{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:14:07Z","timestamp":1793150047972,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011620","name":"Peking-Tsinghua Joint Center for Life Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270672"],"award-info":[{"award-number":["32270672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2432018"],"award-info":[{"award-number":["W2432018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Parasitology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.pt.2026.05.009","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:07:34Z","timestamp":1780373254000},"page":"647-661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gene drives and other transgenic approaches for mosquito control"],"prefix":"10.1016","volume":"42","author":[{"given":"Weizhe","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-3774","authenticated-orcid":false,"given":"Jackson","family":"Champer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pt.2026.05.009_bb0005","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/23744235.2024.2357624","article-title":"Mosquito species identity matters: unraveling the complex interplay in vector-borne diseases","volume":"56","author":"Ferraguti","year":"2024","journal-title":"Infect. Dis. (Lond.)"},{"key":"10.1016\/j.pt.2026.05.009_bb0010","doi-asserted-by":"crossref","DOI":"10.1111\/gcb.70551","article-title":"A scoping review of mosquito vector range shifts: widespread expansions and evidence gaps in climate attribution","volume":"31","author":"Lyberger","year":"2025","journal-title":"Glob. Chang. Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0015","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65655","article-title":"The need for practical insecticide-resistance guidelines to effectively inform mosquito-borne disease control programs","volume":"10","author":"Namias","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.009_bb0020","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev-ento-010814-020828","article-title":"Insecticide resistance in mosquitoes: impact, mechanisms, and research directions","volume":"60","author":"Liu","year":"2015","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.pt.2026.05.009_bb0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40249-024-01242-z","article-title":"Current status of the sterile insect technique for the suppression of mosquito populations on a global scale","volume":"13","author":"Bouyer","year":"2024","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.pt.2026.05.009_bb0030","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev-ento-012424-011039","article-title":"Gene drive and symbiont technologies for control of mosquito-borne diseases","volume":"70","author":"Wang","year":"2025","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.pt.2026.05.009_bb0035","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/s42003-022-04332-6","article-title":"A standalone incompatible insect technique enables mosquito suppression in the urban subtropics","volume":"5","author":"Zeng","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0040","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1073\/pnas.1000251107","article-title":"Female-specific flightless phenotype for mosquito control","volume":"107","author":"Fu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0045","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1126\/science.287.5462.2474","article-title":"Insect population control using a dominant, repressible, lethal genetic system","volume":"287","author":"Thomas","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pt.2026.05.009_bb0050","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msaf048","article-title":"A comparative assessment of self-limiting genetic control strategies for population suppression","volume":"42","author":"Han","year":"2025","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.pt.2026.05.009_bb0055","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-ento-020117-043154","article-title":"Engineering the composition and fate of wild populations with gene drive","volume":"66","author":"Hay","year":"2021","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.pt.2026.05.009_bb0060","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41576-021-00386-0","article-title":"Gene drives gaining speed","volume":"23","author":"Bier","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.pt.2026.05.009_bb0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nbt.3439","article-title":"A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae","volume":"34","author":"Hammond","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.pt.2026.05.009_bb0070","doi-asserted-by":"crossref","first-page":"E6736","DOI":"10.1073\/pnas.1521077112","article-title":"Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi","volume":"112","author":"Gantz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0075","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo1733","article-title":"Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development","volume":"8","author":"Hoermann","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pt.2026.05.009_bb0080","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41586-025-09283-6","article-title":"Driving a protective allele of the mosquito FREP1 gene to combat malaria","volume":"645","author":"Li","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.pt.2026.05.009_bb0085","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/jme\/tjab030","article-title":"Current effector and gene-drive developments to engineer arbovirus-resistant Aedes Aegypti (Diptera: Culicidae) for a sustainable population replacement strategy in the field","volume":"58","author":"Reid","year":"2021","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.pt.2026.05.009_bb0090","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1038\/s41467-023-42183-9","article-title":"Next-generation CRISPR gene-drive systems using Cas12a nuclease","volume":"14","author":"Sanz Juste","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009321","article-title":"Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance","volume":"17","author":"Hammond","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2026.05.009_bb0100","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nbt.4245","article-title":"A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes","volume":"36","author":"Kyrou","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.pt.2026.05.009_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009740","article-title":"Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation","volume":"17","author":"Fuchs","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2026.05.009_bb0110","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/s41587-020-0508-1","article-title":"A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae","volume":"38","author":"Simoni","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.pt.2026.05.009_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58791","article-title":"Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement","volume":"10","author":"Hoermann","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.009_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010244","article-title":"Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae","volume":"18","author":"Ellis","year":"2022","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2026.05.009_bb0125","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41467-024-44907-x","article-title":"Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages","volume":"15","author":"D\u2019Amato","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0130","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1038\/s41467-025-58954-5","article-title":"A