{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:58:21Z","timestamp":1791280701227,"version":"4.1.0"},"reference-count":129,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.pupt.2013.02.007","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T14:33:01Z","timestamp":1362580381000},"page":"498-507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels"],"prefix":"10.1016","volume":"26","author":[{"given":"Megan S.","family":"Grace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dubuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Birrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Belvisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2013.02.007_bib1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1183\/09031936.95.08071193","article-title":"Neurophysiology of the cough reflex","volume":"8","author":"Widdicombe","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2013.02.007_bib2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/bmj.295.6605.1025-a","article-title":"Increased cough reflex associated with angiotensin converting enzyme inhibitor cough","volume":"295","author":"Fuller","year":"1987","journal-title":"Br Med J"},{"issue":"2 Suppl.","key":"10.1016\/j.pupt.2013.02.007_bib3","doi-asserted-by":"crossref","first-page":"133S","DOI":"10.1378\/chest.114.2_Supplement.133S","article-title":"Managing cough as a defense mechanism and as a symptom","volume":"114","author":"Irwin","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2013.02.007_bib4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00101006","article-title":"ERS guidelines on the assessment of cough","volume":"29","author":"Morice","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2013.02.007_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.pupt.2004.09.004","article-title":"Airway inflammation and remodelling changes in patients with chronic cough: do they tell us about the cause of cough?","volume":"17","author":"Niimi","year":"2004","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1378\/chest.105.1.151","article-title":"The relation of sleep complaints to respiratory symptoms in a general population","volume":"105","author":"Klink","year":"1994","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2013.02.007_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/1745-9974-3-5","article-title":"Chronic persistent cough in the community: a questionnaire survey","author":"Everett","year":"2007","journal-title":"Cough"},{"key":"10.1016\/j.pupt.2013.02.007_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jcf.2008.09.002","article-title":"Urinary incontinence in 9\u201316 year olds with cystic fibrosis compared to other respiratory conditions and a normal group","volume":"8","author":"Browne","year":"2009","journal-title":"J\u00a0Cystic Fibrosis"},{"key":"10.1016\/j.pupt.2013.02.007_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/pupt.1999.0207","article-title":"Pharmacological regulation of the cough reflex - from experimental models to antitussive effects in man","volume":"12","author":"Karlsson","year":"1999","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.324.7333.329","article-title":"Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults","volume":"324","author":"Schroeder","year":"2002","journal-title":"Br Med J"},{"key":"10.1016\/j.pupt.2013.02.007_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2710.2008.01010.x","article-title":"Adverse reactions to over-the-counter cough and cold products among children: the cases managed out of hospitals","volume":"34","author":"Vassilev","year":"2009","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tips.2004.09.009","article-title":"The pharmacology of cough","volume":"25","author":"Reynolds","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pupt.2013.02.007_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/thx.2003.013490","article-title":"Cough 7: current and future drugs for the treatment of chronic cough","volume":"59","author":"Belvisi","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2013.02.007_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejphar.2009.12.003","article-title":"Pharmacological profile of the NOP agonist and cough suppressing agent SCH\u00a0486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models","volume":"630","author":"McLeod","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1542\/peds.99.6.918","article-title":"Use of codeine- and dextromethorphan-containing cough remedies in children","volume":"99","author":"American Academy of Pediatrics","year":"1997","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.pupt.2013.02.007_bib16","first-page":"1","article-title":"Infant deaths associated with cough and cold medications \u2013 two states, 2005","volume":"56","author":"Centre for Disease Control","year":"2007","journal-title":"Morbidity Mortality Weekly Rep"},{"key":"10.1016\/j.pupt.2013.02.007_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1113\/jphysiol.2005.104661","article-title":"Reflex regulation of airway sympathetic nerves in guinea-pigs","volume":"573","author":"Oh","year":"2006","journal-title":"J\u00a0Physiol"},{"issue":"3","key":"10.1016\/j.pupt.2013.02.007_bib18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1152\/jappl.1980.48.3.511","article-title":"Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs","volume":"48","author":"Kaufman","year":"1980","journal-title":"J\u00a0Appl Physiol Resp Environ Exerc Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2013.02.007_bib20","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2013.02.007_bib21","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.0705923104","article-title":"4-hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1","volume":"104","author":"Trevisani","year":"2007","journal-title":"Proc Nat Acad Sci"},{"key":"10.1016\/j.pupt.2013.02.007_bib22","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress","volume":"28","author":"Andersson","year":"2008","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.pupt.2013.02.007_bib23","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1113\/jphysiol.2008.153585","article-title":"Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal","volume":"586","author":"Taylor-Clark","year":"2008","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib24","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI34192","article-title":"TRPA1 is a major oxidant sensor in murine airway sensory neurons","volume":"118","author":"Bessac","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pupt.2013.02.007_bib25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0306-4522(92)90239-X","article-title":"The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry","volume":"49","author":"Kummer","year":"1992","journal-title":"Neurosci"},{"key":"10.1016\/j.pupt.2013.02.007_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1471-4892(02)00152-2","article-title":"Neuroregulation