{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:59:15Z","timestamp":1768870755485,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.pupt.2017.03.002","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T18:18:38Z","timestamp":1488910718000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-3639","authenticated-orcid":false,"given":"G.","family":"Rialp Cervera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Raurich Puigdevall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Mor\u00e1n Chorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-4594","authenticated-orcid":false,"given":"M.C.","family":"Mart\u00edn Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Heras la Calle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mas Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Vallverd\u00fa Perapoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2017.03.002_bib1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/00007611-198706000-00016","article-title":"Alkalemia-associated morbidity and mortality in medical and surgical patients","volume":"80","author":"Anderson","year":"1987","journal-title":"South. Med. J."},{"key":"10.1016\/j.pupt.2017.03.002_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/2229-5151.152296","article-title":"Impact of acetazolamide use in severe exacerbation of chronic obstructive pulmonary disease requiring invasive mechanical ventilation","volume":"5","author":"Bahloul","year":"2015","journal-title":"Int.J.Crit Illn.Inj.Sci."},{"key":"10.1016\/j.pupt.2017.03.002_bib3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/15412550903341448","article-title":"Post-hypercapnic alkalosis is associated with ventilator dependence and increased ICU stay","volume":"6","author":"Banga","year":"2009","journal-title":"COPD"},{"key":"10.1016\/j.pupt.2017.03.002_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF01716736","article-title":"Cardiovascular performance and oxyhemoglobin dissociation after acetazolamide in metabolic alkalosis","volume":"8","author":"Berthelsen","year":"1982","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1164\/ajrccm.151.1.7812578","article-title":"d.P. Van, Central apnea index decreases after prolonged treatment with acetazolamide","volume":"151","author":"DeBacker","year":"1995","journal-title":"Am.J.Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1001\/jama.287.3.345","article-title":"Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study","volume":"287","author":"Esteban","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.pupt.2017.03.002_bib7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1001\/jama.2016.0019","article-title":"Effect of acetazolamide vs placebo on duration of invasive mechanical ventilation among patients with chronic obstructive pulmonary disease: a randomized clinical trial","volume":"315","author":"Faisy","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.pupt.2017.03.002_bib8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00134-010-1795-7","article-title":"Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning COPD patients from mechanical ventilation","volume":"36","author":"Faisy","year":"2010","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib9","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1001\/archinte.1972.00320050160023","article-title":"New York heart association classification","volume":"129","author":"Fisher","year":"1972","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib10","series-title":"Estudio Nacional de Vigilancia de Infecci\u00f3n Nosocomial (ENVIN-HELICS). Manual de definiciones y t\u00e9rminos","author":"Grupo de Trabajo de Enfermedades Infecciosas y Sepsis de SEMICYUC","year":"2016"},{"key":"10.1016\/j.pupt.2017.03.002_bib11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/crj.12025","article-title":"Acetazolamide improves oxygenation in patients with respiratory failure and metabolic alkalosis","volume":"7","author":"Gulsvik","year":"2013","journal-title":"Clin. Respir. J."},{"key":"10.1016\/j.pupt.2017.03.002_bib12","doi-asserted-by":"crossref","first-page":"R213","DOI":"10.1186\/cc10448","article-title":"Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patients","volume":"15","author":"Heming","year":"2011","journal-title":"Crit. Care"},{"key":"10.1016\/j.pupt.2017.03.002_bib13","doi-asserted-by":"crossref","first-page":"e86313","DOI":"10.1371\/journal.pone.0086313","article-title":"Population pharmacodynamic modeling and simulation of the respiratory effect of acetazolamide in decompensated COPD patients","volume":"9","author":"Heming","year":"2014","journal-title":"PLoS.One"},{"key":"10.1016\/j.pupt.2017.03.002_bib14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00003246-198012000-00005","article-title":"Incidence of metabolic alkalemia in hospitalized patients","volume":"8","author":"Hodgkin","year":"1980","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1164\/ajrccm.158.3.9802019","article-title":"Pharmacologic treatment of sleep-disordered breathing","volume":"158","author":"Hudgel","year":"1998","journal-title":"Am.J.Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib16","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1164\/rccm.200507-1035OC","article-title":"Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study","volume":"173","author":"Javaheri","year":"2006","journal-title":"Am.J.Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib17","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1378\/chest.81.3.296","article-title":"Compensatory hypoventilation in metabolic alkalosis","volume":"81","author":"Javaheri","year":"1982","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2017.03.002_bib18","first-page":"CD002881","article-title":"Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease","author":"Jones","year":"2001","journal-title":"Cochrane. Database. Syst. Rev."