{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:18:42Z","timestamp":1771013922714,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.pupt.2008.12.013","type":"journal-article","created":{"date-parts":[[2008,12,28]],"date-time":"2008-12-28T09:59:29Z","timestamp":1230458369000},"page":"214-220","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy and safety of ciclesonide once daily and fluticasone propionate twice daily in children with asthma"],"prefix":"10.1016","volume":"22","author":[{"given":"S\u00f8ren","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Engelst\u00e4tter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Jochen","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Barkai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej","family":"Emeryk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2008.12.013_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global strategy for asthma management and prevention: GINA executive summary","volume":"31","author":"Bateman","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.12.013_bib2","unstructured":"National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Programme. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma 2007. Available from: http:\/\/www.nhlbi.nih.gov\/guidelines\/asthma\/asthgdln.pdf (accessed October 2007)."},{"key":"10.1016\/j.pupt.2008.12.013_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaci.2004.04.042","article-title":"Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys","volume":"114","author":"Rabe","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2008.12.013_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1067\/mai.2002.125489","article-title":"Inadequate use of asthma medication in the United States: results of the asthma in America national population survey","volume":"110","author":"Adams","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2008.12.013_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4065\/79.4.453","article-title":"Inhaled corticosteroids: why do physicians and patients fail to comply with guidelines for managing asthma?","volume":"79","author":"Reed","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.pupt.2008.12.013_bib6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1398-9995.2007.01352.x","article-title":"Unmet needs in asthma: Global Asthma Physician and Patient (GAPP) Survey: global adult findings","volume":"62","author":"Canonica","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.pupt.2008.12.013_bib7","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.jaci.2004.09.028","article-title":"Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma","volume":"114","author":"Williams","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2008.12.013_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jpeds.2005.10.028","article-title":"Once-daily ciclesonide in children: efficacy and safety in asthma","volume":"148","author":"Gelfand","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.pupt.2008.12.013_bib9","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/ppul.20474","article-title":"A comparative study of inhaled ciclesonide 160microg\/day and fluticasone propionate 176microg\/day in children with asthma","volume":"41","author":"Pedersen","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.pupt.2008.12.013_bib10","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.rmed.2007.03.001","article-title":"A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma","volume":"101","author":"Boulet","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.pupt.2008.12.013_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pupt.2005.10.003","article-title":"Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma","volume":"19","author":"Buhl","year":"2006","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2008.12.013_bib12","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1183\/09031936.01.00099701","article-title":"Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening","volume":"17","author":"Postma","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.12.013_bib13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.rmed.2005.11.030","article-title":"Comparative efficacy of once-daily ciclesonide and budesonide in the treatment of persistent asthma","volume":"100","author":"Boulet","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.pupt.2008.12.013_bib14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pupt.2005.01.004","article-title":"Effects of inhaled ciclesonide and fluticasone propionate on cortisol secretion and airway responsiveness to adenosine 5\u2032monophosphate in asthmatic patients","volume":"18","author":"Derom","year":"2005","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2008.12.013_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1378\/chest.127.3.851","article-title":"Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma","volume":"127","author":"Lee","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2008.12.013_bib16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1081-1206(10)61117-9","article-title":"Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthma","volume":"94","author":"Lipworth","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.pupt.2008.12.013_bib17","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1378\/chest.128.3.1104","article-title":"Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma","volume":"128","author":"Szefler","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2008.12.013_bib18","article-title":"Low incidence of oropharyngeal adverse events in asthma patients treated with ciclesonide","volume":"26","author":"Engelst\u00e4tter","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2008.12.013_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1399-3038.2007.00538.x","article-title":"Comparison of the efficacy and safety of ciclesonide 160microg once daily vs. budesonide 400microg once daily in children with asthma","volume":"18","author":"von Berg","year":"2007","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.pupt.2008.12.013_bib20","series-title":"Pulmonary function testing in children","author":"Polgar","year":"1971"},{"key":"10.1016\/j.pupt.2008.12.013_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00435967","article-title":"Measuring quality of life in children with asthma","volume":"5","author":"Juniper","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.pupt.2008.12.013_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00435966","article-title":"Measuring quality of life in the parents of children with asthma","volume":"5","author":"Juniper","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.pupt.2008.12.013_bib23","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF03044912","article-title":"Recommendations for implementing bronchial provocation tests with pharmacologic substances. German Society of Pneumology\u2013Scientific \u201cBronchial Provocation Tests\u201d Study Group","volume":"92","author":"Klein","year":"1997","journal-title":"Med Klin (Munich)"},{"key":"10.1016\/j.pupt.2008.12.013_bib24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pupt.2007.05.002","article-title":"Comparison of twice-daily inhaled ciclesonide and fluticasone propionate in patients with moderate-to-severe persistent asthma","volume":"21","author":"Bateman","year":"2008","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2008.12.013_bib25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S1081-1206(10)62140-0","article-title":"Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis","volume":"90","author":"Currie","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.pupt.2008.12.013_bib26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1081-1206(10)62556-2","article-title":"Efficacy and safety of dry powder fluticasone propionate in children with persistent asthma","volume":"85","author":"LaForce","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.pupt.2008.12.013_bib27","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jpeds.2006.07.045","article-title":"Efficacy and safety of fluticasone propionate hydrofluoroalkane inhalation aerosol in pre-school-age children with asthma: a randomized, double-blind, placebo-controlled study","volume":"149","author":"Qaqundah","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.pupt.2008.12.013_bib28","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2006-2206","article-title":"Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma","volume":"121","author":"Skoner","year":"2008","journal-title":"Pediatrics"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553908001454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553908001454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T08:59:33Z","timestamp":1545555573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553908001454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S1094553908001454"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2008.12.013","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}