of cough: implications for drug therapy","volume":"2","author":"Widdicombe","year":"2002","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1113\/jphysiol.2003.060079","article-title":"Subtypes of vagal afferent C-fibres in guinea-pig lungs","volume":"556","author":"Undem","year":"2004","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib28","doi-asserted-by":"crossref","first-page":"R1572","DOI":"10.1152\/ajpregu.90382.2008","article-title":"Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs","volume":"295","author":"Chou","year":"2008","journal-title":"Am J Physiol Reg Int Comp Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0034-5687(97)00030-3","article-title":"Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs","volume":"108","author":"Bergren","year":"1997","journal-title":"Respir Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2005.08.043","article-title":"Nasal sensory nerve populations responding to histamine and capsaicin","volume":"116","author":"Taylor-Clark","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.pupt.2013.02.007_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pupt.2004.12.010","article-title":"Effect of 5-hydroxytryptamine on vagal C-fiber subtypes in guinea pig lungs","volume":"18","author":"Chuaychoo","year":"2005","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/jphysiol.2006.109371","article-title":"Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs","volume":"575","author":"Chuaychoo","year":"2006","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/pulp.1993.1023","article-title":"A\u00a0comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man","volume":"6","author":"Laude","year":"1993","journal-title":"Pulm Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib34","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs","volume":"79","author":"Lalloo","year":"1995","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib35","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/thorax.55.8.643","article-title":"Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease","volume":"55","author":"Doherty","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2013.02.007_bib36","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/thx.2003.012930","article-title":"Antitussive activity of iodo-resiniferatoxin in guinea pigs","volume":"59","author":"Trevisani","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2013.02.007_bib37","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1164\/rccm.200905-0665OC","article-title":"TRPA1 agonists evoke coughing in guinea pig and human volunteers","volume":"180","author":"Birrell","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib38","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1476-5381.2009.00438.x","article-title":"Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents","volume":"158","author":"Andr\u00e8","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.1988.sp017212","article-title":"Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats","volume":"402","author":"Tatar","year":"1988","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib40","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1152\/jappl.1994.76.6.2672","article-title":"Laryngeal and tracheobronchial cough in anesthetized dogs","volume":"76","author":"Tatar","year":"1994","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1113\/jphysiol.1954.sp005034","article-title":"Receptors in the trachea and bronchi of the cat","volume":"123","author":"Widdicombe","year":"1954","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib42","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2003.057885","article-title":"Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs","volume":"557","author":"Canning","year":"2004","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.resp.2006.03.001","article-title":"Vagal afferent nerves regulating the cough reflex","volume":"152","author":"Canning","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib44","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1164\/ajrccm.165.8.2108065","article-title":"Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs","volume":"165","author":"Carr","year":"2002","journal-title":"A\u00a0J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib45","doi-asserted-by":"crossref","first-page":"L775","DOI":"10.1152\/ajplung.00353.2001","article-title":"Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways","volume":"282","author":"Myers","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib46","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1113\/jphysiol.2008.161042","article-title":"Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat","volume":"586","author":"Zhang","year":"2008","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib47","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1152\/ajplung.00366.2011","article-title":"TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors","volume":"302","author":"Lieu","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib48","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1164\/rccm.200507-1043OC","article-title":"Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs","volume":"173","author":"Lee","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib49","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1113\/jphysiol.2007.148379","article-title":"Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs","volume":"586","author":"Nassenstein","year":"2008","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib50","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/thoraxjnl-2011-201443","article-title":"Transient receptor potential ion channels mediate the tussive response to prostaglandin E2 and bradykinin","volume":"67","author":"Grace","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2013.02.007_bib51","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1113\/jphysiol.2004.078725","article-title":"Prostaglandin E2 potentiates a TTX-resistant sodium current in rat capsaicin-sensitive vagal pulmonary sensory neurones","volume":"564","author":"Kwong","year":"2005","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib52","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1164\/rccm.200903-0388OC","article-title":"Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy","volume":"180","author":"Maher","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/jphysiol.1993.sp019802","article-title":"An in\u00a0vitro study of the properties of single fibre afferents innervating guinea-pig