PfAP2-G2 transcription factor is a critical regulator of gametocyte maturation","volume":"115","author":"Singh","year":"2021","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0230","doi-asserted-by":"crossref","first-page":"12824","DOI":"10.1073\/pnas.1504389112","article-title":"Global transcriptional repression: an initial and essential step for Plasmodium sexual development","volume":"112","author":"Yuda","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.09.011_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102403","article-title":"Mechanisms of triggering malaria gametocytogenesis by AP2-G","volume":"84","author":"Yuda","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.pt.2025.09.011_bb0240","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01986-17","article-title":"Systematic CRISPR-Cas9-mediated modifications of Plasmodium yoelii ApiAP2 genes reveal functional insights into parasite development","volume":"8","author":"Zhang","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.pt.2025.09.011_bb0245","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1038\/s41467-024-51201-3","article-title":"Single-cell transcriptomics reveal transcriptional programs underlying male and female cell fate during Plasmodium falciparum gametocytogenesis","volume":"15","author":"Mohammed","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0250","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.pt.2024.09.007","article-title":"Unraveling the complexities of ApiAP2 regulation in Plasmodium falciparum","volume":"40","author":"Singhal","year":"2024","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.09.011_bb0255","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/pathogens8020047","article-title":"ApiAP2 transcription factors in apicomplexan parasites","volume":"8","author":"Jeninga","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.pt.2025.09.011_bb0260","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41598-017-00687-7","article-title":"Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites","volume":"7","author":"Coetzee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2025.09.011_bb0265","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13072-021-00393-9","article-title":"H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum","volume":"14","author":"Connacher","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.pt.2025.09.011_bb0270","doi-asserted-by":"crossref","DOI":"10.1126\/science.adj4088","article-title":"A single cell atlas of sexual development in Plasmodium falciparum","volume":"384","author":"Dogga","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.09.011_bb0275","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz5057","article-title":"Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum","volume":"6","author":"Llora-Batlle","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pt.2025.09.011_bb0280","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1038\/s41467-020-19988-z","article-title":"The transcriptome of circulating sexually committed Plasmodium falciparum ring stage parasites forecasts malaria transmission potential","volume":"11","author":"Prajapati","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0285","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.3390\/ijms20205087","article-title":"The G9a histone methyltransferase inhibitor BIX-01294 modulates gene expression during Plasmodium falciparum gametocyte development and transmission","volume":"20","author":"Ngwa","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pt.2025.09.011_bb0290","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73981-w","article-title":"Heterochromatin dynamics during the initial stages of sexual development in Plasmodium falciparum","volume":"14","author":"Nhim","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2025.09.011_bb0295","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/s41467-018-04295-5","article-title":"Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages","volume":"9","author":"Bunnik","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0300","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.chom.2018.01.008","article-title":"Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites","volume":"23","author":"Fraschka","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0305","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12915-023-01568-4","article-title":"Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation","volume":"21","author":"Jeninga","year":"2023","journal-title":"BMC Biol."},{"key":"10.1016\/j.pt.2025.09.011_bb0310","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12936-019-2707-0","article-title":"Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission","volume":"18","author":"Henry","year":"2019","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2025.09.011_bb0315","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1471-4922(02)02292-4","article-title":"Sexual differentiation and sex determination in the Apicomplexa","volume":"18","author":"Smith","year":"2002","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.09.011_bb0320","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3389\/fcimb.2017.00320","article-title":"Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum","volume":"7","author":"Ngwa","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0325","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41564-021-01045-0","article-title":"The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites","volume":"7","author":"Campelo Morillo","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0330","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13387","article-title":"Zinc finger proteins of Plasmodium falciparum","volume":"23","author":"Ngwa","year":"2021","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0335","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.3390\/ijms26125470","article-title":"The Plasmodium falciparum RING finger protein PfRNF1 forms an interaction network with regulators of sexual development","volume":"26","author":"Farrukh","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pt.2025.09.011_bb0340","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/mmi.15215","article-title":"The Plasmodium falciparum CCCH zinc finger protein MD3 regulates male gametocytogenesis through its interaction with RNA-binding proteins","volume":"121","author":"Farrukh","year":"2024","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0345","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.3390\/cells11101666","article-title":"The