{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T05:31:06Z","timestamp":1792992666531,"version":"4.5.0"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Fondazione Roma"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.pupt.2015.09.004","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T06:15:06Z","timestamp":1441952106000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Therapeutic approaches of uncomplicated arterial hypertension in patients with COPD"],"prefix":"10.1016","volume":"35","author":[{"given":"Nicola","family":"Di Daniele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2015.09.004_bib0010","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"Rabe","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0015","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.rmed.2004.06.006","article-title":"Respiratory symptoms and obstructive pulmonary disease in a population aged over 70 years","volume":"99","author":"Hardie","year":"2005","journal-title":"Respir. Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0020","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1183\/09031936.06.00124605","article-title":"Global burden of COPD: systematic review and meta-analysis","volume":"28","author":"Halbert","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2015.09.004_bib0025","first-page":"1157","article-title":"Impact of beta2-agonists, beta-blockers, and their combination on cardiac function in elderly male patients with chronic obstructive pulmonary disease","volume":"8","author":"Zeng","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.pupt.2015.09.004_bib0030","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1183\/09031936.97.10122794","article-title":"Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease","volume":"10","author":"Antonelli Incalzi","year":"1997","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.pupt.2015.09.004_bib0035","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/2049-6958-8-28","article-title":"INDACO project: a pilot study on incidence of comorbidities in COPD patients referred to pneumology units","volume":"8","author":"Fumagalli","year":"2013","journal-title":"Multidiscip. Respir. Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0040","series-title":"A\u00a0Global Brief on Hypertension","author":"World HEALTH Organization","year":"2013"},{"key":"10.1016\/j.pupt.2015.09.004_bib0045","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/thx.2007.083493","article-title":"Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk","volume":"63","author":"Mills","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2015.09.004_bib0050","doi-asserted-by":"crossref","DOI":"10.1007\/s11739-015-1256-y","article-title":"Attitudes and preferences for the clinical management of patients with hypertension and hypertension with chronic obstructive pulmonary disease in Italy: main results of a survey questionnaire","author":"Tocci","year":"2015","journal-title":"Intern Emerg. Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0055","series-title":"The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure","author":"National Institutes of Health","year":"2004"},{"key":"10.1016\/j.pupt.2015.09.004_bib0060","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1524-6175.2002.02045.x","article-title":"Success and predictors of blood pressure control in diverse North American settings: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)","volume":"4","author":"Cushman","year":"2002","journal-title":"J.\u00a0Clin. Hypertens. (Greenwich)"},{"key":"10.1016\/j.pupt.2015.09.004_bib0065","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/S0140-6736(98)04311-6","article-title":"Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomized trial. HOT Study Group","volume":"351","author":"Hansson","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.pupt.2015.09.004_bib0070","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1001\/jama.289.16.2073","article-title":"Principal results of the controlled onset verapamil investigation of cardiovascular end points (CONVINCE) trial","volume":"289","author":"Black","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.pupt.2015.09.004_bib0075","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","article-title":"Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol","volume":"359","author":"Dahlof","year":"2002","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.pupt.2015.09.004_bib0080","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1001\/jama.288.23.3039","article-title":"The verdict from ALLHAT \u2013 thiazide diuretics are the preferred initial therapy for hypertension","volume":"288","author":"Appel","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.pupt.2015.09.004_bib0085","first-page":"101","article-title":"Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease","volume":"6","author":"Chandy","year":"2013","journal-title":"Integr. Blood Press. Control"},{"issue":"5","key":"10.1016\/j.pupt.2015.09.004_bib0090","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1378\/chest.12-1770","article-title":"Combination antihypertensive therapy among patients with COPD","volume":"143","author":"Herrin","year":"2013","journal-title":"Chest"},{"issue":"4A","key":"10.1016\/j.pupt.2015.09.004_bib0095","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0002-9343(83)90143-2","article-title":"Comparison of the effects of labetalol and hydrochlorothiazide on the ventilator function of hypertensive patients with mild chronic obstructive pulmonary disease","volume":"75","author":"Light","year":"1983","journal-title":"Am. J. Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0100","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1378\/chest.121.1.230","article-title":"The Pharmacologic treatment of uncomplicated arterial hypertension in patients with airway dysfunction","volume":"121","author":"Cazzola","year":"2002","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.pupt.2015.09.004_bib0105","first-page":"45","article-title":"Managing the elderly patient with both hypertension and pulmonary disease","volume":"42","author":"Krane","year":"1987","journal-title":"Geriatrics"},{"key":"10.1016\/j.pupt.2015.09.004_bib0110","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0002-9343(89)90438-5","article-title":"Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol","volume":"86","author":"Lipworth","year":"1989","journal-title":"Am. J. Med"},{"issue":"1","key":"10.1016\/j.pupt.2015.09.004_bib0115","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/archinte.1986.00360130159022","article-title":"Fluid and electrolyte considerations in diuretic therapy for hypertensive patients with chronic obstructive pulmonary disease","volume":"146","author":"Hill","year":"1986","journal-title":"Arch. Intern Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0120","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/CS20120081","article-title":"Renin-angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease","volume":"123","author":"Shrikrishna","year":"2012","journal-title":"Clin. Sci"},{"key":"10.1016\/j.pupt.2015.09.004_bib0125","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1136\/jcp.36.8.938","article-title":"Angiotensin- converting enzyme and its clinical significance: a review","volume":"36","author":"Studdy","year":"1983","journal-title":"J.\u00a0Clin. Pathol"},{"key":"10.1016\/j.pupt.2015.09.004_bib0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1042\/bj1460497","article-title":"Subcellular localization of pulmonary angiotensin converting enzyme","volume":"146","author":"Ryan","year":"1975","journal-title":"Biochem. J."},{"key":"10.1016\/j.pupt.2015.09.004_bib0135","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0006-291X(05)80302-X","article-title":"Angiotensin II type-! receptor subtype cDNAs: differential tissue expression and hormonal regulation","volume":"183","author":"Kakar","year":"1992","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.pupt.2015.09.004_bib0140","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1164\/ajrccm.164.4.2007085","article-title":"Marked sympathetic activation in patients with chronic respiratory failure","volume":"164","author":"Heidl","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0145","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/1381612033455431","article-title":"The pulmonary renin-angiotensin system","volume":"9","author":"Marshall","year":"2003","journal-title":"Curr. Pharm. Des"},{"key":"10.1016\/j.pupt.2015.09.004_bib0150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1165\/rcmb.2010-0264OC","article-title":"Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia","volume":"45","author":"Chao","year":"2011","journal-title":"Am. J. Resp. Cell Mol. Biol"},{"key":"10.1016\/j.pupt.2015.09.004_bib0155","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1165\/rcmb.2011-0289OC","article-title":"LPS-stimulated cytokine production in type I cells is modulated by the renin-angiotensin system","volume":"46","author":"Wong","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"10.1016\/j.pupt.2015.09.004_bib0160","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI46215","article-title":"Angiotensin receptor blockade attenuates cigarette smokeinduced lung injury and rescues lung architecture in mice","volume":"122","author":"Podowski","year":"2012","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.pupt.2015.09.004_bib0165","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pupt.2010.12.006","article-title":"Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model","volume":"24","author":"Raupach","year":"2011","journal-title":"Pulm. Pharmacol. Ther"},{"key":"10.1016\/j.pupt.2015.09.004_bib0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1465-9921-10-45","article-title":"Impact of statins and ACE inhibitors on mortality after COPD