{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:51:42Z","timestamp":1786114302427,"version":"build-2736575974"},"reference-count":97,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["TMAG-3_216166"],"award-info":[{"award-number":["TMAG-3_216166"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32325048"],"award-info":[{"award-number":["32325048"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971953"],"award-info":[{"award-number":["81971953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7182023"],"award-info":[{"award-number":["7182023"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.pt.2026.05.008","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:20:10Z","timestamp":1780114810000},"page":"749-762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fragmented rRNAs and lineage-specific RNA-binding proteins define myzozoan mitoribosomes"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-5718","authenticated-orcid":false,"given":"Chaoyue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-4262","authenticated-orcid":false,"given":"Sari","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0668-8187","authenticated-orcid":false,"given":"Xun","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-2109","authenticated-orcid":false,"given":"Dominique","family":"Soldati-Favre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-7817","authenticated-orcid":false,"given":"Yonggen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2026.05.008_bb0005","doi-asserted-by":"crossref","DOI":"10.1111\/jeu.12906","article-title":"Parasite powerhouse: a review of the Toxoplasma gondii mitochondrion","volume":"69","author":"Usey","year":"2022","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0010","first-page":"663","article-title":"Mitochondrial genomic landscape: a portrait of the mitochondrial genome 40 years after the first complete sequence","volume":"11","author":"Formaggioni","year":"2021","journal-title":"Life (Basel)"},{"key":"10.1016\/j.pt.2026.05.008_bb0015","doi-asserted-by":"crossref","first-page":"10177","DOI":"10.1073\/pnas.1422049112","article-title":"Mitochondrial and plastid genome architecture: reoccurring themes, but significant differences at the extremes","volume":"112","author":"Smith","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.008_bb0020","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1101\/gr.266403.120","article-title":"A novel fragmented mitochondrial genome in the protist pathogen Toxoplasma gondii and related tissue coccidia","volume":"31","author":"Namasivayam","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0025","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41564-019-0605-4","article-title":"Unexpected mitochondrial genome diversity revealed by targeted single-cell genomics of heterotrophic flagellated protists","volume":"5","author":"Wideman","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.751775","article-title":"The elusive mitochondrial genomes of Apicomplexa: where are we now?","volume":"12","author":"Bern\u00e1","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0035","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-micro-032421-120540","article-title":"Unique properties of apicomplexan mitochondria","volume":"77","author":"Lamb","year":"2023","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0040","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38131","article-title":"Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase","volume":"7","author":"Seidi","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.008_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009211","article-title":"Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites","volume":"17","author":"Hayward","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2026.05.008_bb0050","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1038\/s41467-021-23919-x","article-title":"Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum","volume":"12","author":"Evers","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009301","article-title":"Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex","volume":"17","author":"Maclean","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.pt.2026.05.008_bb0060","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.pt.2022.09.008","article-title":"The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain","volume":"38","author":"Maclean","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2026.05.008_bb0065","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1016\/j.cub.2017.10.051","article-title":"A new lineage of eukaryotes illuminates early mitochondrial genome reduction","volume":"27","author":"Janou\u0161kovec","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.pt.2026.05.008_bb0070","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/molbev\/msv021","article-title":"Divergent mitochondrial respiratory chains in phototrophic relatives of apicomplexan parasites","volume":"32","author":"Flegontov","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.pt.2026.05.008_bb0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-micro-091014-104449","article-title":"The organellar genomes of Chromera and Vitrella, the phototrophic relatives of apicomplexan parasites","volume":"69","author":"Oborn\u00edk","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0080","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1038\/s41467-024-55033-z","article-title":"Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0085","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41467-025-56057-9","article-title":"Numerous rRNA molecules form the apicomplexan mitoribosome via repurposed protein and RNA elements","volume":"16","author":"Shikha","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0090","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/iub.489","article-title":"How a neutral evolutionary ratchet can build cellular complexity","volume":"63","author":"Lukes","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.pt.2026.05.008_bb0095","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1016\/j.cub.2021.04.028","article-title":"Parallel functional reduction in the mitochondria of apicomplexan parasites","volume":"31","author":"Mathur","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.pt.2026.05.008_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12915-021-01007-2","article-title":"Gregarine single-cell transcriptomics reveals differential mitochondrial remodeling and adaptation in apicomplexans","volume":"19","author":"Salomaki","year":"2021","journal-title":"BMC Biol."