{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:29:19Z","timestamp":1777620559599,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.pupt.2009.07.001","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T15:03:02Z","timestamp":1248966182000},"page":"543-547","source":"Crossref","is-referenced-by-count":5,"title":["Down-regulation of cough sensitivity after eucapnic dry air provocation in chronic idiopathic cough"],"prefix":"10.1016","volume":"22","author":[{"given":"Ewa-Lena","family":"Johansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Ternesten-Hass\u00e9us","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Millqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2009.07.001_bib1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pupt.2004.09.001","article-title":"Physiological down-regulation of cough","volume":"17","author":"Fontana","year":"2004","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2009.07.001_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.resp.2005.04.013","article-title":"Physiological and pathophysiological down-regulation of cough","volume":"150","author":"Widdicombe","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.pupt.2009.07.001_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1378\/chest.07-0141","article-title":"Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires","volume":"134","author":"Polley","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2009.07.001_bib4","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/01.STR.30.6.1203","article-title":"Assessing the laryngeal cough reflex and the risk of developing pneumonia after stroke: an interhospital comparison","volume":"30","author":"Addington","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.pupt.2009.07.001_bib5","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0140-6736(94)92155-5","article-title":"Relation between glasgow coma score and cough reflex","volume":"343","author":"Moulton","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.pupt.2009.07.001_bib6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1378\/chest.124.3.1009","article-title":"Impaired efficacy of cough in patients with Parkinson disease","volume":"124","author":"Ebihara","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2009.07.001_bib7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/bja\/67.3.257","article-title":"Inhalation induction of anaesthesia with isoflurane: effect of added carbon dioxide","volume":"67","author":"Coleman","year":"1991","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.pupt.2009.07.001_bib8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/bja\/64.6.682","article-title":"Effects of i.v. lignocaine on airway reflexes elicited by irritation of the tracheal mucosa in humans anaesthetized with enflurane","volume":"64","author":"Nishino","year":"1990","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.pupt.2009.07.001_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00000542-199007000-00008","article-title":"Laryngeal and respiratory responses to tracheal irritation at different depths of enflurane anesthesia in humans","volume":"73","author":"Nishino","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pupt.2009.07.001_bib10","first-page":"195","article-title":"Effect of hypoxia and hypercapnoea on the airways defence reflexes","volume":"70","author":"Tatar","year":"1987","journal-title":"Acta Physiol Hung"},{"key":"10.1016\/j.pupt.2009.07.001_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1183\/09031936.04.00027804","article-title":"The diagnosis and management of chronic cough","volume":"24","author":"Morice","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2009.07.001_bib12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1183\/09031936.05.00140803","article-title":"Investigation and management of chronic cough using a probability-based algorithm","volume":"25","author":"Kastelik","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2009.07.001_bib13","doi-asserted-by":"crossref","first-page":"133S","DOI":"10.1378\/chest.114.2_Supplement.133S","article-title":"Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians","volume":"114","author":"Irwin","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2009.07.001_bib14","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1378\/chest.127.5.1710","article-title":"Chronic idiopathic cough: a discrete clinical entity?","volume":"127","author":"Haque","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2009.07.001_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pupt.2008.11.003","article-title":"Are there clinical features of a sensitized cough reflex?","volume":"22","author":"McGarvey","year":"2009","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2009.07.001_bib16","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1136\/thorax.58.12.1066","article-title":"Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2009.07.001_bib17","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1398-9995.1998.tb03843.x","article-title":"Sensory hyperreactivity \u2013 a possible mechanism underlying cough and asthma-like symptoms","volume":"53","author":"Millqvist","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.pupt.2009.07.001_bib18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1398-9995.2000.all2513.x","article-title":"Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms","volume":"55","author":"Millqvist","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.pupt.2009.07.001_bib19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1034\/j.1398-9995.2000.00514.x","article-title":"Quality of life and capsaicin sensitivity in patients with sensory airway hyperreactivity","volume":"55","author":"Millqvist","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.pupt.2009.07.001_bib20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1034\/j.1398-9995.2002.23380.x","article-title":"Sensitivity to methacholine and capsaicin in patients with unclear respiratory symptoms","volume":"57","author":"Ternesten-Hasseus","year":"2002","journal-title":"Allergy"},{"key":"10.1016\/j.pupt.2009.07.001_bib21","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1378\/chest.129.6.1623","article-title":"Relationship between self-reported odor intolerance and sensitivity to inhaled capsaicin: proposed definition of airway sensory hyperreactivity and estimation of its prevalence","volume":"129","author":"Johansson","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2009.07.001_bib22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pupt.2005.04.010","article-title":"Inhalation method determines outcome of capsaicin inhalation in patients with chronic cough due to sensory hyperreactivity","volume":"19","author":"Ternesten-Hasseus","year":"2006","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2009.07.001_bib23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1289\/ehp.9624","article-title":"Quality of life and capsaicin sensitivity in patients with airway symptoms induced by chemicals and scents: a longitudinal