{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:01:35Z","timestamp":1769187695179,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.pupt.2014.10.001","type":"journal-article","created":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T14:08:45Z","timestamp":1413122925000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Hypoxia increases pulmonary arterial thromboxane receptor internalization independent of receptor sensitization"],"prefix":"10.1016","volume":"30","author":[{"given":"J.","family":"Fediuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Sikarwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.P.","family":"Lizotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Nolette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dakshinamurti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0095-5108(05)70109-3","article-title":"Persistent pulmonary hypertension of the newborn. Rational therapy based on pathophysiology","volume":"28","author":"Walsh","year":"2001","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.pupt.2014.10.001_bib2","first-page":"135","article-title":"Persistent pulmonary hypertension of the newborn","volume":"111","author":"Steinhorn","year":"1997","journal-title":"Acta Anaesthesiol Scand Suppl"},{"issue":"1 Pt 1","key":"10.1016\/j.pupt.2014.10.001_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/peds.105.1.14","article-title":"Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes","volume":"105","author":"Walsh-Sukys","year":"2000","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.pupt.2014.10.001_bib4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1113\/expphysiol.1995.sp003892","article-title":"Development of the normal and hypertensive pulmonary vasculature","volume":"80","author":"Haworth","year":"1995","journal-title":"Exp Physiol"},{"issue":"2","key":"10.1016\/j.pupt.2014.10.001_bib5","doi-asserted-by":"crossref","first-page":"L316","DOI":"10.1152\/ajplung.00228.2002","article-title":"Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs","volume":"284","author":"Fike","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"10.1016\/j.pupt.2014.10.001_bib6","doi-asserted-by":"crossref","first-page":"L375","DOI":"10.1152\/ajplung.00307.2005","article-title":"Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes","volume":"290","author":"Hinton","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5","key":"10.1016\/j.pupt.2014.10.001_bib7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cellsig.2003.10.008","article-title":"Cell signalling through thromboxane A2 receptors","volume":"16","author":"Huang","year":"2004","journal-title":"Cell Signal"},{"issue":"1\u20132","key":"10.1016\/j.pupt.2014.10.001_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-5793(98)01455-0","article-title":"The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle","volume":"440","author":"Fu","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pupt.2014.10.001_bib9","doi-asserted-by":"crossref","unstructured":"Fediuk J, Gutsol A, Nolette N, Dakshinamurti S: Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho. Am J Physiol Lung Cell Mol Physiol;302(1):L13\u2013L26.","DOI":"10.1152\/ajplung.00016.2011"},{"issue":"43","key":"10.1016\/j.pupt.2014.10.001_bib10","doi-asserted-by":"crossref","first-page":"28496","DOI":"10.1074\/jbc.273.43.28496","article-title":"Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor","volume":"273","author":"Spurney","year":"1998","journal-title":"J\u00a0Biol Chem"},{"issue":"11","key":"10.1016\/j.pupt.2014.10.001_bib11","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1016\/S0021-9258(18)88892-5","volume":"260","author":"Benovic","year":"1985","journal-title":"J\u00a0Biol Chem"},{"issue":"10","key":"10.1016\/j.pupt.2014.10.001_bib12","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1139\/y96-124","article-title":"G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins","volume":"74","author":"Ferguson","year":"1996","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0092-8674(93)80042-D","article-title":"G\u00a0protein-coupled receptor kinases","volume":"74","author":"Lefkowitz","year":"1993","journal-title":"Cell"},{"issue":"4962","key":"10.1016\/j.pupt.2014.10.001_bib14","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1126\/science.2163110","article-title":"beta-Arrestin: a protein that regulates beta-adrenergic receptor function","volume":"248","author":"Lohse","year":"1990","journal-title":"Science"},{"issue":"13","key":"10.1016\/j.pupt.2014.10.001_bib15","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1074\/jbc.274.13.8941","article-title":"Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization","volume":"274","author":"Parent","year":"1999","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.pupt.2014.10.001_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0301-0082(01)00023-5","article-title":"Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins","volume":"66","author":"Claing","year":"2002","journal-title":"Prog Neurobiol"},{"issue":"14","key":"10.1016\/j.pupt.2014.10.001_bib17","doi-asserted-by":"crossref","first-page":"9773","DOI":"10.1074\/jbc.M511435200","article-title":"Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover","volume":"281","author":"Volovyk","year":"2006","journal-title":"J\u00a0Biol Chem"},{"issue":"6","key":"10.1016\/j.pupt.2014.10.001_bib18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/01.RES.0000242563.47507.ce","article-title":"Trafficking of G protein-coupled receptors","volume":"99","author":"Drake","year":"2006","journal-title":"Circ Res"},{"issue":"Pt 1","key":"10.1016\/j.pupt.2014.10.001_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3220001","article-title":"Regulatory mechanisms that modulate signalling by G-protein-coupled receptors","volume":"322","author":"Bohm","year":"1997","journal-title":"Biochem