{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:27:22Z","timestamp":1771007242923,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.pupt.2015.08.008","type":"journal-article","created":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T22:34:04Z","timestamp":1440887644000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Laryngeal hypersensitivity in chronic cough"],"prefix":"10.1016","volume":"35","author":[{"given":"J.H.","family":"Hull","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2015.08.008_bib0010","series-title":"The Principles and Practice of Medicine","first-page":"1111","author":"Hysteria","year":"1902"},{"issue":"3","key":"10.1016\/j.pupt.2015.08.008_bib0015","first-page":"447","article-title":"The irritable larynx syndrome","volume":"13","author":"Morrison","year":"1999","journal-title":"J.\u00a0Voice"},{"issue":"1","key":"10.1016\/j.pupt.2015.08.008_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-9974-10-1","article-title":"Development and validation of the newcastle laryngeal hypersensitivity questionnaire","volume":"10","author":"Vertigan","year":"2014","journal-title":"Cough"},{"issue":"9853","key":"10.1016\/j.pupt.2015.08.008_bib0025","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0140-6736(12)60776-4","article-title":"Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial","volume":"380","author":"Ryan","year":"2012","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.pupt.2015.08.008_bib0030","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/thx.2006.064337","article-title":"Efficacy of speech pathology management for chronic cough: a randomised placebo controlled trial of treatment efficacy","volume":"61","author":"Vertigan","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2015.08.008_bib0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1745-9974-4-7","article-title":"Extrathoracic airway hyperresponsiveness as a mechanism of post infectious cough: case report","volume":"4","author":"Ryan","year":"2008","journal-title":"Cough"},{"key":"10.1016\/j.pupt.2015.08.008_bib0040","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.rmed.2011.10.007","article-title":"Clinical and physiological features of post infectious chronic cough associated with H1N1 infection","volume":"106","author":"Ryan","year":"2012","journal-title":"Respir. Med"},{"key":"10.1016\/j.pupt.2015.08.008_bib0045","first-page":"1","article-title":"Expert opinion on the cough hypersensitivity syndrome in respiratory medicine","author":"Morice","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2015.08.008_bib0050","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0140-6736(08)60595-4","article-title":"Prevalence, pathogenesis, and causes of chronic cough","author":"Chung","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.pupt.2015.08.008_bib0055","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pupt.2011.01.012","article-title":"Chronic \u201ccough hypersensitivity syndrome\u201d: a more precise label for chronic cough","volume":"24","author":"Chung","year":"2011","journal-title":"Pulm. Pharmacol. Ther"},{"issue":"5","key":"10.1016\/j.pupt.2015.08.008_bib0060","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.pupt.2013.06.010","article-title":"Chronic cough and pain: Janus faces in sensory neurobiology?","volume":"26","author":"O'Neill","year":"2013","journal-title":"Pulm. Pharmacol. Ther"},{"issue":"1","key":"10.1016\/j.pupt.2015.08.008_bib0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00408-011-9351-y","article-title":"Cough hypersensitivity syndrome is an important clinical concept: a pro\/con debate","volume":"190","author":"Morice","year":"2012","journal-title":"Lung"},{"issue":"5","key":"10.1016\/j.pupt.2015.08.008_bib0070","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S2213-2600(13)70043-2","article-title":"Chronic cough as a neuropathic disorder","volume":"1","author":"Chung","year":"2013","journal-title":"Lancet Respir. Med"},{"issue":"10","key":"10.1016\/j.pupt.2015.08.008_bib0075","first-page":"46","article-title":"Differential diagnosis and management of chronic cough","volume":"16","author":"Milgrom","year":"1990","journal-title":"Compr. Ther"},{"issue":"4","key":"10.1016\/j.pupt.2015.08.008_bib0080","first-page":"607","article-title":"PVCM, PVCD, EPL, and irritable larynx syndrome: what are we talking about and how do we treat it?","volume":"14","author":"Andrianopoulos","year":"2000","journal-title":"J.