{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:54:14Z","timestamp":1791388454070,"version":"4.3.3"},"reference-count":122,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["2290"],"award-info":[{"award-number":["2290"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR 2021-05057"],"award-info":[{"award-number":["VR 2021-05057"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.pt.2025.10.007","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:44:46Z","timestamp":1763621086000},"page":"1157-1173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exposing the hidden: establishing immunity to Plasmodium liver stage infection"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7757-7295","authenticated-orcid":false,"given":"Jaclyn","family":"Quin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-1803","authenticated-orcid":false,"given":"Miren","family":"Urrutia Iturritza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-533X","authenticated-orcid":false,"given":"\u00dcmit Yasar","family":"Kina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-8591","authenticated-orcid":false,"given":"Kai","family":"Matuschewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-8493","authenticated-orcid":false,"given":"Johan","family":"Ankarklev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2025.10.007_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000412","article-title":"Some lessons for the future from the Global Malaria Eradication Programme (1955\u20131969)","volume":"8","author":"N\u00e1jera","year":"2011","journal-title":"PLoS Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0010","series-title":"World Malaria Report 2024: Addressing Inequity in the Global Malaria Response","author":"World Health Organization","year":"2024"},{"key":"10.1016\/j.pt.2025.10.007_bb0015","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.90989","article-title":"Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes","volume":"12","author":"Andolina","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.10.007_bb0020","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1084\/jem.20121130","article-title":"Role of host cell traversal by the malaria sporozoite during liver infection","volume":"210","author":"Tavares","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0025","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025486","article-title":"Malaria parasite liver infection and exoerythrocytic biology","volume":"7","author":"Vaughan","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011210","article-title":"Same, same but different: exploring Plasmodium cell division during liver stage development","volume":"19","author":"Roques","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.10.007_bb0035","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/mmi.15141","article-title":"Moving on: how malaria parasites exit the liver","volume":"121","author":"Scheiner","year":"2024","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0040","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1038\/s41467-023-40298-7","article-title":"Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.10.007_bb0045","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41564-024-01905-5","article-title":"Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice","volume":"10","author":"Zangh\u00ed","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune responses in the liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0055","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41586-022-05406-5","article-title":"A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage","volume":"611","author":"Afriat","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.10.007_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111098","article-title":"Direct type I interferon signaling in hepatocytes controls malaria","volume":"40","author":"Marques-da-Silva","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nm.3424","article-title":"Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection","volume":"20","author":"Liehl","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0070","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.celrep.2014.03.018","article-title":"Interferon-mediated innate immune responses against malaria parasite liver stages","volume":"7","author":"Miller","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0075","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210181120","article-title":"AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes","volume":"120","author":"Marques-da-Silva","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0080","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.chom.2022.03.034","article-title":"A single-cell liver atlas of Plasmodium vivax infection","volume":"30","author":"Mancio-Silva","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.10.007_bb0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41418-019-0338-1","article-title":"Liver stage malaria infection is controlled by host regulators of lipid peroxidation","volume":"27","author":"Kain","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.pt.2025.10.007_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-98294-4","article-title":"CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection","volume":"15","author":"Baptista","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112052","article-title":"Elimination of intra-hepatocytic malaria parasites is driven by non-canonical autophagy but not nitric oxide production","volume":"28","author":"Schepis","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.pt.2025.10.007_bb0100","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.chom.2025.03.008","article-title":"Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria","volume":"33","author":"Marques-da-Silva","year":"2025","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.10.007_bb0105","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1038\/s41467-019-11819-0","article-title":"Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites","volume":"10","author":"Minkah","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.10.007_bb0110","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tibs.2021.01.004","article-title":"Beyond autophagy: the expanding roles of ATG8 proteins","volume":"46","author":"Nieto-Torres","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.pt.2025.10.007_bb0115","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.pt.2022.04.004","article-title":"Plasmodium\u2019s fight for survival: escaping elimination while acquiring