{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:06:02Z","timestamp":1788440762986,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.pupt.2021.102005","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T17:39:58Z","timestamp":1614101998000},"page":"102005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Epimedin C modulates the balance between Th9 cells and Treg cells through negative regulation of noncanonical NF-\u03baB pathway and MAPKs activation to inhibit airway inflammation in the ovalbumin\u2013induced murine asthma model"],"prefix":"10.1016","volume":"65","author":[{"given":"Muhua","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.pupt.2021.102005_bib1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cell.2010.03.004","article-title":"Asthma and allergic inflammation","volume":"140","author":"Locksley","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nri3786","article-title":"Type 2 inflammation in asthma--present in most, absent in many","volume":"15","author":"Fahy","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.pupt.2021.102005_bib3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1365-2222.2009.03298.x","article-title":"Intrinsic asthma: not so different from allergic asthma but driven by superantigens?","volume":"39","author":"Barnes","year":"2009","journal-title":"Clin. Exp. Allergy"},{"issue":"4","key":"10.1016\/j.pupt.2021.102005_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041231","article-title":"Expression and regulation of thymic stromal lymphopoietin and thymic stromal lymphopoietin receptor heterocomplex in the innate-adaptive immunity of pediatric asthma","volume":"19","author":"Lin","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.pupt.2021.102005_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.pupt.2021.102005_bib6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nri2262","article-title":"Treatment strategies for allergy and asthma","volume":"8","author":"Holgate","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12560","article-title":"Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma","volume":"278","author":"Tumes","year":"2017","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.pupt.2021.102005_bib8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jaci.2015.01.021","article-title":"TH9 cells are required for tissue mast cell accumulation during allergic inflammation","volume":"136","author":"Sehra","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.medici.2015.01.001","article-title":"Peripheral blood Th9 cells and eosinophil apoptosis in asthma patients","volume":"51","author":"Hoppenot","year":"2015","journal-title":"Medicina (Kaunas)"},{"issue":"4","key":"10.1016\/j.pupt.2021.102005_bib10","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jaci.2011.12.965","article-title":"Activin A and TGF-beta promote T(H)9 cell-mediated pulmonary allergic pathology","volume":"129","author":"Jones","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.pupt.2021.102005_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5575","article-title":"Nitric oxide enhances Th9 cell differentiation and airway inflammation","volume":"5","author":"Niedbala","year":"2014","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.pupt.2021.102005_bib12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni.2390","article-title":"OX40 signaling favors the induction of T(H)9 cells and airway inflammation","volume":"13","author":"Xiao","year":"2012","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00281-016-0601-1","article-title":"Th9 and other IL-9-producing cells in allergic asthma","volume":"39","author":"Koch","year":"2017","journal-title":"Semin. Immunopathol."},{"issue":"2","key":"10.1016\/j.pupt.2021.102005_bib14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.immuni.2010.07.014","article-title":"Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells","volume":"33","author":"Staudt","year":"2010","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.pupt.2021.102005_bib15","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.immuni.2009.08.007","article-title":"Regulatory T cells in asthma","volume":"31","author":"Lloyd","year":"2009","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.pupt.2021.102005_bib16","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/mi.2017.21","article-title":"IL-36gamma signaling controls the induced regulatory T cell-Th9 cell balance via NFkappaB activation and STAT transcription factors","volume":"10","author":"Harusato","year":"2017","journal-title":"Mucosal Immunol."},{"issue":"4","key":"10.1016\/j.pupt.2021.102005_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.anai.2019.11.005","article-title":"GINA updated 2019: landmark changes recommended for asthma management","volume":"124","author":"Hogan","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"6","key":"10.1016\/j.pupt.2021.102005_bib18","first-page":"436","article-title":"Adherence to treatment in asthma and COPD patients in their doctors' assessment","volume":"83","author":"Kardas","year":"2015","journal-title":"Pneumonol. Alergol. Pol."