{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:16:22Z","timestamp":1790709382088,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014857","name":"National Natural Science Foundation of China-Guangdong Joint Fund","doi-asserted-by":"publisher","award":["U2004127"],"award-info":[{"award-number":["U2004127"]}],"id":[{"id":"10.13039\/501100014857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.pupt.2022.102173","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T23:21:14Z","timestamp":1666394474000},"page":"102173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a"],"prefix":"10.1016","volume":"77","author":[{"given":"Ya-li","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-jun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo-xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.pupt.2022.102173_bib1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/nutrit\/nuaa005","article-title":"The role of nutrition in asthma prevention and treatment","volume":"78","author":"Alwarith","year":"2020","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.pupt.2022.102173_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.575936","article-title":"Mimicking antigen-driven asthma in rodent models-how close can we get?","volume":"11","author":"Alessandrini","year":"2020","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.pupt.2022.102173_bib3","doi-asserted-by":"crossref","first-page":"L758","DOI":"10.1152\/ajplung.00224.2019","article-title":"Bnip3 regulates airway smooth muscle cell focal adhesion and proliferation","volume":"317","author":"Pan","year":"2019","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.pupt.2022.102173_bib4","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7422.1","article-title":"Airway hyperresponsiveness; smooth muscle as the principal actor","volume":"5","author":"Lauzon","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.pupt.2022.102173_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102259","article-title":"The airway smooth muscle sodium\/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma","author":"Johnson","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pupt.2022.102173_bib6","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3389\/fphys.2019.01337","article-title":"Upregulation of LncRNA Malat1 induced proliferation and migration of airway smooth muscle cells via miR-150-eIF4E\/Akt signaling","volume":"10","author":"Lin","year":"2019","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.pupt.2022.102173_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yexcr.2018.01.042","article-title":"Vasoactive intestinal peptide inhibits airway smooth muscle cell proliferation in a mouse model of asthma via the ERK1\/2 signaling pathway","volume":"364","author":"Wang","year":"2018","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.pupt.2022.102173_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1462","article-title":"Cold-inducible RNA binding protein in cancer and inflammation","volume":"9","author":"Lujan","year":"2018","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"10.1016\/j.pupt.2022.102173_bib9","first-page":"185","volume":"22","author":"Gebauer","year":"2021"},{"issue":"2","key":"10.1016\/j.pupt.2022.102173_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbrc.2019.08.158","article-title":"The RNA-binding protein Mex-3B plays critical roles in the development of steroid-resistant neutrophilic airway inflammation","volume":"519","author":"Yamazumi","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pupt.2022.102173_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molimm.2021.07.016","article-title":"Knockdown of NOVA1 inhibits inflammation and migration of asthmatic airway smooth muscle cells to regulate PTEN\/Akt pathway by targeting PTBP1","volume":"138","author":"Cheng","year":"2021","journal-title":"Mol. Immunol."},{"issue":"12","key":"10.1016\/j.pupt.2022.102173_bib12","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1172\/JCI127949","article-title":"Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity","volume":"129","author":"Katsuyama","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pupt.2022.102173_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cytogfr.2020.10.008","article-title":"The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system","volume":"57","author":"Paz","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1","key":"10.1016\/j.pupt.2022.102173_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13287-022-02986-x","article-title":"Exosomal lncRNA TUG1 derived from human urine-derived stem cells attenuates renal ischemia\/reperfusion injury by interacting with SRSF1 to regulate ASCL4-mediated ferroptosis","volume":"13","author":"Sun","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.pupt.2022.102173_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ebiom.2018.11.007","article-title":"SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance","volume":"38","author":"Sheng","year":"2018","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.pupt.2022.102173_bib16","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1158\/0008-5472.CAN-16-1508","article-title":"Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation","volume":"77","author":"Malakar","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.pupt.2022.102173_bib17","doi-asserted-by":"crossref","first-page":"12043","DOI":"10.2147\/OTT.S267594","article-title":"MIR155HG knockdown inhibited the progression of cervical cancer by binding SRSF1","volume":"13","author":"Shen","year":"2020","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.pupt.2022.102173_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fcell.2020.00495","article-title":"MicroRNA-221 modulates airway remodeling via the PI3K\/AKT pathway in OVA-induced chronic murine asthma","volume":"8","author":"Pan","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.pupt.2022.102173_bib19","first-page":"3040","volume":"24","author":"Li","year":"2020"},{"issue":"9","key":"10.1016\/j.pupt.2022.102173_bib20","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.celrep.2016.07.062","article-title":"The RNA binding protein Mex-3B is required for IL-33 induction in the development of allergic airway inflammation","volume":"16","author":"Yamazumi","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.pupt.2022.102173_bib21","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.omtn.2019.12.033","article-title":"Nanoparticle delivery of anti-inflammatory LNA oligonucleotides prevents airway inflammation in a HDM model of asthma","volume":"19","author":"Ramelli","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.pupt.2022.102173_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.31491\/APT.2020.03.010","article-title":"Highly expressed ribosomal protein L34 predicts poor prognosis in acute myeloid leukemia and could be a potential therapy target","volume":"2","author":"Wang","year":"2020","journal-title":"Aging Pathobiol. Therapeut."