nutrients","volume":"38","author":"Schroeder","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.10.007_bb0120","article-title":"ATG ubiquitination is required for circumsporozoite protein to subvert host innate immunity against rodent malaria liver stage","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0125","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/mmi.15259","article-title":"LC3B labeling of the parasitophorous vacuole membrane of Plasmodium berghei liver stage parasites depends on the V-ATPase and ATG16L1","volume":"121","author":"Bindschedler","year":"2024","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0130","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/s42003-024-07242-x","article-title":"Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation","volume":"7","author":"Schmuckli-Maurer","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.pt.2025.10.007_bb0135","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pt.2025.10.007_bb0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.pt.2025.10.007_bb0145","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1365-2958.2005.04888.x","article-title":"The liver stage of Plasmodium berghei inhibits host cell apoptosis","volume":"58","author":"van de Sand","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0150","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1016\/j.celrep.2020.03.032","article-title":"Targeting the extrinsic pathway of hepatocyte apoptosis promotes clearance of Plasmodium liver infection","volume":"30","author":"Ebert","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0155","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1086\/429635","article-title":"Apoptotic Plasmodium-infected hepatocytes provide antigens to liver dendritic cells","volume":"191","author":"Leiriao","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.286","article-title":"Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis","volume":"4","author":"Kaushansky","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0165","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.4049\/jimmunol.177.2.1229","article-title":"NK cell responses to Plasmodium infection and control of intrahepatic parasite development","volume":"177","author":"Roland","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0170","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.1073\/pnas.97.15.8461","article-title":"alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria","volume":"97","author":"Gonzalez-Aseguinolaza","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0175","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1128\/IAI.68.4.2224-2230.2000","article-title":"gammadelta T cells are a component of early immunity against preerythrocytic malaria parasites","volume":"68","author":"McKenna","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.pt.2025.10.007_bb0180","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1073\/pnas.91.1.345","article-title":"Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice","volume":"91","author":"Tsuji","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0185","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.4049\/jimmunol.1700314","article-title":"\u0393\u03b4 T cells are required for the induction of sterile immunity during irradiated sporozoite vaccinations","volume":"199","author":"Zaidi","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0190","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm.4110","article-title":"Protection against malaria at 1 year and immune correlates following PfSPZ vaccination","volume":"22","author":"Ishizuka","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0195","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-021-03684-z","article-title":"Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity","volume":"595","author":"Mwakingwe-Omari","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.10.007_bb0200","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1056\/NEJMoa2313892","article-title":"Safety and efficacy of immunization with a late-liver-stage attenuated malaria parasite","volume":"391","author":"Lamers","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0205","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.chom.2019.02.014","article-title":"Monocyte-derived CD11c+ cells acquire Plasmodium from hepatocytes to prime CD8 T cell immunity to liver-stage malaria","volume":"25","author":"Kurup","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.10.007_bb0210","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013390","article-title":"Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination","volume":"13","author":"M\u00fcller","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005075","article-title":"Immunization with radiation-attenuated Plasmodium berghei sporozoites induces liver cCD8alpha+DC that activate CD8+T cells against liver-stage malaria","volume":"4","author":"Jobe","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2025.10.007_bb0220","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/pim.12222","article-title":"Batf3 deficiency proves the pivotal role of CD8\u03b1+dendritic cells in protection induced by vaccination with attenuated Plasmodium sporozoites","volume":"37","author":"Montagna","year":"2015","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0225","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.4049\/jimmunol.166.9.5430","article-title":"Antigen-specific primary activation of CD8+ T cells within the liver","volume":"166","author":"Bertolino","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0230","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3389\/fmicb.2014.00617","article-title":"APC licensing and CD4+T cell help in liver-stage malaria","volume":"5","author":"Crispe","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0235","article-title":"Live imaging of innate and adaptive immune responses in the liver","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0240","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1038\/s41467-024-51418-2","article-title":"Host-pathogen interactions in the Plasmodium-infected mouse liver at spatial and single-cell resolution","volume":"15","author":"Hildebrandt","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.10.007_bb0245","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167408","article-title":"Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine","volume":"9","author":"Senkpeil","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.pt.2025.10.007_bb0250","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.105291.2","article-title":"Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody","volume":"14","author":"Aguirre-Botero","year":"2025","journal-title":"Elife"},{"key":"10.1016\/j.pt.2025.10.007_bb0255","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nm0202-166","article-title":"IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages","volume":"8","author":"Carvalho","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0260","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2353\/ajpath.2007.060792","article-title":"Genetically