study","volume":"115","author":"Ternesten-Hasseus","year":"2007","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.pupt.2009.07.001_bib24","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.pupt.2008.06.002","article-title":"Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity","volume":"21","author":"Millqvist","year":"2008","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2009.07.001_bib25","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1053\/rmed.2002.1340","article-title":"Capsaicin inhalation test for identification of sensory hyperreactivity","volume":"96","author":"Johansson","year":"2002","journal-title":"Respir Med"},{"key":"10.1016\/j.pupt.2009.07.001_bib26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1289\/ehp.7657","article-title":"Changes in levels of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and chemicals","volume":"113","author":"Millqvist","year":"2005","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.pupt.2009.07.001_bib27","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1111\/j.1432-1033.2004.04082.x","article-title":"Biochemical pharmacology of the vanilloid receptor TRPV1. An update","volume":"271","author":"Cortright","year":"2004","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.pupt.2009.07.001_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-3-540-34891-7_9","article-title":"Capsaicin receptor: TRPV1 a promiscuous TRP channel","author":"Pingle","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.pupt.2009.07.001_bib29","doi-asserted-by":"crossref","first-page":"30429","DOI":"10.1074\/jbc.M305051200","article-title":"Activation of TRPV1 by the satiety factor oleoylethanolamide","volume":"278","author":"Ahern","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pupt.2009.07.001_bib30","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/rccm.200402-174OC","article-title":"Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough","volume":"170","author":"Groneberg","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2009.07.001_bib31","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/00042737-200409000-00014","article-title":"Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus","volume":"16","author":"Matthews","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.pupt.2009.07.001_bib32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/01902140590918803","article-title":"Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough","volume":"31","author":"Mitchell","year":"2005","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.pupt.2009.07.001_bib33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.pain.2005.03.010","article-title":"Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain","volume":"115","author":"Pogatzki-Zahn","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.pupt.2009.07.001_bib34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1090-3801(03)00085-5","article-title":"Increased vanilloid receptor VR1 innervation in vulvodynia","volume":"8","author":"Tympanidis","year":"2004","journal-title":"Eur J Pain"},{"key":"10.1016\/j.pupt.2009.07.001_bib35","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.molmed.2006.09.001","article-title":"TRPV1: a therapeutic target for novel analgesic drugs?","volume":"12","author":"Szallasi","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.pupt.2009.07.001_bib36","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.200409070","article-title":"TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity","volume":"168","author":"Andrade","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.pupt.2009.07.001_bib37","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbadis.2007.01.013","article-title":"Role of TRPV receptors in respiratory diseases","volume":"1772","author":"Jia","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pupt.2009.07.001_bib38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/978-3-540-34891-7_28","article-title":"TRPV channels' role in osmotransduction and mechanotransduction","author":"Liedtke","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.pupt.2009.07.001_bib39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1164\/ajrccm.161.1.ats11-99","article-title":"Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999","volume":"161","author":"Crapo","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2009.07.001_bib40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1183\/09041950.053s1693","volume":"16","author":"Sterk","year":"1993","journal-title":"Eur Respir J Suppl"},{"key":"10.1016\/j.pupt.2009.07.001_bib41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.pupt.2006.11.009","article-title":"What is cough and what should be measured?","volume":"20","author":"Fontana","year":"2007","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2009.07.001_bib42","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00101006","article-title":"ERS guidelines on the assessment of cough","volume":"29","author":"Morice","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2009.07.001_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/rmed.2000.0965","article-title":"Capsaicin cough sensitivity is decreased in smokers","volume":"95","author":"Millqvist","year":"2001","journal-title":"Respir Med"},{"key":"10.1016\/j.pupt.2009.07.001_bib44","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1094-5539(02)00149-9","article-title":"Short- and long-term reproducibility of capsaicin cough challenge testing","volume":"16","author":"Dicpinigaitis","year":"2003","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2009.07.001_bib45","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1378\/chest.128.1.196","article-title":"Safety of capsaicin cough challenge testing","volume":"128","author":"Dicpinigaitis","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2009.07.001_bib46","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/02770900802207287","article-title":"Dyspnea from exercise in cold air is not always asthma","volume":"45","author":"Ternesten-Hasseus","year":"2008","journal-title":"J Asthma"},{"key":"10.1016\/j.pupt.2009.07.001_bib47","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1152\/jappl.1989.66.6.2642","article-title":"Inhibitory effects of CO2 on airway defensive reflexes in enflurane-anesthetized humans","volume":"66","author":"Nishino","year":"1989","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2009.07.001_bib48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/pulp.1996.0037","article-title":"Cough and other reflexes on irritation of airway mucosa in man","volume":"9","author":"Nishino","year":"1996","journal-title":"Pulm Pharmacol"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553909000789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553909000789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T05:46:19Z","timestamp":1685079979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553909000789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S1094553909000789"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2009.07.001","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}