{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:29:22Z","timestamp":1790040562116,"version":"4.0.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Economic Area Research"},{"name":"NRGS"},{"DOI":"10.13039\/501100004577","name":"Ministry of Agriculture and Agro-Based Industry, Malaysia","doi-asserted-by":"publisher","award":["NRGS\/NH1014D026"],"award-info":[{"award-number":["NRGS\/NH1014D026"]}],"id":[{"id":"10.13039\/501100004577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.pupt.2018.09.008","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T10:32:30Z","timestamp":1537525950000},"page":"39-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction"],"prefix":"10.1016","volume":"53","author":[{"given":"Ibrahim","family":"Sulaiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaishin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norhafizah","family":"Mohtarrudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Chee Woei","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnson","family":"Stanslas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00063198-200003000-00011","article-title":"Recent advances in occupational asthma","volume":"6","author":"Tarlo","year":"2000","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2004.09.015","article-title":"Gene expression profiling in mouse lung following polymeric hexamethylene diisocyanate exposure","volume":"205","author":"Lee","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/toxsci\/kfv120","article-title":"Phosphatidylinositol 3-kinase mediates \u03b2-catenin dysfunction of airway epithelium in a toluene diisocyanate-induced murine asthma model","volume":"147","author":"Yao","year":"2015","journal-title":"Toxicol. Sci."},{"issue":"6","key":"10.1016\/j.pupt.2018.09.008_bib4","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1164\/ajrccm.162.6.2002086","article-title":"Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo","volume":"162","author":"Wisnewski","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2018.09.008_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1155\/2014\/761264","article-title":"Oxidative stress, prooxidants, and antioxidants: the interplay","volume":"2014","author":"Rahal","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.pupt.2018.09.008_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1067\/mai.2002.126780","article-title":"Oxidative stress in allergic respiratory diseases","volume":"110","author":"Bowler","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/ACI.0b013e3282f3d913","article-title":"Importance of oxidative stress in the pathogenesis and treatment of asthma","volume":"8","author":"Riedl","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.pupt.2018.09.008_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2249.2010.04118.x","article-title":"Toluene diisocyanate (TDI) regulates haem oxygenase-1\/ferritin expression: implications for toluene diisocyanate-induced asthma","volume":"160","author":"Kim","year":"2010","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1465-9921-9-6","article-title":"Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells","volume":"9","author":"Kode","year":"2008","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2332\/allergolint.R-07-154","article-title":"The airway epithelium is central to the pathogenesis of asthma","volume":"57","author":"Holgate","year":"2008","journal-title":"Allergol. Int."},{"issue":"6","key":"10.1016\/j.pupt.2018.09.008_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.it.2011.03.004","article-title":"E-cadherin: gatekeeper of airway mucosa and allergic sensitization","volume":"32","author":"Nawijn","year":"2011","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.pupt.2018.09.008_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1139\/Y08-004","article-title":"Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation","volume":"86","author":"de Boer","year":"2008","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.pupt.2018.09.008_bib13","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jaci.2011.05.038","article-title":"Defective epithelial barrier function in asthma","volume":"128","author":"Xiao","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.pupt.2018.09.008_bib14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/thoraxjnl-2011-200606","article-title":"The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation","volume":"67","author":"Post","year":"2012","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3892\/ijmm.2015.2214","article-title":"1,25-Dihydroxyvitamin D3 prevents toluene diisocyanate-induced airway epithelial barrier disruption","volume":"36","author":"Li","year":"2015","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.pupt.2018.09.008_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/all.13045","article-title":"Blockade of \u03b2-catenin signaling attenuates toluene diisocyanate-induced experimental asthma","volume":"72","author":"Yao","year":"2017","journal-title":"Allergy"},{"issue":"8","key":"10.1016\/j.pupt.2018.09.008_bib17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1164\/rccm.200809-1516OC","article-title":"A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-\u03bab pathway","volume":"179","author":"Bao","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.pupt.2018.09.008_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cmi.2009.49","article-title":"Inhibition of NF-kappaB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide","volume":"6","author":"Li","year":"2009","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12038-015-9513-9","article-title":"Andrographolide suppresses epithelial mesenchymal transition by inhibition of MAPK signalling pathway in lens epithelial cells","volume":"40","author":"Kayastha","year":"2015","journal-title":"J. Biosci."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12974-016-0723-3","article-title":"Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK","volume":"13","author":"Wong","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.pupt.2018.09.008_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pharmthera.2017.08.011","article-title":"Oxidative stress and cellular pathways of asthma and inflammation: therapeutic strategies and pharmacological targets","volume":"181","author":"Mishra","year":"2018","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.pupt.2018.09.008_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.envint.2017.09.017","article-title":"Dermal exposure to toluene diisocyanate and respiratory cancer risk","volume":"109","author":"Prueitt","year":"2017","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-3083.2009.02263.x","article-title":"Immunological determinants in a mouse model of chemical-induced asthma after multiple exposures","volume":"70","author":"Vanoirbeek","year":"2009","journal-title":"Scand. J. Immunol."