{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:27:12Z","timestamp":1788884832468,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["mdconsult.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.pupt.2013.06.004","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T06:00:33Z","timestamp":1371880833000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Intermedin modulates hypoxic pulmonary vascular remodeling by inhibiting pulmonary artery smooth muscle cell proliferation"],"prefix":"10.1016","volume":"27","author":[{"given":"Sun-Zhong","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong-Sheng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Sheng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2013.06.004_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1164\/rccm.200401-006OC","article-title":"Severe pulmonary hypertension and chronic obstructive pulmonary disease","volume":"172","author":"Chaouat","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2013.06.004_bib2","doi-asserted-by":"crossref","first-page":"39S","DOI":"10.1378\/chest.10-0087","article-title":"Pulmonary hypertension in COPD: epidemiology, significance, and management: pulmonary vascular disease: the global perspective","volume":"137","author":"Minai","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2013.06.004_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2174\/138945011794751483","article-title":"Pulmonary hypertension in COPD. Pathophysiology and therapeutic targets","volume":"12","author":"Zakynthinos","year":"2011","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.pupt.2013.06.004_bib4","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2165\/00003495-200969090-00002","article-title":"Pulmonary hypertension in patients with chronic obstructive pulmonary disease: advances in pathophysiology and management","volume":"69","author":"Barber\u00e0","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.pupt.2013.06.004_bib5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.healun.2012.02.029","article-title":"Mechanisms of pulmonary hypertension in chronic obstructive pulmonary disease: a pathophysiologic review","volume":"31","author":"Wrobel","year":"2012","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.pupt.2013.06.004_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physrev.00041.2010","article-title":"Hypoxic pulmonary vasoconstriction","volume":"92","author":"Sylvester","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pupt.2013.06.004_bib7","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1183\/09031936.02.00245902","article-title":"Characterization of pulmonary vascular remodeling in smokers and patients with mild COPD","volume":"19","author":"Santos","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2013.06.004_bib8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/01.RES.0000243584.45145.3f","article-title":"Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms","volume":"99","author":"Stenmark","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.pupt.2013.06.004_bib9","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1161\/CIRCULATIONAHA.106.673988","article-title":"Emerging concepts and translational priorities in pulmonary arterial hypertension","volume":"118","author":"Michelakis","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2013.06.004_bib10","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1074\/jbc.M305332200","article-title":"Intermedin is a calcitonin\/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor\/receptor activity-modifying protein receptor complexes","volume":"279","author":"Roh","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pupt.2013.06.004_bib11","doi-asserted-by":"crossref","first-page":"S247","DOI":"10.1038\/sj.bjp.0707494","article-title":"Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems","volume":"153","author":"Bell","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2013.06.004_bib12","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1152\/japplphysiol.00569.2009","article-title":"Intracoronary intermedin 1\u201347 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and {beta}-adrenoreceptor-mediated nitric oxide release","volume":"107","author":"Grossini","year":"2009","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.pupt.2013.06.004_bib13","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.peptides.2005.10.024","article-title":"Intermedin\/adrenomedullin-2 dilates the rat pulmonary vascular bed: dependence on CGRP receptors and nitric oxide release","volume":"27","author":"Burak Kandilci","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.pupt.2013.06.004_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.peptides.2011.12.016","article-title":"Extracellular signal-regulated kinase 1\/2 activation is involved in intermedin1-53 attenuating myocardial oxidative stress injury induced by ischemia\/reperfusion","volume":"33","author":"Zhao","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.pupt.2013.06.004_bib15","first-page":"206","article-title":"Downregulation of endogenous intermedin augmented myocardial injury in rats ischemic\/reperfusion","volume":"45","author":"Teng","year":"2013","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.pupt.2013.06.004_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.peptides.2012.07.011","article-title":"Intermedin ameliorates atherosclerosis in apoE null mice by modifying lipid profiles","volume":"37","author":"Zhang","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.pupt.2013.06.004_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/cvr\/cvr213","article-title":"Intermedin induces loss of coronary microvascular endothelial barrier via derangement of actin cytoskeleton: role of RhoA and Rac1","volume":"92","author":"Aslam","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pupt.2013.06.004_bib18","doi-asserted-by":"crossref","first-page":"L837","DOI":"10.1152\/ajplung.90608.2008","article-title":"Intermedin\/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability","volume":"297","author":"Pfeil","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.pupt.2013.06.004_bib19","doi-asserted-by":"crossref","first-page":"e35832","DOI":"10.1371\/journal.pone.0035832","article-title":"Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice","volume":"7","author":"M\u00fcller-Redetzky","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pupt.2013.06.004_bib20","first-page":"8","article-title":"Effect of hypoxia on the expressions of intermedin\/adrenomedullin2 in plasma and the tissues of heart and lung in rats","volume":"25","author":"Gong","year":"2009","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"10.1016\/j.pupt.2013.06.004_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/10520298409113858","article-title":"Modified elastic tissue-Masson trichrome stain","volume":"59","author":"Garvey","year":"1984","journal-title":"Stain Technol"},{"key":"10.1016\/j.pupt.2013.06.004_bib22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/rcmb.2008-0442OC","article-title":"Involvement of Gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells","volume":"44","author":"Xia","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pupt.2013.06.004_bib23","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.20071393","article-title":"Divergent roles of endothelial NF-\u03baB in multiple organ injury and bacterial clearance in murine models of sepsis","volume":"205","author":"Ye","year":"2008","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.pupt.2013.06.004_bib24","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pupt.2013.06.004_bib25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2013.06.004_bib26","doi-asserted-by":"crossref","first-page":"H184","DOI":"10.1152\/ajpheart.2002.282.1.H184","article-title":"Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells","volume":"282","author":"Krick","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pupt.2013.06.004_bib27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000077577","article-title":"Exogenous nitric oxide upregulates p21(waf1\/cip1) in pulmonary microvascular smooth muscle cells","volume":"41","author":"Stotz","year":"2004","journal-title":"J\u00a0Vasc Res"},{"key":"10.1016\/j.pupt.2013.06.004_bib28","doi-asserted-by":"crossref","first-page":"12802","DOI":"10.1073\/pnas.211443198","article-title":"Role of p42\/p44 mitogen-activated-protein kinase and p21waf1\/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide","volume":"98","author":"Bauer","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pupt.2013.06.004_bib29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0008-6363(00)00137-1","article-title":"eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis","volume":"47","author":"Sato","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pupt.2013.06.004_bib30","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1161\/CIRCULATIONAHA.112.100586","article-title":"Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase","volume":"125","author":"Baliga","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2013.06.004_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1161\/CIRCULATIONAHA.112.133413","article-title":"Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension","volume":"127","author":"Dromparis","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2013.06.004_bib32","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2013.06.004_bib33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/sj.cdd.4401817","article-title":"Cellular response to endoplasmic reticulum stress: a matter of life or death","volume":"13","author":"Boyce","year":"2006","journal-title":"Cell Death Differ"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391300134X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391300134X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T02:18:37Z","timestamp":1563243517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109455391300134X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S109455391300134X"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2013.06.004","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intermedin modulates hypoxic pulmonary vascular remodeling by inhibiting pulmonary artery smooth muscle cell proliferation","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2013.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}