{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:04:28Z","timestamp":1790888668132,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.pupt.2022.102156","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T10:16:09Z","timestamp":1661422569000},"page":"102156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Pyrroloquinoline quinone (PQQ) improves pulmonary hypertension by regulating mitochondrial and metabolic functions"],"prefix":"10.1016","volume":"76","author":[{"given":"Mohammad","family":"Shafiq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid Rasool","family":"Lone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragya","family":"Bharati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyapriya","family":"Mahapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Nilkanth","family":"Gaikwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaravelu","family":"Jagavelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Hanif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.pupt.2022.102156_bib1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1089\/ars.2018.7705","article-title":"Mitochondrial dysfunction: metabolic drivers of pulmonary hypertension","volume":"31","author":"Suliman","year":"2019","journal-title":"Antioxidants Redox Signal."},{"issue":"5","key":"10.1016\/j.pupt.2022.102156_bib2","doi-asserted-by":"crossref","first-page":"L782","DOI":"10.1152\/ajplung.00331.2017","article-title":"Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both","volume":"314","author":"Marshall","year":"2018","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/CIRCRESAHA.115.301130","article-title":"The metabolic theory of pulmonary arterial hypertension","volume":"115","author":"Paulin","year":"2014","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4103\/2045-8932.109960","article-title":"Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension","volume":"3","author":"Archer","year":"2013","journal-title":"Pulm. Circ."},{"issue":"9","key":"10.1016\/j.pupt.2022.102156_bib5","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1172\/JCI120847","article-title":"Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains","volume":"128","author":"Culley","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/09168451.2015.1062715","article-title":"Recent progress in studies on the health benefits of pyrroloquinoline quinone","volume":"80","author":"Akagawa","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"5","key":"10.1016\/j.pupt.2022.102156_bib7","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/jn\/124.5.744","article-title":"Dietary pyrroloquinoline quinone: growth and immune response in BALB\/c mice","volume":"124","author":"Steinberg","year":"1994","journal-title":"J. Nutr."},{"issue":"12","key":"10.1016\/j.pupt.2022.102156_bib8","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.jnutbio.2013.07.008","article-title":"Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects","volume":"24","author":"Harris","year":"2013","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1074\/jbc.M109.030130","article-title":"Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression","volume":"285","author":"Chowanadisai","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.pupt.2022.102156_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.21037\/cdt-20-129","article-title":"Pyrroloquinoline quinone can prevent chronic heart failure by regulating mitochondrial function","volume":"10","author":"Xu","year":"2020","journal-title":"Cardiovasc. Diagn. Ther."},{"issue":"3","key":"10.1016\/j.pupt.2022.102156_bib11","first-page":"873","article-title":"Pyrroloquinoline quinone attenuates isoproterenol hydrochlorideinduced cardiac hypertrophy in AC16 cells by inhibiting the NFkappaB signaling pathway","volume":"45","author":"Wen","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.pupt.2022.102156_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10557-004-6219-x","article-title":"Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia\/reperfusion","volume":"18","author":"Zhu","year":"2004","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"12","key":"10.1016\/j.pupt.2022.102156_bib13","doi-asserted-by":"crossref","first-page":"e0143600","DOI":"10.1371\/journal.pone.0143600","article-title":"Pyrroloquinoline quinone resists denervation-induced skeletal muscle atrophy by activating PGC-1alpha and integrating mitochondrial electron transport chain complexes","volume":"10","author":"Kuo","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.pupt.2022.102156_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111569","article-title":"Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension","volume":"383","author":"Singh","year":"2019","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.pupt.2022.102156_bib15","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1161\/HYPERTENSIONAHA.120.15229","article-title":"Inhibition of mitogen-activated protein kinase (MAPK)-Activated protein kinase 2 (MK2) is protective in pulmonary hypertension","volume":"77","author":"Shafiq","year":"2021","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.pupt.2022.102156_bib16","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1111\/bph.13495","article-title":"Inhibition of fatty acid synthase is protective in pulmonary hypertension","volume":"173","author":"Singh","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.pupt.2022.102156_bib17","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s12035-018-1272-9","article-title":"AT2R