attenuated Plasmodium berghei liver stages persist and elicit sterile protection primarily via CD8 T cells","volume":"171","author":"Mueller","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pt.2025.10.007_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012943","article-title":"Liver stage P. falciparum antigens highly targeted by CD4+ T cells in malaria-exposed Ugandan children","volume":"21","author":"Acevedo","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.10.007_bb0270","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41591-024-03347-2","article-title":"Single immunization with genetically attenuated Pf\u2206mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial","volume":"31","author":"Roozen","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112589","article-title":"Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans","volume":"28","author":"Colstrup","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.pt.2025.10.007_bb0280","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1600-065X.2008.00671.x","article-title":"Protective CD8 T cells against Plasmodium liver stages: immunobiology of an \u201cunnatural\u201d immune response","volume":"225","author":"Overstreet","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.pt.2025.10.007_bb0285","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1073\/pnas.1303858110","article-title":"In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages","volume":"110","author":"Cockburn","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0290","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.4049\/jimmunol.0903529","article-title":"Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites","volume":"184","author":"Butler","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000998","article-title":"Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites","volume":"6","author":"Schmidt","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.10.007_bb0300","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.immuni.2016.08.011","article-title":"Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection","volume":"45","author":"Fernandez-Ruiz","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.pt.2025.10.007_bb0305","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/330664a0","article-title":"Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites","volume":"330","author":"Schofield","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.10.007_bb0310","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1073\/pnas.85.2.573","article-title":"CD8+ T cells (cytotoxic\/suppressors) are required for protection in mice immunized with malaria sporozoites","volume":"85","author":"Weiss","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109956","article-title":"Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria","volume":"37","author":"Lefebvre","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0320","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.celrep.2018.08.094","article-title":"CD8+ T cell activation leads to constitutive formation of liver tissue-resident memory T cells that seed a large and flexible niche in the liver","volume":"25","author":"Holz","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115295","article-title":"Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination","volume":"44","author":"Chua","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0330","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.chom.2020.04.010","article-title":"A natural peptide antigen within the Plasmodium ribosomal protein RPL6 confers liver TRM cell-mediated immunity against malaria in mice","volume":"27","author":"Valencia-Hernandez","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2025.10.007_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108489","article-title":"More time to kill: a longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria","volume":"26","author":"Yadav","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.pt.2025.10.007_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031247","article-title":"Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites","volume":"7","author":"Weiss","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2025.10.007_bb0345","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1126\/science.1211548","article-title":"Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity","volume":"334","author":"Epstein","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.10.007_bb0350","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1073\/pnas.1615324114","article-title":"Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection","volume":"114","author":"Lyke","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001318","article-title":"Dendritic cells and hepatocytes use distinct pathways to process protective antigen from plasmodium in vivo","volume":"7","author":"Cockburn","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.10.007_bb0360","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/81366","article-title":"Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3","volume":"6","author":"Daubersies","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0365","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.1073\/pnas.1633254100","article-title":"Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data","volume":"100","author":"Doolan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0370","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.007948","article-title":"Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens","volume":"10","author":"Trieu","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.pt.2025.10.007_bb0375","article-title":"Identification of novel pre-erythrocytic malaria antigen candidates for combination vaccines with circumsporozoite protein","volume":"11","author":"Speake","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2025.10.007_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012731","article-title":"Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination","volume":"21","author":"de