{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:29:38Z","timestamp":1767914978672,"version":"3.49.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u201d (CNPq","award":["300531\/2012-5"],"award-info":[{"award-number":["300531\/2012-5"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u201d (CNPq","award":["470495\/2012-0"],"award-info":[{"award-number":["470495\/2012-0"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Apoio \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ","award":["E-26\/110.575\/2010"],"award-info":[{"award-number":["E-26\/110.575\/2010"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Apoio \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ","award":["E-26\/103.184\/2011"],"award-info":[{"award-number":["E-26\/103.184\/2011"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Apoio \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ","award":["E-26\/112.092\/2012"],"award-info":[{"award-number":["E-26\/112.092\/2012"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Apoio \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ","award":["E-26\/201.450\/2014"],"award-info":[{"award-number":["E-26\/201.450\/2014"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.pupt.2018.04.008","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T22:43:10Z","timestamp":1524609790000},"page":"100-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The role of sphingolipid metabolism disruption on lipopolysaccharide-induced lung injury in mice"],"prefix":"10.1016","volume":"50","author":[{"given":"Renata Tiemi","family":"Okuro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Nascimento","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Vasconcelos","family":"Casquilho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7938-2037","authenticated-orcid":false,"given":"Alcendino","family":"Jardim-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alysson","family":"Roncally-Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia Correa","family":"Atella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-9123","authenticated-orcid":false,"given":"Walter Araujo","family":"Zin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2018.04.008_bib1","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Force","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.pupt.2018.04.008_bib2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1164\/rccm.201609-1773CP","article-title":"Fifty years of research in ARDS: the epidemiology of ARDS: a fiftieth birthday review","volume":"195","author":"Pham","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1152\/ajplung.00338.2002","article-title":"Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis","volume":"284","author":"Bannerman","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.pupt.2018.04.008_bib4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-7091-1511-4_11","article-title":"Sphingolipids in acute lung injury","volume":"216","author":"Uhlig","year":"2013","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.pupt.2018.04.008_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nm977","article-title":"PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide","volume":"10","author":"Goggel","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plipres.2011.11.001","article-title":"Chain length-specific properties of ceramides","volume":"51","author":"Grosch","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.pupt.2018.04.008_bib7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pupt.2012.03.002","article-title":"IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model","volume":"25","author":"von Bismarck","year":"2012","journal-title":"Pulm. Pharmacol. Therapeut."},{"key":"10.1016\/j.pupt.2018.04.008_bib8","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1164\/rccm.200705-752OC","article-title":"Improved pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model","volume":"177","author":"von Bismarck","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1124\/jpet.111.181560","article-title":"Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury","volume":"339","author":"Lin","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.pupt.2018.04.008_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2010.04.005","article-title":"Protective effects of imipramine in murine endotoxin-induced acute lung injury","volume":"638","author":"Yang","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pupt.2018.04.008_bib11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/1753465811406772","article-title":"The role of sphingolipids in respiratory disease","volume":"5","author":"Yang","year":"2011","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.pupt.2018.04.008_bib12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0076-6879(92)09053-6","article-title":"Enzymes of ceramide biosynthesis","volume":"209","author":"Merrill","year":"1992","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.pupt.2018.04.008_bib13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrc1411","article-title":"Biologically active sphingolipids in cancer pathogenesis and treatment","volume":"4","author":"Ogretmen","year":"2004","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.pupt.2018.04.008_bib14","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1152\/ajpregu.00416.2005","article-title":"Physiological and pathophysiological aspects of ceramide","volume":"290","author":"Gulbins","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.pupt.2018.04.008_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.prostaglandins.2010.12.003","article-title":"Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2","volume":"94","author":"Chang","year":"2011","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.pupt.2018.04.008_bib16","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1074\/jbc.M112.419978","article-title":"Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages","volume":"288","author":"Schilling","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pupt.2018.04.008_bib17","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1164\/rccm.200309-1258OC","article-title":"Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury","volume":"169","author":"Peng","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nm1238","article-title":"Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice","volume":"11","author":"Petrache","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/cvr\/cvn349","article-title":"Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction","volume":"82","author":"Cogolludo","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pupt.2018.04.008_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1465-9921-14-96","article-title":"Ceramides: a potential therapeutic target in pulmonary emphysema","volume":"14","author":"Tibboel","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.pupt.2018.04.008_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000315101","article-title":"Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications","volume":"26","author":"Kornhuber","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.pupt.2018.04.008_bib22","doi-asserted-by":"crossref","first-page":"41128","DOI":"10.1074\/jbc.M206747200","article-title":"Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase","volume":"277","author":"Luberto","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pupt.2018.04.008_bib23","doi-asserted-by":"crossref","first-page":"14276","DOI":"10.1021\/ja4059876","article-title":"The chemical basis of serine palmitoyltransferase inhibition by myriocin","volume":"135","author":"Wadsworth","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.pupt.2018.04.008_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.anifeedsci.2007.06.007","article-title":"Fumonisins: toxicokinetics, mechanisms of action and toxicity","volume":"137","author":"Voss","year":"2007","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.pupt.2018.04.008_bib25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1152\/jappl.1992.72.1.302","article-title":"Alveolar pressure measurement in open-chest rats","volume":"72","author":"Saldiva","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.pupt.2018.04.008_bib26","series-title":"Lung Mechanics: an Inverse