{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:48:12Z","timestamp":1761518892960},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.pupt.2008.10.010","type":"journal-article","created":{"date-parts":[[2008,11,9]],"date-time":"2008-11-09T09:56:56Z","timestamp":1226224616000},"page":"177-182","source":"Crossref","is-referenced-by-count":10,"title":["Acute effects of higher than standard doses of salbutamol and ipratropium on tiotropium-induced bronchodilation in patients with stable COPD"],"prefix":"10.1016","volume":"22","author":[{"given":"Mario","family":"Cazzola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierachille","family":"Santus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"D'Adda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Pizzolato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiano","family":"Di Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Centanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2008.10.010_bib1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1183\/09031936.04.00014304","article-title":"ATS\/ERS task force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS\/ERS position paper","volume":"23","author":"Celli","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.10.010_bib2","unstructured":"Chronic obstructive pulmonary disease. National clinical guideline on management of chronic obstructive pulmonary disease in adults in primary and secondary care, Thorax 2004; 59(Suppl 1): 1\u2013232."},{"key":"10.1016\/j.pupt.2008.10.010_bib3","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"Rabe","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl 12A","key":"10.1016\/j.pupt.2008.10.010_bib4","first-page":"24S","article-title":"The role of anticholinergics in chronic obstructive pulmonary disease","volume":"117","author":"Barnes","year":"2004","journal-title":"Am J Med"},{"key":"10.1016\/j.pupt.2008.10.010_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1378\/chest.125.1.9","article-title":"Long-acting bronchodilators are the first-choice option for the treatment of stable COPD","volume":"125","author":"Cazzola","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2008.10.010_bib6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.pupt.2006.02.003","article-title":"Tiotropium for the treatment of stable chronic obstructive pulmonary disease: a systematic review with meta-analysis","volume":"20","author":"Rodrigo","year":"2007","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2008.10.010_bib7","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/thx.2006.063271","article-title":"Tiotropium for stable chronic obstructive pulmonary disease: a meta-analysis","volume":"61","author":"Barr","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2008.10.010_bib8","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1056\/NEJMoa0805800","article-title":"A 4-year trial of tiotropium in chronic obstructive pulmonary disease","volume":"359","author":"Tashkin","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pupt.2008.10.010_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1183\/09031936.02.00269802","article-title":"A\u00a0long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease","volume":"19","author":"Casaburi","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.10.010_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1183\/09031936.02.00238702","article-title":"Improved health outcomes in patients with COPD during 1yr's treatment with tiotropium","volume":"19","author":"Vincken","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.10.010_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1378\/chest.122.1.47","article-title":"A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol","volume":"122","author":"Donohue","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2008.10.010_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1465-9921-8-45","article-title":"Efficacy and safety of tiotropium in COPD patients in primary care\u2014the SPiRiva Usual CarE (SPRUCE) study","volume":"8","author":"Freeman","year":"2007","journal-title":"Respir Res"},{"key":"10.1016\/j.pupt.2008.10.010_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0954-6111(96)90178-X","article-title":"A combination with clinical recommended dosages of salmeterol and ipratropium is not more effective than salmeterol alone in patients with chronic obstructive pulmonary disease","volume":"90","author":"Matera","year":"1996","journal-title":"Respir Med"},{"key":"10.1016\/j.pupt.2008.10.010_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1742-1241.1999.tb11699.x","article-title":"Bronchodilatory responses to formoterol, ipratropium, and their combination in patients with stable COPD","volume":"53","author":"Sichletidis","year":"1999","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.pupt.2008.10.010_bib15","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1136\/thx.54.12.1083","article-title":"Acute effect of pretreatment with single conventional dose of salmeterol on dose-response curve to oxitropium bromide in chronic obstructive pulmonary disease","volume":"54","author":"Cazzola","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2008.10.010_bib16","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1183\/09031936.98.11061337","article-title":"Effects of formoterol, salmeterol or oxitropium bromide on airway responses to salbutamol in COPD","volume":"11","author":"Cazzola","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.10.010_bib17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.rmed.2004.10.004","article-title":"Bronchodilator response to formoterol after regular tiotropium or to tiotropium after regular formoterol in COPD patients","volume":"99","author":"Cazzola","year":"2005","journal-title":"Respir Med"},{"key":"10.1016\/j.pupt.2008.10.010_bib18","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1378\/chest.129.3.509","article-title":"Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD","volume":"129","author":"van Noord","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2008.10.010_bib19","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1378\/chest.06-3059","article-title":"Effects of short-acting bronchodilators added to maintenance tiotropium therapy","volume":"132","author":"Kerstjens","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2008.10.010_bib20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF00542540","article-title":"The influence of theophylline on maximal response to salbutamol in severe chronic obstructive pulmonary disease","volume":"22","author":"Barclay","year":"1982","journal-title":"Eur J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.pupt.2008.10.010_bib21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/arrd.1986.133.1.14","article-title":"Bronchodilator response in chronic obstructive pulmonary disease","volume":"133","author":"Anthonisen","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2008.10.010_bib22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/thorax.58.8.659","article-title":"Bronchodilator reversibility testing in chronic obstructive pulmonary disease","volume":"58","author":"Calverley","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2008.10.010_bib23","doi-asserted-by":"crossref","first-page":"125S","DOI":"10.1378\/chest.126.2_suppl_1.125S","article-title":"Therapeutic responses in asthma and COPD","volume":"126","author":"Donohue","year":"2004","journal-title":"Bronchodilators. Chest"},{"key":"10.1016\/j.pupt.2008.10.010_bib24","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2165\/00003495-200565120-00001","article-title":"Inhaled \u03b22-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease","volume":"65","author":"Cazzola","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.pupt.2008.10.010_bib25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2165\/00002512-200421060-00005","article-title":"Cardiovascular safety of \u03b22-adrenoceptor agonist use in patients with obstructive airway disease: a systematic review","volume":"21","author":"Salpeter","year":"2004","journal-title":"Drugs Aging"},{"key":"10.1016\/j.pupt.2008.10.010_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/thx.50.1.62","article-title":"Comparative dose-response study of three anticholinergic agents and fenoterol using a metered dose inhaler in patients with chronic obstructive pulmonary disease","volume":"50","author":"Ikeda","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2008.10.010_bib27","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1164\/ajrccm\/138.4.850","article-title":"High-dose inhaled albuterol in severe chronic airflow limitation","volume":"138","author":"Vathenen","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2008.10.010_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000195114","article-title":"Acute controlled study of the dose response relationship of fenoterol, ipratropium bromide and their combination","volume":"50","author":"Serra","year":"1986","journal-title":"Respiration"},{"key":"10.1016\/j.pupt.2008.10.010_bib29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0196-0644(95)70260-1","article-title":"Effects of combined treatment with glycopyrrolate and albuterol in acute exacerbation of chronic obstructive pulmonary disease","volume":"25","author":"Cydulka","year":"1995","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.pupt.2008.10.010_bib30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1183\/09031936.96.09010100","article-title":"Comparison of nebulized glycopyrrolate and metaproterenol in chronic obstructive pulmonary disease","volume":"9","author":"Tzelepis","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.10.010_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pupt.2003.09.001","article-title":"The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD","volume":"17","author":"Cazzola","year":"2004","journal-title":"Pulm Pharmacol Ther"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553908001077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553908001077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T23:18:48Z","timestamp":1684624728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553908001077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S1094553908001077"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2008.10.010","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}