J"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib20","doi-asserted-by":"crossref","first-page":"L654","DOI":"10.1152\/ajplung.00229.2006","article-title":"Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kinetics","volume":"292","author":"Hinton","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"10.1016\/j.pupt.2014.10.001_bib21","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1476-5381.2011.01306.x","article-title":"Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes","volume":"163","author":"Santhosh","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.pupt.2014.10.001_bib22","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1172\/JCI110139","article-title":"Increased alpha-adrenergic receptors in ischemic cat myocardium. A potential mediator of electrophysiological derangements","volume":"67","author":"Corr","year":"1981","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1124\/mol.104.003822","article-title":"Arrestin-independent internalization of G protein-coupled receptors","volume":"66","author":"van Koppen","year":"2004","journal-title":"Mol Pharmacol"},{"issue":"5","key":"10.1016\/j.pupt.2014.10.001_bib24","doi-asserted-by":"crossref","first-page":"L884","DOI":"10.1152\/ajplung.2000.279.5.L884","article-title":"L-type Ca(2+) channels, resting [Ca(2+)](i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes","volume":"279","author":"Shimoda","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"7","key":"10.1016\/j.pupt.2014.10.001_bib25","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1074\/jbc.275.7.5163","article-title":"Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in\u00a0vivo observations","volume":"275","author":"Bubb","year":"2000","journal-title":"J\u00a0Biol Chem"},{"issue":"Pt 5","key":"10.1016\/j.pupt.2014.10.001_bib26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1242\/jcs.114.5.1025","article-title":"Effects of cytochalasin D and latrunculin B on mechanical properties of cells","volume":"114","author":"Wakatsuki","year":"2001","journal-title":"J\u00a0Cell Sci"},{"issue":"1","key":"10.1016\/j.pupt.2014.10.001_bib27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1073\/pnas.76.1.86","article-title":"Competitive inhibition of colchicine binding to tubulin by microtubule-associated proteins","volume":"76","author":"Nunez","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.pupt.2014.10.001_bib28","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1152\/japplphysiol.01337.2004","article-title":"Thromboxane inhibition reduces an early stage of chronic hypoxia-induced pulmonary hypertension in piglets","volume":"99","author":"Fike","year":"2005","journal-title":"J\u00a0Appl Physiol"},{"issue":"6310","key":"10.1016\/j.pupt.2014.10.001_bib29","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/349617a0","article-title":"Cloning and expression of cDNA for a human thromboxane A2 receptor","volume":"349","author":"Hirata","year":"1991","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.pupt.2014.10.001_bib30","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1074\/jbc.M009375200","article-title":"Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: identification of a distinct motif for tonic internalization","volume":"276","author":"Parent","year":"2001","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib31","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0304-4165(98)00109-3","article-title":"Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms","volume":"1425","author":"Miggin","year":"1998","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.pupt.2014.10.001_bib32","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1074\/jbc.274.5.2645","article-title":"Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets","volume":"274","author":"Habib","year":"1999","journal-title":"J\u00a0Biol Chem"},{"issue":"11","key":"10.1016\/j.pupt.2014.10.001_bib33","doi-asserted-by":"crossref","first-page":"7191","DOI":"10.1074\/jbc.272.11.7191","article-title":"Rapid, agonist-dependent phosphorylation in\u00a0vivo of human thromboxane receptor isoforms. Minimal involvement of protein kinase C","volume":"272","author":"Habib","year":"1997","journal-title":"J\u00a0Biol Chem"},{"issue":"9","key":"10.1016\/j.pupt.2014.10.001_bib34","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.bbalip.2006.07.012","article-title":"Homologous desensitization of signalling by the beta (beta) isoform of the human thromboxane A2 receptor","volume":"1761","author":"Kelley-Hickie","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"20","key":"10.1016\/j.pupt.2014.10.001_bib35","doi-asserted-by":"crossref","first-page":"17827","DOI":"10.1074\/jbc.M210319200","article-title":"Galphaq-coupled receptor internalization specifically induced by Galphaq signaling. Regulation by EBP50","volume":"278","author":"Rochdi","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib36","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0022-3565(24)29499-4","article-title":"Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases","volume":"298","author":"Zhou","year":"2001","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"51","key":"10.1016\/j.pupt.2014.10.001_bib37","doi-asserted-by":"crossref","first-page":"51190","DOI":"10.1074\/jbc.M309314200","article-title":"The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin","volume":"278","author":"Reid","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"10","key":"10.1016\/j.pupt.2014.10.001_bib38","first-page":"952","article-title":"Serine 331 is major site of phosphorylation and desensitization induced by protein kinase C in thromboxane receptor alpha","volume":"23","author":"Yan","year":"2002","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"10.1016\/j.pupt.2014.10.001_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.bjp.0705695","article-title":"EP1- and FP-mediated cross-desensitization of the alpha (alpha) and beta (beta) isoforms of the human thromboxane A2 receptor","volume":"142","author":"Kelley-Hickie","year":"2004","journal-title":"Br J Pharmacol"},{"issue":"41","key":"10.1016\/j.pupt.2014.10.001_bib40","doi-asserted-by":"crossref","first-page":"32037","DOI":"10.1074\/jbc.M003873200","article-title":"Internalization and sequestration of the human prostacyclin