airways","volume":"469","author":"Fox","year":"1993","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib54","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.bjp.0705056","article-title":"RSD931, a novel anti-tussive agent acting on airway sensory nerves","volume":"138","author":"Adcock","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib55","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/jappl.1988.65.3.1007","article-title":"Afferent neural pathways in cough and reflex bronchoconstriction","volume":"65","author":"Karlsson","year":"1988","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1748-1716.1991.tb09105.x","article-title":"Hyperresponsiveness to tussive stimuli in cigarette smoke exposed guinea-pigs: a role for capsaicin-sensitive, calcitonin gene-related peptide-containing nerves","volume":"141","author":"Karlsson","year":"1991","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.pupt.2013.02.007_bib57","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.pupt.2006.12.001","article-title":"Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig","volume":"20","author":"Lewis","year":"2007","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib58","series-title":"Advanced topics in environmental health and air pollution case studies","first-page":"97","article-title":"Tobacco smoke induced cough: mechanisms driving acute and chronic cough pathology","author":"Grace","year":"2011"},{"key":"10.1016\/j.pupt.2013.02.007_bib59","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0034-5687(01)00193-1","article-title":"Chronic tobacco smoke exposure increases cough to capsaicin in awake guinea pigs","volume":"126","author":"Bergren","year":"2001","journal-title":"Respir Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib60","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1513\/pats.200706-064TH","article-title":"The similarities and differences of epidemic cycles of chronic obstructive pulmonary disease and asthma exacerbations","volume":"4","author":"Johnston","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.pupt.2013.02.007_bib61","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3109\/01902148.2010.540768","article-title":"Cough reflex sensitivity is increased in guinea pigs with parainfluenza virus infection","volume":"37","author":"Ye","year":"2011","journal-title":"Exper Lung Res"},{"key":"10.1016\/j.pupt.2013.02.007_bib62","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1365-2222.2007.02740.x","article-title":"Animal models of asthma","volume":"37","author":"Zosky","year":"2007","journal-title":"Clin Exper Allergy"},{"key":"10.1016\/j.pupt.2013.02.007_bib63","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1378\/chest.10-0438","article-title":"A\u00a0novel approach to studying the relationship between subjective and objective measures of cough","volume":"139","author":"Kelsall","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2013.02.007_bib64","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/0896-6273(89)90069-X","article-title":"Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction","volume":"2","author":"Montell","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.pupt.2013.02.007_bib65","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","article-title":"TRP channels as cellular sensors","volume":"426","author":"Clapham","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2013.02.007_bib66","doi-asserted-by":"crossref","first-page":"54062","DOI":"10.1074\/jbc.M409708200","article-title":"Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia","volume":"279","author":"Arniges","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pupt.2013.02.007_bib67","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bbadis.2007.02.002","article-title":"TRP channels in disease","volume":"1772","author":"Nilius","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pupt.2013.02.007_bib68","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1093\/hmg\/ddp111","article-title":"Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease","volume":"18","author":"Zhu","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.pupt.2013.02.007_bib69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1152\/physiol.00026.2008","article-title":"Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control","volume":"23","author":"Bessac","year":"2008","journal-title":"Physiology"},{"key":"10.1016\/j.pupt.2013.02.007_bib70","first-page":"535","article-title":"Transient receptor potential channels as novel drug targets in respiratory diseases","volume":"11","author":"Nassini","year":"2010","journal-title":"Curr Opin Invest Drugs"},{"key":"10.1016\/j.pupt.2013.02.007_bib71","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1073\/pnas.100129497","article-title":"Acid potentiation of the capsaicin receptor determined by a key extracellular site","volume":"97","author":"Jordt","year":"2000","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.pupt.2013.02.007_bib72","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/22761","article-title":"Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide","volume":"400","author":"Zygmunt","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2013.02.007_bib73","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/sj.bjp.0704950","article-title":"Anandamide induces cough in conscious guinea-pigs through VR1 receptors","volume":"137","author":"Jia","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib74","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.bjp.0704840","article-title":"Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve","volume":"137","author":"Kagaya","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib75","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1124\/jpet.102.043422","article-title":"A\u00a0role for TRPV1 in bradykinin-induced excitation of vagal airway afferent nerve terminals","volume":"304","author":"Carr","year":"2003","journal-title":"J\u00a0Pharmacol Exper Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib76","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1113\/jphysiol.2003.054890","article-title":"Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1\u2212\/\u2212 mice","volume":"555","author":"Kollarik","year":"2004","journal-title":"J\u00a0Physiol"},{"issue":"3","key":"10.1016\/j.pupt.2013.02.007_bib77","article-title":"Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins","volume":"1","author":"Moriyama","year":"2005","journal-title":"Mol Pain"},{"key":"10.1016\/j.pupt.2013.02.007_bib78","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.0306-5251.2001.01475.x","article-title":"Cough challenge in the assessment of cough