{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:53:06Z","timestamp":1778039586661,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.pupt.2011.11.001","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T16:59:36Z","timestamp":1322758776000},"page":"163-168","source":"Crossref","is-referenced-by-count":23,"title":["Effect of verapamil on bronchial goblet cells of asthma: An experimental study on sensitized animals"],"prefix":"10.1016","volume":"25","author":[{"given":"Mohammad Reza","family":"Khakzad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Mirsadraee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirhooshang","family":"Mohammadpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamram","family":"Ghafarzadegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raziye","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdiye","family":"Saghari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Meshkat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2011.11.001_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1357-2725(02)00083-3","article-title":"The airway goblet cell","volume":"35","author":"Duncan","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.pupt.2011.11.001_bib2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1183\/09031936.94.07091678","article-title":"Airway goblet cells: responsive and adaptable front-line defenders","volume":"7","author":"Rogers","year":"1994","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2011.11.001_bib3","first-page":"L413","article-title":"Mucins: structure, function, and role in pulmonary disease","volume":"263","author":"Rose","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pupt.2011.11.001_bib4","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jaci.2007.06.031","article-title":"Asthma therapy and airway remodeling","volume":"120","author":"Mauad","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.pupt.2011.11.001_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/15412550500218148","article-title":"The role of airway secretions in COPD \u2013 clinical applications","volume":"2","author":"Henke","year":"2005","journal-title":"COPD"},{"issue":"2","key":"10.1016\/j.pupt.2011.11.001_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1164\/ajrccm.163.2.2004039","article-title":"Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression","volume":"163","author":"Ordo\u00f1ez","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2011.11.001_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1620\/tjem.209.75","article-title":"Airway remodeling in asthma and its influence on clinical pathophysiology","volume":"209","author":"Yamauchi","year":"2006","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.pupt.2011.11.001_bib8","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1073\/pnas.081510898","article-title":"Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma","volume":"98","author":"Nakanishi","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"40","key":"10.1016\/j.pupt.2011.11.001_bib9","doi-asserted-by":"crossref","first-page":"15858","DOI":"10.1073\/pnas.0707413104","article-title":"Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids","volume":"104","author":"Woodruff","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pupt.2011.11.001_bib10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1183\/09031936.05.00006005","article-title":"T-helper cell type-2 regulation in allergic disease","volume":"26","author":"Georas","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2011.11.001_bib11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.pharmthera.2011.02.001","article-title":"Airway remodeling in asthma: new mechanisms and potential for pharmacological intervention","volume":"130","author":"Girodet","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pupt.2011.11.001_bib12","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/ajrccm\/148.3.720","article-title":"Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3D morphometric study","volume":"148","author":"Ebina","year":"1993","journal-title":"Am Rev Respir Dis"},{"issue":"1","key":"10.1016\/j.pupt.2011.11.001_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1152\/physrev.00018.2008","article-title":"Sarcoplasmic reticulum function in smooth muscle","volume":"90","author":"Wray","year":"2010","journal-title":"Physiol Rev"},{"issue":"6","key":"10.1016\/j.pupt.2011.11.001_bib14","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0091-6749(87)90247-8","article-title":"Nifedipine treatment of patients with bronchial asthma","volume":"79","author":"Patakas","year":"1987","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.pupt.2011.11.001_bib15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2165\/00002018-199106060-00003","article-title":"Poisoning due to calcium antagonists. Experience with verapamil, diltiazem and nifedipine","volume":"6","author":"Pearigen","year":"1991","journal-title":"Drug Saf"},{"issue":"4","key":"10.1016\/j.pupt.2011.11.001_bib16","first-page":"39","article-title":"Acute effect of water pipe smoke on sensitized animals","volume":"9","author":"Mirsadraee","year":"2010","journal-title":"Tanaffos"},{"key":"10.1016\/j.pupt.2011.11.001_bib17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1183\/09031936.03.00026403","article-title":"ERS task force, murine model of asthma","volume":"22","author":"Kips","year":"2003","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.pupt.2011.11.001_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/07853890600585795","article-title":"Treatment of airway mucus hypersecretion","volume":"38","author":"Rogers","year":"2006","journal-title":"Ann Med"},{"issue":"2","key":"10.1016\/j.pupt.2011.11.001_bib19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1172\/JCI27690","article-title":"Mucus in chronic airway diseases: sorting out the sticky details","volume":"116","author":"Cohn","year":"2006","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.pupt.2011.11.001_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1172\/JCI25167","article-title":"Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals","volume":"116","author":"Tyner","year":"2006","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.pupt.2011.11.001_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1165\/rcmb.2004-0372OC","article-title":"Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma","volume":"33","author":"Robichaud","year":"2005","journal-title":"Am J Respir Cell Mol Biol."},{"issue":"2","key":"10.1016\/j.pupt.2011.11.001_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/187221308784543638","article-title":"Dihydropyridine receptor blockade in the treatment of asthma","volume":"2","author":"Pelletier","year":"2008","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"issue":"5 Pt 2","key":"10.1016\/j.pupt.2011.11.001_bib23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0091-6749(84)90298-7","article-title":"Airway smooth muscle, asthma, and calcium ions","volume":"73","author":"Middletone","year":"1984","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.pupt.2011.11.001_bib24","doi-asserted-by":"crossref","first-page":"202B","DOI":"10.1016\/0002-9149(85)90632-0","article-title":"Calcium-channel blockers in prophylaxis and treatment of asthma","volume":"55","author":"Fanta","year":"1985","journal-title":"Am J Cardiol"},{"issue":"2 Pt 1","key":"10.1016\/j.pupt.2011.11.001_bib25","first-page":"201","article-title":"Effect of verapamil on allergen-induced asthma in patients with respiratory allergy","volume":"51","author":"Miadonna","year":"1983","journal-title":"Ann Allergy"},{"key":"10.1016\/j.pupt.2011.11.001_bib26","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.4049\/jimmunol.172.5.2903","article-title":"A\u00a0novel anti-inflammatory role of simvastatin in a murine model of allergic asthma","volume":"172","author":"McKay","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.pupt.2011.11.001_bib27","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.4049\/jimmunol.172.8.5016","article-title":"Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation","volume":"172","author":"Edwan","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.pupt.2011.11.001_bib28","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1084\/jem.20030298","article-title":"Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT","volume":"198","author":"Myou","year":"2003","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.pupt.2011.11.001_bib29","doi-asserted-by":"crossref","first-page":"320S","DOI":"10.1378\/chest.122.6_suppl.320S","article-title":"Goblet cell and mucin gene abnormalities in asthma","volume":"122","author":"Fahy","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2011.11.001_bib30","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1084\/jem.178.3.889","volume":"178","author":"McMenamin","year":"1993","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.pupt.2011.11.001_bib31","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1172\/JCI8124","article-title":"Airway remodeling in asthma","volume":"104","author":"Elias","year":"1999","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pupt.2011.11.001_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ccm.2005.11.001","article-title":"Airway remodeling from bench to bedside: current perspectives","volume":"27","author":"Slade","year":"2006","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.pupt.2011.11.001_bib33","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1164\/rccm.200801-084OC","article-title":"Goblet cell rebound and airway dysfunction with corticosteroid withdrawal in a mouse model of asthma","volume":"178","author":"Southam","year":"2008","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391100160X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391100160X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T06:53:44Z","timestamp":1543388024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109455391100160X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S109455391100160X"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2011.11.001","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}