{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:10:09Z","timestamp":1778800209656,"version":"3.51.4"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL33052"],"award-info":[{"award-number":["HL33052"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P30HD40677"],"award-info":[{"award-number":["1P30HD40677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.pupt.2016.04.004","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:36:22Z","timestamp":1462062982000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["A novel dissociative steroid VBP15 reduces MUC5AC gene expression in airway epithelial cells but lacks the GRE mediated transcriptional properties of dexamethasone"],"prefix":"10.1016","volume":"38","author":[{"given":"Lindsay M.","family":"Garvin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse M.","family":"Damsker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary C.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2016.04.004_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/humupd\/5.4.280","article-title":"Mammalian reproductive tract mucins","volume":"5","author":"Lagow","year":"1999","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.pupt.2016.04.004_bib2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI0215217","article-title":"Mucus clearance as a primary innate defense mechanism for mammalian airways","volume":"109","author":"Knowles","year":"2002","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.pupt.2016.04.004_bib3","first-page":"20","article-title":"Mucins: vital components of the mucosal defensive barrier","volume":"3","author":"Corfield","year":"2003","journal-title":"Genomic\/Proteomic Technol."},{"key":"10.1016\/j.pupt.2016.04.004_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00010.2005","article-title":"Respiratory tract mucin genes and mucin glycoproteins in health and disease","volume":"86","author":"Rose","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pupt.2016.04.004_bib5","doi-asserted-by":"crossref","first-page":"L92","DOI":"10.1152\/ajplung.90388.2008","article-title":"Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?","volume":"296","author":"Kesimer","year":"2009","journal-title":"Am. J. Physiol. (Lung Cell Mol. Physiol. )"},{"key":"10.1016\/j.pupt.2016.04.004_bib6","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMra0910061","article-title":"Airway mucus function and dysfunction","volume":"363","author":"Fahy","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.pupt.2016.04.004_bib7","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1126\/science.1223012","article-title":"A\u00a0periciliary brush promotes the lung health by separating the mucus layer from airway epithelia","volume":"337","author":"Button","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.pupt.2016.04.004_bib8","first-page":"111","article-title":"The viscoelasticity of fractionated canine tracheal mucus","volume":"11","author":"Litt","year":"1974","journal-title":"Biorheology"},{"key":"10.1016\/j.pupt.2016.04.004_bib9","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1021\/bi00585a029","article-title":"Resolution of the major components of human lung mucosal gel and their capabilities for reaggregation and gel formation","volume":"18","author":"Rose","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.pupt.2016.04.004_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/bj3610537","article-title":"Heterogeneity of airway mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B","volume":"361","author":"Kirkham","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.pupt.2016.04.004_bib11","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1165\/ajrcmb.17.5.2798","article-title":"Developmental expression of mucin genes in the human respiratory tract","volume":"17","author":"Reid","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib12","doi-asserted-by":"crossref","first-page":"16528","DOI":"10.1073\/pnas.1206552109","article-title":"Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs","volume":"109","author":"Ehre","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pupt.2016.04.004_bib13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nature12807","article-title":"Muc5b Is required for airway defence","volume":"505","author":"Roy","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2016.04.004_bib14","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1038\/ncomms7281","article-title":"The polymeric mucin Muc5ac is required for allergic airway hyperreactivity","volume":"6","author":"Evans","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pupt.2016.04.004_bib15","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1164\/ajrccm.153.5.8630597","article-title":"Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity","volume":"153","author":"Vestbo","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2016.04.004_bib16","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1183\/09031936.97.10081914","article-title":"Lung mucus: a clinician's view","volume":"10","author":"Kim","year":"1997","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2016.04.004_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/0470868678.ch5","article-title":"Mucus hypersecretion in chronic obstructive pulmonary diseases","volume":"234","author":"Rogers","year":"2001","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.pupt.2016.04.004_bib18","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1172\/JCI73469","article-title":"Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure","volume":"124","author":"Henderson","year":"2014","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.pupt.2016.04.004_bib19","doi-asserted-by":"crossref","first-page":"a009589","DOI":"10.1101\/cshperspect.a009589","article-title":"CFTR, mucins, and mucus obstruction in cystic fibrosis","volume":"2","author":"Kreda","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.pupt.2016.04.004_bib20","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bbrc.2004.09.157","article-title":"Nontypeable haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent P38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-KappaB signaling pathways","volume":"324","author":"Chen","year":"2004","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"10.1016\/j.pupt.2016.04.004_bib21","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.4049\/jimmunol.0900614","article-title":"Regulation of airway MUC5AC expression by IL-1b and IL-17A; the NF-KB paradigm","volume":"183","author":"Fujisawa","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.pupt.2016.04.004_bib22","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1183\/09031936.00026910","article-title":"Rhinovirus induces MUC5AC in a human infection model and in\u00a0vitro via NF-KappaB and EGFR pathways","volume":"36","author":"Hewson","year":"2010","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2016.04.004_bib23","doi-asserted-by":"crossref","first-page":"L797","DOI":"10.1152\/ajplung.00347.2013","article-title":"IL-1beta induction of MUC5AC gene expression is mediated by CREB and NF-KappaB and repressed by