{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:24:42Z","timestamp":1790504682126,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.pupt.2016.06.007","type":"journal-article","created":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T03:53:33Z","timestamp":1466913213000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Nefopam, a non-opioid analgesic, does not alleviate experimental work\/effort dyspnoea in healthy humans: A randomised controlled trial"],"prefix":"10.1016","volume":"39","author":[{"given":"Laurence","family":"Dangers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Laviolette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9ny","family":"Charbit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Mor\u00e9lot-Panzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.pupt.2016.06.007_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1164\/rccm.201111-2042ST","article-title":"An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea","volume":"185","author":"Parshall","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"8","key":"10.1016\/j.pupt.2016.06.007_bib2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1164\/rccm.201101-0005OC","article-title":"Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response","volume":"184","author":"Banzett","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7414","key":"10.1016\/j.pupt.2016.06.007_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/bmj.327.7414.523","article-title":"Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea","volume":"327","author":"Abernethy","year":"2003","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.pupt.2016.06.007_bib4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1089\/jpm.2012.0591","article-title":"The longitudinal pattern of response when morphine is used to treat chronic refractory dyspnea","volume":"16","author":"Currow","year":"2013","journal-title":"J.\u00a0Palliat. Med."},{"issue":"10","key":"10.1016\/j.pupt.2016.06.007_bib5","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1097\/00001756-200007140-00012","article-title":"Breathlessness in humans activates insular cortex","volume":"11","author":"Banzett","year":"2000","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.pupt.2016.06.007_bib6","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1152\/jn.2002.88.3.1500","article-title":"BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger","volume":"88","author":"Evans","year":"2002","journal-title":"J.\u00a0Neurophysiol."},{"issue":"1","key":"10.1016\/j.pupt.2016.06.007_bib7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuroimage.2009.06.015","article-title":"Dyspnea and pain share emotion-related brain network","volume":"48","author":"von Leupoldt","year":"2009","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.pupt.2016.06.007_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/BF00599245","article-title":"A\u00a0selective suppression of human pain sensitivity by carbon dioxide: central mechanisms implicated","volume":"68","author":"Gronroos","year":"1994","journal-title":"Eur. J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0006-8993(90)91416-E","article-title":"Hypercapnia depresses nociception: endogenous opioids implicated","volume":"514","author":"Gamble","year":"1990","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib10","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1152\/jn.00116.2006","article-title":"Dyspnea as a noxious sensation: inspiratory threshold loading may trigger diffuse noxious inhibitory controls in humans","volume":"97","author":"Morelot-Panzini","year":"2007","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.pupt.2016.06.007_bib11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.1987.sp016658","article-title":"Heterotopic activation of A delta and C fibres triggers inhibition of trigeminal and spinal convergent neurones in the rat","volume":"389","author":"Bouhassira","year":"1987","journal-title":"J.\u00a0Physiol. (Lond.)"},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000186050","article-title":"Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents","volume":"83","author":"Verleye","year":"2009","journal-title":"Pharmacology"},{"issue":"1","key":"10.1016\/j.pupt.2016.06.007_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.rmed.2014.11.001","article-title":"Cough reduction using capsaicin","volume":"109","author":"Ternesten-Hasseus","year":"2015","journal-title":"Respir. Med."},{"issue":"4","key":"10.1016\/j.pupt.2016.06.007_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2165\/00003495-198019040-00001","article-title":"Nefopam: a review of its pharmacological properties and therapeutic efficacy","volume":"19","author":"Heel","year":"1980","journal-title":"Drugs"},{"issue":"1\u20132","key":"10.1016\/j.pupt.2016.06.007_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0304-3959(98)00238-3","article-title":"Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans","volume":"80","author":"Guirimand","year":"1999","journal-title":"Pain"},{"issue":"1\u20132","key":"10.1016\/j.pupt.2016.06.007_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(02)01418-8","article-title":"Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat","volume":"441","author":"Buritova","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.pupt.2016.06.007_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1213\/01.ANE.0000138037.19757.ED","article-title":"Nefopam and ketamine comparably enhance postoperative analgesia","volume":"100","author":"Kapfer","year":"2005","journal-title":"Anesth. Analg."},{"issue":"12","key":"10.1016\/j.pupt.2016.06.007_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/00003643-200312000-00013","article-title":"Morphine-sparing effect of nefopam by continuous intravenous injection after abdominal surgery by laparotomy","volume":"20","author":"Tramoni","year":"2003","journal-title":"Eur. J. Anaesthesiol."},{"issue":"6","key":"10.1016\/j.pupt.2016.06.007_bib19","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/bja\/aeg264","article-title":"Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery","volume":"91","author":"Du Manoir","year":"2003","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0014-2999(91)90695-M","article-title":"Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound","volume":"204","author":"Ohkubo","year":"1991","journal-title":"Eur. J. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.pupt.2016.06.007_bib21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-2999(98)00837-1","article-title":"The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception","volume":"365","author":"Gray","year":"1999","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/cpt1975182175","article-title":"Respiratory effects of nefopam","volume":"18","author":"Gasser","year":"1975","journal-title":"Clin. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.pupt.2016.06.007_bib23","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1152\/japplphysiol.01055.2011","article-title":"Dyspnea-pain counterirritation induced by inspiratory threshold loading: a laser-evoked potentials study","volume":"112","author":"Bouvier","year":"2012","journal-title":"J.\u00a0Appl. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.pupt.2016.06.007_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pain.2009.06.018","article-title":"Excitatory and inhibitory pain mechanisms during the menstrual cycle in healthy women","volume":"146","author":"Tousignant-Laflamme","year":"2009","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.pupt.2016.06.007_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pain.2007.04.026","article-title":"Peripheral and central components of habituation of heat pain perception and evoked potentials in humans","volume":"132","author":"Greffrath","year":"2007","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.pupt.2016.06.007_bib26","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1469-8986.1995.tb01229.x","article-title":"Somatosensory responses during selective spatial attention: the N120-to-N140 transition","volume":"32","author":"Garcia-Larrea","year":"1995","journal-title":"Psychophysiology"},{"issue":"6","key":"10.1016\/j.pupt.2016.06.007_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1034\/j.1600-0773.2003.920605.x","article-title":"Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers","volume":"92","author":"Aymard","year":"2003","journal-title":"Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00007691-200304000-00010","article-title":"Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam","volume":"25","author":"Chawla","year":"2003","journal-title":"Ther. Drug Monit."},{"issue":"6","key":"10.1016\/j.pupt.2016.06.007_bib29","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1183\/09031936.00038914","article-title":"Multidimensional Dyspnea Profile: an instrument for clinical and laboratory research","volume":"45","author":"Banzett","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejpain.2009.05.001","article-title":"Laser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugs","volume":"14","author":"Truini","year":"2010","journal-title":"Eur. J. Pain"},{"issue":"4","key":"10.1016\/j.pupt.2016.06.007_bib31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3344\/kjp.2014.27.4.326","article-title":"Effects of nefopam on streptozotocin-induced diabetic neuropathic pain in rats","volume":"27","author":"Nam","year":"2014","journal-title":"Korean J. Pain"},{"issue":"3","key":"10.1016\/j.pupt.2016.06.007_bib32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF00315203","article-title":"Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine\u2013a quantitative evaluation by laser induced pain","volume":"40","author":"Arendt-Nielsen","year":"1991","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-0270(88)90054-4","article-title":"Selective averaging of argon laser induced pre-pain and pain related cortical responses","volume":"24","author":"Arendt-Nielsen","year":"1988","journal-title":"J.\u00a0Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.pupt.2016.06.007_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/204946370900300205","article-title":"Placebo analgesia \u2013 understanding the mechanisms and implications for clinical practice","volume":"3","author":"Finniss","year":"2009","journal-title":"Rev. Pain"},{"issue":"3","key":"10.1016\/j.pupt.2016.06.007_bib35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbi.2006.01.007","article-title":"Placebo effects in laser-evoked pain potentials","volume":"20","author":"Wager","year":"2006","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.pupt.2016.06.007_bib36","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1152\/japplphysiol.00027.2013","article-title":"Intravenous adenosine activates diffuse nociceptive inhibitory controls in humans","volume":"115","author":"Morelot-Panzini","year":"2013","journal-title":"J.\u00a0Appl. Physiol."},{"issue":"1","key":"10.1016\/j.pupt.2016.06.007_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1440-1681.12506","article-title":"Nefopam analgesia and its role in multimodal analgesia: a review of preclinical and clinical studies","volume":"43","author":"Girard","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"2\u20133","key":"10.1016\/j.pupt.2016.06.007_bib38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejphar.2008.02.012","article-title":"Nefopam and ketoprofen synergy in rodent models of antinociception","volume":"584","author":"Girard","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.pupt.2016.06.007_bib39","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1440-1681.2011.05477.x","article-title":"Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception","volume":"38","author":"Girard","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"4","key":"10.1016\/j.pupt.2016.06.007_bib40","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.pbb.2004.01.018","article-title":"Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat","volume":"77","author":"Girard","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.pupt.2016.06.007_bib41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/thoraxjnl-2013-204701","article-title":"The active identification and management of chronic refractory breathlessness is a human right","volume":"69","author":"Currow","year":"2014","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.pupt.2016.06.007_bib42","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1183\/13993003.00653-2015","article-title":"The need to research refractory breathlessness","volume":"47","author":"Currow","year":"2016","journal-title":"Eur. Respir. J."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916300475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916300475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T06:19:35Z","timestamp":1568096375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553916300475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":42,"alternative-id":["S1094553916300475"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2016.06.007","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nefopam, a non-opioid analgesic, does not alleviate experimental work\/effort dyspnoea in healthy humans: A randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2016.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}