Plasmodium falciparum CCCH zinc finger protein ZNF4 plays an important role in gametocyte exflagellation through the regulation of male enriched transcripts","volume":"11","author":"Hanhsen","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.pt.2025.09.011_bb0350","first-page":"3144","article-title":"The RNA-binding protein Puf1 functions in the maintenance of gametocytes in Plasmodium falciparum","volume":"129","author":"Shrestha","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.pt.2025.09.011_bb0355","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41586-022-05509-z","article-title":"A transcriptional switch controls sex determination in Plasmodium falciparum","volume":"612","author":"Gomes","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.09.011_bb0360","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02014-23","article-title":"The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries","volume":"14","author":"Azizan","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.pt.2025.09.011_bb0365","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.chom.2022.12.011","article-title":"Regulators of male and female sexual development are critical for the transmission of a malaria parasite","volume":"31","author":"Russell","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0370","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw2619","article-title":"The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle","volume":"365","author":"Howick","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.09.011_bb0375","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/microorganisms12020279","article-title":"The multiple roles of LCCL domain-containing proteins for malaria parasite transmission","volume":"12","author":"Bennink","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.pt.2025.09.011_bb0380","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1101\/gad.1656508","article-title":"The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes","volume":"22","author":"Liu","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.pt.2025.09.011_bb0385","doi-asserted-by":"crossref","first-page":"16813","DOI":"10.1073\/pnas.0501858102","article-title":"Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis","volume":"102","author":"Furuya","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.09.011_bb0390","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051660","article-title":"Plasmodium transcription repressor AP2-O3 regulates sex-specific identity of gene expression in female gametocytes","volume":"22","author":"Li","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.pt.2025.09.011_bb0395","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/mmi.14334","article-title":"Female-specific gene regulation in malaria parasites by an AP2-family transcription factor","volume":"113","author":"Yuda","year":"2020","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0400","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.88317","article-title":"Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors","volume":"12","author":"Murata","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.09.011_bb0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010890","article-title":"PbAP2-FG2 and PbAP2R-2 function together as a transcriptional repressor complex essential for Plasmodium female development","volume":"19","author":"Nishi","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004905","article-title":"Genome-wide identification of the target genes of AP2-O, a Plasmodium AP2-Family transcription factor","volume":"11","author":"Kaneko","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010510","article-title":"Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development","volume":"18","author":"Nishi","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0420","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1365-2958.2009.06609.x","article-title":"Identification of a transcription factor in the mosquito-invasive stage of malaria parasites","volume":"71","author":"Yuda","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0425","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1038\/s41467-024-49002-9","article-title":"An axonemal intron splicing program sustains Plasmodium male development","volume":"15","author":"Guan","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0430","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cels.2024.10.008","article-title":"Systematic screens for fertility genes essential for malaria parasite transmission reveal conserved aspects of sex in a divergent eukaryote","volume":"15","author":"Sayers","year":"2024","journal-title":"Cell Syst."},{"key":"10.1016\/j.pt.2025.09.011_bb0435","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1093\/nar\/gkw536","article-title":"Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression","volume":"44","author":"Lasonder","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.09.011_bb0440","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00578-22","article-title":"PfARID regulates P. falciparum malaria parasite male gametogenesis and female fertility and is critical for parasite transmission to the mosquito vector","volume":"13","author":"Kumar","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.pt.2025.09.011_bb0445","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1093\/nar\/gkae207","article-title":"PbARID-associated chromatin remodeling events are essential for gametocyte development in Plasmodium","volume":"52","author":"Nishi","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2025.09.011_bb0450","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13059-019-1756-6","article-title":"Alternative splicing is required for stage differentiation in malaria parasites","volume":"20","author":"Yeoh","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.pt.2025.09.011_bb0455","article-title":"5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes","volume":"119","author":"Liu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.09.011_bb0460","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1038\/s41467-023-40883-w","article-title":"Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum","volume":"14","author":"Batugedara","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0465","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1038\/s41598-020-63121-5","article-title":"An