{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:33:59Z","timestamp":1770510839880,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Jordan Scientific Research Support Fund (SRSF) at the Ministry of Higher Education and Scientific Research","award":["MPH\/2\/11\/2014"],"award-info":[{"award-number":["MPH\/2\/11\/2014"]}]},{"name":"Al-Ahliyya Amman University, Jordan"},{"name":"The Jordan Scientific Research Support Fund (SRSF), Amman, Jordan"},{"name":"Al-Ahliyya Amman University, Jordan"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.pupt.2019.101829","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T11:46:46Z","timestamp":1564055206000},"page":"101829","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluation of patients\u2019 real-world post-dispensing use and storage environments of tiotropium bromide Respimat\u00ae soft mist inhaler on its in vitro dose delivery and lung deposition"],"prefix":"10.1016","volume":"58","author":[{"given":"Wesam G.","family":"Ammari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Khalil Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabab F.","family":"Tayyem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.pupt.2019.101829_bib1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1183\/09031936.95.08091506","article-title":"Tiotropium bromide, a new long-acting antimuscarinic bronchodilator - a pharmacodynamic study in patients with chronic obstructive pulmonary-disease (Copd)","volume":"8","author":"Maesen","year":"1995","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.pupt.2019.101829_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.rmed.2008.10.002","article-title":"The efficacy of tiotropium administered via Respimat (R) soft MistT (TM) inhaler or HandiHaler (R) in COPD patients","volume":"103","author":"van Noord","year":"2009","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.pupt.2019.101829_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12931-015-0175-9","article-title":"A randomised dose-ranging study of tiotropium Respimat\u00ae in children with symptomatic asthma despite inhaled corticosteroids","volume":"16","author":"Vogelberg","year":"2015","journal-title":"Respir. Res."},{"issue":"9","key":"10.1016\/j.pupt.2019.101829_bib4","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.rmed.2014.06.011","article-title":"Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: a randomised dose-ranging study","volume":"108","author":"Vogelberg","year":"2014","journal-title":"Respir. Med."},{"issue":"3","key":"10.1016\/j.pupt.2019.101829_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s40265-018-0862-1","article-title":"Efficacy and Safety of Tiotropium in Children and Adolescents","volume":"78","author":"Hamelmann","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.pupt.2019.101829_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.rmed.2018.03.010","article-title":"In vitro and clinical characterization of the valved holding chamber AeroChamber Plus((R)) Flow-Vu((R)) for administrating tiotropium Respimat((R)) in 1-5-year-old children with persistent asthmatic symptoms","volume":"137","author":"Wachtel","year":"2018","journal-title":"Respir. Med."},{"issue":"2","key":"10.1016\/j.pupt.2019.101829_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/jamp.2015.1270","article-title":"Bridging the gap between science and clinical efficacy: physiology, imaging, and modeling of aerosols in the lung","volume":"29","author":"Darquenne","year":"2016","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"10.1016\/j.pupt.2019.101829_bib8","first-page":"105","article-title":"Effects of device design on patient complience: comparing the same drug in different devices","volume":"1","author":"Chrystyn","year":"2009","journal-title":"Respir. Drug Deliv. Eur."},{"issue":"6","key":"10.1016\/j.pupt.2019.101829_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/jamp.2011.0883","article-title":"In vitro validation of a Respimat\u00ae adapter for delivery of inhaled bronchodilators during mechanical ventilation","volume":"24","author":"Dellweg","year":"2011","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"10.1016\/j.pupt.2019.101829_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pupt.2017.02.002","article-title":"Mastery of pMDI technique, asthma control and quality-of-life of children with asthma: a randomized controlled study comparing two inhaler technique training approaches","volume":"43","author":"Ammari","year":"2017","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.pupt.2019.101829_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jamp.2018.1480","article-title":"Effect of unintentional storage and handling errors of inhaled medications: what does this mean for therapeutic equivalence considerations?","volume":"32","author":"Wolkenhauer","year":"2019","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"10.1016\/j.pupt.2019.101829_bib12","author":"European Medicines Agency"},{"key":"10.1016\/j.pupt.2019.101829_bib13","author":"U.S. FDA"},{"key":"10.1016\/j.pupt.2019.101829_bib14","series-title":"Quality Solutions for Inhaler Testing","author":"Copley Scientific Ltd","year":"2015"},{"issue":"9","key":"10.1016\/j.pupt.2019.101829_bib15","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1183\/09031936.97.10092127","article-title":"Airway deposition and airway effects of antiasthma drugs delivered from metered-dose inhalers","volume":"10","author":"Pauwels","year":"1997","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.pupt.2019.101829_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1365-2125.2001.01304.x","article-title":"Methods to identify drug deposition in the lungs following inhalation","volume":"51","author":"Chrystyn","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.pupt.2019.101829_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1089\/jamp.2016.1297","article-title":"The history of therapeutic aerosols: a chronological review","volume":"30","author":"Stein","year":"2017","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"10.1016\/j.pupt.2019.101829_bib18","author":"International Conference On Harmonisation (ICH)"},{"issue":"21","key":"10.1016\/j.pupt.2019.101829_bib19","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.2146\/ajhp050067","article-title":"Effects of extreme temperatures on drug delivery of albuterol sulfate hydrofluoroalkane inhalation aerosols","volume":"62","author":"Hoye","year":"2005","journal-title":"Am. J. Health Syst. Pharm."