},{"key":"10.1016\/j.pupt.2022.102173_bib23","first-page":"425","volume":"133","author":"Hu","year":"2019"},{"issue":"1","key":"10.1016\/j.pupt.2022.102173_bib24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s13046-020-01793-7","article-title":"CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression","volume":"39","author":"Zhang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.pupt.2022.102173_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108772","article-title":"RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a","volume":"114","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.pupt.2022.102173_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ebiom.2018.12.061","article-title":"Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation","volume":"41","author":"Wang","year":"2019","journal-title":"EBioMedicine"},{"issue":"10","key":"10.1016\/j.pupt.2022.102173_bib27","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1167\/iovs.19-26983","article-title":"Induction of fibroblast senescence during mouse corneal wound healing","volume":"60","author":"Wang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.pupt.2022.102173_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.579889","article-title":"Posttranscriptional gene regulatory networks in chronic airway inflammatory diseases: in silico mapping of RNA-binding protein expression in airway epithelium","volume":"11","author":"Ricciardi","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.pupt.2022.102173_bib29","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1038\/s41467-022-32176-5","article-title":"RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R","volume":"13","author":"Badrani","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.pupt.2022.102173_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2119\/molmed.2013.00127","article-title":"Conditional knockout of the RNA-binding protein HuR in CD4\u207a T cells reveals a gene dosage effect on cytokine production","volume":"20","author":"Gubin","year":"2014","journal-title":"Mol. Med."},{"issue":"20","key":"10.1016\/j.pupt.2022.102173_bib31","article-title":"SRSF6 is upregulated in asthmatic horses and involved in the MYH11 SMB expression","volume":"6","author":"Issouf","year":"2018","journal-title":"Phys. Rep."},{"issue":"4","key":"10.1016\/j.pupt.2022.102173_bib32","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1073\/pnas.1312993111","article-title":"Cyclin D2 is a GATA4 cofactor in cardiogenesis","volume":"111","author":"Yamak","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.pupt.2022.102173_bib33","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.bbrc.2020.02.165","article-title":"Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells","volume":"525","author":"Inoue","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pupt.2022.102173_bib34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ebiom.2019.01.032","article-title":"MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression","volume":"40","author":"Huang","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pupt.2022.102173_bib35","first-page":"2717","volume":"8","author":"Ding","year":"2019"},{"issue":"5","key":"10.1016\/j.pupt.2022.102173_bib36","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/carcin\/bgz125","article-title":"Long non-coding RNA JPX correlates with poor prognosis and tumor progression in non-small-cell lung cancer by interacting with miR-145-5p and CCND2","volume":"41","author":"Jin","year":"2020","journal-title":"Carcinogenesis"},{"issue":"1 Pt 1","key":"10.1016\/j.pupt.2022.102173_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jfma.2018.04.013","article-title":"MiR-17-92 cluster and immunity","volume":"118","author":"Kuo","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"issue":"4","key":"10.1016\/j.pupt.2022.102173_bib38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.arbr.2019.09.011","article-title":"Eosinophilic COPD patients display a distinctive serum miRNA profile from asthma and non-eosinophilic COPD","volume":"56","author":"Asensio","year":"2020","journal-title":"Arch. Bronconeumol.(Engl. Ed.)"},{"issue":"2","key":"10.1016\/j.pupt.2022.102173_bib39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.aller.2017.09.015","article-title":"The role of regulatory RNAs (miRNAs) in asthma","volume":"46","author":"Svitich","year":"2018","journal-title":"Allergol. Immunopathol.(Madr)"},{"key":"10.1016\/j.pupt.2022.102173_bib40","first-page":"869","volume":"36","author":"Chen","year":"2020"},{"key":"10.1016\/j.pupt.2022.102173_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.biopha.2018.09.030","article-title":"miR-217 represses TGF-\u03b21-induced airway smooth muscle cell proliferation and migration through targeting ZEB1","volume":"108","author":"Gao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.pupt.2022.102173_bib42","first-page":"569","volume":"17","author":"Cao","year":"2020"},{"key":"10.1016\/j.pupt.2022.102173_bib43","volume":"2020","author":"Xie","year":"2020"},{"issue":"7","key":"10.1016\/j.pupt.2022.102173_bib44","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/cbin.10597","article-title":"Schisandrin B inhibits the proliferation of airway smooth muscle cells via microRNA-135a suppressing the expression of transient receptor potential channel 1","volume":"40","author":"Zhang","year":"2016","journal-title":"Cell Biol. Int."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553922000645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553922000645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:38:41Z","timestamp":1778798321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553922000645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":44,"alternative-id":["S1094553922000645"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2022.102173","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2022.102173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102173"}}