{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:36:19Z","timestamp":1789209379850,"version":"build-2803163510"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.pupt.2017.02.004","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T10:30:17Z","timestamp":1487673017000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Methacholine challenge tests to demonstrate therapeutic equivalence of terbutaline sulfate via different Turbuhaler \u00ae devices in patients with mild to moderate asthma: Appraisal of a four-way crossover design"],"prefix":"10.1016","volume":"44","author":[{"given":"Leif","family":"Bjermer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail M.","family":"Gauvreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirkje S.","family":"Postma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"O'Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"van den Berge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis-Philippe","family":"Boulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Beckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tore","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2214-3569","authenticated-orcid":false,"given":"Jonas","family":"Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Carlholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-2989","authenticated-orcid":false,"given":"Kajs-Marie","family":"Sch\u00fctzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Eckerwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2017.02.004_bib1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1164\/ajrccm.160.4.9806101","article-title":"Therapeutic equivalence of Spiros dry powder inhaler and Ventolin metered dose inhaler. A bioassay using methacholine","volume":"160","author":"Ahrens","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.02.004_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0091-6749(79)90125-8","article-title":"Bronchial responsiveness to inhaled histamine and exercise","volume":"63","author":"Anderton","year":"1979","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.pupt.2017.02.004_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2222.1977.tb01448.x","article-title":"Bronchial reactivity to inhaled histamine: a method and clinical survey","volume":"7","author":"Cockcroft","year":"1977","journal-title":"Clin. Allergy"},{"key":"10.1016\/j.pupt.2017.02.004_bib4","unstructured":"European Medicines Agency Committee for Medicinal Products for Human Use (CHMP). Guideline on the requirements for clinical documentation for orally inhaled products (OIP) including the requirements for demonstration of therapeutic equivalence between two inhaled products for use in the treatment of asthma and chronic obstructive pulmonary disease (COPD) in adults and for use in the treatment of asthma in children and adolescents. London: European Medicines Agency. CHMP; 22 January 2009.. Doc Ref.\u00a0CPMP\/EWP\/4151\/00 Rev1. Available from http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500003504.pdf."},{"key":"10.1016\/j.pupt.2017.02.004_bib5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/thx.52.11.975","article-title":"Dose equivalence and bronchoprotective effects of salmeterol and salbutamol in asthma","volume":"52","author":"Higham","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2017.02.004_bib6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/thx.36.8.575","article-title":"Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma","volume":"36","author":"Juniper","year":"1981","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2017.02.004_bib7","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1183\/09031936.97.10112474","article-title":"Differences in bronchodilating potency of salbutamol in Turbuhaler as compared with a pressurized metered-dose inhaler formulation in patients with reversible airway obstruction","volume":"10","author":"Lofdahl","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2017.02.004_bib8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.20452\/pamw.825","article-title":"Clinical equivalence testing of inhaled bronchodilators","volume":"119","author":"Nair","year":"2009","journal-title":"Pol. Arch. Med. Wewnetrznej"},{"key":"10.1016\/j.pupt.2017.02.004_bib9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1183\/09031936.03.00045902","article-title":"Protection against methacholine-induced bronchospasm: salbutamol pMDI versus Clickhaler DPI","volume":"21","author":"Newhouse","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2017.02.004_bib10","first-page":"281","article-title":"Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to methacholine","volume":"125","author":"O'Byrne","year":"1982","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.pupt.2017.02.004_bib11","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1164\/ajrccm.160.1.9812035","article-title":"Protection against methacholine bronchoconstriction to assess relative potency of inhaled beta2-agonist","volume":"160","author":"Parameswaran","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.02.004_bib12","first-page":"674","article-title":"Establishing equivalence or non-inferiority in clinical trials: Part 20 of a series on evaluation of scientific publications","volume":"109","author":"Wellek","year":"2012","journal-title":"Dtsch. Arztebl Int."},{"key":"10.1016\/j.pupt.2017.02.004_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1155\/1998\/865042","article-title":"Dose-response protective effect of salbutamol on methacholine airway responsiveness using pressurized metered dose inhalers and Turbuhalers","volume":"5","author":"Wong","year":"1998","journal-title":"Can. Respir. J."}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916301559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916301559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T14:55:14Z","timestamp":1749999314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553916301559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":13,"alternative-id":["S1094553916301559"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2017.02.004","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methacholine challenge tests to demonstrate therapeutic equivalence of terbutaline sulfate via different Turbuhaler\u00ae devices in patients with mild to moderate asthma: Appraisal of a four-way crossover design","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2017.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}