suppression-modification gene drive for malaria control targeting the ultra-conserved RNA gene mir-184","volume":"16","author":"Verkuijl","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0135","article-title":"Engineering resilient gene drives towards sustainable malaria control: predicting, testing and overcoming target site resistance","author":"Morianou","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2026.05.009_bb0140","doi-asserted-by":"crossref","first-page":"9446","DOI":"10.1038\/s41467-025-64489-6","article-title":"A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae","volume":"16","author":"Strampelli","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0145","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221118120","article-title":"Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii","volume":"120","author":"Carballar-Lejaraz\u00fa","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0150","doi-asserted-by":"crossref","first-page":"22805","DOI":"10.1073\/pnas.2010214117","article-title":"Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae","volume":"117","author":"Carballar-Lejaraz\u00fa","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0155","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.93142","article-title":"A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes","volume":"12","author":"Green","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.009_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008440","article-title":"Experimental population modification of the malaria vector mosquito, Anopheles stephensi","volume":"15","author":"Pham","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2026.05.009_bb0165","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1038\/s41467-020-19426-0","article-title":"Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi","volume":"11","author":"Adolfi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0170","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41467-025-56290-2","article-title":"Gene drive-based population suppression in the malaria vector Anopheles stephensi","volume":"16","author":"Xu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13071-025-06688-0","article-title":"Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi","volume":"18","author":"Larrosa-Godall","year":"2025","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.pt.2026.05.009_bb0180","article-title":"A confined gene drive for population modification in the malaria vector Anopheles stephensi","author":"Xu","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2026.05.009_bb0185","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1038\/s41467-023-41834-1","article-title":"CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus","volume":"14","author":"Harvey-Samuel","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0190","article-title":"Sequence mismatch between gene-drive and target-site flanking regions significantly impairs homing efficiency in Culex quinquefasciatus","author":"Harvey-Samuel","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2026.05.009_bb0195","article-title":"Self-limiting population suppression gene drive in the West Nile vector mosquito, Culex quinquefasciatus","author":"Feng","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2026.05.009_bb0200","article-title":"Development of a confinable gene drive system in the human disease vector Aedes aegypti","volume":"9","author":"Li","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.009_bb0205","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1038\/s41467-022-34739-y","article-title":"A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias","volume":"13","author":"Verkuijl","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0210","doi-asserted-by":"crossref","DOI":"10.1093\/g3journal\/jkac280","article-title":"Assessing single-locus CRISPR\/Cas9-based gene drive variants in the mosquito Aedes aegypti via single-generation crosses and modeling","volume":"12","author":"Reid","year":"2022","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.pt.2026.05.009_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011757","article-title":"Performance of two low-threshold population replacement gene drives in cage populations of the yellow fever mosquito, Aedes aegypti","volume":"21","author":"Speth","year":"2025","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pt.2026.05.009_bb0220","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41467-023-36029-7","article-title":"Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements","volume":"14","author":"Anderson","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0225","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41467-024-44956-2","article-title":"A multiplexed, confinable CRISPR\/Cas9 gene drive can propagate in caged Aedes aegypti populations","volume":"15","author":"Anderson","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0230","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s10340-024-01864-0","article-title":"Assessment of drive efficiency and resistance allele formation of a homing gene drive in the mosquito Aedes aegypti","volume":"98","author":"Yang","year":"2025","journal-title":"J. Pest Sci."},{"key":"10.1016\/j.pt.2026.05.009_bb0235","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.79121","article-title":"Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure","volume":"11","author":"Champer","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.009_bb0240","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz0525","article-title":"Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs","volume":"6","author":"Champer","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pt.2026.05.009_bb0245","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/s41467-020-14960-3","article-title":"A toxin-antidote CRISPR gene drive system for regional population modification","volume":"11","author":"Champer","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0250","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1073\/pnas.1816928116","article-title":"Cleave and rescue, a novel selfish genetic element and general strategy for gene drive","volume":"116","author":"Oberhofer","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0255","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/eva.13180","article-title":"Design and analysis of CRISPR-based underdominance toxin-antidote gene drives","volume":"14","author":"Champer","year":"2021","journal-title":"Evol. Appl."