},{"key":"10.1016\/j.pt.2026.05.008_bb0105","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1126\/science.1249410","article-title":"Structure of the yeast mitochondrial large ribosomal subunit","volume":"343","author":"Amunts","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.008_bb0110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.aaa1193","article-title":"Ribosome. The structure of the human mitochondrial ribosome","volume":"348","author":"Amunts","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.008_bb0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.aaa3872","article-title":"Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome","volume":"348","author":"Greber","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.008_bb0120","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.aal2415","article-title":"The structure of the yeast mitochondrial ribosome","volume":"355","author":"Desai","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.008_bb0125","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.95407","article-title":"Small RNAs from mitochondrial genome recombination sites are incorporated into T. gondii mitoribosomes","volume":"13","author":"Tetzlaff","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.008_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038320","article-title":"The fragmented mitochondrial ribosomal RNAs of Plasmodium falciparum","volume":"7","author":"Feagin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2026.05.008_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101990","article-title":"Expression of fragmented ribosomal RNA from the mitochondrial genome of Eimeria tenella","volume":"81","author":"Kruth","year":"2025","journal-title":"Mitochondrion"},{"key":"10.1016\/j.pt.2026.05.008_bb0140","first-page":"10417","article-title":"Identification of clustered organellar short (cos) RNAs and of a conserved family of organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in the malaria parasite","volume":"46","author":"Hillebrand","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0145","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.gene.2011.03.004","article-title":"Characterization of the complete mitochondrial genomes of five Eimeria species from domestic chickens","volume":"480","author":"Lin","year":"2011","journal-title":"Gene"},{"key":"10.1016\/j.pt.2026.05.008_bb0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exppara.2015.09.003","article-title":"The complete mitochondrial genomes of five Eimeria species infecting domestic rabbits","volume":"159","author":"Liu","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.pt.2026.05.008_bb0155","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/gbe\/evr122","article-title":"The mitochondrial genome and transcriptome of the basal dinoflagellate Hematodinium sp.: character evolution within the highly derived mitochondrial genomes of dinoflagellates","volume":"4","author":"Jackson","year":"2012","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.pt.2026.05.008_bb0160","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59264","article-title":"Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation","volume":"9","author":"Tobiasson","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.008_bb0165","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1038\/s41467-021-27200-z","article-title":"How to build a ribosome from RNA fragments in Chlamydomonas mitochondria","volume":"12","author":"Waltz","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0170","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1038\/s41467-022-33582-5","article-title":"Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements","volume":"13","author":"Tobiasson","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0175","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nsmb.2994","article-title":"High-resolution structure of the Escherichia coli ribosome","volume":"22","author":"Noeske","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.pt.2026.05.008_bb0180","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41467-023-36742-3","article-title":"The translating bacterial ribosome at 1.55\u00c5 resolution generated by cryo-EM imaging services","volume":"14","author":"Fromm","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0185","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau7735","article-title":"Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes","volume":"362","author":"Ramrath","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.008_bb0190","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1126\/science.aaw5570","article-title":"Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery","volume":"365","author":"Saurer","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.008_bb0195","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1093\/nar\/gkad422","article-title":"Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway","volume":"51","author":"Valach","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.sbi.2014.01.002","article-title":"A new system for naming ribosomal proteins","volume":"24","author":"Ban","year":"2014","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.pt.2026.05.008_bb0205","doi-asserted-by":"crossref","first-page":"R1177","DOI":"10.1016\/j.cub.2017.09.015","article-title":"The origin and diversification of mitochondria","volume":"27","author":"Roger","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.pt.2026.05.008_bb0210","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0523","article-title":"Protein moonlighting: what is it, and why is it important?","volume":"373","author":"Jeffery","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.pt.2026.05.008_bb0215","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1093\/nar\/gki709","article-title":"Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains","volume":"33","author":"Balaji","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0220","doi-asserted-by":"crossref","first-page":"9264","DOI":"10.1093\/nar\/gkab683","article-title":"A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum","volume":"49","author":"Shang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2023.102383","article-title":"Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm","volume":"76","author":"Zarringhalam","year":"2023","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0230","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3390\/ijms25020893","article-title":"Understanding AP2\/ERF transcription factor responses and tolerance to various abiotic stresses in plants: a comprehensive review","volume":"25","author":"Ma","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pt.2026.05.008_bb0235","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.chom.2020.09.011","article-title":"A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions","volume":"28","author":"Barylyuk","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pt.2026.05.008_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0273357","article-title":"Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum","volume":"17","author":"Lamb","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2026.05.008_bb0245","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1093\/nar\/gku500","article-title":"The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems","volume":"42","author":"Oberstaller","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0250","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.celrep.2015.01.063","article-title":"A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function","volume":"10","author":"Jourdain","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2026.05.008_bb0255","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1093\/nar\/gkx772","article-title":"The FASTK family of proteins: emerging regulators of mitochondrial RNA biology","volume":"45","author":"Jourdain","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0260","article-title":"Identification and phylogenetic analysis of RNA binding domain abundant in apicomplexans or RAP proteins","volume":"7","author":"Hollin","year":"2021","journal-title":"Microb. Genom."