},{"issue":"3","key":"10.1016\/j.pupt.2019.101829_bib20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1089\/jam.2005.18.304","article-title":"An in vivo and in vitro comparison of two powder inhalers following storage at hot\/humid conditions","volume":"18","author":"Borgstrom","year":"2005","journal-title":"J. Aerosol Med."},{"issue":"4","key":"10.1016\/j.pupt.2019.101829_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/jamp.2012.0991","article-title":"In vitro investigation of the effect of ambient humidity on regional delivered dose with solution and suspension MDIs","volume":"26","author":"Shemirani","year":"2013","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"issue":"5","key":"10.1016\/j.pupt.2019.101829_bib22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/jamp.2015.1216","article-title":"Spiromax, a new dry powder inhaler: dose consistency under simulated real-world conditions","volume":"28","author":"Canonica","year":"2015","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"10.1016\/j.pupt.2019.101829_bib23","doi-asserted-by":"crossref","first-page":"16053","DOI":"10.1038\/npjpcrm.2016.53","article-title":"Difference in resistance to humidity between commonly used dry powder inhalers: an in vitro study","volume":"26","author":"Janson","year":"2016","journal-title":"npj Prim. Care Respir. Med."},{"key":"10.1016\/j.pupt.2019.101829_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40248-016-0057-0","article-title":"Need of education for dry powder inhaler storage and retention - a patient-reported survey","volume":"11","author":"Norderud Laerum","year":"2016","journal-title":"Multidiscip. Respir. Med."},{"key":"10.1016\/j.pupt.2019.101829_bib25","author":"The Intergovernmental Panel on Climate Change (IPCC)"},{"key":"10.1016\/j.pupt.2019.101829_bib26","doi-asserted-by":"crossref","DOI":"10.1089\/jamp.2015.1232","article-title":"The evolution of pressurized metered-dose inhalers from early to modern devices","author":"Roche","year":"2016","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"issue":"1\u20132","key":"10.1016\/j.pupt.2019.101829_bib27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijpharm.2015.05.076","article-title":"Effect of inhalation profile and throat geometry on predicted lung deposition of budesonide and formoterol (BF) in COPD: an in-vitro comparison of Spiromax with Turbuhaler","volume":"491","author":"Chrystyn","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.pupt.2019.101829_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/08942680252908593","article-title":"Mass output and particle size distribution of glucocorticosteroids emitted from different inhalation devices depending on various inspiratory parameters","volume":"15","author":"Kamin","year":"2002","journal-title":"J. Aerosol Med."},{"issue":"3","key":"10.1016\/j.pupt.2019.101829_bib29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/089426801316970268","article-title":"Effective delivery of particles with the HandiHaler dry powder inhalation system over a range of chronic obstructive pulmonary disease severity","volume":"14","author":"Chodosh","year":"2001","journal-title":"J. Aerosol Med."},{"issue":"9","key":"10.1016\/j.pupt.2019.101829_bib30","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.rmed.2006.01.008","article-title":"The need to improve inhalation technique in europe: a report from the aerosol drug management improvement team","volume":"100","author":"Crompton","year":"2006","journal-title":"Respir. Med."},{"key":"10.1016\/j.pupt.2019.101829_bib31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1368-504X.2005.00722.x","article-title":"Can patients use all dry powder inhalers equally well?","volume":"59","author":"Gustafsson","year":"2005","journal-title":"Int. J. Clin. Pract."},{"issue":"6","key":"10.1016\/j.pupt.2019.101829_bib32","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.rmed.2011.01.005","article-title":"Inhaler mishandling remains common in real life and is associated with reduced disease control","volume":"105","author":"Melani","year":"2011","journal-title":"Respir. Med."},{"issue":"5","key":"10.1016\/j.pupt.2019.101829_bib33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/02770903.2013.783064","article-title":"Optimizing the inhalation flow and technique through metered dose inhalers of asthmatic adults and children attending a community pharmacy","volume":"50","author":"Ammari","year":"2013","journal-title":"J. Asthma"},{"key":"10.1016\/j.pupt.2019.101829_bib34","first-page":"79","article-title":"Influence of different inhalation modes on the efficacy of pressurized aerosol bronchodilators","volume":"63","author":"Clarke","year":"1982","journal-title":"Eur. J. Respir. Dis."},{"issue":"2","key":"10.1016\/j.pupt.2019.101829_bib35","first-page":"A","article-title":"Whistle training aid and smartphone App. provide objective data","volume":"31","author":"Sanders","year":"2018","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"issue":"1","key":"10.1016\/j.pupt.2019.101829_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41533-017-0016-z","article-title":"Device errors in asthma and COPD: systematic literature review and meta-analysis","volume":"27","author":"Chrystyn","year":"2017","journal-title":"npj Prim. Care Respir. Med."},{"issue":"1","key":"10.1016\/j.pupt.2019.101829_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s41030-018-0051-0","article-title":"Identifying critical errors: addressing inhaler technique in the context of asthma management","volume":"4","author":"Bosnic-Anticevich","year":"2018","journal-title":"Pulm. Ther."},{"key":"10.1016\/j.pupt.2019.101829_bib38","series-title":"Practice","first-page":"785","article-title":"Addressing the impact and unmet needs of nonadherence in asthma and chronic obstructive pulmonary disease: where do we go from here?, the journal of allergy and clinical immunology","volume":"vol. 6","author":"Dekhuijzen","year":"2018"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553919300720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553919300720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:29:25Z","timestamp":1761082165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553919300720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":38,"alternative-id":["S1094553919300720"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101829","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of patients\u2019 real-world post-dispensing use and storage environments of tiotropium bromide Respimat\u00ae soft mist inhaler on its in vitro dose delivery and lung deposition","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101829","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101829"}}