{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:59:24Z","timestamp":1773154764597,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.pupt.2007.08.002","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T11:13:26Z","timestamp":1187781206000},"page":"455-460","source":"Crossref","is-referenced-by-count":13,"title":["Insights into the mechanisms of histamine-induced inflammation in the nasal mucosa"],"prefix":"10.1016","volume":"21","author":[{"given":"Thomas E.","family":"Taylor-Clark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2007.08.002_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000236109","article-title":"Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs","volume":"97","author":"Namimatsu","year":"1992","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.pupt.2007.08.002_bib2","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1164\/ajrccm\/148.6_Pt_1.1616","article-title":"Reflex activation of nasal secretion by unilateral inhalation of cold dry air","volume":"148","author":"Philip","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2007.08.002_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2125.1999.00972.x","article-title":"The nasal airways response in normal subjects to oxymetazoline spray: randomized double-blind placebo-controlled trial","volume":"48","author":"Bickford","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.pupt.2007.08.002_bib4","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1152\/jappl.1992.73.5.1867","article-title":"Neuropeptide Y is a vasoconstrictor in human nasal mucosa","volume":"73","author":"Baraniuk","year":"1992","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2007.08.002_bib5","first-page":"721","article-title":"The effects of cromolyn sodium on the nasal mast cells","volume":"55","author":"Okuda","year":"1985","journal-title":"Ann Allergy"},{"key":"10.1016\/j.pupt.2007.08.002_bib6","first-page":"597","article-title":"Mediator release after nasal airway challenge with allergen","volume":"128","author":"Naclerio","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2007.08.002_bib7","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0091-6749(05)80156-3","article-title":"Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy","volume":"86","author":"Doyle","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2007.08.002_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1164\/ajrccm\/136.2.357","article-title":"Behavior and clinical relevance of histamine and leukotrienes C4 and B4 in grass pollen-induced rhinitis","volume":"136","author":"Miadonna","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2007.08.002_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bjp.0706118","article-title":"Histamine receptors that influence blockage of the normal human nasal airway","author":"Taylor-Clark","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2007.08.002_bib10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/000348940411300707","article-title":"Immunohistochemical localization of histamine receptor subtypes in human inferior turbinates","volume":"113","author":"Nakaya","year":"2004","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.pupt.2007.08.002_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2273.1994.tb01146.x","article-title":"Histamine receptors in the human nose","volume":"19","author":"Shelton","year":"1994","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"10.1016\/j.pupt.2007.08.002_bib12","first-page":"58","article-title":"A computed tomographic study of nasal mucosa: effects of vasoactive substances","volume":"12","author":"Cole","year":"1983","journal-title":"J Otolaryngol"},{"key":"10.1016\/j.pupt.2007.08.002_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1748-1716.1988.tb08302.x","article-title":"Differential vasomotor action of noradrenaline, serotonin, and histamine in isolated basilar artery from rat and guinea-pig","volume":"132","author":"Chang","year":"1988","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.pupt.2007.08.002_bib14","first-page":"762","article-title":"Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors","volume":"260","author":"Ortiz","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pupt.2007.08.002_bib15","first-page":"H988","article-title":"Endothelium-dependent and -independent responses to vasoactive substances of isolated human coronary arteries","volume":"257","author":"Toda","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pupt.2007.08.002_bib16","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.1476-5381.1996.tb15521.x","article-title":"Attenuation of human nasal airway responses to bradykinin and histamine by inhibitors of nitric oxide synthase","volume":"118","author":"Dear","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2007.08.002_bib17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0091-6749(83)90528-6","article-title":"Effects of aspirin on nasal responses in atopic subjects","volume":"72","author":"McLean","year":"1983","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2007.08.002_bib18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.coph.2004.12.004","article-title":"Histamine-mediated mechanisms in the human nasal airway","volume":"5","author":"Taylor-Clark","year":"2005","journal-title":"Curr Opin Pharmacol"},{"issue":"Suppl. 