exacerbations","volume":"10","author":"Mortensen","year":"2009","journal-title":"Respir. Res"},{"key":"10.1016\/j.pupt.2015.09.004_bib0175","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1183\/09031936.06.00098105","article-title":"Angiotensin II blockers in obstructive pulmonary disease: a randomised controlled trial","volume":"27","author":"Andreas","year":"2006","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.pupt.2015.09.004_bib0180","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1378\/chest.13-2483","article-title":"A\u00a0randomized controlled trial of angiotensin-Converting enzyme inhibition for skeletal muscle dysfunction in COPD","volume":"146","author":"Shrikrishna","year":"2014","journal-title":"Chest"},{"issue":"9319","key":"10.1016\/j.pupt.2015.09.004_bib0185","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0140-6736(02)08024-8","article-title":"Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study","volume":"359","author":"Onder","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.pupt.2015.09.004_bib0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pupt.2010.01.004","article-title":"Effect of enalapril on exercise cardiopulmonary performance in chronic obstructive pulmonary disease: a pilot study","volume":"23","author":"Di Marco","year":"2010","journal-title":"Pulm. Pharmacol. Ther"},{"issue":"7","key":"10.1016\/j.pupt.2015.09.004_bib0195","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/thorax.58.7.629","article-title":"Effects of captopril administration on pulmonary haemodynamics and tissue oxygenation during exercise in ACE gene subtype patients with COPD: a preliminary study","volume":"58","author":"Kanazawa","year":"2003","journal-title":"Thorax"},{"issue":"suppl 2","key":"10.1016\/j.pupt.2015.09.004_bib0200","first-page":"S43","article-title":"Cough with angiotensin converting enzyme inhibitors: how much of a problem?","volume":"12","author":"Fletcher","year":"1994","journal-title":"J.\u00a0Hypertens"},{"key":"10.1016\/j.pupt.2015.09.004_bib0205","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2165\/00002018-199716020-00006","article-title":"Pharmaco-epidemiology of ACE inhibitor-induced cough","volume":"16","author":"Tomlinson","year":"1997","journal-title":"Drug Saf"},{"key":"10.1016\/j.pupt.2015.09.004_bib0210","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2165\/00002018-199615010-00006","article-title":"ACE inhibitors-induced cough and bronchospasm: incidence, mechanism and management","volume":"15","author":"Overlack","year":"1996","journal-title":"Drug Saf"},{"key":"10.1016\/j.pupt.2015.09.004_bib0215","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0895-7061(99)00165-X","article-title":"Candesartan cilexetil is not associated with cough in hypertensive patients with enalapril-induced cough","volume":"13","author":"Tanser","year":"2000","journal-title":"Am. J. Hypertens"},{"key":"10.1016\/j.pupt.2015.09.004_bib0220","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0149-2918(98)80079-9","article-title":"Use losartan in the treatment of hypertensive patients with a history of cough induced by angiotensin converting enzyme inhibitors","volume":"20","author":"Paster","year":"1998","journal-title":"Clin. Ther"},{"key":"10.1016\/j.pupt.2015.09.004_bib0225","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.CIR.104.3.281","article-title":"Effects of candesartan on cough and bronchial hyperresponsiveness in mildly to moderately hypertensive patients with symptomatic asthma","volume":"104","author":"Tanaka","year":"2001","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.pupt.2015.09.004_bib0230","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2710.2009.01028.x","article-title":"Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans","volume":"34","author":"Woo","year":"2009","journal-title":"J.\u00a0Clin. Pharm. Ther"},{"key":"10.1016\/j.pupt.2015.09.004_bib0235","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1183\/09031936.00133805","article-title":"Mortality in COPD: role of comorbidities","volume":"28","author":"Sin","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2015.09.004_bib0240","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1016\/j.jacc.2006.04.039","article-title":"Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease","volume":"47","author":"Mancini","year":"2006","journal-title":"J.\u00a0Am. Coll. Cardiol"},{"key":"10.1016\/j.pupt.2015.09.004_bib0245","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1155\/1998\/678027","article-title":"Calcium handling in airway smooth muscle: mechanism and therapeutic implications","volume":"5","author":"Janssen","year":"1998","journal-title":"Can. Respir. J."},{"issue":"4","key":"10.1016\/j.pupt.2015.09.004_bib0250","first-page":"612","article-title":"Deleterious effect of nifedipine on pulmonary gas exchange in chronic obstructive pulmonary disease","volume":"130","author":"Melot","year":"1984","journal-title":"Am. Rev. Respir. Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0255","first-page":"175","article-title":"Combined effect of nifedipine and dialtiazem on methacholineinduced bronchoconstriction in asthmatic patients","volume":"68","author":"Kivity","year":"1992","journal-title":"Ann. Allergy"},{"key":"10.1016\/j.pupt.2015.09.004_bib0260","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/bmj.282.6268.932","article-title":"Calcium antagonists in exercise-induced asthma","volume":"282","author":"Patel","year":"1981","journal-title":"Br. Med. J."},{"issue":"1","key":"10.1016\/j.pupt.2015.09.004_bib0265","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1164\/ajrccm\/138.1.54","article-title":"Felodipine, a new calcium antagonist, modifies exercise-induced asthma","volume":"138","author":"Patel","year":"1988","journal-title":"Am. Rev. Respir. Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0270","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000194627","article-title":"Effect of a calcium antagonist, nifedipine, in exercise-induced asthma","volume":"45","author":"Crimi","year":"1984","journal-title":"Respiration"},{"key":"10.1016\/j.pupt.2015.09.004_bib0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1398-9995.1984.tb01928.x","article-title":"Nifedipine-a calcium channel blocker-in asthmatic patients: interaction with terbutaline","volume":"39","author":"Svedmyr","year":"1984","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.pupt.2015.09.004_bib0280","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0091-6749(87)90247-8","article-title":"Nifedipine treatment of patients with bronchial asthma","volume":"79","author":"Patakas","year":"1987","journal-title":"J.\u00a0Allergy Clin. Immunol"},{"issue":"3","key":"10.1016\/j.pupt.2015.09.004_bib0285","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.0306-5251.2001.01560.x","article-title":"Efficacy of calcium channel blockers as maintenance therapy for asthma","volume":"53","author":"Ann Twins","year":"2002","journal-title":"Br. J. Clin. Pharmacol"},{"issue":"3","key":"10.1016\/j.pupt.2015.09.004_bib0290","first-page":"541","article-title":"Autoradiographic visualization of beta-adrenoceptor subtypes in human lung","volume":"132","author":"Carstairs","year":"1985","journal-title":"Am. Rev. Respir. Dis"},{"issue":"suppl","key":"10.1016\/j.pupt.2015.09.004_bib0295","doi-asserted-by":"crossref","first-page":"325S","DOI":"10.1111\/j.1365-2125.1982.tb01937.x","article-title":"Assessment of \u03b2-adrenoceptor antagonists in asthmatic patients","volume":"13","author":"Ruffin","year":"1982","journal-title":"Br. J. Clin. Pharmacol"},{"issue":"4","key":"10.1016\/j.pupt.2015.09.004_bib0300","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0007-0971(78)90062-1","article-title":"The effects of oral propranolol and metoprolol on lung function and exercise performance in chronic airways obstruction","volume":"72","author":"McGavin","year":"1978","journal-title":"Br. J. Dis. Chest"},{"key":"10.1016\/j.pupt.2015.09.004_bib0305","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2125.1985.tb05062.x","article-title":"Ventilatory effects of long-term treatment with pindolol and metoprolol in hypertensive patients with chronic obstructive lung disease","volume":"20","author":"Lammer","year":"1985","journal-title":"Br. J. Clin. Pharmacol"},{"key":"10.1016\/j.pupt.2015.09.004_bib0310","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1378\/chest.127.3.818","article-title":"Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers","volume":"127","author":"van der Woude","year":"2005","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.pupt.2015.09.004_bib0315","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/qjmed\/hci080","article-title":"Under-use of beta-blockers in patients with ischaemic heart disease and concomitant chronic obstructive pulmonary disease","volume":"98","author":"Egred","year":"2005","journal-title":"QJM"},{"issue":"8","key":"10.1016\/j.pupt.2015.09.004_bib0320","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1056\/NEJM199808203390801","article-title":"Effect of beta-blockade on mortality among high-risk patients after myocardial infarction","volume":"339","author":"Gottlieb","year":"1998","journal-title":"N.\u00a0Engl. J. Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0325","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1378\/chest.118.5.1322","article-title":"Comparison of the effects of single oral doses of nebivolol and celiprolol on airways in patients with mild asthma","volume":"118","author":"Cazzola","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2015.09.004_bib0330","first-page":"CD003566","article-title":"Cardioselective \u03b2-blockers for chronic obstructive pulmonary disease (Cochrane Review)","volume":"2","author":"Salpeter","year":"2002","journal-title":"Cochrane Database Syst. Rev"},{"issue":"10","key":"10.1016\/j.pupt.2015.09.004_bib0335","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0954-6111(03)00168-9","article-title":"Cardioselective beta-blockers for chronic obstructive pulmonary disease: a meta-analysis","volume":"97","author":"Salpeter","year":"2003","journal-title":"Respir. Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0340","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1378\/chest.11-2032","article-title":"The impact of COPD on management and outcomes of patients hospitalized with acute myocardial infarction. A ten-year retrospective observational study","volume":"141","author":"Stefan","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2015.09.004_bib0345","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1136\/thoraxjnl-2012-201945","article-title":"Association between \u03b2-blocker therapy and outcomes in patients hospitalized with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension","volume":"67","author":"Stefan","year":"2012","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.pupt.2015.09.004_bib0350","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.amjcard.2008.09.081","article-title":"Get with the guidelines steering committee. Current use of beta blockers in patients with reactive airway disease who are hospitalized with acute coronary syndromes","volume":"103","author":"Olenchock","year":"2009","journal-title":"Am. J. Cardiol"},{"issue":"11","key":"10.1016\/j.pupt.2015.09.004_bib0355","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/pds.963","article-title":"Use and adherence to beta-blockers for secondary prevention of myocardial infarction: who is not getting the treatment?","volume":"13","author":"Wei","year":"2004","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.pupt.2015.09.004_bib0360","first-page":"1157","article-title":"Impact of beta2-agonists, beta-blockers, and their combination on cardiac function in elderly male patients with chronic obstructive pulmonary disease","volume":"8","author":"Zeng","year":"2013","journal-title":"Clin Interv. Aging"},{"key":"10.1016\/j.pupt.2015.09.004_bib0365","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/eurjhf\/hfr063","article-title":"Are beta2-agonists responsible for increased mortality in hearth failure?","volume":"13","author":"Bermingham","year":"2011","journal-title":"Eur. J. Hearth Fail"},{"key":"10.1016\/j.pupt.2015.09.004_bib0370","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1161\/01.CIR.99.18.2402","article-title":"Inotropic and sympathetic responses to the intracoronary infusion of a beta2-receptor agonist: a human in\u00a0vivo study","volume":"99","author":"Newton","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2015.09.004_bib0375","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1445-5994.2009.02109.x","article-title":"Cardiovascular mortality and morbidity in chronic obstructive pulmonary disease: the impact of bronchodilator treatment","volume":"40","author":"Wood-Baker","year":"2010","journal-title":"Intern Med. J."},{"key":"10.1016\/j.pupt.2015.09.004_bib0380","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ahj.2004.03.048","article-title":"Association between chronic heart failure and inhaled beta-2- adrenoceptor agonists","volume":"148","author":"Au","year":"2004","journal-title":"Am. Heart J."},{"key":"10.1016\/j.pupt.2015.09.004_bib0385","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1161\/01.CIR.94.11.2807","article-title":"Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure: MOCHA investigators","volume":"94","author":"Bristow","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2015.09.004_bib0390","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/eurheartj\/ehn309","volume":"29","author":"Dickstein","year":"2008","journal-title":"Eur. Heart J."},{"issue":"suppl. 12","key":"10.1016\/j.pupt.2015.09.004_bib0395","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1524-6175.2006.06041.x","article-title":"Targeting nitric oxide with drug therapy","volume":"8","author":"Mason","year":"2006","journal-title":"J.\u00a0Clin. Hypertens"},{"issue":"2","key":"10.1016\/j.pupt.2015.09.004_bib0400","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1751-7176.2011.00553.x","article-title":"\u03b2-Blockade: benefits beyond blood pressure reduction?","volume":"14","author":"Cockcroft","year":"2012","journal-title":"J.\u00a0Clin. Hypertens"},{"key":"10.1016\/j.pupt.2015.09.004_bib0405","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00627916","article-title":"Cardio-selective of atenolol in asthmatic patients","volume":"21","author":"Me","year":"1981","journal-title":"Eur. J. Clin. Pharmacol"},{"key":"10.1016\/j.pupt.2015.09.004_bib0410","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003566.pub2","article-title":"Cardio-selective beta-blockers for chronic obstructive pulmonary disease","author":"Salpeter","year":"2005","journal-title":"Cochrane Database Syst. Rev"},{"key":"10.1016\/j.pupt.2015.09.004_bib0415","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1164\/rccm.200803-384OC","article-title":"Impact of cardioselective b-blockers on mortality in patients with chronic obstructive pulmonary disease and atherosclerosis","volume":"178","author":"van