activation prevents microglia pro-inflammatory activation in a NOX-dependent manner: inhibition of PKC activation and p47(phox) phosphorylation by PP2A","volume":"56","author":"Bhat","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.pupt.2022.102156_bib18","first-page":"3301","article-title":"Upregulated miR-17 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation and apoptosis by targeting mitofusin 2","volume":"22","author":"Lu","year":"2016","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"issue":"3","key":"10.1016\/j.pupt.2022.102156_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00109-015-1263-5","article-title":"Mitochondrial dynamics in pulmonary arterial hypertension","volume":"93","author":"Ryan","year":"2015","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.pupt.2022.102156_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.redox.2015.07.016","article-title":"Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells","volume":"6","author":"Rafikov","year":"2015","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.pupt.2022.102156_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","article-title":"HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption","volume":"3","author":"Papandreou","year":"2006","journal-title":"Cell Metabol."},{"issue":"2","key":"10.1016\/j.pupt.2022.102156_bib22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCRESAHA.112.300699","article-title":"Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension","volume":"113","author":"Dromparis","year":"2013","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.pupt.2022.102156_bib23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1165\/rcmb.2012-0361OC","article-title":"Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model","volume":"49","author":"Pak","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib24","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1038\/s41598-018-26962-9","article-title":"PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3beta\/Akt signaling pathway in mouse","volume":"8","author":"Zhou","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib25","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1038\/s41467-018-06376-x","article-title":"Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway","volume":"9","author":"Dai","year":"2018","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.pupt.2022.102156_bib26","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1152\/japplphysiol.00643.2013","article-title":"HIF and pulmonary vascular responses to hypoxia","volume":"116","author":"Shimoda","year":"1985","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.pupt.2022.102156_bib27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00441-016-2539-y","article-title":"Pulmonary vascular remodeling in pulmonary hypertension","volume":"367","author":"Tuder","year":"2017","journal-title":"Cell Tissue Res."},{"issue":"7","key":"10.1016\/j.pupt.2022.102156_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.7150\/jca.9002","article-title":"Pyrroloquinoline quinone induces cancer cell apoptosis via mitochondrial-dependent pathway and down-regulating cellular bcl-2 protein expression","volume":"5","author":"Min","year":"2014","journal-title":"J. Cancer"},{"key":"10.1016\/j.pupt.2022.102156_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis*","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/sj.cdd.4400597","article-title":"Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells","volume":"7","author":"Murphy","year":"2000","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.pupt.2022.102156_bib31","first-page":"1614","article-title":"Apoptotic effect of pyrroloquinoline quinone on chondrosarcoma cells through activation of the mitochondrial caspasedependent and caspaseindependent pathways","volume":"40","author":"Wu","year":"2018","journal-title":"Oncol. Rep."},{"issue":"6","key":"10.1016\/j.pupt.2022.102156_bib32","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1183\/09031936.00046612","article-title":"Pathobiology of pulmonary arterial hypertension and right ventricular failure","volume":"40","author":"Voelkel","year":"2012","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.pupt.2022.102156_bib33","first-page":"243","article-title":"Right heart failure in pulmonary hypertension","volume":"38","author":"Cassady","year":"2020","journal-title":"Cardiol. Clin."},{"issue":"11","key":"10.1016\/j.pupt.2022.102156_bib34","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.peptides.2008.08.003","article-title":"Endothelin-3-dependent pulmonary vasoconstriction in monocrotaline-induced pulmonary arterial hypertension","volume":"29","author":"Sauvageau","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.pupt.2022.102156_bib35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"issue":"11","key":"10.1016\/j.pupt.2022.102156_bib36","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/aps.2014.4","article-title":"Pyrroloquinoline quinone protects mouse brain endothelial cells from high glucose-induced damage in vitro","volume":"35","author":"Wang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"12","key":"10.1016\/j.pupt.2022.102156_bib37","doi-asserted-by":"crossref","first-page":"13617","DOI":"10.1096\/fj.201901123R","article-title":"Adiponectin deficiency induces mitochondrial dysfunction and promotes endothelial activation and pulmonary vascular injury","volume":"33","author":"Shah","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.pupt.2022.102156_bib38","first-page":"37","article-title":"Mitochondrial bioenergetics and pulmonary dysfunction: current progress and future directions","volume":"34","author":"Ten","year":"2020","journal-title":"Paediatr. Respir. Rev."