},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/1872213X09666150302105225","article-title":"Complementary and alternative medicine for childhood asthma: an overview of evidence and patents","volume":"9","author":"Hon","year":"2015","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"10.1016\/j.pupt.2021.102005_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112635","article-title":"Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulas","volume":"252","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.pupt.2021.102005_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070685","article-title":"Advanced molecular knowledge of therapeutic drugs and natural Products focusing on inflammatory cytokines in asthma","volume":"8","author":"Lin","year":"2019","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.pupt.2021.102005_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23071656","article-title":"Comparison of the active compositions between raw and processed epimedium from different species","volume":"23","author":"Zhang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.pupt.2021.102005_bib23","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jep.2015.01.016","article-title":"Bu-Shen-Yi-Qi formulae suppress chronic airway inflammation and regulate Th17\/Treg imbalance in the murine ovalbumin asthma model","volume":"164","author":"Wei","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.pupt.2021.102005_bib24","series-title":"Epimedium Flavonoids Counteract the Side Effects of Glucocorticoids on Hypothalamic-Pituitary-Adrenal Axis","author":"Huang","year":"2013"},{"issue":"4","key":"10.1016\/j.pupt.2021.102005_bib25","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1055\/s-2006-957690","article-title":"Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense","volume":"63","author":"Liang","year":"1997","journal-title":"Planta Med."},{"key":"10.1016\/j.pupt.2021.102005_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9266","article-title":"GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation","volume":"6","author":"Xiao","year":"2015","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.pupt.2021.102005_bib27","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ni.1899","article-title":"Effector T cell plasticity: flexibility in the face of changing circumstances","volume":"11","author":"Murphy","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.pupt.2021.102005_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12033","article-title":"NF-kappa B: roles and regulation in different CD4(+) T-cell subsets","volume":"252","author":"Oh","year":"2013","journal-title":"Immunol. Rev."},{"issue":"13","key":"10.1016\/j.pupt.2021.102005_bib29","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1073\/pnas.0400885101","article-title":"Differential dependence of CD4(+)CD25(+) regulatory and natural killer-like T cells on signals leading to NF-kappa B activation","volume":"101","author":"Schmidt-Supprian","year":"2004","journal-title":"P Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12967-018-1436-4","article-title":"OX40L induces helper T cell differentiation during cell immunity of asthma through PI3K\/AKT and P38 MAPK signaling pathway","volume":"16","author":"Huang","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.pupt.2021.102005_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13223-018-0249-6","article-title":"Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model","volume":"14","author":"Li","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"issue":"12","key":"10.1016\/j.pupt.2021.102005_bib32","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.4049\/jimmunol.1500485","article-title":"Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38alpha MAPK","volume":"194","author":"Ebel","year":"2015","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.pupt.2021.102005_bib33","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.1074\/jbc.M112210200","article-title":"A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells","volume":"277","author":"Dhawan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pupt.2021.102005_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-018-2363-x","article-title":"Epimedium sagittatum inhibits TLR4\/MD-2 mediated NF-B signaling pathway with anti-inflammatory activity","volume":"18","author":"Yan","year":"2018","journal-title":"Bmc Complem Altern M"},{"issue":"5","key":"10.1016\/j.pupt.2021.102005_bib35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1142\/S0192415X1550055X","article-title":"Inhibitory effects of epimedium herb on the inflammatory response in vitro and in vivo","volume":"43","author":"Oh","year":"2015","journal-title":"Am. J. Chin. Med."