},{"key":"10.1016\/j.pt.2026.05.009_bb0260","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12915-020-0761-2","article-title":"Performance analysis of novel toxin-antidote CRISPR gene drive systems","volume":"18","author":"Champer","year":"2020","journal-title":"BMC Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0265","doi-asserted-by":"crossref","first-page":"24377","DOI":"10.1073\/pnas.2004373117","article-title":"A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population","volume":"117","author":"Champer","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0270","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1111\/eva.12827","article-title":"Tethered homing gene drives: a new design for spatially restricted population replacement and suppression","volume":"12","author":"Dhole","year":"2019","journal-title":"Evol. Appl."},{"key":"10.1016\/j.pt.2026.05.009_bb0275","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12915-022-01292-5","article-title":"Experimental demonstration of tethered gene drive systems for confined population modification or suppression","volume":"20","author":"Metzloff","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0280","doi-asserted-by":"crossref","DOI":"10.1111\/mec.17530","article-title":"Deployment of tethered gene drive for confined suppression in continuous space requires avoiding drive wave interference","volume":"33","author":"Feng","year":"2024","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.pt.2026.05.009_bb0285","article-title":"Gene drive for population genetic control: non-functional resistance and parental effects","volume":"286","author":"Beaghton","year":"2019","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.pt.2026.05.009_bb0290","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1038\/s41467-024-52473-5","article-title":"Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0295","article-title":"Stronger population suppression by gene drive targeting doublesex from dominant female-sterile resistance alleles","author":"Chen","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2026.05.009_bb0300","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jgg.2024.04.001","article-title":"A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance","volume":"51","author":"Hou","year":"2024","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.pt.2026.05.009_bb0305","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1038\/s44318-025-00683-y","article-title":"Assessing target genes for homing suppression gene drive","volume":"45","author":"Xu","year":"2026","journal-title":"EMBO J."},{"key":"10.1016\/j.pt.2026.05.009_bb0310","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1016\/j.cell.2025.10.008","article-title":"A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito","volume":"188","author":"Goldman","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.pt.2026.05.009_bb0315","article-title":"Finding the perfect promoter: correlating single-cell transcriptome data with gene drive performance","author":"Wu","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2026.05.009_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042771","article-title":"Open field release of genetically engineered sterile male Aedes aegypti in Malaysia","volume":"7","author":"Lacroix","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pt.2026.05.009_bb0325","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nbt.2350","article-title":"Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes","volume":"30","author":"Harris","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.pt.2026.05.009_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001724","article-title":"Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus","volume":"6","author":"Labbe","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.pt.2026.05.009_bb0335","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.975786","article-title":"New self-sexing Aedes aegypti strain eliminates barriers to scalable and sustainable vector control for governments and communities in dengue-prone environments","volume":"10","author":"Spinner","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.pt.2026.05.009_bb0340","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2312456121","article-title":"Eliminating malaria vectors with precision-guided sterile males","volume":"121","author":"Apte","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0345","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1038\/s41467-021-25421-w","article-title":"Suppressing mosquito populations with precision guided sterile males","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0350","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71230","article-title":"Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression","volume":"11","author":"Upadhyay","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.pt.2026.05.009_bb0355","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1038\/s41467-020-18348-1","article-title":"Engineering multiple species-like genetic incompatibilities in insects","volume":"11","author":"Maselko","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0360","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1038\/s41467-024-50992-9","article-title":"Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails","volume":"15","author":"Johnson","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0365","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/eva.12583","article-title":"Invasion and migration of spatially self-limiting gene drives: a comparative analysis","volume":"11","author":"Dhole","year":"2018","journal-title":"Evol. Appl."},{"key":"10.1016\/j.pt.2026.05.009_bb0370","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1073\/pnas.1716358116","article-title":"Daisy-chain gene drives for the alteration of local populations","volume":"116","author":"Noble","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0375","article-title":"Development and testing of a novel killer-rescue self-limiting gene drive system in Drosophila melanogaster","volume":"287","author":"Webster","year":"2020","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.pt.2026.05.009_bb0380","article-title":"Self-limiting population genetic control with sex-linked genome editors","volume":"285","author":"Burt","year":"2018","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.pt.2026.05.009_bb0385","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1038\/s41467-024-49387-7","article-title":"Targeting mosquito X-chromosomes reveals complex transmission dynamics of sex ratio distorting gene