{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:11:27Z","timestamp":1790629887951,"version":"4.1.0"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","award":["1134\/2018"],"award-info":[{"award-number":["1134\/2018"]}],"id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.pupt.2019.101856","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T20:01:35Z","timestamp":1571169695000},"page":"101856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques"],"prefix":"10.1016","volume":"59","author":[{"given":"Martina","family":"Oriano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Terranova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Sotgiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Saderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Bellofiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Retucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gramegna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Miglietta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Carnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Marchisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Aliberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2019.101856_bib1","first-page":"50","article-title":"European Respiratory Society guidelines for the management of adult bronchiectasis","author":"Polverino","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2019.101856_bib2","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jpeds.2016.09.064","article-title":"Diagnosis of cystic fibrosis: consensus guidelines from the cystic fibrosis foundation","volume":"181","author":"Farrell","year":"2018","journal-title":"J. Pediatr."},{"key":"10.1016\/j.pupt.2019.101856_bib3","article-title":"Persistent sputum cellularity and neutrophils may predict bronchiectasis","volume":"18","author":"Drost","year":"2011","journal-title":"Can. Respir. J."},{"key":"10.1016\/j.pupt.2019.101856_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1164\/rccm.200808-1250OC","article-title":"Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs","volume":"180","author":"Voglis","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2019.101856_bib5","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1164\/ajrccm.162.5.9907064","article-title":"Neutrophil-mediated degradation of lung proteoglycans","volume":"162","author":"SHUM","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2019.101856_bib6","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1164\/rccm.201605-1027OC","article-title":"Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis","volume":"195","author":"Chalmers","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2019.101856_bib7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1172\/JCI114699","article-title":"Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch","volume":"86","author":"Tosi","year":"1990","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.pupt.2019.101856_bib8","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1136\/thx.39.9.663","article-title":"Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine proteinase effect","volume":"39","author":"Smallman","year":"1984","journal-title":"Thorax"},{"key":"10.1016\/j.pupt.2019.101856_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1165\/ajrcmb\/4.1.26","article-title":"Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium","volume":"4","author":"Amitani","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2019.101856_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-017-0691-x","article-title":"Neutrophil elastase in bronchiectasis","volume":"18","author":"Gramegna","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.pupt.2019.101856_bib11","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nprot.2008.63","article-title":"Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates","volume":"3","author":"Korkmaz","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.pupt.2019.101856_bib12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1165\/rcmb.2003-0139OC","article-title":"Design and use of highly specific substrates of neutrophil elastase and proteinase 3","volume":"30","author":"Korkmaz","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pupt.2019.101856_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1183\/09031936.00163208","article-title":"Sputum colour: a useful clinical tool in non-cystic fibrosis bronchiectasis","volume":"34","author":"Murray","year":"2009","journal-title":"Eur. Respir. J."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553919301361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553919301361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:28:53Z","timestamp":1761082133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553919301361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":13,"alternative-id":["S1094553919301361"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101856","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101856"}}