Modeling Approach","first-page":"15","author":"Bates","year":"2009"},{"key":"10.1016\/j.pupt.2018.04.008_bib27","series-title":"Models of Lung Disease: Microscopy and Structural Methods","author":"Gil","year":"1990"},{"key":"10.1016\/j.pupt.2018.04.008_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev-physiol-021115-105221","article-title":"Ceramide signaling and metabolism in pathophysiological states of the lung","volume":"78","author":"Petrache","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.pupt.2018.04.008_bib29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pharmthera.2006.04.004","article-title":"Bioactive sphingolipids in the modulation of the inflammatory response","volume":"112","author":"El Alwani","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.pupt.2018.04.008_bib30","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.biocel.2013.03.012","article-title":"The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS","volume":"45","author":"Hartmann","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.pupt.2018.04.008_bib31","doi-asserted-by":"crossref","first-page":"27855","DOI":"10.1074\/jbc.R111.254359","article-title":"Many ceramides","volume":"286","author":"Hannun","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pupt.2018.04.008_bib32","doi-asserted-by":"crossref","first-page":"15926","DOI":"10.1038\/srep15926","article-title":"Ceramides and stress signalling intersect with autophagic defects in neurodegenerative Drosophila blue cheese (bchs) mutants","volume":"5","author":"Hebbar","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pupt.2018.04.008_bib33","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/381800a0","article-title":"Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate","volume":"381","author":"Cuvillier","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2018.04.008_bib34","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1164\/rccm.200309-1258OC","article-title":"Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury","volume":"169","author":"Peng","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ymeth.2006.05.004","article-title":"Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry","volume":"39","author":"Bielawski","year":"2006","journal-title":"Methods"},{"key":"10.1016\/j.pupt.2018.04.008_bib36","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1164\/rccm.200804-595SO","article-title":"Sphingolipids in the lungs","volume":"178","author":"Uhlig","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/japplphysiol.00184.2002","article-title":"Alveolar sphingolipids generated in response to TNF-\u03b1 modifies surfactant biophysical activity","volume":"94","author":"Ryan","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.pupt.2018.04.008_bib38","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1084\/jem.186.11.1831","article-title":"Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation","volume":"186","author":"Haimovitz-Friedman","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib39","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1096\/fj.04-2842fje","article-title":"Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis","volume":"19","author":"Claus","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.pupt.2018.04.008_bib40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.abb.2003.08.031","article-title":"Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase","volume":"419","author":"Lightle","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.pupt.2018.04.008_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1165\/rcmb.2010-0019OC","article-title":"An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils","volume":"44","author":"Sitrin","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2018.04.008_bib42","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2174\/138955706777435643","article-title":"Ceramide involvement in apoptosis and apoptotic diseases","volume":"6","author":"Thevissen","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.pupt.2018.04.008_bib43","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1165\/rcmb.2009-0422OC","article-title":"Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury","volume":"44","author":"Filosto","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2018.04.008_bib44","doi-asserted-by":"crossref","first-page":"L125","DOI":"10.1152\/ajplung.00031.2009","article-title":"Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death","volume":"297","author":"Levy","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.pupt.2018.04.008_bib45","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1016\/j.yexcr.2007.04.002","article-title":"Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells","volume":"313","author":"Castillo","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.pupt.2018.04.008_bib46","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/jcp.22611","article-title":"Neutral sphingomyelinase NADPH oxidase reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction","volume":"226","author":"Frazziano","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.pupt.2018.04.008_bib47","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/01.ATV.18.8.1257","article-title":"Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin","volume":"18","author":"Memon","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.pupt.2018.04.008_bib48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1388-1981(03)00059-3","article-title":"Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism","volume":"1632","author":"Hanada","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pupt.2018.04.008_bib49","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1006\/bbrc.1995.1827","article-title":"Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1\/myriocin","volume":"211","author":"Miyake","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pupt.2018.04.008_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005765","article-title":"Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity","volume":"5","author":"Worgall","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pupt.2018.04.008_bib51","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1177\/0300985813480510","article-title":"Use of computed tomography and histopathologic review for lung lesions produced by the interaction between Mycoplasma hyopneumoniae and fumonisin mycotoxins in pigs","volume":"50","author":"Posa","year":"2013","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.pupt.2018.04.008_bib52","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1177\/0960327108099525","article-title":"A review of the toxic effects and mechanisms of action of fumonisin B1","volume":"27","author":"Stockmann-Juvala","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.pupt.2018.04.008_bib53","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/S0024-3205(02)01988-4","article-title":"Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice","volume":"71","author":"He","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.pupt.2018.04.008_bib54","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1124\/jpet.107.131565","article-title":"Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation","volume":"324","author":"Masini","year":"2008","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.pupt.2018.04.008_bib55","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1194\/jlr.M500001-JLR200","article-title":"LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia","volume":"46","author":"Xu","year":"2005","journal-title":"J. Lipid Res."}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553917302699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553917302699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T03:20:08Z","timestamp":1534908008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553917302699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":55,"alternative-id":["S1094553917302699"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2018.04.008","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of sphingolipid metabolism disruption on lipopolysaccharide-induced lung injury in mice","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2018.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}