Menezes","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.10.007_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/0035-9203(74)90129-1","article-title":"Sporozoite induced immunity in man against an Ethiopian strain of Plasmodium falciparum","author":"Rieckmann","year":"1974","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2025.10.007_bb0390","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00000441-197309000-00002","article-title":"Immunization of man against sporozite-induced falciparum malaria","volume":"266","author":"Clyde","year":"1973","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.pt.2025.10.007_bb0395","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJMoa0805832","article-title":"Protection against a malaria challenge by sporozoite inoculation","volume":"361","author":"Roestenberg","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0400","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001058","article-title":"Natural immunization against malaria: causal prophylaxis with antibiotics","volume":"2","author":"Friesen","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0405","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature21060","article-title":"Sterile protection against human malaria by chemoattenuated PfSPZ vaccine","volume":"542","author":"Mordm\u00fcller","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.10.007_bb0410","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pt.2024.12.015","article-title":"Genetically attenuated parasites show promise as a next-generation malaria vaccine","volume":"41","author":"Hafalla","year":"2025","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2025.10.007_bb0415","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/s42003-024-07063-y","article-title":"A conserved Plasmodium nuclear protein is critical for late liver stage development","volume":"7","author":"Goswami","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.pt.2025.10.007_bb0420","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S1473-3099(17)30104-4","article-title":"Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial","volume":"17","author":"Sissoko","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0425","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4269\/ajtmh.17-1014","article-title":"Safety, immunogenicity, and protective efficacy against controlled human malaria infection of Plasmodium falciparum sporozoite vaccine in Tanzanian adults","volume":"99","author":"Jongo","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2025.10.007_bb0430","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41591-021-01470-y","article-title":"Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial","volume":"27","author":"Oneko","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0435","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/embor.2011.213","article-title":"Superinfection in malaria: Plasmodium shows its iron will","volume":"12","author":"Portugal","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.pt.2025.10.007_bb0440","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/s41467-024-46270-3","article-title":"Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin","volume":"15","author":"Patel","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.10.007_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009594","article-title":"PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: a randomized, placebo-controlled trial with controlled human malaria infection","volume":"17","author":"Murphy","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2025.10.007_bb0450","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cellimm.2004.03.010","article-title":"Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells","volume":"228","author":"Behboudi","year":"2004","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0455","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nm1628","article-title":"CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes","volume":"13","author":"Chakravarty","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0460","doi-asserted-by":"crossref","first-page":"46","DOI":"10.20411\/pai.v10i2.794","article-title":"Early activation of lung CD8+ T cells after immunization with live Plasmodium berghei malaria sporozoites","volume":"10","author":"van Schuijlenburg","year":"2025","journal-title":"Pathog. Immun."},{"key":"10.1016\/j.pt.2025.10.007_bb0465","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1073\/pnas.1303834110","article-title":"A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations","volume":"110","author":"Murphy","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2025.10.007_bb0470","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(13)62238-2","article-title":"Malaria vaccine technology roadmap","volume":"382","author":"Moorthy","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.pt.2025.10.007_bb0475","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03671-22","article-title":"Single-cell transcriptomics to define Plasmodium falciparum stage transition in the mosquito midgut","volume":"11","author":"Mohammed","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.pt.2025.10.007_bb0480","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev-micro-041320-010046","article-title":"Division and transmission: malaria parasite development in the mosquito","volume":"76","author":"Guttery","year":"2022","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0485","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41579-024-01065-7","article-title":"Malaria vaccines: a new era of prevention and control","volume":"22","author":"Duffy","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0490","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4939-9550-9_7","article-title":"Controlled human malaria infection (CHMI) studies: Over 100 years of experience with parasite injections","volume":"2013","author":"Matuschewski","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.pt.2025.10.007_bb0495","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12936-022-04199-2","article-title":"Systems biology of malaria explored with nonhuman primates","volume":"21","author":"Galinski","year":"2022","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2025.10.007_bb0500","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/d41586-023-03533-1","article-title":"How wild monkeys \u201claundered\u201d for science could undermine research","volume":"623","author":"Conroy","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.10.007_bb0505","article-title":"Colombian officials halt research, seize animals at NIH-supported facility after alleged monkey