},{"key":"10.1016\/j.pt.2026.05.008_bb0265","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41467-022-28981-7","article-title":"Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum","volume":"13","author":"Hollin","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0270","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cell.2017.06.030","article-title":"Functional profiling of a Plasmodium genome reveals an abundance of essential genes","volume":"170","author":"Bushell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pt.2026.05.008_bb0275","doi-asserted-by":"crossref","DOI":"10.1126\/science.aap7847","article-title":"Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis","volume":"360","author":"Zhang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.008_bb0280","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.cell.2016.08.019","article-title":"A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes","volume":"166","author":"Sidik","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.pt.2026.05.008_bb0285","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06974","article-title":"Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites","volume":"4","author":"Woo","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.008_bb0290","doi-asserted-by":"crossref","first-page":"33774","DOI":"10.1074\/jbc.M301934200","article-title":"Proteomic characterization of the Chlamydomonas reinhardtii chloroplast ribosome. Identification of proteins unique to the 70S ribosome","volume":"278","author":"Yamaguchi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2026.05.008_bb0295","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tibs.2004.09.005","article-title":"RAP\u2013a putative RNA-binding domain","volume":"29","author":"Lee","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.pt.2026.05.008_bb0300","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1105\/tpc.114.122853","article-title":"RAP, the sole octotricopeptide repeat protein in Arabidopsis, is required for chloroplast 16S rRNA maturation","volume":"26","author":"Kleinknecht","year":"2014","journal-title":"Plant Cell"},{"key":"10.1016\/j.pt.2026.05.008_bb0305","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1093\/emboj\/20.7.1765","article-title":"Identification of an RNA-protein complex involved in chloroplast group II intron trans-splicing in Chlamydomonas reinhardtii","volume":"20","author":"Rivier","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.pt.2026.05.008_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115928","article-title":"RAP proteins regulate apicoplast noncoding RNA processing in Plasmodium falciparum","volume":"44","author":"Hollin","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2026.05.008_bb0315","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.celrep.2015.01.030","article-title":"Mitochondrial RNA granules are centers for posttranscriptional RNA processing and ribosome biogenesis","volume":"10","author":"Antonicka","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.pt.2026.05.008_bb0320","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1093\/nar\/gkx164","article-title":"FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain","volume":"45","author":"Boehm","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pt.2026.05.008_bb0325","doi-asserted-by":"crossref","first-page":"25877","DOI":"10.1074\/jbc.M116.730291","article-title":"Role of FAST kinase domains 3 (FASTKD3) in post-transcriptional regulation of mitochondrial gene expression","volume":"291","author":"Boehm","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2026.05.008_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009873","article-title":"The FASTK family proteins fine-tune mitochondrial RNA processing","volume":"17","author":"Ohkubo","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2026.05.008_bb0335","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1093\/hmg\/ddae023","article-title":"The molecular machinery for maturation of primary mtDNA transcripts","volume":"33","author":"Vu\u010dkovi\u0107","year":"2024","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pt.2026.05.008_bb0340","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1093\/plcell\/koad049","article-title":"Plant organellar RNA maturation","volume":"35","author":"Small","year":"2023","journal-title":"Plant Cell"},{"key":"10.1016\/j.pt.2026.05.008_bb0345","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/molbev\/msn057","article-title":"On the expansion of the pentatricopeptide repeat gene family in plants","volume":"25","author":"O\u2019Toole","year":"2008","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.pt.2026.05.008_bb0350","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0968-0004(99)01520-0","article-title":"The PPR motif \u2013 a TPR-related motif prevalent in plant organellar proteins","volume":"25","author":"Small","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.pt.2026.05.008_bb0355","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature12651","article-title":"Structural basis for the modular recognition of single-stranded RNA by PPR proteins","volume":"504","author":"Yin","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.pt.2026.05.008_bb0360","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/tpj.13121","article-title":"Redefining the structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land plants","volume":"85","author":"Cheng","year":"2016","journal-title":"Plant J."},{"key":"10.1016\/j.pt.2026.05.008_bb0365","doi-asserted-by":"crossref","first-page":"11285","DOI":"10.1038\/ncomms11285","article-title":"Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins","volume":"7","author":"Shen","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0370","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1365-313X.2011.04657.x","article-title":"Dual functions of the nucleus-encoded factor TDA1 in trapping and translation activation of atpA transcripts in Chlamydomonas reinhardtii chloroplasts","volume":"67","author":"Eberhard","year":"2011","journal-title":"Plant J."