drives","volume":"15","author":"Haber","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0390","doi-asserted-by":"crossref","DOI":"10.1093\/g3journal\/jkae025","article-title":"The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive","volume":"14","author":"Lawler","year":"2024","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.pt.2026.05.009_bb0395","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2301525120","article-title":"CRISPR\/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii","volume":"120","author":"Yadav","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0400","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41467-024-55391-8","article-title":"A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae","volume":"16","author":"Tolosana","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0405","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2414207122","article-title":"Engineering drive\u2013selection balance for localized population suppression with neutral dynamics","volume":"122","author":"Willis","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pt.2026.05.009_bb0410","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibtech.2020.08.011","article-title":"Embracing dynamic models for gene drive management","volume":"39","author":"Golnar","year":"2021","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.pt.2026.05.009_bb0415","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tig.2023.04.004","article-title":"Leveraging eco-evolutionary models for gene drive risk assessment","volume":"39","author":"Combs","year":"2023","journal-title":"Trends Genet."},{"key":"10.1016\/j.pt.2026.05.009_bb0420","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1111\/ele.14194","article-title":"Incorporating ecology into gene drive modelling","volume":"26","author":"Kim","year":"2023","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.pt.2026.05.009_bb0425","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pt.2023.02.001","article-title":"When less is more: accounting for overcompensation in mosquito SIT projects","volume":"39","author":"Bouyer","year":"2023","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.pt.2026.05.009_bb0430","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1111\/ele.14232","article-title":"Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models","volume":"26","author":"Liu","year":"2023","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.pt.2026.05.009_bb0435","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/emph\/eoz014","article-title":"Gene-drive-mediated extinction is thwarted by population structure and evolution of sib mating","volume":"2019","author":"Bull","year":"2019","journal-title":"Evol. Med. Public Health"},{"key":"10.1016\/j.pt.2026.05.009_bb0440","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00285-021-01702-2","article-title":"Demographic feedbacks can hamper the spatial spread of a gene drive","volume":"83","author":"Girardin","year":"2021","journal-title":"J. Math. Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0445","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1111\/mec.16598","article-title":"Slow and steady wins the race: spatial and stochastic processes and the failure of suppression gene drives","volume":"31","author":"Paril","year":"2022","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.pt.2026.05.009_bb0450","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/mec.15788","article-title":"Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles","volume":"30","author":"Champer","year":"2021","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.pt.2026.05.009_bb0455","article-title":"Population dynamics in spatial suppression gene drive models and the effect of resistance, density dependence, and life history","author":"Zhang","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.pt.2026.05.009_bb0460","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12915-020-00834-z","article-title":"Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility","volume":"18","author":"North","year":"2020","journal-title":"BMC Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0465","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1111\/2041-210X.14432","article-title":"Resource-explicit interactions in spatial population models","volume":"15","author":"Champer","year":"2024","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.pt.2026.05.009_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1012133","article-title":"MGDrivE 3: a decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillance","volume":"20","author":"Mondal","year":"2024","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0475","doi-asserted-by":"crossref","first-page":"8976","DOI":"10.1038\/s41467-024-53065-z","article-title":"The potential of gene drives in malaria vector species to control malaria in African environments","volume":"15","author":"Hancock","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pt.2026.05.009_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2026.115221","article-title":"A simulation-based deep learning framework for spatially explicit malaria modeling of CRISPR suppression gene drive mosquitoes","volume":"29","author":"Allegretti","year":"2026","journal-title":"iScience"},{"key":"10.1016\/j.pt.2026.05.009_bb0485","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009030","article-title":"MGDrivE 2: a simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics","volume":"17","author":"Wu","year":"2021","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0490","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0005026","article-title":"A model-informed target product profile for population modification gene drives for malaria control","volume":"5","author":"Mondal","year":"2025","journal-title":"PLOS Glob. Public Health"},{"key":"10.1016\/j.pt.2026.05.009_bb0495","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12915-025-02414-5","article-title":"Requirements for designing cluster randomised control trials to detect suppression of malaria vector population densities","volume":"23","author":"Hancock","year":"2025","journal-title":"BMC Biol."},{"key":"10.1016\/j.pt.2026.05.009_bb0500","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12936-024-04952-9","article-title":"Considerations for first field trials of low-threshold gene drive for malaria vector control","volume":"23","author":"Connolly","year":"2024","journal-title":"Malar. J."}],"container-title":["Trends in Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492226001327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471492226001327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:00:39Z","timestamp":1783144839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471492226001327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":100,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1471492226001327"],"URL":"https:\/\/doi.org\/10.1016\/j.pt.2026.05.009","relation":{},"ISSN":["1471-4922"],"issn-type":[{"value":"1471-4922","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene drives and other transgenic approaches for mosquito control","name":"articletitle","label":"Article Title"},{"value":"Trends in Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pt.2026.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}