Gestel","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0420","first-page":"177","article-title":"Beta-blockers and health-related quality of life in patients with peripheral arterial disease and COPD","volume":"4","author":"van Gestel","year":"2009","journal-title":"Int. J. COPD"},{"issue":"7","key":"10.1016\/j.pupt.2015.09.004_bib0425","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1164\/rccm.201208-1565OC","article-title":"Effects of cardiovascular drugs on mortality in severe chronic obstructive pulmonary disease. A time-dependent analysis","volume":"187","author":"Ekstr\u00f6m","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.pupt.2015.09.004_bib0430","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000099201","article-title":"Influence of nebivolol and metoprolol on inflammatory mediators in human coronary endothelial or smooth muscle cells. Effects on neointima formation after balloon denudation in carotid arteries of rats treated with nebivolol","volume":"4","author":"Wolf","year":"2007","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.pupt.2015.09.004_bib0435","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1161\/CIRCULATIONAHA.105.556233","article-title":"Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans","volume":"112","author":"Mason","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2015.09.004_bib0440","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/hc3001.094207","article-title":"Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double blind, crossover study","volume":"104","author":"Tzemos","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pupt.2015.09.004_bib0445","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/01.HYP.0000137983.45556.6e","article-title":"Nebivolol increases arterial distensibility in\u00a0vivo","volume":"44","author":"McEniery","year":"2004","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.pupt.2015.09.004_bib0450","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/1753944709339968","article-title":"Pulmonary effects of nebivolol","volume":"3","author":"Dal Negro","year":"2009","journal-title":"Ther. Adv. Cardiovasc Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0455","first-page":"36","article-title":"Assessment of safety and antihypertensive efficacy of a cardioselective b-blocker nebivolol in patients with hypertension and concomitant chronic obstructive bronchitis","volume":"42","author":"Iakushin","year":"2002","journal-title":"Kardiologiia"},{"key":"10.1016\/j.pupt.2015.09.004_bib0460","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000076677","article-title":"Comparative effects of a two-week treatment with nebivolol and nifedipine in hypertensive patients suffering from COPD","volume":"71","author":"Cazzola","year":"2004","journal-title":"Respiration"},{"issue":"3","key":"10.1016\/j.pupt.2015.09.004_bib0465","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1210\/jc.2012-3424","article-title":"Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome","volume":"98","author":"Schinzari","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab"},{"issue":"7","key":"10.1016\/j.pupt.2015.09.004_bib0470","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/sj.ejcn.1602800","article-title":"Effect of a moderately hypoenergetic Mediterranean diet and exercise program on body cell mass and cardiovascular risk factors in obese women","volume":"62","author":"Andreoli","year":"2008","journal-title":"Eur. J. Clin. Nutr"},{"key":"10.1016\/j.pupt.2015.09.004_bib0475","doi-asserted-by":"crossref","first-page":"e1552","DOI":"10.1038\/cddis.2014.520","article-title":"Koschei the immortal and anti-aging drugs","volume":"5","author":"Blagosklonny","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0480","doi-asserted-by":"crossref","first-page":"e1141","DOI":"10.1038\/cddis.2014.87","article-title":"p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells","volume":"5","author":"Kim","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0485","doi-asserted-by":"crossref","first-page":"e1116","DOI":"10.1038\/cddis.2014.82","article-title":"A\u00a0stress-induced cellular aging model with postnatal neural stem cells","volume":"5","author":"Dong","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0490","doi-asserted-by":"crossref","first-page":"e1054","DOI":"10.1038\/cddis.2014.11","article-title":"Early and sustained altered expression of aging-related genes in young 3xTg-AD mice","volume":"5","author":"Gatta","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0495","doi-asserted-by":"crossref","first-page":"e970","DOI":"10.1038\/cddis.2013.501","article-title":"In serum veritas-in serum sanitas? cell nonautonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathway","volume":"4","author":"Geissler","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0500","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.arr.2014.04.003","article-title":"MicroRNAs in human skin ageing","volume":"17","author":"Mancini","year":"2014","journal-title":"Ageing