},{"key":"10.1016\/j.pupt.2017.03.002_bib19","first-page":"354","article-title":"Metabolic alkalosis","volume":"46","author":"Khanna","year":"2001","journal-title":"Respir. Care"},{"key":"10.1016\/j.pupt.2017.03.002_bib20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1164\/ajrccm.163.2.9911075","article-title":"Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits","volume":"163","author":"Kiwull-Schone","year":"2001","journal-title":"Am.J.Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1399-6576.1983.tb01946.x","article-title":"Carbon dioxide elimination after acetazolamide in patients with chronic obstructive pulmonary disease and metabolic alkalosis","volume":"27","author":"Krintel","year":"1983","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.pupt.2017.03.002_bib22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00134-015-3649-9","article-title":"Increased serum bicarbonate in critically ill patients: a retrospective analysis","volume":"41","author":"Liborio","year":"2015","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib23","first-page":"455","article-title":"Acetazolamide in the treatment of metabolic alkalosis in critically ill patients","volume":"20","author":"Marik","year":"1991","journal-title":"Heart Lung"},{"key":"10.1016\/j.pupt.2017.03.002_bib24","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1097\/00003246-199907000-00004","article-title":"Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial","volume":"27","author":"Mazur","year":"1999","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib25","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00134-005-2763-5","article-title":"SAPS 3\u2013From evaluation of the patient to evaluation of the intensive care unit. Part 2: development of a prognostic model for hospital mortality at ICU admission","volume":"31","author":"Moreno","year":"2005","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib26","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/cc3970","article-title":"Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients","volume":"10","author":"Moviat","year":"2006","journal-title":"Crit. Care"},{"key":"10.1016\/j.pupt.2017.03.002_bib27","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.amjmed.2005.03.042","article-title":"The obesity hypoventilation syndrome","volume":"118","author":"Olson","year":"2005","journal-title":"Am. J. Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib28","first-page":"1442","article-title":"Hypercapnic respiratory failure in obesity-hypoventilation syndrome: CO(2) response and acetazolamide treatment effects","volume":"55","author":"Raurich","year":"2010","journal-title":"Respir. Care"},{"key":"10.1016\/j.pupt.2017.03.002_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.medin.2013.10.004","article-title":"Respiratory CO2 response depends on plasma bicarbonate concentration in mechanically ventilated patients","volume":"38","author":"Rialp","year":"2014","journal-title":"Med. Intensiva"},{"key":"10.1016\/j.pupt.2017.03.002_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1152\/jappl.1993.74.1.230","article-title":"Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in men","volume":"74","author":"Swenson","year":"1993","journal-title":"J.Appl. Physiol."},{"key":"10.1016\/j.pupt.2017.03.002_bib31","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1164\/ajrccm.160.5.9903088","article-title":"Acetazolamide and breathing. Does a clinical dose alter peripheral and central CO(2) sensitivity?","volume":"160","author":"Teppema","year":"1999","journal-title":"Am.J.Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2170\/jjphysiol.36.511","article-title":"Difference in the effects of acetazolamide and ammonium chloride acidosis on ventilatory responses to CO2 and hypoxia in humans","volume":"36","author":"Tojima","year":"1986","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.pupt.2017.03.002_bib33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am.J.Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related organ failure assessment) score to describe organ dysfunction\/failure. On behalf of the working group on sepsis-related problems of the european society of intensive care medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2017.03.002_bib35","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1183\/09031936.94.07050850","article-title":"Effects of chlormadinone acetate, acetazolamide and oxygen on awake and asleep gas exchange in patients with chronic obstructive pulmonary disease (COPD)","volume":"7","author":"Vos","year":"1994","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2017.03.002_bib36","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1378\/chest.123.5.1450","article-title":"Comparison of acetazolamide and medroxyprogesterone as respiratory stimulants in hypercapnic patients with COPD","volume":"123","author":"Wagenaar","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.pupt.2017.03.002_bib37","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/10408369991239286","article-title":"Metabolic alkalosis in the critically ill","volume":"36","author":"Webster","year":"1999","journal-title":"Crit. Rev.Clin.Lab Sci."},{"key":"10.1016\/j.pupt.2017.03.002_bib38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/archsurg.1972.04180080051009","article-title":"Severe alkalosis in critically ill surgical patients","volume":"105","author":"Wilson","year":"1972","journal-title":"Arch. Surg."}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916302012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553916302012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T14:28:08Z","timestamp":1692714488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553916302012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":38,"alternative-id":["S1094553916302012"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2017.03.002","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2017.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}