dexamethasone","volume":"306","author":"Chen","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.pupt.2016.04.004_bib24","doi-asserted-by":"crossref","first-page":"23243","DOI":"10.1074\/jbc.M300096200","article-title":"Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK\/P38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells","volume":"278","author":"Song","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pupt.2016.04.004_bib25","doi-asserted-by":"crossref","first-page":"26869","DOI":"10.1074\/jbc.M802507200","article-title":"CAMP-responding element-binding protein and C-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression","volume":"283","author":"Song","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pupt.2016.04.004_bib26","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.0713637","article-title":"CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression","volume":"182","author":"Chung","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.pupt.2016.04.004_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/mi.2011.67","article-title":"C-Ets1 inhibits the interaction of NF-KappaB and CREB, and downregulates IL-1beta-induced MUC5AC overproduction during airway inflammation","volume":"5","author":"Song","year":"2012","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.pupt.2016.04.004_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jmb.2004.09.059","article-title":"PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF\/TGF-alpha, Ras\/Raf, MEK, ERK and Sp1-dependent mechanisms","volume":"344","author":"Hewson","year":"2004","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib29","first-page":"L484","article-title":"Dexamethasone suppresses mucus production and MUC2 and MUC5AC gene expression by NCI-H292 Cells","volume":"271","author":"Kai","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.pupt.2016.04.004_bib30","doi-asserted-by":"crossref","first-page":"L52","DOI":"10.1152\/ajplung.00104.2004","article-title":"Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells","volume":"288","author":"Lu","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.pupt.2016.04.004_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/rcmb.2005-0176OC","article-title":"Dexmethasone-mediated repression of MUC5AC mucin gene expression in human lung epithelial cells","volume":"34","author":"Chen","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib32","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1165\/rcmb.2012-0009OC","article-title":"Glucocorticoid receptor and histone deacetylase-2 mediate dexamethasone-induced repression of MUC5AC gene expression","volume":"47","author":"Chen","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.pupt.2016.04.004_bib34","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1253\/jcj.43.1043","article-title":"Experimental study of cardiomyopathy induced by glucocorticoids","volume":"43","author":"Ito","year":"1979","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.pupt.2016.04.004_bib35","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1001\/jama.1993.03500160080036","article-title":"Side effects of glucocorticoid treatment. experience of the optic neuritis treatment trial","volume":"269","author":"Chrousos","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.pupt.2016.04.004_bib36","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jama.1997.03540330044033","article-title":"Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucoma","volume":"277","author":"Garbe","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.pupt.2016.04.004_bib37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1350-9462(98)00035-4","article-title":"Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma","volume":"18","author":"Wordinger","year":"1999","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.pupt.2016.04.004_bib38","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/mpo.10339","article-title":"Effect of glucocorticoids on bone density","volume":"41","author":"Rehman","year":"2003","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.pupt.2016.04.004_bib39","first-page":"CD003725","article-title":"Glucocorticoid corticosteroids for duchenne muscular dystrophy","author":"Manzur","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.pupt.2016.04.004_bib40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jsbmb.2010.02.027","article-title":"Selective glucocorticoid receptor modulators","volume":"120","author":"DeBosscher","year":"2010","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0163-7258(02)00297-8","article-title":"Mechanisms involved in the side effects of glucocorticoids","volume":"96","author":"Schacke","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.pupt.2016.04.004_bib42","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids\u2013new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.pupt.2016.04.004_bib43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1124\/jpet.112.194340","article-title":"Delta-9,11 modification of glucocorticoids dissociates nuclear factor-kappab inhibitory efficacy from glucocorticoid response element-associated side effects","volume":"343","author":"Baudy","year":"2012","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pupt.2016.04.004_bib44","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.bmc.2013.02.009","article-title":"VBP15: preclinical characterization of a novel Anti-inflammatory delta 9,11 steroid","volume":"21","author":"Reeves","year":"2013","journal-title":"Bioorg Med. Chem."},{"key":"10.1016\/j.pupt.2016.04.004_bib45","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/emmm.201302621","article-title":"VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects","volume":"5","author":"Heier","year":"2013","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"10.1016\/j.pupt.2016.04.004_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-014-0133-y","article-title":"VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis","volume":"35","author":"Dillingham","year":"2015","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.pupt.2016.04.004_bib47","doi-asserted-by":"crossref","first-page":"e63871","DOI":"10.1371\/journal.pone.0063871","article-title":"VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice","volume":"8","author":"Damsker","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pupt.2016.04.004_bib48","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1165\/ajrcmb.20.3.3383","article-title":"Respiratory carcinoma cell lines: MUC genes and glycoconjugates","volume":"20","author":"Berger","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib49","first-page":"612","article-title":"Human respiratory mucus","volume":"134","author":"Kaliner","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.pupt.2016.04.004_bib50","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1111\/j.1432-1033.2004.04342.x","article-title":"Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release","volume":"271","author":"Chivers","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.pupt.2016.04.004_bib51","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1073\/pnas.81.14.4275","article-title":"Detecting protein-DNA interactions in\u00a0vivo: distribution of RNA polymerase on specific bacterial genes","volume":"81","author":"Gilmour","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pupt.2016.04.004_bib52","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-KappaB or activator protein-1: molecular mechanisms for gene repression","volume":"24","author":"DeBosscher","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.pupt.2016.04.004_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0092-8674(02)00817-6","article-title":"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition","volume":"110","author":"Bledsoe","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2016.04.004_bib54","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0022-4731(89)90521-9","article-title":"DNA regulatory elements for steroid hormones","volume":"32","author":"Beato","year":"1989","journal-title":"J.