epigenetic map of malaria parasite development from host to vector","volume":"10","author":"Witmer","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2025.09.011_bb0470","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.1073\/pnas.0902515106","article-title":"Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum","volume":"106","author":"Salcedo-Amaya","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.09.011_bb0475","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/cmi.12604","article-title":"The development of malaria parasites in the mosquito midgut","volume":"18","author":"Bennink","year":"2016","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0480","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.chom.2012.11.013","article-title":"Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut","volume":"13","author":"Simon","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.09.011_bb0485","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1111\/mmi.14388","article-title":"The molecular machinery of translational control in malaria parasites","volume":"112","author":"Bennink","year":"2019","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0490","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1126\/science.1125129","article-title":"Regulation of sexual development of Plasmodium by translational repression","volume":"313","author":"Mair","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.09.011_bb0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000767","article-title":"Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development","volume":"6","author":"Mair","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0500","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1089\/dna.2004.23.753","article-title":"Characterization of PfPuf2, member of the Puf family RNA-binding proteins from the malaria parasite Plasmodium falciparum","volume":"23","author":"Fan","year":"2004","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.pt.2025.09.011_bb0505","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1242\/jcs.059824","article-title":"The Puf-family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparum","volume":"123","author":"Miao","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.pt.2025.09.011_bb0510","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007164","article-title":"Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1\/CCR4\/NOT complex","volume":"15","author":"Hart","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0515","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00435-17","article-title":"Nuclear, cytosolic, and surface-localized Poly(A)-binding proteins of Plasmodium yoelii","volume":"3","author":"Minns","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.pt.2025.09.011_bb0520","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/mmi.13762","article-title":"ALBA4 modulates its stage-specific interactions and specific mRNA fates during Plasmodium yoelii growth and transmission","volume":"106","author":"Munoz","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.09.011_bb0525","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1038\/s41467-024-48140-4","article-title":"The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum","volume":"15","author":"Min","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.09.011_bb0530","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007249","article-title":"A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum","volume":"14","author":"Bennink","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0535","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012823","article-title":"Widespread release of translational repression across Plasmodium's host-to-vector transmission event","volume":"21","author":"Rios","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.09.011_bb0540","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pt.2018.12.001","article-title":"Gametocyte sex ratio: the key to understanding Plasmodium falciparum transmission?","volume":"35","author":"Tadesse","year":"2019","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.09.011_bb0545","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0022-5193(03)00142-5","article-title":"Even more extreme fertility insurance and the sex ratios of protozoan blood parasites","volume":"223","author":"Gardner","year":"2003","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.pt.2025.09.011_bb0550","first-page":"3721","article-title":"Density-dependent impact of the human malaria parasite Plasmodium falciparum gametocyte sex ratio on mosquito infection rates","volume":"276","author":"Mitri","year":"2009","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.pt.2025.09.011_bb0555","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1645\/0022-3395(2002)088[0258:FIATSR]2.0.CO;2","article-title":"Fertility insurance and the sex ratios of malaria and related hemospororin blood parasites","volume":"88","author":"West","year":"2002","journal-title":"J. Parasitol."},{"key":"10.1016\/j.pt.2025.09.011_bb0560","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34463","article-title":"Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density","volume":"7","author":"Bradley","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.09.011_bb0565","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature06954","article-title":"Sex ratio adjustment and kin discrimination in malaria parasites","volume":"453","author":"Reece","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.09.011_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.molbiopara.2021.111372","article-title":"Vesicle dynamics during the egress of malaria gametocytes from the red blood cell","volume":"243","author":"Bennink","year":"2021","journal-title":"Mol. Biochem. Parasitol."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492225002880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492225002880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:53:50Z","timestamp":1778615630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492225002880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":114,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1471492225002880"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2025.09.011","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pink or blue: sex determination in malaria gametocytes","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2025.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}