reflex","volume":"52","author":"Morice","year":"2001","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib79","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1074\/jbc.274.11.7325","article-title":"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts","volume":"274","author":"Jaquemar","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pupt.2013.02.007_bib80","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2013.02.007_bib81","doi-asserted-by":"crossref","first-page":"12248","DOI":"10.1073\/pnas.0505356102","article-title":"Pungent products from garlic activate the sensory ion channel TRPA1","volume":"102","author":"Bautista","year":"2005","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.pupt.2013.02.007_bib82","first-page":"116","article-title":"Increase in numbers of CD8 positive lymphocytes and eosinophils in peripheral blood of subjects with late asthmatic reactions induced by toluene diisocyanate","volume":"48","author":"Finotto","year":"1991","journal-title":"Br J Indust Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib83","first-page":"213","article-title":"Occupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives","volume":"50","author":"Vandenplas","year":"1993","journal-title":"Br J Indust Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib84","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.pupt.2013.02.007_bib85","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","volume":"445","author":"Macpherson","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2013.02.007_bib86","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1124\/mol.107.040832","article-title":"Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1)","volume":"73","author":"Taylor-Clark","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib87","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/ajrccm\/140.1.137","article-title":"Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine","volume":"140","author":"Choudry","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.pupt.2013.02.007_bib88","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm0796-814","article-title":"Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough","volume":"2","author":"Fox","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib89","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1164\/ajrccm.162.2.9910059","article-title":"Prostaglandin E2 enhances chemical and mechanical sensitivities of pulmonary C fibers in the rat","volume":"162","author":"Ho","year":"2000","journal-title":"A\u00a0J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib90","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1471-4892(02)00149-2","article-title":"Hot channels in airways: pharmacology of the vanilloid receptor","volume":"2","author":"Hwang","year":"2002","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib91","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/pupt.2002.0338","article-title":"Hypersensitivity of bronchopulmonary C-fibers induced by airway mucosal inflammation: cellular mechanisms","volume":"15","author":"Lee","year":"2002","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib92","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2125.1985.tb05077.x","article-title":"Characteristics of prostaglandin induced cough in man","volume":"20","author":"Costello","year":"1985","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib93","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1620\/tjem.164.103","article-title":"Bradykinin-induced cough reflex markedly increases in patients with cough associated with captopril and enalapril","volume":"164","author":"Katsumata","year":"1991","journal-title":"Tohoku J Exper Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib94","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1164\/ajrccm.161.3.9911005","article-title":"Endogenous airway acidification: implications for asthma pathophysiology","volume":"161","author":"Hunt","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib95","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1164\/rccm.200111-068OC","article-title":"pH in expired breath condensate of patients with inflammatory airway diseases","volume":"165","author":"Kostikas","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib96","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1113\/jphysiol.2002.022848","article-title":"Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig","volume":"543","author":"Kollarik","year":"2002","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib97","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.pupt.2006.11.010","article-title":"Acid-sensitive vagal sensory pathways and cough","volume":"20","author":"Kollarik","year":"2007","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib98","doi-asserted-by":"crossref","first-page":"22664","DOI":"10.1074\/jbc.M302561200","article-title":"Impaired pressure sensation in mice lacking TRPV4","volume":"278","author":"Suzuki","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pupt.2013.02.007_bib99","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1085\/jgp.201110615","article-title":"A\u00a0TRPA1-dependent mechanism for the pungent sensation of weak acids","volume":"137","author":"Wang","year":"2011","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib100","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nn1843","article-title":"Direct activation of the ion channel TRPA1 by Ca2+","volume":"10","author":"Zurborg","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pupt.2013.02.007_bib101","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.neuroscience.2008.04.048","article-title":"Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states","volume":"154","author":"Cavanaugh","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.pupt.2013.02.007_bib102","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/thoraxjnl-2011-200365","article-title":"A\u00a0role for sensory nerves in the late asthmatic response","volume":"67","author":"Raemdonck","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2013.02.007_bib103","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2013.02.007_bib104","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A\u00a0TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2013.02.007_bib105","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-4-22","article-title":"TRPM8 mechanism of autonomic nerve response to cold in respiratory airway","volume":"4","author":"Xing","year":"2008","journal-title":"Mol Pain"},{"key":"10.1016\/j.pupt.2013.02.007_bib106","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1517\/13543776.2012.696099","article-title":"TRP channels as therapeutic targets in airway disorders: a patent review","volume":"22","author":"Preti","year":"2012","journal-title":"Expert Opin Ther