1","key":"10.1016\/j.pupt.2007.08.002_bib19","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1007\/s000110300050","article-title":"H1 antagonists: receptor affinity versus selectivity","volume":"52","author":"Gillard","year":"2003","journal-title":"Inflamm Res"},{"key":"10.1016\/j.pupt.2007.08.002_bib20","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1046\/j.1365-2222.2001.01130.x","article-title":"Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine","volume":"31","author":"Schroeder","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.pupt.2007.08.002_bib21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0306-4522(97)00324-2","article-title":"Identification and neuropeptide content of trigeminal neurons innervating the rat nasal epithelium","volume":"83","author":"Hunter","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.pupt.2007.08.002_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0143-4179(03)00065-9","article-title":"Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa","volume":"37","author":"Dinh","year":"2003","journal-title":"Neuropeptides"},{"key":"10.1016\/j.pupt.2007.08.002_bib23","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2005.08.043","article-title":"Nasal sensory nerve populations responding to histamine and capsaicin","volume":"116","author":"Taylor-Clark","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 3","key":"10.1016\/j.pupt.2007.08.002_bib24","first-page":"101","article-title":"Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers","volume":"55","author":"Plevkova","year":"2004","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.pupt.2007.08.002_bib25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0091-6749(94)90122-8","article-title":"The human nasal response to capsaicin","volume":"94","author":"Philip","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2007.08.002_bib26","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1172\/JCI28553","article-title":"Frontiers in pruritus research: scratching the brain for more effective itch therapy","volume":"116","author":"Paus","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pupt.2007.08.002_bib27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-3959(97)03339-3","article-title":"Cutaneous field stimulation (CFS): a new powerful method to combat itch","volume":"71","author":"Nilsson","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.pupt.2007.08.002_bib28","first-page":"163","article-title":"Capsaicin prevents histamine-induced itching","volume":"6","author":"Toth-Kasa","year":"1986","journal-title":"Int J Clin Pharmacol Res"},{"key":"10.1016\/j.pupt.2007.08.002_bib29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2273.1996.tb01085.x","article-title":"Histamine and the nasal vasculature: the influence of H1 and H2-histamine receptor antagonism","volume":"21","author":"Wood-Baker","year":"1996","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"10.1016\/j.pupt.2007.08.002_bib30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1398-9995.1989.tb01070.x","article-title":"Effects of topical treatment with H1 and H2 antagonists on clinical symptoms and nasal vascular reactions in patients with allergic rhinitis","volume":"44","author":"Holmberg","year":"1989","journal-title":"Allergy"},{"key":"10.1016\/j.pupt.2007.08.002_bib31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/00016489609137720","article-title":"Effect of H1 and H2 antagonists on nasal symptoms and mediator release in atopic patients after nasal allergen challenge during the pollen season","volume":"116","author":"Wang","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.pupt.2007.08.002_bib32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2500\/105065899781367483","article-title":"Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion","volume":"13","author":"McLeod","year":"1999","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.pupt.2007.08.002_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2003.10.051","article-title":"Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction","volume":"484","author":"Varty","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pupt.2007.08.002_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0014-2999(02)02336-1","article-title":"Histamine H3 receptor activation inhibits neurogenic sympathetic vasoconstriction in porcine nasal mucosa","volume":"452","author":"Varty","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pupt.2007.08.002_bib35","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000275998","article-title":"Nasal obstruction after cervical sympathectomy: Horner's syndrome revisited","volume":"50","author":"Whittet","year":"1988","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"Suppl. 1","key":"10.1016\/j.pupt.2007.08.002_bib36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000052318","article-title":"Clinical pharmacology of alpha1-adrenoceptor antagonists","volume":"36","author":"Kirby","year":"1999","journal-title":"Eur Urol"},{"key":"10.1016\/j.pupt.2007.08.002_bib37","unstructured":"Malm L, Okuda M, Dieges PH. Direct and reflex actions of biochemical mediators. In: Mygind N, Pipkorn U, editors. Allergic and vasomotor rhinitis: pathophysiological Aspects; 1987. p. 214\u201319."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553907000739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553907000739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T11:00:13Z","timestamp":1556794813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553907000739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S1094553907000739"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2007.08.002","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}