},{"issue":"5","key":"10.1016\/j.pupt.2021.102005_bib36","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.neuropharm.2012.06.025","article-title":"Epimedium flavonoids ameliorate experimental autoimmune encephalomyelitis in rats by modulating neuroinflammatory and neurotrophic responses","volume":"63","author":"Yin","year":"2012","journal-title":"Neuropharmacology"},{"issue":"11","key":"10.1016\/j.pupt.2021.102005_bib38","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.phymed.2014.06.006","article-title":"Pharmacological investigation of a HPLC\/MS standardized three herbal extracts containing formulae (Bu-Shen-Yi-Qi-Tang) on airway inflammation and hypothalamic-pituitary-adrenal axis activity in asthmatic mice","volume":"21","author":"Luo","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.pupt.2021.102005_bib39","article-title":"Animal models of airway sensitization","volume":"15","author":"Pichavant","year":"2007","journal-title":"Curr Protoc Immunol Chapter"},{"issue":"5","key":"10.1016\/j.pupt.2021.102005_bib40","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jaci.2010.01.054","article-title":"In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif","volume":"125","author":"Tachdjian","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jep.2014.03.041","article-title":"BuShenYiQi Formula strengthens Th1 response and suppresses Th2-Th17 responses in RSV-induced asthma exacerbated mice","volume":"154","author":"Wang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.pupt.2021.102005_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pupt.2018.09.008","article-title":"Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction","volume":"53","author":"Sulaiman","year":"2018","journal-title":"Pulm. Pharmacol. Therapeut."},{"issue":"604","key":"10.1016\/j.pupt.2021.102005_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaw8151","article-title":"CD45 functions as a signaling gatekeeper in T cells","volume":"12","author":"Courtney","year":"2019","journal-title":"Sci. Signal."},{"issue":"7","key":"10.1016\/j.pupt.2021.102005_bib44","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/icb.2008.46","article-title":"CD45 glycosylation controls T-cell life and death","volume":"86","author":"Earl","year":"2008","journal-title":"Immunol. Cell Biol."},{"issue":"4","key":"10.1016\/j.pupt.2021.102005_bib45","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4049\/jimmunol.1701310","article-title":"Role of the NF-kappaB family member RelB in regulation of Foxp3(+) regulatory T cells in vivo","volume":"200","author":"Li","year":"2018","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.pupt.2021.102005_bib46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000490895","article-title":"Interleukin 4 leads to sustained phosphorylation of the STAT6 and ERK pathways in the retina and disrupts subcortical visual circuitry in rodents","volume":"25","author":"Goulart","year":"2018","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.pupt.2021.102005_bib47","first-page":"11","article-title":"TEC and MAPK kinase signalling pathways in T helper (TH) cell development, TH2 differentiation and allergic asthma","volume":"12","author":"Kannan","year":"2012","journal-title":"J Clin Cell Immunol Suppl"},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib48","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12906-017-1891-0","article-title":"Effects of the combined extracts of Herba Epimedii and Fructus Ligustrilucidi on airway remodeling in the asthmatic rats with the treatment of budesonide","volume":"17","author":"Tang","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.pupt.2021.102005_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7961231","article-title":"Active ingredients of Epimedii folium and ligustri lucidi fructus balanced GR\/HSP90 to improve the sensitivity of asthmatic rats to budesonide","author":"Tang","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"issue":"10","key":"10.1016\/j.pupt.2021.102005_bib50","first-page":"1497","article-title":"[Experimental study on effect of combination of Epimedii Folium\/Ligustri Lucidi Fructus and dexamethasone on asthmatic rats]","volume":"37","author":"Liu","year":"2012","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"13","key":"10.1016\/j.pupt.2021.102005_bib51","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1080\/14786419.2018.1481840","article-title":"A novel icariin type flavonoid from Epimedium pseudowushanense","volume":"33","author":"Ti","year":"2019","journal-title":"Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.pupt.2021.102005_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23061322","article-title":"Development and validation of a HPLC-MS\/MS method for simultaneous determination of twelve bioactive compounds in epimedium: application to a pharmacokinetic study in rats","volume":"23","author":"Sun","year":"2018","journal-title":"Molecules"},{"issue":"23","key":"10.1016\/j.pupt.2021.102005_bib53","first-page":"4709","article-title":"[Effective components and signaling pathways of Epimedium brevicornumbased on network pharmacology]","volume":"43","author":"Zhang","year":"2018","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"8","key":"10.1016\/j.pupt.2021.102005_bib54","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/thx.2005.052241","article-title":"Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study","volume":"61","author":"Brutsche","year":"2006","journal-title":"Thorax"},{"issue":"15","key":"10.1016\/j.pupt.2021.102005_bib55","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJMoa022363","article-title":"A longitudinal, population-based, cohort study of childhood asthma followed to adulthood","volume":"349","author":"Sears","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.pupt.2021.102005_bib56","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1378\/chest.11-1748","article-title":"A