},{"issue":"6","key":"10.1016\/j.pupt.2018.09.008_bib24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00580-012-1539-x","article-title":"Acute and subacute toxicity study of andrographolide bioactive in rodents: evidence for the medicinal use as an alternative medicine","volume":"22","author":"Bothiraja","year":"2013","journal-title":"Comp. Clin. Pathol."},{"key":"10.1016\/j.pupt.2018.09.008_bib25","first-page":"276","article-title":"Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride","volume":"92","author":"Handa","year":"1990","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.pupt.2018.09.008_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2016.04.004","article-title":"A semisynthetic diterpenoid lactone inhibits NF-\u03baB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model","volume":"302","author":"Lim","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.pupt.2018.09.008_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Meth."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.aller.2013.11.002","article-title":"A human monoclonal anti-TNF alpha antibody (adalimumab) reduces airway inflammation and ameliorates lung histology in a murine model of acute asthma","volume":"43","author":"Catal","year":"2015","journal-title":"Allergol. Immunopathol."},{"issue":"9","key":"10.1016\/j.pupt.2018.09.008_bib29","doi-asserted-by":"crossref","first-page":"5774","DOI":"10.4049\/jimmunol.174.9.5774","article-title":"Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway","volume":"174","author":"McMillan","year":"2005","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib30","doi-asserted-by":"crossref","first-page":"L185","DOI":"10.1152\/ajplung.90367.2008","article-title":"New asthma biomarkers: lessons from murine models of acute and chronic asthma","volume":"296","author":"Di Valentin","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.toxlet.2013.03.033","article-title":"Mechanism of E-cadherin redistribution in bronchial airway epithelial cells in a TDI-induced asthma model","volume":"220","author":"Song","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.pupt.2018.09.008_bib32","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fnmol.2017.00182","article-title":"Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the Hippocampus accompany heightened systemic inflammation and oxidative stress in an animal model of gulf war illness","volume":"10","author":"Shetty","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"11","key":"10.1016\/j.pupt.2018.09.008_bib33","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.4049\/jimmunol.1502114","article-title":"Andrographolide restores steroid sensitivity to block lipopolysaccharide\/IFN-\u03b3\u2013induced IL-27 and airway hyperresponsiveness in mice","volume":"196","author":"Liao","year":"2016","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.pupt.2018.09.008_bib34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.apsb.2016.02.002","article-title":"Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-\u03baB pathways","volume":"6","author":"Peng","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2005.09.013","article-title":"TDI can induce respiratory allergy with Th2-dominated response in mice","volume":"218","author":"Ban","year":"2006","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.pupt.2018.09.008_bib36","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra1301758","article-title":"Occupational asthma","volume":"370","author":"Tarlo","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib37","doi-asserted-by":"crossref","first-page":"L207","DOI":"10.1152\/ajplung.00157.2005","article-title":"Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate","volume":"292","author":"Tarkowski","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"7","key":"10.1016\/j.pupt.2018.09.008_bib38","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00204-015-1606-6","article-title":"Toluene diisocyanate and methylene diphenyl diisocyanate: asthmatic response and cross-reactivity in a mouse model","volume":"90","author":"Pollaris","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"10","key":"10.1016\/j.pupt.2018.09.008_bib39","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00011-012-0499-6","article-title":"AMPK activation reduces vascular permeability and airway inflammation by regulating HIF\/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma","volume":"61","author":"Park","year":"2012","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.pupt.2018.09.008_bib40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chemosphere.2014.04.065","article-title":"Effect of sulfur dioxide on inflammatory and immune regulation in asthmatic rats","volume":"112","author":"Li","year":"2014","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/toxsci\/kfw074","article-title":"A role for regulatory T cells in a murine model of epicutaneous toluene diisocyanate sensitization","volume":"152","author":"Long","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.pupt.2018.09.008_bib42","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subphenotypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib43","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jaci.2013.07.036","article-title":"Measures of gene expression in sputum cells can identify TH2 high and TH2-low subtypes of asthma","volume":"133","author":"Peters","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"40","key":"10.1016\/j.pupt.2018.09.008_bib44","doi-asserted-by":"crossref","first-page":"15858","DOI":"10.1073\/pnas.0707413104","article-title":"Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids","volume":"104","author":"Woodruff","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"13","key":"10.1016\/j.pupt.2018.09.008_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14814\/phy2.13347","article-title":"Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells","volume":"5","author":"Mertens","year":"2017","journal-title":"Physiol. Rep."