{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:30:19Z","timestamp":1781242219412,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.pupt.2014.11.003","type":"journal-article","created":{"date-parts":[[2014,11,30]],"date-time":"2014-11-30T01:34:31Z","timestamp":1417311271000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Effect of tiotropium on neural respiratory drive during exercise in severe COPD"],"prefix":"10.1016","volume":"30","author":[{"given":"Yin-Yin","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Fa","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Zhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jie","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Ming","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Shan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.pupt.2014.11.003_bib1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1164\/ajrccm.163.5.2101039","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI\/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary","volume":"163","author":"Pauwels","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.pupt.2014.11.003_bib2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"Rabe","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.pupt.2014.11.003_bib3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1183\/09031936.04.00116004","article-title":"Effects of tiotropium on lung hyperinflation. Dyspnea, and, exercise tolerance in COPD","volume":"23","author":"O'Donnell","year":"2004","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.pupt.2014.11.003_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1136\/thx.2003.019620","article-title":"Effect of salmeterol on resoiratory muscle activity during exercise in poorly reversible COPD","volume":"59","author":"Man","year":"2004","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.pupt.2014.11.003_bib5","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1378\/chest.126.6.1855","article-title":"Simplified detection of dynamic hyperinflation","volume":"126","author":"Gelb","year":"2004","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.pupt.2014.11.003_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00408-005-2582-z","article-title":"Single dose of tiotropium improves the 6-minute walk distance in chronic obstructive pulmonary disease","volume":"184","author":"Okudan","year":"2006","journal-title":"Lung"},{"issue":"7","key":"10.1016\/j.pupt.2014.11.003_bib7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/thx.2010.151332","article-title":"Neural respiratory drive as a physiological biomarker to monitor change during acute exacerbations of COPD","volume":"66","author":"Murphy","year":"2011","journal-title":"Thorax"},{"issue":"5","key":"10.1016\/j.pupt.2014.11.003_bib8","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3109\/15412555.2011.594464","article-title":"Effect of indacaterol on dynamic lung hyperinflation and breathlessness in hyperinflated patients with COPD","volume":"8","author":"Beeh","year":"2011","journal-title":"COPD"},{"issue":"3","key":"10.1016\/j.pupt.2014.11.003_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1513\/pats.200508-084SF","article-title":"Dynamic hyperinflation: is it worth measuring?","volume":"3","author":"Calverley","year":"2006","journal-title":"Proc Am Thorac Soc"},{"issue":"6","key":"10.1016\/j.pupt.2014.11.003_bib10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1378\/chest.09-2824","article-title":"Efficiency of neural drive during exercise in patients with COPD and healthy subjects","volume":"138","author":"Qin","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2014.11.003_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.resp.2004.12.014","article-title":"Measurement of neural respiratory drive in patients with COPD","volume":"146","author":"Luo","year":"2005","journal-title":"Respir Physiol Neurobiol"},{"issue":"5","key":"10.1016\/j.pupt.2014.11.003_bib12","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1152\/jappl.2001.90.5.1691","article-title":"Effect of diaphragm fatigue on neural respiratory drive","volume":"90","author":"Luo","year":"2001","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.pupt.2014.11.003_bib13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1183\/09031936.00093408","article-title":"Neural respiratory drive in healthy subjects and in COPD","volume":"33","author":"Jolley","year":"2009","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.pupt.2014.11.003_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00008483-198704000-00014","article-title":"Principles of exercise testing and interpretation","volume":"7","author":"Wasserman","year":"1987","journal-title":"J\u00a0Cardiopulm Rehabil Prev"},{"issue":"5","key":"10.1016\/j.pupt.2014.11.003_bib15","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1378\/chest.08-1695","article-title":"Distinguishing obstructive from central sleep apnea events: diaphragm electromyogram and esophageal pressure compared","volume":"135","author":"Luo","year":"2009","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.pupt.2014.11.003_bib16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1183\/09031936.98.12030693","article-title":"Maximum rate of change in oesophageal pressure assessed from unoccluded breaths: an option where mouth occlusion pressure is impractical","volume":"12","author":"Hamneg\u00e5rd","year":"1998","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.pupt.2014.11.003_bib17","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1152\/jappl.1998.85.4.1322","article-title":"Influence of acute lung volume change on contractile properties of human diaphragm","volume":"85","author":"Polkey","year":"1998","journal-title":"J\u00a0Appl Physiol"},{"issue":"1","key":"10.1016\/j.pupt.2014.11.003_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1164\/ajrccm\/146.1.16","article-title":"Abdominal muscle use during breathing in patients with chronic airflow obstruction","volume":"146","author":"Ninane","year":"1992","journal-title":"Am Rev Respir Dis"},{"issue":"20","key":"10.1016\/j.pupt.2014.11.003_bib19","first-page":"3629","article-title":"Effect of expiratory load on neural inspiratory drive","volume":"125","author":"Xiao","year":"2012","journal-title":"Chin Med J"},{"issue":"7","key":"10.1016\/j.pupt.2014.11.003_bib20","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1164\/ajrccm.163.7.2007033","article-title":"Diaphragm activation during exercise in chronic obstructive pulmonary disease","volume":"163","author":"Sinderby","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.pupt.2014.11.003_bib21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000317136","article-title":"Neural respiratory drive in patients with COPD during exercise tests","volume":"81","author":"Luo","year":"2011","journal-title":"Respiration"},{"key":"10.1016\/j.pupt.2014.11.003_bib22","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1164\/ajrccm.161.6.9905045","article-title":"The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests","volume":"161","author":"Oga","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2014.11.003_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/rccm.167.2.211","article-title":"ATS\/ACCP statement on cardiopulmonary exercise testing","volume":"167","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2014.11.003_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1378\/chest.117.2_suppl.42S","article-title":"Assessment of bronchodilator efficacy in symptomatic COPD: is spirometry useful?","volume":"117","author":"O'Donnell","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2014.11.003_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1164\/ajrccm.162.1.9909054","article-title":"Factor analysis of changes in dyspnea and lung function parameters after bronchodilation in chronic obstructive pulmonary disease","volume":"162","author":"Taube","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pupt.2014.11.003_bib26","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1183\/09031936.01.00216501","article-title":"Evaluation of bronchodilator responses in patients with \u201cirreversible\u201d emphysema","volume":"18","author":"O'Donnell","year":"2001","journal-title":"Eur Respir J"},{"issue":"10","key":"10.1016\/j.pupt.2014.11.003_bib27","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1742-1241.2003.tb10639.x","article-title":"Tiotropium bromide: a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease","volume":"57","author":"Joos","year":"2003","journal-title":"Int J Clin Pract"},{"issue":"12","key":"10.1016\/j.pupt.2014.11.003_bib28","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1345\/aph.1L250","article-title":"Long-acting bronchodilator therapy for the treatment of chronic obstructive pulmonary disease","volume":"42","author":"Chen","year":"2008","journal-title":"Ann Pharmacother"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553914001369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553914001369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T09:58:00Z","timestamp":1690711080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553914001369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":28,"alternative-id":["S1094553914001369"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2014.11.003","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of tiotropium on neural respiratory drive during exercise in severe COPD","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2014.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}