Res. Rev"},{"issue":"3","key":"10.1016\/j.pupt.2015.09.004_bib0505","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/cdd.2013.167","article-title":"The miR-106b\u223c25 cluster promotes bypass of doxorubicin-induced senescence and increase in motility and invasion by targeting the E-cadherin transcriptional activator EP300","volume":"21","author":"Zhou","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pupt.2015.09.004_bib0510","doi-asserted-by":"crossref","first-page":"e1528","DOI":"10.1038\/cddis.2014.489","article-title":"Characterization of novel markers of senescence and their prognostic potential in cancer","volume":"5","author":"Althubiti","year":"2014","journal-title":"Cell Death Dis"},{"issue":"10","key":"10.1016\/j.pupt.2015.09.004_bib0515","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/cdd.2014.61","article-title":"p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells","volume":"21","author":"Fatt","year":"2014","journal-title":"Cell Death Differ"},{"issue":"2","key":"10.1016\/j.pupt.2015.09.004_bib0520","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/cdd.2013.161","article-title":"Sprouty1 induces a senescence-associated secretory phenotype by regulating NF\u03baB activity: implications for tumorigenesis","volume":"21","author":"Maci\u00e0","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pupt.2015.09.004_bib0525","doi-asserted-by":"crossref","first-page":"e1531","DOI":"10.1038\/cddis.2014.481","article-title":"PKC\u03b7 promotes senescence induced by oxidative stress and chemotherapy","volume":"5","author":"Zurgil","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0530","doi-asserted-by":"crossref","first-page":"e1168","DOI":"10.1038\/cddis.2014.138","article-title":"Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice","volume":"5","author":"Ewald","year":"2014","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.pupt.2015.09.004_bib0535","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cdd.2014.137","article-title":"Essential versus accessory aspects of cell death: recommendations of the NCCD 2015","volume":"22","author":"Galluzzi","year":"2015","journal-title":"Cell Death Differ"},{"issue":"8","key":"10.1016\/j.pupt.2015.09.004_bib0540","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/cdd.2014.46","article-title":"ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation","volume":"21","author":"Huang","year":"2014","journal-title":"Cell Death Differ"},{"issue":"11","key":"10.1016\/j.pupt.2015.09.004_bib0545","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/cdd.2014.88","article-title":"Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress","volume":"21","author":"Kim","year":"2014","journal-title":"Cell Death Differ"},{"issue":"10","key":"10.1016\/j.pupt.2015.09.004_bib0550","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/cdd.2014.74","article-title":"Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence","volume":"21","author":"Grasso","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pupt.2015.09.004_bib0555","doi-asserted-by":"crossref","first-page":"e1246","DOI":"10.1038\/cddis.2014.219","article-title":"Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence","volume":"5","author":"Ramachandran","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0560","doi-asserted-by":"crossref","first-page":"e1226","DOI":"10.1038\/cddis.2014.168","article-title":"Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice","volume":"5","author":"Lu","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0565","doi-asserted-by":"crossref","first-page":"e1189","DOI":"10.1038\/cddis.2014.140","article-title":"Adiponectin deficiency exacerbates age-related hearing impairment","volume":"5","author":"Tanigawa","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0570","doi-asserted-by":"crossref","first-page":"e1519","DOI":"10.1038\/cddis.2014.476","article-title":"The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes","volume":"5","author":"Wennmann","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pupt.2015.09.004_bib0575","doi-asserted-by":"crossref","first-page":"e377","DOI":"10.1038\/cddis.2012.112","article-title":"Erythrocyte glutathione transferase: a new biomarker for hemodialysis adequacy, overcoming the Kt\/V(urea) dogma?","volume":"3","author":"Noce","year":"2012","journal-title":"Cell Death Dis"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391500098X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391500098X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T10:38:17Z","timestamp":1567161497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109455391500098X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":114,"alternative-id":["S109455391500098X"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2015.09.004","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic approaches of uncomplicated arterial hypertension in patients with COPD","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2015.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}