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib46","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1038\/s41598-017-03675-z","article-title":"Andrographolide ameliorates inflammation and fibrogenesis and attenuates inflammasome activation in experimental non-alcoholic steatohepatitis","volume":"7","author":"Cabrera","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.pupt.2018.09.008_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.161","article-title":"Toluene diisocyanate exposure induces airway inflammation of bronchial epithelial cells via the activation of transient receptor potential melastatin 8","volume":"49","author":"Kim","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.pupt.2018.09.008_bib48","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.febslet.2006.02.052","article-title":"Epigallocatechin-3-gallate protects toluene diisocyanate-induced airway inflammation in a murine model of asthma","volume":"580","author":"Kim","year":"2006","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/ACI.0b013e32835e0322","article-title":"Cells and mediators in diisocyanate-induced occupational asthma","volume":"13","author":"Shin","year":"2013","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib50","first-page":"239","article-title":"Effect of toluene diisocyanate on reactive oxygen species production and permeability of human bronchial epithelial cells in vitro","volume":"31","author":"Mo","year":"2011","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"11","key":"10.1016\/j.pupt.2018.09.008_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.180","article-title":"Epithelial folliculin is involved in airway inflammation in workers exposed to toluene diisocyanate","volume":"49","author":"Pham","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"10.1016\/j.pupt.2018.09.008_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107768","article-title":"Antioxidants maintain E-cadherin levels to limit Drosophila prohemocyte differentiation","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.pupt.2018.09.008_bib53","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1111\/bph.12054","article-title":"Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity","volume":"168","author":"Guan","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.pupt.2018.09.008_bib54","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.bbagen.2016.07.005","article-title":"Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2\/HO-1 mediated via adenosine A2a receptor signalling","volume":"1860","author":"Mittal","year":"2016","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"8","key":"10.1016\/j.pupt.2018.09.008_bib55","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.3390\/ijms18081638","article-title":"Multi-targeting andrographolide, a novel NF-\u03baB inhibitor, as a potential therapeutic agent for stroke","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib56","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1165\/rcmb.2006-0331TR","article-title":"The role of heme oxygenase-1 in pulmonary disease","volume":"36","author":"Fredenburgh","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.pupt.2018.09.008_bib57","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/187221308786241929","article-title":"Heme oxygenase-1 and carbon monoxide: emerging therapeutic targets in inflammation and allergy","volume":"2","author":"Pae","year":"2008","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"10.1016\/j.pupt.2018.09.008_bib58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.trsl.2015.12.002","article-title":"Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats","volume":"170","author":"Yen","year":"2016","journal-title":"Transl. Res."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib59","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bcp.2014.06.024","article-title":"Andrographolide inhibits TNF\u03b1-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K\/Akt\/Nrf2 and PI3K\/Akt\/AP-1 pathways in human endothelial cells","volume":"91","author":"Lu","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pupt.2018.09.008_bib60","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.freeradbiomed.2016.09.012","article-title":"Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK\/Akt pathway","volume":"101","author":"Ma","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.toxlet.2015.04.011","article-title":"Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model","volume":"236","author":"Liang","year":"2015","journal-title":"Toxicol. Lett."},{"issue":"2","key":"10.1016\/j.pupt.2018.09.008_bib62","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/toxsci\/kfx043","article-title":"Short thymic stromal lymphopoietin attenuates toluene diisocyanate-induced airway inflammation and inhibits high mobility group box 1-receptor for advanced glycation end products and long thymic stromal lymphopoietin expression","volume":"157","author":"Wang","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.pupt.2018.09.008_bib63","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/cea.12370","article-title":"The effects of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild-to-moderate asthma","volume":"44","author":"Leaker","year":"2014","journal-title":"Clin. Exp. Allergy"},{"issue":"5","key":"10.1016\/j.pupt.2018.09.008_bib64","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.pupt.2018.09.008_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0034634","article-title":"Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury","volume":"7","author":"Ci","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pupt.2018.09.008_bib66","doi-asserted-by":"crossref","first-page":"20196","DOI":"10.1038\/srep20196","article-title":"GSK-3\u03b2 downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.pupt.2018.09.008_bib67","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/j.febslet.2008.06.045","article-title":"The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38\/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress","volume":"582","author":"Hwang","year":"2008","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553918301500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553918301500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T08:43:51Z","timestamp":1568969031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553918301500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":67,"alternative-id":["S1094553918301500"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2018.09.008","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2018.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}