{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:02:12Z","timestamp":1760295732108},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.pupt.2013.02.004","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T21:19:15Z","timestamp":1361308755000},"page":"388-394","source":"Crossref","is-referenced-by-count":17,"title":["ER homeostasis and motility of NSCLC cell lines can be therapeutically targeted with combined Hsp90 and HDAC inhibitors"],"prefix":"10.1016","volume":"26","author":[{"given":"Victoria","family":"Zismanov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Drucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Gottfried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2013.02.004_bib1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJMra0802714","article-title":"Lung cancer","volume":"359","author":"Herbst","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pupt.2013.02.004_bib2","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1172\/JCI31809","article-title":"New molecularly targeted therapies for lung cancer","volume":"117","author":"Sun","year":"2007","journal-title":"J\u00a0Clin Invest"},{"issue":"Suppl. 7","key":"10.1016\/j.pupt.2013.02.004_bib3","doi-asserted-by":"crossref","first-page":"vii31","DOI":"10.1093\/annonc\/mdn445","article-title":"Newer opportunities in systemic therapy of lung cancer","volume":"19","author":"Rajan","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.pupt.2013.02.004_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2407-8-229","article-title":"Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells","volume":"8","author":"Jorgensen","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.pupt.2013.02.004_bib5","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.leukres.2009.05.025","article-title":"ER-Golgi network\u2013a future target for anti-cancer therapy","volume":"33","author":"Wlodkowic","year":"2009","journal-title":"Leuk Res"},{"key":"10.1016\/j.pupt.2013.02.004_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/1078-0432.CCR-08-0132","article-title":"Heat shock protein 90 as a drug target: some like it hot","volume":"15","author":"Banerji","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.pupt.2013.02.004_bib7","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/JTO.0b013e3181bc9419","article-title":"Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition","volume":"4","author":"Kakihana","year":"2009","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.pupt.2013.02.004_bib8","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/cdd.2011.71","article-title":"SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis","volume":"18","author":"Li","year":"2011","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pupt.2013.02.004_bib9","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1097\/JTO.0b013e318174ea3a","article-title":"Heat shock protein 90 inhibition in lung cancer","volume":"3","author":"Shimamura","year":"2008","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.pupt.2013.02.004_bib10","doi-asserted-by":"crossref","first-page":"e14573","DOI":"10.1371\/journal.pone.0014573","article-title":"Expression-based in silico screening of candidate therapeutic compounds for lung adenocarcinoma","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pupt.2013.02.004_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.critrevonc.2008.03.002","article-title":"The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer","volume":"68","author":"Gridelli","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.pupt.2013.02.004_bib12","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jnci\/51.5.1417","article-title":"In\u00a0vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors","volume":"51","author":"Giard","year":"1973","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.pupt.2013.02.004_bib13","first-page":"2732s","article-title":"Neuromedin B is present in lung cancer cell lines","volume":"52","author":"Giaccone","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/j.pupt.2013.02.004_bib14","first-page":"1187","article-title":"Intermediate filament and cross-linked envelope expression in human lung tumor cell lines","volume":"45","author":"Banks-Schlegel","year":"1985","journal-title":"Cancer Res"},{"key":"10.1016\/j.pupt.2013.02.004_bib15","article-title":"The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor","author":"Kobayashi","year":"2011","journal-title":"Lung Cancer"},{"key":"10.1016\/j.pupt.2013.02.004_bib16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/jm049207j","article-title":"Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates","volume":"48","author":"Suzuki","year":"2005","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.pupt.2013.02.004_bib17","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1158\/0008-5472.CAN-08-4511","article-title":"Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells","volume":"69","author":"Kawabe","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.pupt.2013.02.004_bib18","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.4161\/cbt.8.13.8726","article-title":"Co-treatment with heat\u00a0shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells","volume":"8","author":"Rao","year":"2009","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.pupt.2013.02.004_bib19","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1158\/1535-7163.MCT-07-2104","article-title":"HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair","volume":"7","author":"Koll","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.pupt.2013.02.004_bib20","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/sj.bjc.6605291","article-title":"Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling","volume":"101","author":"Zismanov","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.pupt.2013.02.004_bib21","first-page":"148","article-title":"Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats","volume":"25","author":"Su","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.pupt.2013.02.004_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-8722-4-8","article-title":"Unfolded protein response in cancer: the physician's perspective","volume":"4","author":"Li","year":"2011","journal-title":"J\u00a0Hematol Oncol"},{"key":"10.1016\/j.pupt.2013.02.004_bib23","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1101\/gad.436407","article-title":"HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates","volume":"21","author":"Boyault","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.pupt.2013.02.004_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0609.2009.01403.x","article-title":"Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma","volume":"84","author":"Kaiser","year":"2010","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.pupt.2013.02.004_bib25","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1182\/blood-2004-09-3413","article-title":"Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3","volume":"105","author":"George","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.pupt.2013.02.004_bib26","doi-asserted-by":"crossref","first-page":"794901","DOI":"10.1155\/2009\/794901","article-title":"Synergism of heat shock protein 90 and histone deacetylase inhibitors in synovial sarcoma","volume":"2009","author":"Nguyen","year":"2009","journal-title":"Sarcoma"},{"key":"10.1016\/j.pupt.2013.02.004_bib27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1513\/pats.201001-015AW","article-title":"The unfolded protein response in lung disease","volume":"7","author":"Marcinak","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.pupt.2013.02.004_bib28","first-page":"919","article-title":"Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells","volume":"26","author":"Zhao","year":"2011","journal-title":"Oncol Rep"},{"key":"10.1016\/j.pupt.2013.02.004_bib29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pharmthera.2012.02.003","article-title":"Stress management at the ER: regulators of ER stress-induced apoptosis","volume":"134","author":"Gorman","year":"2012","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.004_bib30","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1021\/jm200017g","article-title":"A\u00a0novel monocarbonyl analogue of curcumin, (1E,4E)-1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathway","volume":"54","author":"Wang","year":"2011","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.pupt.2013.02.004_bib31","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1038\/sj.onc.1208499","article-title":"Geldanamycins exquisitely inhibit HGF\/SF-mediated tumor cell invasion","volume":"24","author":"Xie","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.pupt.2013.02.004_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/pros.22525","article-title":"Low dosed interferon alpha augments the anti-tumor potential of histone deacetylase inhibition on prostate cancer cell growth and invasion","author":"Hudak","year":"2012","journal-title":"Prostate"},{"key":"10.1016\/j.pupt.2013.02.004_bib33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1478-811X-9-18","article-title":"Interaction of tumor cells with the microenvironment","volume":"9","author":"Ungefroren","year":"2011","journal-title":"Cell Commun Signal"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553913000618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553913000618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T10:53:16Z","timestamp":1539859996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553913000618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1094553913000618"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2013.02.004","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}