{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:51:40Z","timestamp":1789725100920,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.pupt.2007.02.004","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T11:54:53Z","timestamp":1173182093000},"page":"208-213","source":"Crossref","is-referenced-by-count":20,"title":["Effects of airway anesthesia on dyspnea and ventilatory response to intravenous injection of adenosine in healthy human subjects"],"prefix":"10.1016","volume":"21","author":[{"given":"Nausherwan K.","family":"Burki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sheatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Yuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2007.02.004_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.1990.tb37674.x","article-title":"Adenosine receptors. Roles and pharmacology","volume":"603","author":"Bruns","year":"1990","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pupt.2007.02.004_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0033-0620(89)90015-7","article-title":"The cardiac effects of adenosine","volume":"32","author":"Belardinelli","year":"1989","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.pupt.2007.02.004_bib3","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/01.CIR.68.6.1254","article-title":"Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia","volume":"68","author":"DiMarco","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2007.02.004_bib4","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0002-9343(92)90784-9","article-title":"Adenosine and the treatment of supraventricular tachycardia","volume":"92","author":"Rankin","year":"1992","journal-title":"Am J Med"},{"key":"10.1016\/j.pupt.2007.02.004_bib5","series-title":"Breathing: Hering\u2013Breuer centenary symposium","first-page":"315","article-title":"Experimental results of vagal block in cardiopulmonary disease","author":"Guz","year":"1970"},{"key":"10.1016\/j.pupt.2007.02.004_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0027715","article-title":"Afferent vagal C fibre innervation of the lungs and airways and its functional significance","volume":"99","author":"Coleridge","year":"1984","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1016\/j.pupt.2007.02.004_bib7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1113\/jphysiol.1995.sp020513","article-title":"Sensory origin of lobeline-induced sensations: a correlative study in man and cats","volume":"482","author":"Raj","year":"1995","journal-title":"J Physiol (London)"},{"key":"10.1016\/j.pupt.2007.02.004_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0034-5687(00)00204-8","article-title":"Afferent properties and reflex functions of bronchopulmonary C-fibers","volume":"125","author":"Lee","year":"2001","journal-title":"Respir Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1469-7793.1998.109br.x","article-title":"Activation of pulmonary C fibers by adenosine in anaesthetized rats: role of adenosine A1 receptors","volume":"508","author":"Hong","year":"1998","journal-title":"J Physiol (London)"},{"key":"10.1016\/j.pupt.2007.02.004_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1152\/jappl.1998.84.2.417","article-title":"Role of pulmonary C fibers in adenosine-induced respiratory inhibition in anesthetized rats","volume":"84","author":"Kwong","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib11","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1152\/japplphysiol.00107.2003","article-title":"Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats","volume":"95","author":"Gu","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/japplphysiol.00913.2004","article-title":"Intravenous adenosine and dyspnea in man","volume":"98","author":"Burki","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2125.1987.tb03081.x","article-title":"Adenosine-induced respiratory stimulation in man depends on site of infusion. Evidence for an action on the carotid body?","volume":"23","author":"Watt","year":"1987","journal-title":"Br J Clin Pharmac"},{"key":"10.1016\/j.pupt.2007.02.004_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/cs0780025","article-title":"Ventilatory effects of hypoxia and adenosine infusion in patients after bilateral carotid endarterectomy","volume":"78","author":"Griffiths","year":"1990","journal-title":"Clin Sci"},{"key":"10.1016\/j.pupt.2007.02.004_bib15","first-page":"635","article-title":"The effects of airway anesthesia on detection of added inspiratory elastic loads","volume":"122","author":"Chaudhary","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2007.02.004_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1164\/arrd.1983.127.1.2","article-title":"The effect of airway anesthesia on magnitude estimation of added inspiratory resistive and elastic loads","volume":"127","author":"Burki","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2007.02.004_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0034-5687(87)90038-7","article-title":"Blockade of \u201calveolar\u201d and airway reflexes by local anesthetic aerosol in dogs","volume":"67","author":"Hamilton","year":"1987","journal-title":"Respir Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/thx.51.8.793","article-title":"Respiratory sensation during bronchial challenge testing with methacholine, sodium metabisulphite, and adenosine monophosphate","volume":"51","author":"Marks","year":"1996","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2007.02.004_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0034-5687(81)90053-0","article-title":"Ability of healthy men to discriminate between added inspiratory resistive and elastic loads","volume":"45","author":"Zechman","year":"1981","journal-title":"Respir Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib20","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1152\/jappl.1984.57.3.888","article-title":"Scaling of added loads to breathing: magnitude estimation vs handgrip matching","volume":"57","author":"Muza","year":"1984","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib21","first-page":"225","article-title":"Effects of bronchodilation on magnitude estimation of added resistive loads in asthmatic subjects","volume":"129","author":"Burki","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2007.02.004_bib22","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1152\/jappl.1989.67.3.933","article-title":"Reassessment of the interruption technique for measuring airflow resistance in