{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:12:50Z","timestamp":1785535970790,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.pupt.2019.101884","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T11:27:30Z","timestamp":1577446050000},"page":"101884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The small quinolone derived compound HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo"],"prefix":"10.1016","volume":"61","author":[{"given":"R.T.","family":"Amison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-E.","family":"Faure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.G.","family":"O'Shaughnessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.D.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Coates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.P.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2019.101884_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jhin.2006.01.001","article-title":"Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities","volume":"63","author":"Coia","year":"2006","journal-title":"J Hosp Infect [Internet]"},{"issue":"6","key":"10.1016\/j.pupt.2019.101884_bib2","article-title":"The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial","volume":"37","author":"Climo","year":"2009","journal-title":"Crit Care Med [Internet]"},{"issue":"9","key":"10.1016\/j.pupt.2019.101884_bib3","article-title":"Topical antibiotic ear drops: are they safe?","volume":"60","author":"Pappas","year":"2006","journal-title":"Int J Clin Pract [Internet]"},{"key":"10.1016\/j.pupt.2019.101884_bib4","first-page":"212527","article-title":"A continuous publication, open access, peer-reviewed journal Citation","volume":"7","author":"Bassetti","year":"2018","journal-title":"Drugs Context [Internet]"},{"issue":"14","key":"10.1016\/j.pupt.2019.101884_bib5","article-title":"Current and future therapies for Pseudomonas aeruginosa infection in patients with cystic fibrosis","volume":"364","author":"Smith","year":"2017","journal-title":"FEMS Microbiol Lett [Internet]"},{"issue":"4","key":"10.1016\/j.pupt.2019.101884_bib6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1128\/CMR.00040-09","article-title":"Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms","volume":"22","author":"Lister","year":"2009","journal-title":"Clin Microbiol Rev [Internet]"},{"key":"10.1016\/j.pupt.2019.101884_bib7","article-title":"Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: mechanisms and epidemiology","volume":"45","author":"Potron","year":"2015","journal-title":"Int J Antimicrob Agents [Internet]"},{"issue":"11","key":"10.1016\/j.pupt.2019.101884_bib8","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nrd940","article-title":"The future challenges facing the development of new antimicrobial drugs","volume":"1","author":"Coates","year":"2002","journal-title":"Nat Rev Drug Discov [Internet]"},{"key":"10.1016\/j.pupt.2019.101884_bib9","first-page":"520","volume":"vol. 70","author":"Martens","year":"2017"},{"key":"10.1016\/j.pupt.2019.101884_bib10","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/jac\/dks384","article-title":"Enhancement by novel anti-MRSA compound HT61 of the activity of other antibiotics","volume":"68","author":"Hu","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"issue":"7","key":"10.1016\/j.pupt.2019.101884_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011818","article-title":"A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for Staphylococcal infections","volume":"5","author":"Hu","year":"2010","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.pupt.2019.101884_bib12","article-title":"Mechanism of action of a membrane-active quinoline-based antimicrobial on natural and model bacterial membranes","volume":"56","author":"Hubbard","year":"2017","journal-title":"Biochemistry [Internet]"},{"issue":"10","key":"10.1016\/j.pupt.2019.101884_bib13","article-title":"Comparing the action of HT61 and chlorhexidine on natural and model Staphylococcus aureus membranes","volume":"70","author":"Hubbard","year":"2017","journal-title":"J Antibiot (Tokyo) [Internet]"},{"issue":"1","key":"10.1016\/j.pupt.2019.101884_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/dkp159","article-title":"Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects","volume":"64","author":"Coates","year":"2009","journal-title":"J Antimicrob Chemother [Internet]"},{"key":"10.1016\/j.pupt.2019.101884_bib15","series-title":"Efficacy of the Novel Antibiotic POL7001 in Preclinical Models of Pseudomonas aeruginosa Pneumonia","author":"Cigana","year":"2016"},{"issue":"1","key":"10.1016\/j.pupt.2019.101884_bib16","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1186\/s12864-015-2276-8","article-title":"Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection","volume":"16","author":"Bianconi","year":"2015","journal-title":"BMC Genomics [Internet]"},{"issue":"2","key":"10.1016\/j.pupt.2019.101884_bib17","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat Protoc [Internet]"},{"issue":"9","key":"10.1016\/j.pupt.2019.101884_bib19","article-title":"Synergistic effect of membrane-active peptides polymyxin B and gramicidin S on multidrug-resistant strains and biofilms of Pseudomonas aeruginosa","volume":"59","author":"Berditsch","year":"2015","journal-title":"Antimicrob Agents Chemother [Internet]"},{"issue":"1","key":"10.1016\/j.pupt.2019.101884_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J Antimicrob Chemother [Internet]"},{"issue":"2","key":"10.1016\/j.pupt.2019.101884_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0031-6997(25)00026-2","article-title":"What is synergy?","volume":"41","author":"Berenbaum","year":"1989","journal-title":"Pharmacol Rev [Internet]"},{"key":"10.1016\/j.pupt.2019.101884_bib22","series-title":"M26-A Methods for Determining Bactericidal