{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:13:53Z","timestamp":1789596833389,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Japanese Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","award":["21591294"],"award-info":[{"award-number":["21591294"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.pupt.2014.05.006","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T06:47:04Z","timestamp":1402037224000},"page":"165-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells"],"prefix":"10.1016","volume":"28","author":[{"given":"Koichi","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Morinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Kaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Izumikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kakeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshige","family":"Mikamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2014.05.006_bib1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1056\/NEJMra070741","article-title":"Acinetobacter infection","volume":"358","author":"Munoz-Price","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pupt.2014.05.006_bib2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1086\/529198","article-title":"Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options","volume":"46","author":"Maragakis","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pupt.2014.05.006_bib3","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1086\/500202","article-title":"The epidemiology and control of Acinetobacter baumannii in health care facilities","volume":"42","author":"Fournier","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pupt.2014.05.006_bib4","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1183\/09031936.00093010","article-title":"Determinants of prescription and choice of empirical therapy for hospital-acquired and ventilator-associated pneumonia","volume":"37","author":"Rello","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2014.05.006_bib5","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1128\/JCM.01284-07","article-title":"Antimicrobial resistance among gram-negative bacilli causing infections in intensive care unit patients in the United States between 1993 and 2004","volume":"45","author":"Lockhart","year":"2007","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.pupt.2014.05.006_bib6","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1128\/AAC.01665-09","article-title":"Trends in antimicrobial resistance of Acinetobacter baumannii isolates from a metropolitan Detroit health system","volume":"54","author":"Reddy","year":"2010","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.pupt.2014.05.006_bib7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1128\/AAC.01169-07","article-title":"Clinical and economic impact of common multidrug-resistant gram-negative bacilli","volume":"52","author":"Giske","year":"2008","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.pupt.2014.05.006_bib8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00134-003-1701-7","article-title":"High levels of sulfated mucins in bronchoalveolar lavage fluid of ICU patients with ventilator-associated pneumonia","volume":"29","author":"Dennesen","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.pupt.2014.05.006_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00010.2005","article-title":"Respiratory tract mucin genes and mucin genes and mucin glycoproteins in health and disease","volume":"86","author":"Rose","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pupt.2014.05.006_bib10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1165\/rcmb.2005-0436SF","article-title":"Airway mucus: from production to secretion","volume":"34","author":"Williams","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pupt.2014.05.006_bib11","doi-asserted-by":"crossref","first-page":"6812","DOI":"10.1074\/jbc.273.12.6812","article-title":"Cloning of the aminoterminal and 5\u2032-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts","volume":"273","author":"Li","year":"1998","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pupt.2014.05.006_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/ajrcmb.24.1.4122","article-title":"Lipopolysaccharide induces mucus cell metaplasia in mouse lung","volume":"24","author":"Yanagihara","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pupt.2014.05.006_bib13","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1128\/AAC.48.9.3457-3461.2004","article-title":"Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-oxododecanoyl) homoserine lactone in NCI-H292 cells","volume":"48","author":"Imamura","year":"2004","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.pupt.2014.05.006_bib14","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1164\/ajrccm.157.6.9710075","article-title":"Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythmycin","volume":"157","author":"Kudoh","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2014.05.006_bib15","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1086\/529439","article-title":"Effect of clarithromycin in patients with sepsis and ventilator-associated pneumonia","volume":"46","author":"Giamarellos-Bourboulis","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pupt.2014.05.006_bib16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1164\/rccm.200212-1437OC","article-title":"In\u00a0vivo and in\u00a0vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells","volume":"168","author":"Shimizu","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2014.05.006_bib17","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1128\/JCM.01021-06","article-title":"Identification of Acinetobacter baumannii by detection of the blaoxa-51-like carbapenemase gene intrinsic to this species","volume":"44","author":"Turton","year":"2006","journal-title":"J\u00a0Clin Mirobiol"},{"key":"10.1016\/j.pupt.2014.05.006_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0925-4439(98)00010-6","article-title":"Mucin gene (MUC2 and MUC5AC) upregulation by Gram-positive and Gram-negative bacteria","volume":"1406","author":"Dohrman","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pupt.2014.05.006_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.resp.2005.11.006","article-title":"Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells","volume":"154","author":"Inoue","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.pupt.2014.05.006_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/eji.200324174","article-title":"Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte response","volume":"34","author":"Litjens","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.pupt.2014.05.006_bib21","series-title":"Multidrug-resistant Acinetobacter infections, 1995\u20132004","first-page":"27","author":"Carry","year":"2006"},{"key":"10.1016\/j.pupt.2014.05.006_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejphar.2010.06.056","article-title":"Azithromycin inhibits nontypeable Haemophilus influenza-induced MUC5AC expression and secretion via inhibition of activator protein-1 in human airway epithelial cells","volume":"644","author":"Araki","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pupt.2014.05.006_bib23","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.pupt.2009.08.004","article-title":"Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumonia in airway epithelial cells","volume":"22","author":"Morinaga","year":"2009","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.pupt.2014.05.006_bib24","first-page":"151","article-title":"Live Legionella pneumophila induces MUC5AC production by airway epithelial cells independently of intracellular invasion","volume":"58","author":"Morinaga","year":"2012","journal-title":"Can J Mirobiol"},{"key":"10.1016\/j.pupt.2014.05.006_bib25","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bbrc.2004.09.157","article-title":"Nontypeable Haemophilus influenza lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKK\u03b2-I\u03baB\u03b1-NF\u03baB signaling pathways","volume":"324","author":"Chen","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pupt.2014.05.006_bib26","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1183\/09031936.02.00001402","article-title":"Pseudomonas aeruginosa induces MUC5AC production via epithelial growth factor receptor","volume":"20","author":"Kohri","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2014.05.006_bib27","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1183\/09031936.00026910","article-title":"Rhinovirus induces MUC5AC in a human infection model and in\u00a0vitro via NF-\u03baB and EGFR pathways","volume":"36","author":"Hewson","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pupt.2014.05.006_bib28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2249.2007.03299.x","article-title":"Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells","volume":"147","author":"Sugiyama","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.pupt.2014.05.006_bib29","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1128\/AAC.40.10.2375","article-title":"Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin","volume":"40","author":"Patel","year":"1996","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.pupt.2014.05.006_bib30","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1128\/AAC.47.8.2450-2457.2003","article-title":"Steady-state plasma and bronchopulmonary concentration of intravenous levofloxacin and azithromycin in healthy adults","volume":"47","author":"Rodvold","year":"2003","journal-title":"Antimicrobial Agents Chemother"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553914000649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553914000649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:27:47Z","timestamp":1761082067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553914000649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1094553914000649"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2014.05.006","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2014.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}