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Rep."},{"key":"10.1016\/j.pt.2026.08.005_bb0420","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skab107","article-title":"Effects of vaccination against brucellosis and clostridia on the intake, performance, feeding behaviour, blood parameters, and immune responses of dairy heifers calves","volume":"99","author":"Diniz Neto","year":"2021","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.pt.2026.08.005_bb0425","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41590-020-0598-4","article-title":"Germinal centre B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis","volume":"21","author":"Weisel","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.pt.2026.08.005_bb0430","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41590-025-02169-9","article-title":"Antibiotics, microbiota and the calibration of infant vaccine responses","volume":"26","author":"Feng","year":"2025","journal-title":"Nat. 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Dis."},{"key":"10.1016\/j.pt.2026.08.005_bb0460","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41586-023-05715-3","article-title":"Molecular fate-mapping of serum antibody responses to repeat immunization","volume":"615","author":"Schiepers","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.pt.2026.08.005_bb0465","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.exppara.2005.01.006","article-title":"Boophilus microplus: the pattern of bovine immunoglobulin isotype responses to high and low tick infestations","volume":"110","author":"Kashino","year":"2005","journal-title":"Exp. 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