{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:28:09Z","timestamp":1791966489209,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.pupt.2010.11.002","type":"journal-article","created":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T07:19:52Z","timestamp":1289546392000},"page":"286-288","source":"Crossref","is-referenced-by-count":62,"title":["TRPA1 receptors in cough"],"prefix":"10.1016","volume":"24","author":[{"given":"Megan S.","family":"Grace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Belvisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2010.11.002_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/pulp.1993.1023","article-title":"A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man","volume":"6","author":"Laude","year":"1993","journal-title":"Pulm Pharmacol"},{"key":"10.1016\/j.pupt.2010.11.002_bib2","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs","volume":"79","author":"Lalloo","year":"1995","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.pupt.2010.11.002_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/thx.2003.012930","article-title":"Antitussive activity of iodo-resiniferatoxin in guinea pigs","volume":"59","author":"Trevisani","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2010.11.002_bib4","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/rccm.200402-174OC","article-title":"Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough","volume":"170","author":"Groneberg","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2010.11.002_bib5","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2010.11.002_bib6","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1074\/jbc.274.11.7325","article-title":"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts","volume":"274","author":"Jaquemar","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pupt.2010.11.002_bib7","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2010.11.002_bib8","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pupt.2010.11.002_bib9","first-page":"2574","article-title":"Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents","volume":"118","author":"Andr\u00e8","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pupt.2010.11.002_bib10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.pupt.2010.11.002_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","article-title":"Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1","volume":"427","author":"Jordt","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2010.11.002_bib12","doi-asserted-by":"crossref","first-page":"12248","DOI":"10.1073\/pnas.0505356102","article-title":"Pungent products from garlic activate the sensory ion channel TRPA1","volume":"102","author":"Bautista","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.pupt.2010.11.002_bib13","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1113\/jphysiol.2008.153585","article-title":"Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autocoid 4-oxononenal","volume":"586","author":"Taylor-Clark","year":"2008","journal-title":"J Physiol"},{"key":"10.1016\/j.pupt.2010.11.002_bib14","first-page":"2383","article-title":"How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways","volume":"118","author":"Simon","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pupt.2010.11.002_bib15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","volume":"445","author":"Macpherson","year":"2007","journal-title":"Nat Lett"},{"key":"10.1016\/j.pupt.2010.11.002_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nn1843","article-title":"Direct activation of the ion channel TRPA1 by Ca2+","volume":"10","author":"Zurgorg","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pupt.2010.11.002_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.pupt.2010.11.002_bib18","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.0705923104","article-title":"4-hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1","volume":"104","author":"Trevisani","year":"2007","journal-title":"PNAS"},{"key":"10.1016\/j.pupt.2010.11.002_bib19","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1073\/pnas.0808487106","article-title":"TRPA1 acts as a cold sensor in vitro and in vivo","volume":"106","author":"Karashima","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.pupt.2010.11.002_bib20","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1523\/JNEUROSCI.0013-05.2005","article-title":"Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing","volume":"25","author":"Nagata","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pupt.2010.11.002_bib21","series-title":"Morbidity statistics from general practice, fourth national study 1991-1992","article-title":"Office of population censuses and surveys","author":"McCormick","year":"1995"},{"key":"10.1016\/j.pupt.2010.11.002_bib22","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/thx.2006.060087","article-title":"Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms","volume":"61","author":"Ford","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2010.11.002_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/bmj.324.7333.329","article-title":"Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults","volume":"324","author":"Schroeder","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.pupt.2010.11.002_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tips.2004.09.009","article-title":"The pharmacology of cough","volume":"25","author":"Reynolds","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pupt.2010.11.002_bib25","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/thx.2003.013490","article-title":"Cough 7: Current and future drugs for the treatment of chronic cough","volume":"59","author":"Belvisi","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2010.11.002_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/pupt.1999.0207","article-title":"Pharmacological regulation of the cough reflex\u2013from experimental models to antitussive effects in man","volume":"12","author":"Karlsson","year":"1999","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2010.11.002_bib27","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI34192","article-title":"TRPA1 is a major oxidant sensor in murine airway sensory neurons","volume":"118","author":"Bessac","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pupt.2010.11.002_bib28","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1113\/jphysiol.2007.148379","article-title":"Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs","volume":"586","author":"Nassenstein","year":"2008","journal-title":"J Physiol"},{"key":"10.1016\/j.pupt.2010.11.002_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pupt.2008.12.019","article-title":"TRPA1: a potential target for antitussive therapy","volume":"22","author":"Taylor-Clark","year":"2009","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2010.11.002_bib30","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1164\/rccm.200905-0665OC","article-title":"TRPA1 agonists evoke coughing in guinea pig and human volunteers","volume":"180","author":"Birrell","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2010.11.002_bib31","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1476-5381.2009.00438.x","article-title":"Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents","volume":"158","author":"Andr\u00e8","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2010.11.002_bib32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/thorax.55.8.643","article-title":"Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease","volume":"55","author":"Doherty","year":"2000","journal-title":"Thorax"},{"issue":"Suppl. 6","key":"10.1016\/j.pupt.2010.11.002_bib33","first-page":"557","article-title":"Cough reflex sensitivity testing in seasonal allergic rhinitis patients and healthy volunteers","volume":"59","author":"Pecova","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.pupt.2010.11.002_bib34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0091-6749(76)90028-2","article-title":"Serum prostaglandin levels in asthmatic patients","volume":"57","author":"Nemoto","year":"1976","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2010.11.002_bib35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/thorax.58.7.585","article-title":"Exhaled leukotrienes and prostaglandins in COPD","volume":"58","author":"Montuschi","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2010.11.002_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0091-6749(03)01889-X","article-title":"Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia","volume":"112","author":"Profita","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2010.11.002_bib37","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.neuroscience.2008.04.048","article-title":"Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states","volume":"154","author":"Cavanaugh","year":"2008","journal-title":"Neuroscience"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553910001409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553910001409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T03:28:46Z","timestamp":1559791726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553910001409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1094553910001409"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2010.11.002","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}