{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:39:13Z","timestamp":1774363153812,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.pupt.2011.12.007","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T14:12:38Z","timestamp":1324563158000},"page":"94-98","source":"Crossref","is-referenced-by-count":16,"title":["Bronchopulmonary pharmacokinetic and pharmacodynamic profiles of levofloxacin 750\u00a0mg once daily in adults undergoing treatment for acute exacerbation of chronic bronchitis"],"prefix":"10.1016","volume":"25","author":[{"given":"David P.","family":"Nicolau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Winget","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Baughman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2011.12.007_bib1","series-title":"Levaquin [package insert]","year":"2010"},{"key":"10.1016\/j.pupt.2011.12.007_bib2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1183\/09031936.05.00106404","article-title":"Patient stratification in the management of acute bacterial exacerbation of chronic bronchitis: the role of levofloxacin 750\u00a0mg","volume":"25","author":"Martinez","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2011.12.007_bib3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1086\/377539","article-title":"High-dose, short-course levofloxacin for community-acquired pneumonia: a new treatment paradigm","volume":"37","author":"Dunbar","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"suppl","key":"10.1016\/j.pupt.2011.12.007_bib4","first-page":"S1","article-title":"A\u00a0new dosing paradigm: high-dose, short-course fluoroquinolone therapy for community-acquired pneumonia","volume":"3","author":"File","year":"2003","journal-title":"Clin Cornerstone"},{"key":"10.1016\/j.pupt.2011.12.007_bib5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1128\/AAC.42.4.885","article-title":"Double-blind evaluation of the safety and pharmacokinetics of multiple oral once-daily 750-mg and 1-gram doses of levofloxacin in healthy volunteers","volume":"42","author":"Chien","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.pupt.2011.12.007_bib6","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1378\/chest.119.4.1114","article-title":"Steady-state plasma and intrapulmonary concentrations of levofloxacin and ciprofloxacin in healthy adult subjects","volume":"119","author":"Gotfried","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2011.12.007_bib7","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1128\/AAC.47.8.2450-2457.2003","article-title":"Steady-state and bronchopulmonary concentrations of intravenous levofloxacin and azithromycin in healthy adults","volume":"47","author":"Rodvold","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.pupt.2011.12.007_bib8","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1378\/chest.125.3.965","article-title":"Steady-state intrapulmonary concentrations of moxifloxacin, levofloxacin, and azithromycin in older adults","volume":"125","author":"Capitano","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2011.12.007_bib9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ijantimicag.2007.05.023","article-title":"Intrapulmonary pharmacodynamics of high-dose levofloxacin in subjects with chronic bronchitis or chronic obstructive pulmonary disease","volume":"30","author":"Conte","year":"2007","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.pupt.2011.12.007_bib10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/01.CCM.0000150265.42067.4C","article-title":"Pharmacokinetics and intrapulmonary diffusion of levofloxacin in critically ill patients with severe community-acquired pneumonia","volume":"33","author":"Boselli","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pupt.2011.12.007_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","article-title":"Antibiotic therapy in exacerbations of chronic pulmonary disease","volume":"106","author":"Anthonisen","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pupt.2011.12.007_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0924-8579(98)00087-9","article-title":"Comparative efficacies of levofloxacin and ciprofloxacin against Streptococcus pneumoniae in a mouse model of experimental septicemia","volume":"12","author":"Onyeji","year":"1999","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.pupt.2011.12.007_bib13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1152\/jappl.1986.60.2.532","article-title":"Estimation of volume of epithelial lining fluid recovered by lavage using urea as a marker of dilution","volume":"60","author":"Rennard","year":"1986","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.pupt.2011.12.007_bib14","first-page":"429","article-title":"Antibiotic uptake by alveolar macrophages","volume":"85","author":"Johnson","year":"1980","journal-title":"J\u00a0Lab Clin Med"},{"issue":"suppl","key":"10.1016\/j.pupt.2011.12.007_bib15","first-page":"S1","article-title":"Resistance issues and community-acquired respiratory infections","volume":"3","author":"Sahm","year":"2003","journal-title":"Clin Cornerstone"},{"key":"10.1016\/j.pupt.2011.12.007_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/516284","article-title":"Pharmacokinetic\/pharmacodynamic parameters: rationale for antimicrobial dosing of mice and men","volume":"226","author":"Craig","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pupt.2011.12.007_bib17","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1378\/chest.128.4.2093","article-title":"Pharmacodynamics of levofloxacin in patients with acute exacerbations of chronic bronchitis","volume":"128","author":"Cazzola","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2011.12.007_bib18","first-page":"407","article-title":"Pulmonary disposition of lomefloxacin in patients with acute exacerbation of chronic obstructive pulmonary disease. A multiple-dose study","volume":"13","author":"Cazzola","year":"2001","journal-title":"J\u00a0Chemother"},{"key":"10.1016\/j.pupt.2011.12.007_bib19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0954-6111(05)80262-8","article-title":"Comparative bronchoalveolar concentrations of ciprofloxacin and lomefloxacin following oral administration","volume":"87","author":"Baldwin","year":"1993","journal-title":"Respir Med"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553911001726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553911001726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T03:37:06Z","timestamp":1561088226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553911001726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1094553911001726"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2011.12.007","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}