},{"issue":"2","key":"10.1016\/j.pupt.2022.102156_bib39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/jn\/136.2.390","article-title":"Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice","volume":"136","author":"Stites","year":"2006","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.pupt.2022.102156_bib40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/bies.201400188","article-title":"What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research","volume":"37","author":"Hoitzing","year":"2015","journal-title":"Bioessays"},{"issue":"10","key":"10.1016\/j.pupt.2022.102156_bib41","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.bbabio.2012.02.033","article-title":"Bioenergetic role of mitochondrial fusion and fission","volume":"1817","author":"Westermann","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.pupt.2022.102156_bib42","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCRESAHA.111.263848","article-title":"Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension","volume":"110","author":"Marsboom","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.pupt.2022.102156_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neulet.2018.09.031","article-title":"Mitochondrial regulation by pyrroloquinoline quinone prevents rotenone-induced neurotoxicity in Parkinson's disease models","volume":"687","author":"Lu","year":"2018","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.pupt.2022.102156_bib44","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41401-020-0487-2","article-title":"Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson's disease model via AMPK activation","volume":"42","author":"Cheng","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib45","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"146","key":"10.1016\/j.pupt.2022.102156_bib46","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0094-2017","article-title":"Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice","volume":"26","author":"Chan","year":"2017","journal-title":"Eur. Respir. Rev."},{"issue":"413","key":"10.1016\/j.pupt.2022.102156_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4583","article-title":"Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients","volume":"9","author":"Michelakis","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.pupt.2022.102156_bib48","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"Suppl 1","key":"10.1016\/j.pupt.2022.102156_bib49","article-title":"Pulmonary arterial hypertension and insulin resistance","volume":"2","author":"Bradley","year":"2014","journal-title":"J. Mol. Genet. Med."},{"issue":"42","key":"10.1016\/j.pupt.2022.102156_bib50","doi-asserted-by":"crossref","first-page":"72910","DOI":"10.18632\/oncotarget.20582","article-title":"5-HT induces PPAR gamma reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3beta\/beta-catenin pathway","volume":"8","author":"Ke","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.pupt.2022.102156_bib51","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2012.10.055","article-title":"Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A(y) mice","volume":"428","author":"Takada","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","article-title":"Inflammation and insulin resistance","volume":"582","author":"de Luca","year":"2008","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.113.301141","article-title":"Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension","volume":"115","author":"Rabinovitch","year":"2014","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.pupt.2022.102156_bib54","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1161\/CIRCRESAHA.108.182014","article-title":"Interleukin-6 overexpression induces pulmonary hypertension","volume":"104","author":"Steiner","year":"2009","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.pupt.2022.102156_bib55","doi-asserted-by":"crossref","first-page":"e109502","DOI":"10.1371\/journal.pone.0109502","article-title":"Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-kappaB and p38\/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pupt.2022.102156_bib56","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1080\/21655979.2021.1935136","article-title":"Pyrroloquinoline quinone (PQQ) alleviated sepsis-induced acute liver injury, inflammation, oxidative stress and cell apoptosis by downregulating CUL3 expression","volume":"12","author":"Wu","year":"2021","journal-title":"Bioengineered"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553922000475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553922000475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:31:07Z","timestamp":1761082267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553922000475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":56,"alternative-id":["S1094553922000475"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2022.102156","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyrroloquinoline quinone (PQQ) improves pulmonary hypertension by regulating mitochondrial and metabolic functions","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2022.102156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102156"}}