{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:24:40Z","timestamp":1778599480707,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.pupt.2016.03.003","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T12:19:02Z","timestamp":1457525942000},"page":"85-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Effect of CArbocisteine in Prevention of exaceRbation of chronic obstructive pulmonary disease (CAPRI study): An observational study"],"prefix":"10.1016","volume":"37","author":[{"given":"Antonietta","family":"Esposito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria","family":"Valentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Bruzzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Bocchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7670-1167","authenticated-orcid":false,"given":"Antonio","family":"Ponticiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Stanziola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sanduzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2016.03.003_bib1","unstructured":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. GOLD website. http:\/\/www.goldcopd.org (accessed 21.08.15)."},{"key":"10.1016\/j.pupt.2016.03.003_bib2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1513\/pats.200603-087MS","article-title":"Airway and parenchymal disease in chronic obstructive pulmonary disease are distinct phenotypes","volume":"3","author":"Patel","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.pupt.2016.03.003_bib3","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(96)07492-2","article-title":"Alternative projections of mortality and disability by cause 1990\u20132020","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.pupt.2016.03.003_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00063198-200203000-00003","article-title":"Chronic obstructive pulmonary disease in the United Kingdom: trends in mortality, morbidity, and smoking","volume":"8","author":"Pride","year":"2002","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.pupt.2016.03.003_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.taap.2009.10.022","article-title":"Current concepts on oxidative\/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease","volume":"254","author":"Yao","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.pupt.2016.03.003_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/thorax.56.1.36","article-title":"Relationship between airway, inflammation and the frequency of exacerbations in patients with smoking related COPD","volume":"56","author":"Gompertz","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2016.03.003_bib7","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1164\/rccm.200210-1253OC","article-title":"Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease","volume":"167","author":"Corradi","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2016.03.003_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3109\/15412555.2011.579202","article-title":"Plasma antioxidants are associated with, impaired lung function and COPD exacerbations in smokers","volume":"8","author":"Nicks","year":"2011","journal-title":"COPD"},{"key":"10.1016\/j.pupt.2016.03.003_bib9","first-page":"CD001287","article-title":"Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease","volume":"3","author":"Poole","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pupt.2016.03.003_bib10","first-page":"CD001287","article-title":"Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease","volume":"8","author":"P1","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"issue":"9629","key":"10.1016\/j.pupt.2016.03.003_bib11","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/S0140-6736(08)60869-7","article-title":"Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study","volume":"371","author":"Zheng","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.pupt.2016.03.003_bib12","doi-asserted-by":"crossref","unstructured":"Development and first validation of the COPD Assessment Test. P. W. Jones, G. Harding, P. Berry, I. Wiklund, W-H. Chen, N. Kline Leidy, http:\/\/dx.doi.org\/10.1183\/09031936.00102509 Published 1 September 2009.","DOI":"10.1183\/09031936.00102509"},{"key":"10.1016\/j.pupt.2016.03.003_bib13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","article-title":"Antibiotic therapy in exacerbation of chronic obstructive pulmonary disease","volume":"106","author":"Anthonisen","year":"1987","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.pupt.2016.03.003_bib14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1378\/chest.06-0702","article-title":"Development and validation of an improved, COPD-specific version of the St. George respiratory questionnaire*","volume":"132","author":"Meguro","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2016.03.003_bib15","first-page":"CD001287","article-title":"Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease","volume":"3","author":"Poole","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pupt.2016.03.003_bib16","first-page":"CD001287","article-title":"Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease","volume":"2","author":"Poole","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pupt.2016.03.003_bib17","first-page":"CD001287","article-title":"Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease","volume":"7","author":"Poole","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pupt.2016.03.003_bib18","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0140-6736(05)66456-2","article-title":"Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial","volume":"365","author":"Decramer","year":"2005","journal-title":"Lancet"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.pupt.2016.03.003_bib19","first-page":"S27","article-title":"Predictors of survival in COPD: more than just the FEV1","volume":"102","author":"BR1","year":"2008","journal-title":"Respir. Med."}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391630013X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109455391630013X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T08:57:18Z","timestamp":1536915438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109455391630013X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":19,"alternative-id":["S109455391630013X"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2016.03.003","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of CArbocisteine in Prevention of exaceRbation of chronic obstructive pulmonary disease (CAPRI study): An observational study","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2016.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}