\u00a0Steroid Biochem."},{"key":"10.1016\/j.pupt.2016.04.004_bib55","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1128\/MCB.20.12.4328-4339.2000","article-title":"Novel mechanism of steroid action in skin through glucocorticoid receptor monomers","volume":"20","author":"Radoja","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/j.1460-2075.1993.tb05640.x","article-title":"Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene","volume":"12","author":"Drouin","year":"1993","journal-title":"EMBO"},{"key":"10.1016\/j.pupt.2016.04.004_bib57","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1073\/pnas.91.2.752","article-title":"Physical association and functional antagonism between the P65 subunit of transcription factor NF-Kappa B and the glucocorticoid receptor","volume":"91","author":"Ray","year":"1994","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pupt.2016.04.004_bib58","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.270.5234.283","article-title":"Role of transcriptional activation of I Kappa B alpha in mediation of immunosuppression by glucocorticoids","volume":"270","author":"Scheinman","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.pupt.2016.04.004_bib59","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.270.5234.286","article-title":"Immunosuppression by glucocorticoids: inhibition of NF-Kappa B activity through induction of I Kappa B synthesis","volume":"270","author":"Auphan","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.pupt.2016.04.004_bib60","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1089\/dna.1997.16.919","article-title":"Glucocorticoid-dependent transcriptional repression of the osteocalcin gene by competitive binding at the TATA box","volume":"16","author":"Meyer","year":"1997","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib61","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.4049\/jimmunol.159.11.5450","article-title":"Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-KappaB-mediated transcription","volume":"159","author":"Parry","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.pupt.2016.04.004_bib62","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1073\/pnas.95.5.2122","article-title":"CREB-binding protein in androgen receptor-mediated signaling","volume":"95","author":"Aarnisalo","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pupt.2016.04.004_bib63","doi-asserted-by":"crossref","first-page":"31853","DOI":"10.1074\/jbc.273.48.31853","article-title":"CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1","volume":"273","author":"Fronsdal","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pupt.2016.04.004_bib64","doi-asserted-by":"crossref","first-page":"36865","DOI":"10.1074\/jbc.R100041200","article-title":"Coregulator codes of transcriptional regulation by nuclear receptors","volume":"276","author":"Rosenfeld","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pupt.2016.04.004_bib65","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0092-8674(02)00641-4","article-title":"Combinatorial control of gene expression by nuclear receptors and coregulators","volume":"108","author":"McKenna","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.pupt.2016.04.004_bib66","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0014-2999(01)01332-2","article-title":"Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation","volume":"429","author":"Kagoshima","year":"2001","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.pupt.2016.04.004_bib67","doi-asserted-by":"crossref","first-page":"32423","DOI":"10.1074\/jbc.C100315200","article-title":"Steroid hormone receptor-mediated histone deacetylation and transcription at the mouse mammary tumor virus promoter","volume":"276","author":"Sheldon","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.pupt.2016.04.004_bib68","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1091\/mbc.e08-02-0123","article-title":"Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter","volume":"19","author":"Johnson","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.pupt.2016.04.004_bib69","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1165\/rcmb.2009-0313OC","article-title":"NF-{Kappa}B mediates IL-1ss- and IL-17A-induced MUC5B expression in the airway epithelial cells","volume":"45","author":"Fujisawa","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2016.04.004_bib70","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.4049\/jimmunol.0803022","article-title":"Interleukin-8 regulates mucin gene expression at the post-transcriptional level in lung epithelial cells","volume":"183","author":"Bautista","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.pupt.2016.04.004_bib71","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.2174\/1381612043383601","article-title":"Negative glucocorticoid receptor response elements and their role in glucocorticoid action","volume":"10","author":"Dostert","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.pupt.2016.04.004_bib72","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1096\/fj.05-5457com","article-title":"Competition between glucocorticoid receptor and NFkappaB for control of the human FasL promoter","volume":"20","author":"Novac","year":"2006","journal-title":"Faseb J."},{"key":"10.1016\/j.pupt.2016.04.004_bib73","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1210\/me.2010-0073","article-title":"The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP\/P300 during ultradian ligand treatment","volume":"25","author":"Conway-Campbell","year":"2011","journal-title":"Mol. Endocrinol."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916300256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916300256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:38:39Z","timestamp":1778798319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553916300256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":73,"alternative-id":["S1094553916300256"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2016.04.004","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel dissociative steroid VBP15 reduces MUC5AC gene expression in airway epithelial cells but lacks the GRE mediated transcriptional properties of dexamethasone","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2016.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}