mistreatment","author":"Wadman","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.pt.2025.10.007_bb0510","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.pt.2025.10.007_bb0515","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.1038\/s41467-021-27354-w","article-title":"Spatial transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver","volume":"12","author":"Hildebrandt","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.10.007_bb0520","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1038\/ncomms8690","article-title":"Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice","volume":"6","author":"Soulard","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2025.10.007_bb0525","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1172\/JCI62684","article-title":"Complete Plasmodium falciparum liver-stage development in liver-chimeric mice","volume":"122","author":"Vaughan","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pt.2025.10.007_bb0530","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-immunol-082523-124415","article-title":"Engineering mice to study human immunity","volume":"43","author":"Sefik","year":"2025","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0535","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41564-024-01645-6","article-title":"Organ-on-chip models for infectious disease research","volume":"9","author":"Alonso-Roman","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2025.10.007_bb0540","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/cid\/cit174","article-title":"An intensive longitudinal cohort study of Malian children and adults reveals no evidence of acquired immunity to Plasmodium falciparum infection","volume":"57","author":"Tran","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0545","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12879-022-07044-8","article-title":"Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response","volume":"22","author":"Kapulu","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0550","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1080\/14760584.2023.2245890","article-title":"Sporozoite immunization: innovative translational science to support the fight against malaria","volume":"22","author":"Richie","year":"2023","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.pt.2025.10.007_bb0555","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1086\/339409","article-title":"Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites","volume":"185","author":"Hoffman","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0560","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1365-3024.2002.00450.x","article-title":"Effects of irradiation on Plasmodium falciparum sporozoite hepatic development: implications for the design of pre-erythrocytic malaria vaccines","volume":"24","author":"Silvie","year":"2002","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0565","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.4269\/ajtmh.21-0942","article-title":"Multi-dose priming regimens of PfSPZ Vaccine: safety and efficacy against controlled human malaria infection in equatoguinean adults","volume":"106","author":"Jongo","year":"2022","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.pt.2025.10.007_bb0570","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1086\/597121","article-title":"Vaccine-like immunity against malaria by repeated causal-prophylactic treatment of liver-stage Plasmodium parasites","volume":"199","author":"Putrianti","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0575","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1038\/s44321-025-00301-8","article-title":"Complete attenuation of Plasmodium falciparum sporozoites by atovaquone-proguanil","volume":"17","author":"Borrmann","year":"2025","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0580","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.4049\/jimmunol.172.4.2487","article-title":"Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment","volume":"172","author":"Belnoue","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.pt.2025.10.007_bb0585","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz5629","article-title":"A double-blind, placebo-controlled phase 1\/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1","volume":"12","author":"Roestenberg","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2025.10.007_bb0590","doi-asserted-by":"crossref","first-page":"7452","DOI":"10.1016\/j.vaccine.2015.09.096","article-title":"Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines","volume":"33","author":"Richie","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.pt.2025.10.007_bb0595","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1475-2875-11-421","article-title":"A rapid and scalable density gradient purification method for Plasmodium sporozoites","volume":"11","author":"Kennedy","year":"2012","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2025.10.007_bb0600","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12936-025-05471-x","article-title":"A 3D culture model facilitates mass production of in vitro Plasmodium falciparum haemolymph-like sporozoites","volume":"24","author":"Hatzakis","year":"2025","journal-title":"Malar. J."},{"key":"10.1016\/j.pt.2025.10.007_bb0605","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1093\/infdis\/jix336","article-title":"Rapid establishment of a cold chain capacity of -60\u00b0C or colder for the STRIVE Ebola vaccine trial during the Ebola outbreak in Sierra Leone","volume":"217","author":"Jusu","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.pt.2025.10.007_bb0610","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/taae007","article-title":"Piloting delivery of PfSPZ vaccines for malaria through a cryogenic vaccine cold chain to travel and military medicine clinics","volume":"31","author":"James","year":"2024","journal-title":"J. Travel Med."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492225002971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492225002971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:54:08Z","timestamp":1778615648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492225002971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":122,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1471492225002971"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2025.10.007","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposing the hidden: establishing immunity to Plasmodium liver stage infection","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2025.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}