receptor","volume":"275","author":"Smyth","year":"2000","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.pupt.2014.10.001_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/jpet.302.1.219","article-title":"Differential internalization of the prostaglandin f(2alpha) receptor isoforms: role of protein kinase C and clathrin","volume":"302","author":"Srinivasan","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"2\u20133","key":"10.1016\/j.pupt.2014.10.001_bib42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2006.11.058","article-title":"Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2","volume":"557","author":"Gallant","year":"2007","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib43","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-5793(00)02156-6","article-title":"Agonist-induced long-term desensitization of the human prostacyclin receptor","volume":"484","author":"Nilius","year":"2000","journal-title":"FEBS Lett"},{"issue":"7","key":"10.1016\/j.pupt.2014.10.001_bib44","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/sj.bjp.0702234","article-title":"The effect of inhibitors of receptor internalization on the desensitization and resensitization of three Gs-coupled receptor responses","volume":"125","author":"Mundell","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pupt.2014.10.001_bib45","doi-asserted-by":"crossref","unstructured":"Gong Y, Yi M, Fediuk J, Lizotte PP, Dakshinamurti S: Hypoxic neonatal pulmonary arterial myocytes are sensitized to ROS-generated 8-isoprostane. Free Radic Biol Med;48(7):882\u2013894.","DOI":"10.1016\/j.freeradbiomed.2010.01.009"},{"issue":"8","key":"10.1016\/j.pupt.2014.10.001_bib46","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1016\/S0021-9258(19)39553-5","article-title":"Cyclic oxidation-reduction reactions regulate thromboxane A2\/prostaglandin H2 receptor number and affinity in human platelet membranes","volume":"265","author":"Dorn","year":"1990","journal-title":"J\u00a0Biol Chem"},{"issue":"6","key":"10.1016\/j.pupt.2014.10.001_bib47","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1194\/jlr.M800447-JLR200","article-title":"Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species","volume":"50","author":"Wilson","year":"2009","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.pupt.2014.10.001_bib48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.pharmtox.48.113006.094646","article-title":"G\u00a0protein-coupled receptor sorting to endosomes and lysosomes","volume":"48","author":"Marchese","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"5","key":"10.1016\/j.pupt.2014.10.001_bib49","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1600-0854.2007.00551.x","article-title":"Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis","volume":"8","author":"Wolfe","year":"2007","journal-title":"Traffic"},{"issue":"6","key":"10.1016\/j.pupt.2014.10.001_bib50","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.bbamcr.2007.03.012","article-title":"Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling","volume":"1773","author":"Kelley-Hickie","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib51","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/bph.12487","article-title":"Thromboxane receptor hyper-responsiveness in hypoxic pulmonary hypertension requires serine 324","volume":"171","author":"Santhosh","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.pupt.2014.10.001_bib52","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.molonc.2009.06.001","article-title":"Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis","volume":"3","author":"Pyrzynska","year":"2009","journal-title":"Mol Oncol"},{"issue":"3","key":"10.1016\/j.pupt.2014.10.001_bib53","doi-asserted-by":"crossref","first-page":"031206","DOI":"10.1117\/1.2943286","article-title":"Rab4 and Rab11 coordinately regulate the recycling of angiotensin II type I receptor as demonstrated by fluorescence resonance energy transfer microscopy","volume":"13","author":"Li","year":"2008","journal-title":"J\u00a0Biomed Opt"},{"issue":"9","key":"10.1016\/j.pupt.2014.10.001_bib54","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/01.RES.0000071748.48338.25","article-title":"Organelle proteomics: implications for subcellular fractionation in proteomics","volume":"92","author":"Huber","year":"2003","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.pupt.2014.10.001_bib55","doi-asserted-by":"crossref","first-page":"C215","DOI":"10.1152\/ajpcell.00103.2013","article-title":"Vasoconstrictor-induced endocytic recycling regulates focal adhesion protein localization and function in vascular smooth muscle","volume":"305","author":"Poythress","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.pupt.2014.10.001_bib56","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev.biochem.69.1.277","article-title":"Structural insights into microtubule function","volume":"69","author":"Nogales","year":"2000","journal-title":"Annu Rev Biochem"},{"issue":"24","key":"10.1016\/j.pupt.2014.10.001_bib57","doi-asserted-by":"crossref","first-page":"23215","DOI":"10.1074\/jbc.M414071200","article-title":"Involvement of actin in agonist-induced endocytosis of the G protein-coupled receptor for thromboxane A2: overcoming of actin disruption by arrestin-3 but not arrestin-2","volume":"280","author":"Laroche","year":"2005","journal-title":"J\u00a0Biol Chem"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553914001187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553914001187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T03:28:45Z","timestamp":1746415725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553914001187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":57,"alternative-id":["S1094553914001187"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2014.10.001","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia increases pulmonary arterial thromboxane receptor internalization independent of receptor sensitization","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2014.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}