{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:19:50Z","timestamp":1790623190494,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"am","delay-in-days":291,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Association pour la Promotion \u00e0 Tours de la R\u00e9animation M\u00e9dicale"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.pupt.2019.101807","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T12:07:41Z","timestamp":1557922061000},"page":"101807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Intra-tracheal amikacin spray delivery in healthy mechanically ventilated piglets"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-8620","authenticated-orcid":false,"given":"Antoine","family":"Guillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Darrouzain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Heuz\u00e9-Vourc\u2019h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Petitcollin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Barc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Vecellio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Cormier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lanotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sarradin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Dequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0158-1356","authenticated-orcid":false,"given":"Gilles","family":"Paintaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ehrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2019.101807_bib1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1128\/CMR.00101-15","article-title":"Inhaled antibiotics for Gram-negative respiratory infections","volume":"29","author":"Wenzler","year":"2016","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.pupt.2019.101807_bib2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.4187\/respcare.04519","article-title":"Intratracheal administration of antimicrobial agents in mechanically ventilated adults: an international survey on delivery practice and safety","volume":"61","author":"Sol\u00e9-Lleonart","year":"2016","journal-title":"Respir. Care"},{"key":"10.1016\/j.pupt.2019.101807_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cmi.2015.12.016","article-title":"Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines","volume":"22","author":"Sol\u00e9-Lleonart","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.pupt.2019.101807_bib4","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/ALN.0000000000001570","article-title":"Nebulization of antiinfective agents in invasively mechanically ventilated adults: a systematic review and meta-analysis","volume":"126","author":"Sol\u00e9-Lleonart","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pupt.2019.101807_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13613-017-0301-6","article-title":"Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care","volume":"7","author":"Ehrmann","year":"2017","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.pupt.2019.101807_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/jamp.2011.0936","article-title":"Inhalation therapy in patients receiving mechanical ventilation: an update","volume":"25","author":"Ari","year":"2012","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"10.1016\/j.pupt.2019.101807_bib7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00134-015-4114-5","article-title":"Aerosol therapy in intensive and intermediate care units: prospective observation of 2808 critically ill patients","volume":"42","author":"Ehrmann","year":"2016","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2019.101807_bib8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00134-012-2778-7","article-title":"The importance of protecting the mechanical ventilator during colistin methanesulfonate nebulization","volume":"39","author":"Mojoli","year":"2013","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2019.101807_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1164\/rccm.201011-1894OC","article-title":"Nebulized Antibiotics Study Group: nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa","volume":"184","author":"Lu","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2019.101807_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00134-011-2420-0","article-title":"BAY41-6551 achieves bactericidal tracheal aspirate amikacin concentrations in mechanically ventilated patients with Gram-negative pneumonia","volume":"38","author":"Niederman","year":"2012","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2019.101807_bib11","doi-asserted-by":"crossref","first-page":"R200","DOI":"10.1186\/cc8206","article-title":"Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia","volume":"13","author":"Luyt","year":"2009","journal-title":"Crit. Care"},{"key":"10.1016\/j.pupt.2019.101807_bib12","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.4187\/respcare.02637","article-title":"Ventilator-integrated jet nebulization systems: tidal volume control and efficiency of synchronization","volume":"59","author":"Ehrmann","year":"2014","journal-title":"Respir. Care"},{"key":"10.1016\/j.pupt.2019.101807_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/jac\/dkp282","article-title":"Antibacterial activities of a fosfomycin\/tobramycin combination: a novel inhaled antibiotic for bronchiectasis","volume":"64","author":"MacLeod","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.pupt.2019.101807_bib14","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/jat.3386","article-title":"Comparision of the local pulmonary distribution of nanoparticles administered intratracheally to rats via gavage needle of microsprayer delivery devices","volume":"37","author":"Zhang","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.pupt.2019.101807_bib15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejpb.2005.04.009","article-title":"Non-invasive pulmonary aerosol delivery in mice by the endotracheal route","volume":"61","author":"Bivas-Benita","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.pupt.2019.101807_bib16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ijpharm.2012.05.013","article-title":"Pulmonary delivery of dry powders to rats : tolerability limits of an intra-racheal administration model","volume":"434","author":"Guillon","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.pupt.2019.101807_bib17","first-page":"30442","article-title":"Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs","volume":"S0378\u20135173","author":"Salzano","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.pupt.2019.101807_bib18","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1038\/s41598-017-05453-3","article-title":"Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles","volume":"7","author":"Costa-Gouveia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pupt.2019.101807_bib19","doi-asserted-by":"crossref","first-page":"136859","DOI":"10.1155\/2013\/136859","article-title":"Biodistribution of amikacin solid lipid nanoparticles after pulmonary delivery","volume":"2013","author":"Varshosaz","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.pupt.2019.101807_bib22","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00134-007-0935-1","article-title":"Pharmacokinetics of high-dose nebulizer amikacin in mechanically ventilated healthy subjects","volume":"34","author":"Ehrmann","year":"2008","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.pupt.2019.101807_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1164\/ajrccm.165.2.2107025","article-title":"Lung tissue concentrations of nebulized amikacin during mechanical ventilation in piglets with healthy lungs","volume":"165","author":"Goldstein","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2019.101807_bib24","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1006\/mthe.2002.0698","article-title":"Deposition and expression of aerosolized rAAV vectors in the lungs of Rhesus macaques","volume":"6","author":"Beck","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.pupt.2019.101807_bib25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/humc.2017.067","article-title":"A preclinical study in Rhesus macaques for cystic fibrosis to assess gene transfer and transduction by AAV1 and AAV5 with a dual-luciferase reporter system","volume":"28","author":"Guggino","year":"2017","journal-title":"Hum Gene Ther Clin Dev"},{"key":"10.1016\/j.pupt.2019.101807_bib26","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1097\/CCM.0b013e31817c0f9e","article-title":"Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit","volume":"36","author":"Palmer","year":"2008","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.pupt.2019.101807_bib27","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.4161\/mabs.34454","article-title":"VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations","volume":"6","author":"Herv\u00e9","year":"2014","journal-title":"mAbs"},{"key":"10.1016\/j.pupt.2019.101807_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2016.05.018","article-title":"Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin","volume":"234","author":"Respaud","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.pupt.2019.101807_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jconrel.2004.01.027","article-title":"Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats","volume":"96","author":"Bosquillon","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.pupt.2019.101807_bib30","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/17425247.2017.1252329","article-title":"Inhaled phage therapy: a promising and challenging approach to treat bacterial respiratory infections","volume":"4","author":"Bodier-Montagutelli","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.pupt.2019.101807_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4103\/roaic.roaic_102_16","article-title":"Bronchoscopic instillation of amikacin in patients with ventilator-associated pneumonia","volume":"4","author":"Fathya","year":"2017","journal-title":"Research and Opinion in Anesthesia & Intensive Care"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553918301032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553918301032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:28:26Z","timestamp":1761082106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553918301032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":29,"alternative-id":["S1094553918301032"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101807","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intra-tracheal amikacin spray delivery in healthy mechanically ventilated piglets","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101807","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101807"}}