randomized primary care trial of steroid titration against mannitol in persistent asthma STAMINA trial","volume":"141","author":"Lipworth","year":"2012","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.pupt.2021.102005_bib57","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1164\/ajrccm.159.4.9806052","article-title":"Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment","volume":"159","author":"Sont","year":"1999","journal-title":"Am J Resp Crit Care"},{"issue":"2","key":"10.1016\/j.pupt.2021.102005_bib58","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1164\/ajrccm\/136.2.379","article-title":"Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects","volume":"136","author":"Kirby","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"issue":"7","key":"10.1016\/j.pupt.2021.102005_bib59","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/resp.12142","article-title":"Relationship between airway pathophysiology and airway inflammation in older asthmatics","volume":"18","author":"Porsbjerg","year":"2013","journal-title":"Respirology"},{"issue":"22","key":"10.1016\/j.pupt.2021.102005_bib60","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJMoa012705","article-title":"Mast-cell infiltration of airway smooth muscle in asthma","volume":"346","author":"Brightling","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pupt.2021.102005_bib61","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pupt.2016.07.005","article-title":"Molecularly targeted therapies for asthma: current development, challenges and potential clinical translation","volume":"40","author":"Sulaiman","year":"2016","journal-title":"Pulm. Pharmacol. Therapeut."},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib62","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.immuni.2008.05.010","article-title":"Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation","volume":"29","author":"Curotto de Lafaille","year":"2008","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.pupt.2021.102005_bib63","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jaci.2016.06.003","article-title":"Regulatory T cells in allergic diseases","volume":"138","author":"Noval Rivas","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2021.102005_bib64","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12865-017-0220-1","article-title":"Detection of IL-9 producing T cells in the PBMCs of allergic asthmatic patients","volume":"18","author":"Jia","year":"2017","journal-title":"BMC Immunol."},{"key":"10.1016\/j.pupt.2021.102005_bib65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.pupt.2021.102005_bib66","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.4049\/jimmunol.1800042","article-title":"The alternative NF-kappaB pathway in regulatory T cell homeostasis and suppressive function","volume":"200","author":"Grinberg-Bleyer","year":"2018","journal-title":"J. Immunol."},{"issue":"13","key":"10.1016\/j.pupt.2021.102005_bib67","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1073\/pnas.0400885101","article-title":"Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation","volume":"101","author":"Schmidt-Supprian","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.pupt.2021.102005_bib69","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.immuni.2012.03.012","article-title":"NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kappaB signaling","volume":"36","author":"Allen","year":"2012","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.pupt.2021.102005_bib70","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1073\/pnas.96.3.1024","article-title":"T cell antigen receptor-mediated activation of the Ras\/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation","volume":"96","author":"Yamashita","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.pupt.2021.102005_bib71","doi-asserted-by":"crossref","first-page":"968","DOI":"10.4049\/jimmunol.1102840","article-title":"STAT6-dependent regulation of Th9 development","volume":"188","author":"Goswami","year":"2012","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.pupt.2021.102005_bib72","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/eji.201242889","article-title":"ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis","volume":"43","author":"Liu","year":"2013","journal-title":"Eur. J. Immunol."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553921000171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553921000171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:30:36Z","timestamp":1761082236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553921000171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":70,"alternative-id":["S1094553921000171"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2021.102005","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epimedin C modulates the balance between Th9 cells and Treg cells through negative regulation of noncanonical NF-\u03baB pathway and MAPKs activation to inhibit airway inflammation in the ovalbumin\u2013induced murine asthma model","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2021.102005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102005"}}