Patents"},{"key":"10.1016\/j.pupt.2013.02.007_bib107","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/pulp.1994.1021","article-title":"The antitussive effects of menthol, camphor and cineole in conscious guinea pigs","volume":"7","author":"Laude","year":"1994","journal-title":"Pulm Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib108","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/thx.49.10.1024","article-title":"Effect of inhaled menthol on citric acid induced cough in normal subjects","volume":"49","author":"Morice","year":"1994","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2013.02.007_bib109","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ppul.20797","article-title":"Does inhaling menthol affect nasal patency or cough?","volume":"43","author":"Kenia","year":"2008","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.pupt.2013.02.007_bib110","doi-asserted-by":"crossref","first-page":"L272","DOI":"10.1152\/ajplung.00393.2003","article-title":"Functional TRPV4 channels are expressed in human airway smooth muscle cells","volume":"287","author":"Jia","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib111","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.RES.0000247065.11756.19","article-title":"Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury","volume":"99","author":"Alvarez","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.pupt.2013.02.007_bib112","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pharmthera.2006.05.013","article-title":"Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells","volume":"112","author":"Dietrich","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib113","doi-asserted-by":"crossref","first-page":"L1267","DOI":"10.1152\/ajplung.00515.2005","article-title":"Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle","volume":"290","author":"Yang","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib114","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/jphysiol.2006.121111","article-title":"Protease-activated receptor 2 sensitises the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia","volume":"578","author":"Grant","year":"2007","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pupt.2013.02.007_bib115","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)00143-4","article-title":"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor","volume":"103","author":"Liedtke","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2013.02.007_bib116","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35036318","article-title":"OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity","volume":"2","author":"Strotmann","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.pupt.2013.02.007_bib117","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0954-6111(96)90099-2","article-title":"Capsaicin cough sensitivity increases during upper respiratory infection","volume":"90","author":"O'Connell","year":"1996","journal-title":"Respir Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib118","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/pupt.2002.0341","article-title":"Chronic cough and the cough reflex in common lung diseases","volume":"15","author":"Higenbottam","year":"2002","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib119","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2332\/allergolint.55.149","article-title":"Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation","volume":"55","author":"Nakajima","year":"2006","journal-title":"Aller Int"},{"issue":"Suppl. 4","key":"10.1016\/j.pupt.2013.02.007_bib120","first-page":"289","article-title":"Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold","volume":"57","author":"Plevkova","year":"2006","journal-title":"J\u00a0Physiol Pharmacol"},{"issue":"Suppl. 6","key":"10.1016\/j.pupt.2013.02.007_bib121","first-page":"557","article-title":"Cough reflex sensitivity testing in seasonal allergic rhinitis patients and healthy volunteers","volume":"59","author":"Pecova","year":"2008","journal-title":"J\u00a0Physiol Pharmacol"},{"key":"10.1016\/j.pupt.2013.02.007_bib122","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/rccm.200402-174OC","article-title":"Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough","volume":"170","author":"Groneberg","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.02.007_bib123","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pain.2008.01.024","article-title":"Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans","volume":"136","author":"Gavva","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.pupt.2013.02.007_bib124","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1124\/jpet.107.132233","article-title":"Antihyperalgesic effects of (R, E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats","volume":"326","author":"Lehto","year":"2008","journal-title":"J\u00a0Pharmacol Exper Ther"},{"key":"10.1016\/j.pupt.2013.02.007_bib125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrd2757","article-title":"Transient receptor potential channels: targeting pain at the source","volume":"8","author":"Patapoutian","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pupt.2013.02.007_bib126","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.drudis.2008.11.005","article-title":"Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway","volume":"14","author":"Gunthorpe","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.pupt.2013.02.007_bib127","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1172\/JCI25437","article-title":"TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury","volume":"115","author":"Obata","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pupt.2013.02.007_bib128","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1744-8069-4-48","article-title":"HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity","volume":"4","author":"Eid","year":"2008","journal-title":"Mol Pain"},{"key":"10.1016\/j.pupt.2013.02.007_bib129","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1021\/jm100062h","article-title":"Transient receptor potential Ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents","volume":"53","author":"Baraldi","year":"2010","journal-title":"J\u00a0Med Chem"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553913000746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553913000746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T11:05:58Z","timestamp":1562756758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553913000746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":129,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S1094553913000746"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2013.02.007","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2013.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}