{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:40:16Z","timestamp":1792784416170,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100002020","name":"CHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002020","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Denny Hamlin Foundation"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.pupt.2017.11.001","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T22:01:07Z","timestamp":1510264867000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Activating prostaglandin E2 receptor subtype EP4 increases secreted mucin from airway goblet cells"],"prefix":"10.1016","volume":"48","author":[{"given":"Tomohiro","family":"Akaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosaku","family":"Komiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Suzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tamaoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce K.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.pupt.2017.11.001_bib1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nm.2737","article-title":"The airway epithelium in asthma","volume":"18","author":"Lambrecht","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.pupt.2017.11.001_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/ppul.1950262336","article-title":"Histopathology of fatal asthma: drowning in mucus","volume":"S23","author":"Rubin","year":"2001","journal-title":"Pediatr. Pulmonol."},{"issue":"2","key":"10.1016\/j.pupt.2017.11.001_bib3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.08-0412","article-title":"Mucins, mucus, and sputum","volume":"135","author":"Voynow","year":"2009","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.pupt.2017.11.001_bib4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1164\/ajrccm.163.2.2004039","article-title":"Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression","volume":"163","author":"Ordonez","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.pupt.2017.11.001_bib5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1165\/rcmb.2010-0327OC","article-title":"Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells","volume":"45","author":"Tanabe","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.pupt.2017.11.001_bib6","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1165\/rcmb.4682","article-title":"Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium","volume":"27","author":"Kondo","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.pupt.2017.11.001_bib7","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1378\/chest.15-1029","article-title":"Prostanoids in asthma and COPD: actions, dysregulation, and therapeutic opportunities","volume":"148","author":"Zaslona","year":"2015","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.pupt.2017.11.001_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1365-2222.2009.03386.x","article-title":"Prostaglandin E2 and cysteinyl leukotriene concentrations in sputum: association with asthma severity and eosinophilic inflammation","volume":"40","author":"Aggarwal","year":"2010","journal-title":"Clin. Exp. Allergy"},{"issue":"3","key":"10.1016\/j.pupt.2017.11.001_bib9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.pharmthera.2013.03.006","article-title":"E-type prostanoid receptor 4 (EP4) in disease and therapy","volume":"138","author":"Konya","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.pupt.2017.11.001_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pupt.2011.12.012","article-title":"PGE(2) receptor (EP(4)) agonists: potent dilators of human bronchi and future asthma therapy?","volume":"25","author":"Benyahia","year":"2012","journal-title":"Pulmon Pharmacol. Ther."},{"issue":"12","key":"10.1016\/j.pupt.2017.11.001_bib11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1136\/thx.2010.158568","article-title":"EP4 receptor as a new target for bronchodilator therapy","volume":"66","author":"Buckley","year":"2011","journal-title":"Thorax"},{"issue":"8","key":"10.1016\/j.pupt.2017.11.001_bib12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/thoraxjnl-2014-206592","article-title":"Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype","volume":"70","author":"Birrell","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2017.11.001_bib13","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1164\/rccm.200903-0388OC","article-title":"Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy","volume":"180","author":"Maher","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.pupt.2017.11.001_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1124\/mol.66.2.337","article-title":"Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling","volume":"66","author":"Gray","year":"2004","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.pupt.2017.11.001_bib15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1164\/ajrccm.155.2.9032172","article-title":"Phospholipase A2 and arachidonate increase in bronchoalveolar lavage fluid after inhaled antigen challenge in asthmatics","volume":"155","author":"Bowton","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.pupt.2017.11.001_bib16","doi-asserted-by":"crossref","first-page":"L62","DOI":"10.1152\/ajplung.00181.2006","article-title":"Secretory phospholipases A2 stimulate mucus secretion, induce airway inflammation, and produce secretory hyperresponsiveness to neutrophil elastase in ferret trachea","volume":"292","author":"Okamoto","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"6","key":"10.1016\/j.pupt.2017.11.001_bib17","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1378\/chest.14-0258","article-title":"Secretory phospholipases A2 are secreted from ciliated cells and increase mucin and eicosanoid secretion from goblet cells","volume":"147","author":"Tanabe","year":"2015","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.pupt.2017.11.001_bib18","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1183\/09031936.00131606","article-title":"Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-alpha release from human alveolar macrophages","volume":"29","author":"Ratcliffe","year":"2007","journal-title":"Eur. Respir. J."},{"issue":"8","key":"10.1016\/j.pupt.2017.11.001_bib19","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.1074\/jbc.M412722200","article-title":"Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK\/RSK1\/cAMP response element binding protein activation in human airway epithelial cells","volume":"280","author":"Cho","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.pupt.2017.11.001_bib20","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.0713637","article-title":"CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression","volume":"182","author":"Chung","year":"2009","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.pupt.2017.11.001_bib21","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1398-9995.2007.01417.x","article-title":"Variable p-CREB expression depicts different asthma phenotypes","volume":"62","author":"Chiappara","year":"2007","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.pupt.2017.11.001_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1165\/rcmb.2006-0295OC","article-title":"8-iso-PGE2 stimulates anion efflux from airway epithelial cells via the EP4 prostanoid receptor","volume":"38","author":"Joy","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.pupt.2017.11.001_bib23","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.jaci.2006.01.049","article-title":"Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13","volume":"117","author":"Trudeau","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.pupt.2017.11.001_bib24","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/000348940911800714","article-title":"Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats","volume":"118","author":"Hattori","year":"2009","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.pupt.2017.11.001_bib25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12931-014-0100-7","article-title":"Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis\/nasal polyps with and without aspirin hypersensitivity","volume":"15","author":"Machado-Carvalho","year":"2014","journal-title":"Respir. Res."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553917301566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553917301566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T10:11:28Z","timestamp":1719569488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553917301566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":25,"alternative-id":["S1094553917301566"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2017.11.001","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activating prostaglandin E2 receptor subtype EP4 increases secreted mucin from airway goblet cells","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2017.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}