humans","volume":"67","author":"Liistro","year":"1989","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib23","series-title":"Statistical methods","author":"Snedecor","year":"1989"},{"key":"10.1016\/j.pupt.2007.02.004_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF02714443","article-title":"Dyspnea\u2014Editorial Review","volume":"165","author":"Burki","year":"1987","journal-title":"Lung"},{"key":"10.1016\/j.pupt.2007.02.004_bib25","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJM199512073332307","article-title":"Pathophysiology of dyspnea","volume":"333","author":"Manning","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pupt.2007.02.004_bib26","series-title":"Lung biology in health and disease, regulation of breathing","first-page":"429","article-title":"Nervous receptors in the respiratory tree and lungs","author":"Widdicombe","year":"1981"},{"key":"10.1016\/j.pupt.2007.02.004_bib27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1152\/physrev.1982.62.2.531","article-title":"Information arising from the tracheobronchial tree of mammals","volume":"62","author":"Sant\u2019Ambrogio","year":"1982","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pupt.2007.02.004_bib28","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1152\/jappl.1991.71.6.2183","article-title":"Effects of bronchoconstriction and external resistive loading on the sensation of dyspnea","volume":"71","author":"Taguchi","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1042\/cs0680215","article-title":"The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man","volume":"68","author":"Winning","year":"1985","journal-title":"Clin Sci"},{"key":"10.1016\/j.pupt.2007.02.004_bib30","first-page":"238","article-title":"Sensations from J receptors","volume":"10","author":"Paintal","year":"1995","journal-title":"NIPS"},{"key":"10.1016\/j.pupt.2007.02.004_bib31","first-page":"624","article-title":"Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma","volume":"151","author":"Polosa","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2007.02.004_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1042\/CS19980228","article-title":"Adenosine induces histamine release from human bronchoalveolar lavage mast cells","volume":"96","author":"Forsythe","year":"1999","journal-title":"Clin Sci"},{"key":"10.1016\/j.pupt.2007.02.004_bib33","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/thorax.57.7.649","article-title":"Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease","volume":"57","author":"Polosa","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2007.02.004_bib34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0952-8180(92)90139-R","article-title":"Lidocaine blood levels following aerosolization and intravenous administration","volume":"4","author":"Baughman","year":"1992","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.pupt.2007.02.004_bib35","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1152\/jappl.1993.74.3.1419","article-title":"Effect of nebulized lidocaine on ventilatory response to CO2 in healthy subjects","volume":"74","author":"Mador","year":"1993","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.02.004_bib36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1042\/cs0440519","article-title":"The effect of local anaesthesia of the airway on respiratory reflexes in the rabbit","volume":"44","author":"Jain","year":"1973","journal-title":"Clin Sci"},{"key":"10.1016\/j.pupt.2007.02.004_bib37","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1161\/01.CIR.90.6.2919","article-title":"Role of arterial chemoreceptors in mediating the effects of endogenous adenosine on sympathetic nerve activity","volume":"90","author":"Engelstein","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2007.02.004_bib38","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2125.1986.tb02838.x","article-title":"Transient bradycardia and subsequent tachycardia produced by intravenous adenosine in healthy adult subjects","volume":"21","author":"Watt","year":"1986","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.pupt.2007.02.004_bib39","first-page":"779","article-title":"Cardiovascular and respiratory effects of adenosine in conscious man","volume":"61","author":"Biaggioni","year":"1987","journal-title":"Evidence for chemoreceptor activation. Circ Res"},{"key":"10.1016\/j.pupt.2007.02.004_bib40","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/CS19980348","article-title":"Effect of adenosine on heart rate variability in humans","volume":"96","author":"Rongen","year":"1999","journal-title":"Clin Sci"},{"key":"10.1016\/j.pupt.2007.02.004_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/hrt.82.2.163","article-title":"Imaging of adenosine bolus transit following intravenous administration: insights into antiarrhythmic efficacy","volume":"82","author":"Ng","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.pupt.2007.02.004_bib42","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2125.1987.tb03174.x","article-title":"Circulatory and respiratory effects of infused adenosine in conscious man","volume":"24","author":"Fuller","year":"1987","journal-title":"Br J Clin Parmacol"},{"key":"10.1016\/j.pupt.2007.02.004_bib43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/cs0800107","article-title":"Effects of theophylline and dipyridamole on the respiratory response to isocapnic hypoxia in normal human subjects","volume":"80","author":"Parsons","year":"1991","journal-title":"Clin Sci"},{"key":"10.1016\/j.pupt.2007.02.004_bib44","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09031936.97.10010156","article-title":"The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine","volume":"10","author":"Griffiths","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2007.02.004_bib45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0034-5687(00)00223-1","article-title":"Role of vagal afferents in the reflex effects of capsaicin and lobeline in monkeys","volume":"125","author":"Deep","year":"2001","journal-title":"Respir Physiol"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553907000296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553907000296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T07:39:32Z","timestamp":1556177972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553907000296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S1094553907000296"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2007.02.004","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}