},{"key":"10.1016\/j.pt.2026.05.008_bb0375","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1365-313X.2012.05111.x","article-title":"Identification of an OPR protein involved in the translation initiation of the PsaB subunit of photosystem I","volume":"72","author":"Rahire","year":"2012","journal-title":"Plant J."},{"key":"10.1016\/j.pt.2026.05.008_bb0380","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41477-020-0631-5","article-title":"Cryo-EM structure of the RNA-rich plant mitochondrial ribosome","volume":"6","author":"Waltz","year":"2020","journal-title":"Nat. Plants"},{"key":"10.1016\/j.pt.2026.05.008_bb0385","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13108","article-title":"An essential pentatricopeptide repeat protein in the apicomplexan remnant chloroplast","volume":"21","author":"Hicks","year":"2019","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0390","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/s41467-024-45519-1","article-title":"Proteome-wide identification of RNA-dependent proteins and an emerging role for RNAs in Plasmodium falciparum protein complexes","volume":"15","author":"Hollin","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.008_bb0395","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41477-018-0339-y","article-title":"Small is big in Arabidopsis mitochondrial ribosome","volume":"5","author":"Waltz","year":"2019","journal-title":"Nat. Plants"},{"key":"10.1016\/j.pt.2026.05.008_bb0400","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1073\/pnas.1423790112","article-title":"Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives","volume":"112","author":"Janou\u0161kovec","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.008_bb0405","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/AAC.35.2.293","article-title":"Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii","volume":"35","author":"Araujo","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.pt.2026.05.008_bb0410","doi-asserted-by":"crossref","first-page":"15936","DOI":"10.1073\/pnas.1208069109","article-title":"Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis","volume":"109","author":"Doggett","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.008_bb0415","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.20151519","article-title":"Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone","volume":"213","author":"Lawres","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pt.2026.05.008_bb0420","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005029","article-title":"Quinolone-3-diarylethers: a new class of antimalarial drug","volume":"5","author":"Nilsen","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pt.2026.05.008_bb0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(00)00184-5","article-title":"Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance","volume":"108","author":"McFadden","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.pt.2026.05.008_bb0430","doi-asserted-by":"crossref","first-page":"27458","DOI":"10.1074\/jbc.M502319200","article-title":"Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system","volume":"280","author":"Mather","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2026.05.008_bb0435","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/mmi.14357","article-title":"Identification of the Toxoplasma gondii mitochondrial ribosome, and characterisation of a protein essential for mitochondrial translation","volume":"112","author":"Lacombe","year":"2019","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0440","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/microorganisms10050863","article-title":"Identification and validation of Toxoplasma gondii mitoribosomal large subunit components","volume":"10","author":"Shikha","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.pt.2026.05.008_bb0445","doi-asserted-by":"crossref","first-page":"8128","DOI":"10.1074\/jbc.RA118.002552","article-title":"The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in Plasmodium falciparum","volume":"293","author":"Ke","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2026.05.008_bb0450","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0274993","article-title":"Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23","volume":"17","author":"Dass","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2026.05.008_bb0455","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1074\/jbc.RA120.012646","article-title":"Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions","volume":"295","author":"Ling","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pt.2026.05.008_bb0460","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.pt.2022.08.010","article-title":"Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids","volume":"38","author":"Gahura","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2026.05.008_bb0465","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-biochem-062917-011942","article-title":"Ribosome-targeting antibiotics: modes of action, mechanisms of resistance, and implications for drug design","volume":"87","author":"Lin","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.pt.2026.05.008_bb0470","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s41594-023-01047-y","article-title":"Structural conservation of antibiotic interaction with ribosomes","volume":"30","author":"Paternoga","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.pt.2026.05.008_bb0475","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrmicro3155","article-title":"Ribosome-targeting antibiotics and mechanisms of bacterial resistance","volume":"12","author":"Wilson","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.pt.2026.05.008_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpddr.2025.100597","article-title":"Resistance to apicoplast translational inhibitors in Plasmodium","volume":"28","author":"Home","year":"2025","journal-title":"Int. J. Parasitol. Drugs Drug. Resist."},{"key":"10.1016\/j.pt.2026.05.008_bb0485","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1038\/s41467-025-57302-x","article-title":"Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492226001315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492226001315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T20:43:44Z","timestamp":1785962624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492226001315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":97,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1471492226001315"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2026.05.008","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fragmented rRNAs and lineage-specific RNA-binding proteins define myzozoan mitoribosomes","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2026.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}