{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:40:33Z","timestamp":1773297633513,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Taichung Hospital, Ministry of Health and Welfare","award":["98-02"],"award-info":[{"award-number":["98-02"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.pupt.2016.06.002","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T09:42:59Z","timestamp":1467020579000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Activation of cannabinoid CB1 receptors suppresses the ROS-induced hypersensitivity of rat vagal lung C-fiber afferents"],"prefix":"10.1016","volume":"40","author":[{"given":"Chou-Ming","family":"Yeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien-Huan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2016.06.002_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.coph.2009.02.002","article-title":"Role of TRPV1 in inflammation-induced airway hypersensitivity","volume":"9","author":"Lee","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.pupt.2016.06.002_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.resp.2011.03.004","article-title":"Airway inflammation and hypersensitivity induced by chronic smoking","volume":"178","author":"Kou","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/thorax.55.8.643","article-title":"Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease","volume":"55","author":"Doherty","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2016.06.002_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1749-6632.2010.05562.x","article-title":"The role of oxidative stress in the pathogenesis and treatment of asthma","volume":"1203","author":"Dozor","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.pupt.2016.06.002_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/ACI.0b013e3282f3d913","article-title":"Importance of oxidative stress in the pathogenesis and treatment of asthma","volume":"8","author":"Riedl","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.pupt.2016.06.002_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0034-5687(00)00204-8","article-title":"Afferent properties and reflex functions of bronchopulmonary C-fibers","volume":"125","author":"Lee","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib7","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1152\/japplphysiol.00222.2006","article-title":"Transduction mechanisms in airway sensory nerves","volume":"101","author":"Taylor-Clark","year":"2006","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1094-5539(02)00178-5","article-title":"Overview of neural pathways in allergy and asthma","volume":"16","author":"Widdicombe","year":"2003","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.pupt.2016.06.002_bib9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1152\/japplphysiol.01099.2007","article-title":"Ovalbumin sensitizes vagal pulmonary C-fiber afferents in Brown Norway rats","volume":"105","author":"Kuo","year":"2008","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1152\/japplphysiol.01367.2007","article-title":"Sensitizing effects of chronic exposure and acute inhalation of ovalbumin aerosol on pulmonary C fibers in rats","volume":"105","author":"Zhang","year":"2008","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib11","doi-asserted-by":"crossref","first-page":"R1175","DOI":"10.1152\/ajpregu.00227.2012","article-title":"Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1","volume":"303","author":"Shen","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib12","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1152\/japplphysiol.91517.2008","article-title":"Role of ATP in the ROS-mediated laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats","volume":"106","author":"Tsai","year":"2009","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1152\/japplphysiol.00064.2006","article-title":"Neural and hydroxyl radical mechanisms underlying laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats","volume":"101","author":"Tsai","year":"2006","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib14","doi-asserted-by":"crossref","first-page":"e91763","DOI":"10.1371\/journal.pone.0091763","article-title":"Sensitization by pulmonary reactive oxygen species of rat vagal lung C-fibers: the roles of the TRPV1, TRPA1, and P2X receptors","volume":"9","author":"Ruan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pupt.2016.06.002_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1124\/pr.110.003491","article-title":"The highs and lows of cannabinoid receptor expression in disease: mechanisms and their therapeutic implications","volume":"63","author":"Miller","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.pupt.2016.06.002_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pharmthera.2009.01.005","article-title":"The therapeutic potential of novel cannabinoid receptors","volume":"122","author":"Kreitzer","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.pupt.2016.06.002_bib17","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nn1916","article-title":"Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors","volume":"10","author":"Agarwal","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pupt.2016.06.002_bib18","first-page":"956","article-title":"Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat","volume":"192","author":"Aizawa","year":"2014","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.pupt.2016.06.002_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroscience.2013.05.003","article-title":"The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain","volume":"247","author":"Uhelski","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.pupt.2016.06.002_bib20","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1046\/j.1460-9568.2000.00101.x","article-title":"Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats","volume":"12","author":"Drew","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pupt.2016.06.002_bib21","doi-asserted-by":"crossref","first-page":"11593","DOI":"10.1523\/JNEUROSCI.3322-08.2008","article-title":"Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists","volume":"28","author":"Fioravanti","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.pupt.2016.06.002_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.pain.2006.04.001","article-title":"Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist","volume":"124","author":"Amaya","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.pupt.2016.06.002_bib23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.pain.2004.02.020","article-title":"Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury","volume":"109","author":"Johanek","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.pupt.2016.06.002_bib24","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1152\/jn.00886.2003","article-title":"Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation","volume":"92","author":"Nackley","year":"2004","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000283042","article-title":"The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways","volume":"152","author":"Fukuda","year":"2010","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.pupt.2016.06.002_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000087361","article-title":"Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways","volume":"138","author":"Yoshihara","year":"2005","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.pupt.2016.06.002_bib27","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1164\/rccm.200306-775OC","article-title":"Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways","volume":"170","author":"Yoshihara","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2016.06.002_bib28","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.bjp.0705435","article-title":"Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation","volume":"140","author":"Patel","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pupt.2016.06.002_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/35040576","article-title":"Bidirectional control of airway responsiveness by endogenous cannabinoids","volume":"408","author":"Calignano","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2016.06.002_bib30","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2174\/138945012800675786","article-title":"The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke","volume":"13","author":"Pini","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.pupt.2016.06.002_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.pupt.2013.02.002","article-title":"The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig","volume":"26","author":"Dud\u00e1\u0161ov\u00e1","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.pupt.2016.06.002_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/1479972310391283","article-title":"Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety","volume":"8","author":"Pickering","year":"2011","journal-title":"Chron. Respir. Dis."},{"key":"10.1016\/j.pupt.2016.06.002_bib33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/sj.bjp.0705422","article-title":"Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetised rats","volume":"140","author":"Padley","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pupt.2016.06.002_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/japplphysiol.00977.2012","article-title":"Perivagal antagonist treatment in rats selectively blocks the reflex and afferent responses of vagal lung C fibers to intravenous agonists","volume":"114","author":"Lin","year":"2013","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib35","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1113\/jphysiol.2005.086181","article-title":"Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats","volume":"565","author":"Ruan","year":"2005","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib36","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/physrev.00004.2003","article-title":"Role of endogenous cannabinoids in synaptic signaling","volume":"83","author":"Freund","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pupt.2016.06.002_bib37","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1073\/pnas.89.9.3825","article-title":"Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells","volume":"89","author":"Mackie","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pupt.2016.06.002_bib38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2170\/jjphysiol.36.225","article-title":"Axonal transport of radiolabeled materials in afferent fibers of rabbit vagus nerve following supranodose vagotomy","volume":"36","author":"Sato","year":"1986","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.pupt.2016.06.002_bib39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pneurobio.2009.11.004","article-title":"Fast intra-axonal transport: beginning, development and post-genome advances","volume":"90","author":"Dahlstrom","year":"2010","journal-title":"Prog. Neurobiol."}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916300426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916300426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T19:25:21Z","timestamp":1536607521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553916300426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":39,"alternative-id":["S1094553916300426"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2016.06.002","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of cannabinoid CB1 receptors suppresses the ROS-induced hypersensitivity of rat vagal lung C-fiber afferents","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2016.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}