\u00a0Voice"},{"issue":"4","key":"10.1016\/j.pupt.2015.08.008_bib0085","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/01.MLG.0000201906.41316.FC","article-title":"Involuntary glottal closure during inspiration in muscle tension dysphonia","volume":"116","author":"Vertigan","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.pupt.2015.08.008_bib0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1745-9974-5-4","article-title":"Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement","volume":"5","author":"Ryan","year":"2009","journal-title":"Cough"},{"issue":"3","key":"10.1016\/j.pupt.2015.08.008_bib0095","first-page":"361","article-title":"Voice and upper airway symptoms in people with chronic cough and paradoxical vocal fold movement","volume":"21","author":"Vertigan","year":"2007","journal-title":"J.\u00a0Voice"},{"issue":"6","key":"10.1016\/j.pupt.2015.08.008_bib0100","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/resp.12103","article-title":"Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome","volume":"18","author":"Vertigan","year":"2013","journal-title":"Respirology"},{"issue":"7","key":"10.1016\/j.pupt.2015.08.008_bib0105","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/lary.25186","article-title":"Neurogenic cough","volume":"125","author":"Altman","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.pupt.2015.08.008_bib0110","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pupt.2015.06.006","article-title":"Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity","volume":"33","author":"Undem","year":"2015","journal-title":"Pulm. Pharmacol. Ther. Engl"},{"issue":"5","key":"10.1016\/j.pupt.2015.08.008_bib0115","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/archoto.2010.59","article-title":"Use of botulinum toxin type a for chronic cough: a neuropathic model","volume":"136","author":"Chu","year":"2010","journal-title":"Arch. Otolaryngol. Head. Neck Surg"},{"issue":"6","key":"10.1016\/j.pupt.2015.08.008_bib0120","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/thx.2004.033894","article-title":"Patients with gastro-oesophageal reflux disease and cough have impaired laryngopharyngeal mechanosensitivity","volume":"60","author":"Phua","year":"2005","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.pupt.2015.08.008_bib0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/000348940511400401","article-title":"Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment","volume":"114","author":"Lee","year":"2005","journal-title":"Ann. Otol. Rhinol. Laryngol"},{"issue":"5","key":"10.1016\/j.pupt.2015.08.008_bib0130","first-page":"624","article-title":"Surface-evoked laryngeal sensory action potential evaluation in neurogenic chronic cough","volume":"28","author":"Bock","year":"2015","journal-title":"J.\u00a0Voice"},{"key":"10.1016\/j.pupt.2015.08.008_bib0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1398-9995.1991.tb00559.x","article-title":"Histamine hyperresponsiveness of the extrathoracic airway in patients with asthmatic symptoms","volume":"46","author":"Bucca","year":"1991","journal-title":"Allergy"},{"key":"10.1016\/j.pupt.2015.08.008_bib0140","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jaci.2010.10.038","article-title":"Chronic cough and irritable larynx","volume":"127","author":"Bucca","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol"},{"key":"10.1016\/j.pupt.2015.08.008_bib0145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0091-6749(95)70152-4","article-title":"Extrathoracic and intrathoracic airway responsiveness in sinusitis","volume":"95","author":"Bucca","year":"1995","journal-title":"J.\u00a0Allergy Clin. Immunol"},{"key":"10.1016\/j.pupt.2015.08.008_bib0150","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0091-6749(97)70194-5","article-title":"Damage of the pharyngeal mucosa and hyperresponsiveness of airway in sinusitis","volume":"100","author":"Rolla","year":"1997","journal-title":"J.\u00a0Allergy Clin. Immunol"},{"key":"10.1016\/j.pupt.2015.08.008_bib0155","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/ijcp.12001","article-title":"Effect of iron supplementation in women with chronic cough and iron deficiency","volume":"66","author":"Bucca","year":"2012","journal-title":"Int. J. Clin. Pract"},{"issue":"2","key":"10.1016\/j.pupt.2015.08.008_bib0160","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1378\/chest.127.2.550","article-title":"Cough and glottic-stop reflex sensitivity in health and disease","volume":"127","author":"Prudon","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2015.08.008_bib0165","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/lary.20114","article-title":"Characterization of laryngeal dysfunction in chronic persistent cough","volume":"119","author":"Ryan","year":"2009","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.pupt.2015.08.008_bib0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.otohns.2006.02.003","article-title":"Sensory neuropathic cough: a common and treatable cause of chronic cough","volume":"135","author":"Bastian","year":"2006","journal-title":"Otolaryngol. Head. Neck Surg"},{"issue":"9","key":"10.1016\/j.pupt.2015.08.008_bib0175","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1002\/lary.20553","article-title":"A\u00a0new