{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:48:56Z","timestamp":1774118936193,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.pupt.2008.12.005","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T10:32:05Z","timestamp":1230201125000},"page":"199-207","source":"Crossref","is-referenced-by-count":28,"title":["IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space\u00a0after exposure to endotoxin from Escherichia coli in vivo \u2013 effects of anti-inflammatory pharmacotherapy"],"prefix":"10.1016","volume":"22","author":[{"given":"Olof","family":"Prause","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolos","family":"Bossios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Silverpil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Bozinovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Vlahos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Sj\u00f6strand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary P.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Lind\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2008.12.005_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.pupt.2008.12.005_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1183\/09031936.04.00032904","article-title":"Neutrophils, interleukin-17A and lung disease","volume":"25","author":"Linden","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.12.005_bib3","doi-asserted-by":"crossref","first-page":"re4","DOI":"10.1126\/stke.3982007re4","article-title":"A role for the cytoplasmic adaptor protein Act1 in mediating IL-17 signaling","volume":"2007","author":"Linden","year":"2007","journal-title":"Sci STKE"},{"issue":"2","key":"10.1016\/j.pupt.2008.12.005_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1586\/17476348.1.2.279","article-title":"Th-17 cells in the lungs?","volume":"1","author":"Ivanov","year":"2007","journal-title":"Expert Rev Resp Med"},{"key":"10.1016\/j.pupt.2008.12.005_bib5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.pupt.2008.12.005_bib6","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1189\/jlb.1006610","article-title":"Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17","volume":"81","author":"Nakae","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.pupt.2008.12.005_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/intimm\/dxm045","article-title":"IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state","volume":"19","author":"Nishihara","year":"2007","journal-title":"Int Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1165\/rcmb.2006-0020OC","article-title":"Functional relevance of the IL-23-IL-17 axis in lungs in vivo","volume":"36","author":"Ivanov","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pupt.2008.12.005_bib9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.20061551","article-title":"Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia","volume":"204","author":"Michel","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.pupt.2008.12.005_bib10","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.4049\/jimmunol.178.7.4466","article-title":"Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production","volume":"178","author":"Shibata","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib11","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection","volume":"177","author":"Lockhart","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1183\/09031936.02.00280902","article-title":"Free, soluble interleukin-17 protein during severe inflammation in human airways","volume":"19","author":"Laan","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.12.005_bib13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1067\/mai.2001.117929","article-title":"IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines","volume":"108","author":"Molet","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","article-title":"Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis","volume":"175","author":"McAllister","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1465-9921-6-44","article-title":"Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust","volume":"6","author":"Ivanov","year":"2005","journal-title":"Respir Res"},{"key":"10.1016\/j.pupt.2008.12.005_bib16","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.4049\/jimmunol.170.4.2106","article-title":"IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger","volume":"170","author":"Ferretti","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib17","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.4049\/jimmunol.170.9.4665","article-title":"Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways","volume":"170","author":"Miyamoto","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1473-3099(08)70041-0","article-title":"Extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae: an emerging public health concern","volume":"8","author":"Pitout","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.pupt.2008.12.005_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01487403","article-title":"The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo","volume":"20","author":"Yi","year":"1996","journal-title":"Inflammation"},{"key":"10.1016\/j.pupt.2008.12.005_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1165\/ajrcmb.14.6.8652191","article-title":"Cyclosporin A attenuates genetic airway hyperresponsiveness in mice but not through inhibition of CD4+ or CD8+ T cells","volume":"14","author":"Ewart","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pupt.2008.12.005_bib21","doi-asserted-by":"crossref","first-page":"L877","DOI":"10.1152\/ajplung.00275.2003","article-title":"Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4","volume":"286","author":"Bozinovski","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pupt.2008.12.005_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/09629359890910","article-title":"Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma","volume":"7","author":"van der Velden","year":"1998","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.pupt.2008.12.005_bib23","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1084\/jem.20050193","article-title":"Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae","volume":"202","author":"Happel","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.pupt.2008.12.005_bib24","doi-asserted-by":"crossref","first-page":"L519","DOI":"10.1152\/ajplung.00312.2006","article-title":"IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice","volume":"292","author":"Dubin","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pupt.2008.12.005_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1513\/pats.200402-018MS","article-title":"Glucocorticoids suppress inflammation but spare innate immune responses in airway epithelium","volume":"1","author":"Schleimer","year":"2004","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.pupt.2008.12.005_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/BF02263501","article-title":"Additive effects of suboptimal doses of estrogen and cortisone on the suppression of T lymphocyte dependent inflammatory responses in mice","volume":"45","author":"Carlsten","year":"1996","journal-title":"Inflamm Res"},{"key":"10.1016\/j.pupt.2008.12.005_bib27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s000110050630","article-title":"Action of dexamethasone in the suppression of delayed-type hypersensitivity in reconstituted SCID mice","volume":"49","author":"Taube","year":"2000","journal-title":"Inflamm Res"},{"key":"10.1016\/j.pupt.2008.12.005_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-2999(03)01341-4","article-title":"Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells","volume":"462","author":"Prause","year":"2003","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.pupt.2008.12.005_bib29","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.4049\/jimmunol.162.4.2347","article-title":"Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways","volume":"162","author":"Laan","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.imlet.2006.11.001","article-title":"Cyclosporine A inhibits IL-15-induced IL-17 production in CD4(+) T cells via down-regulation of PI3 K\/Akt and NF-kappaB","volume":"108","author":"Cho","year":"2007","journal-title":"Immunol Lett"},{"issue":"5","key":"10.1016\/j.pupt.2008.12.005_bib31","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.4049\/jimmunol.164.5.2832","article-title":"High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism","volume":"164","author":"Ziolkowska","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.pupt.2008.12.005_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1016-8478(23)13236-5","article-title":"Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells","volume":"20","author":"Liu","year":"2005","journal-title":"Mol Cells"},{"key":"10.1016\/j.pupt.2008.12.005_bib33","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1164\/ajrccm.160.5.9811058","article-title":"Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease","volume":"160","author":"Culpitt","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2008.12.005_bib34","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1164\/rccm.2105025","article-title":"The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo\u2013controlled biopsy study","volume":"165","author":"Hattotuwa","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2008.12.005_bib35","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1164\/ajrccm.155.2.9032192","article-title":"Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD","volume":"155","author":"Keatings","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2008.12.005_bib36","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/thx.47.8.588","article-title":"Controlled trial of intravenous corticosteroids in severe acute asthma","volume":"47","author":"Morell","year":"1992","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2008.12.005_bib37","doi-asserted-by":"crossref","first-page":"822","DOI":"10.7326\/0003-4819-112-11-822","article-title":"Early administration of corticosteroids in emergency room treatment of acute asthma","volume":"112","author":"Stein","year":"1990","journal-title":"Ann Intern Med"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553908001338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553908001338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T14:16:52Z","timestamp":1709821012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553908001338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S1094553908001338"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2008.12.005","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}