Activity of Antimicrobial Agents; Approved Guideline This Document Provides Procedures for Determining the Lethal Activity of Antimicrobial Agents [Internet]","year":"1999"},{"issue":"1","key":"10.1016\/j.pupt.2019.101884_bib23","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1038\/npjbiofilms.2016.6","article-title":"Tobramycin and bicarbonate synergise to kill planktonic Pseudomonas aeruginosa, but antagonise to promote biofilm survival","volume":"2","author":"Kaushik","year":"2016","journal-title":"npj Biofilms Microbiomes [Internet]"},{"issue":"6","key":"10.1016\/j.pupt.2019.101884_bib24","article-title":"The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms","volume":"37","author":"Ceri","year":"1999","journal-title":"J Clin Microbiol [Internet]"},{"key":"10.1016\/j.pupt.2019.101884_bib25","article-title":"Platelet depletion impairs host defence to pulmonary infection with Pseudomonas aeruginosa in mice","author":"Amison","year":"2017","journal-title":"Am J Respir Cell Mol Biol [Internet]"},{"issue":"3","key":"10.1016\/j.pupt.2019.101884_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tips.2007.12.001","article-title":"Targeting non-multiplying organisms as a way to develop novel antimicrobials","volume":"29","author":"Coates","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.pupt.2019.101884_bib27","series-title":"Novel Approaches to Developing New Antibiotics for Bacterial Infections","first-page":"1147","author":"Hu","year":"2007"},{"key":"10.1016\/j.pupt.2019.101884_bib28","article-title":"Enhancement by novel anti-methicillin-resistant Staphylococcus aureus compound HT61 of the activity of neomycin, gentamicin, mupirocin and chlorhexidine: in vitro and in vivo studies","volume":"68","author":"Hu","year":"2013","journal-title":"J Antmicrobial Chemother [Internet]"},{"issue":"7","key":"10.1016\/j.pupt.2019.101884_bib29","article-title":"Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis","volume":"65","author":"Prayle","year":"2010","journal-title":"Thorax [Internet]"},{"issue":"1","key":"10.1016\/j.pupt.2019.101884_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ppul.20138","article-title":"Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use","volume":"39","author":"Al-Aloul","year":"2005","journal-title":"Pediatr Pulmonol [Internet]"},{"issue":"12","key":"10.1016\/j.pupt.2019.101884_bib31","article-title":"Frequency of mitochondrial 12S ribosomal RNA variants in an adult cystic fibrosis population","volume":"18","author":"Conrad","year":"2008","journal-title":"Pharmacogenet Genomics [Internet]"},{"issue":"4","key":"10.1016\/j.pupt.2019.101884_bib32","article-title":"The effects of intravenous tobramycin on renal tubular function in children with cystic fibrosis","volume":"4","author":"Glass","year":"2005","journal-title":"J Cyst Fibros [Internet]"},{"issue":"10","key":"10.1016\/j.pupt.2019.101884_bib33","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1128\/AAC.01245-15","article-title":"Antimicrobial peptide novicidin synergizes with rifampin, ceftriaxone, and ceftazidime against antibiotic-resistant Enterobacteriaceae in vitro","volume":"59","author":"Soren","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.pupt.2019.101884_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0732-8893(87)90101-5","article-title":"Determination of synergy by two methods with eight antimicrobial combinations against tobramycin-susceptible and tobramycin-resistant strains of pseudomonas","volume":"6","author":"Chan","year":"1987","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.pupt.2019.101884_bib35","series-title":"Novel Antimicrobial Agents and Strategies [Internet]","first-page":"17","article-title":"Conventional Antibiotics\u2009-\u2009Revitalized by new agents","author":"Coates","year":"2014"},{"key":"10.1016\/j.pupt.2019.101884_bib36","article-title":"Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?","author":"Brown","year":"2015","journal-title":"Nat Publ Gr [Internet]"},{"issue":"3","key":"10.1016\/j.pupt.2019.101884_bib37","article-title":"Evolution of Pseudomonas aeruginosa antimicrobial resistance and fitness under low and high mutation rates","volume":"60","author":"Cabot","year":"2016","journal-title":"Antimicrob Agents Chemother [Internet]"},{"issue":"34","key":"10.1016\/j.pupt.2019.101884_bib38","article-title":"Relationship of membrane curvature to the formation of pores by magainin 2","volume":"37","author":"Matsuzaki","year":"1998","journal-title":"Biochemistry [Internet]"},{"issue":"5","key":"10.1016\/j.pupt.2019.101884_bib39","article-title":"Lipid domains in bacterial membranes","volume":"61","author":"Matsumoto","year":"2006","journal-title":"Mol Microbiol [Internet]"},{"issue":"1","key":"10.1016\/j.pupt.2019.101884_bib40","article-title":"The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens","volume":"57","author":"Randall","year":"2013","journal-title":"Antimicrob Agents Chemother [Internet]"},{"issue":"4","key":"10.1016\/j.pupt.2019.101884_bib41","article-title":"Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling","volume":"59","author":"Bulitta","year":"2015","journal-title":"Antimicrob Agents Chemother [Internet]"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553919303219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553919303219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:28:37Z","timestamp":1761082117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553919303219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":40,"alternative-id":["S1094553919303219"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101884","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The small quinolone derived compound HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2019.101884","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101884"}}