treatment option for laryngeal sensory neuropathy","volume":"119","author":"Halum","year":"2009","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.pupt.2015.08.008_bib0180","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1164\/rccm.201103-0582ED","article-title":"Vocal cord dysfunction and severe asthma","volume":"184","author":"Ayres","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med. Am. Thorac. Soc. AJRCCM"},{"issue":"9","key":"10.1016\/j.pupt.2015.08.008_bib0185","doi-asserted-by":"crossref","DOI":"10.1177\/014556131209100907","article-title":"The effect of chronic obstructive pulmonary disease on laryngopharyngeal sensitivity","volume":"91","author":"Clayton","year":"2012","journal-title":"Ear Nose Throat J"},{"issue":"3","key":"10.1016\/j.pupt.2015.08.008_bib0190","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/thoraxjnl-2014-205940","article-title":"Dynamic laryngeal narrowing during exercise: a mechanism for generating intrinsic PEEP in COPD?","volume":"70","author":"Baz","year":"2015","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.pupt.2015.08.008_bib0195","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1136\/thoraxjnl-2015-206953","article-title":"Dynamic laryngeal narrowing in COPD may have effects on the trachea","volume":"70","author":"Haji","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2015.08.008_bib0200","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0140-6736(95)91617-2","article-title":"Are asthma-like symptoms due to bronchial or extrathoracic airway dysfunction?","volume":"346","author":"Bucca","year":"1995","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.pupt.2015.08.008_bib0205","first-page":"979","article-title":"Upper and lower airway hyperreactivity in recurrent croup","volume":"121","author":"Zach","year":"1980","journal-title":"Am. Rev. Respir. Dis"},{"key":"10.1016\/j.pupt.2015.08.008_bib0210","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1378\/chest.98.5.1133","article-title":"Hyperresponsiveness of the extrathoracic airway in patients with captopril-induced cough","volume":"98","author":"Bucca","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2015.08.008_bib0215","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1378\/chest.98.6.1426","article-title":"Effect of inhaled methacholine on inspiratory flow","volume":"98","author":"Kelso","year":"1990","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.pupt.2015.08.008_bib0220","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/ajrccm.156.1.9605044","article-title":"A\u00a0systematic evaluation of mechanisms in chronic cough","volume":"156","author":"Carney","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.pupt.2015.08.008_bib0225","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0091-6749(98)70087-9","article-title":"Extrathoracic airway dysfunction in cough associated with gastroesophageal reflux","volume":"102","author":"Rolla","year":"1998","journal-title":"J.\u00a0Allergy Clin. Immunol"},{"key":"10.1016\/j.pupt.2015.08.008_bib0230","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1034\/j.1399-3003.2000.15d10.x","article-title":"Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis","volume":"15","author":"Brightling","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2015.08.008_bib0235","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ppul.10077","article-title":"Extrathoracic airway responsiveness in children with asthma-like symptoms, including chronic persistent cough","volume":"34","author":"Turktas","year":"2002","journal-title":"Pediatr. Pulmonol"},{"key":"10.1016\/j.pupt.2015.08.008_bib0240","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1398-9995.2007.01589.x","article-title":"Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma","volume":"63","author":"Ribeiro","year":"2008","journal-title":"Allergy Eur. J. Allergy Clin. Immunol"},{"key":"10.1016\/j.pupt.2015.08.008_bib0245","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3945\/ajcn.110.000802","article-title":"Unexplained chronic cough and vitamin B-12 deficiency","volume":"93","author":"Bucca","year":"2011","journal-title":"Am. J. Clin. Nutr"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553915000930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553915000930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:34:21Z","timestamp":1567125261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553915000930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":48,"alternative-id":["S1094553915000930"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2015.08.008","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Laryngeal hypersensitivity in chronic cough","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2015.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}